{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:29:48Z","timestamp":1786969788438,"version":"build-2736575974"},"reference-count":244,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/004a2wv92","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"NNational Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21DE033813"],"award-info":[{"award-number":["R21DE033813"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"NNational Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS129998"],"award-info":[{"award-number":["R01NS129998"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"NNational Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21DE032468"],"award-info":[{"award-number":["R21DE032468"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"award":["R21DE033813"],"award-info":[{"award-number":["R21DE033813"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01NS129998"],"award-info":[{"award-number":["R01NS129998"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R21DE032468"],"award-info":[{"award-number":["R21DE032468"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer of the oral cavity, pharynx, larynx and upper airway. HNSCC is subdivided into distinct clinical entities based on the presence or absence of high-risk human papillomavirus (HPV) infection. While HPV-positive HNSCC patients respond better to conventional and targeted therapies than HPV-negative cases, recurrence is more frequent in HPV-negative cases with limited treatment options. Ferroptosis is a form of iron-based programmed cell death caused by excessive lipid peroxide accumulation. Biomarkers of ferroptosis have proven useful for identifying and triggering ferroptosis in models of treatment-resistant cancers. Identifying and understanding ferroptosis biomarker function in HPV-negative HNSCC allows the possibility for more effective treatment strategies. Methods: Literature searches combined with the public online ferroptosis database FerrDB V3 were utilized for the objective identification and classification of established and non-established ferroptosis biomarkers in HPV-negative HNSCC. Additional novel biomarkers were identified based on known roles in HNSCC oncogenesis. Results: A total of 30 ferroptosis biomarkers were identified associated with HPV-negative disease. Biomarkers were grouped according to shared biological functions, with each marker summarized for prognostic and mechanistic roles in HNSCC ferroptosis. Conclusions: The described biomarkers present a means for stratifying tumors for ferroptotic induction, with several offering potential novel methods for overcoming refractory HPV-negative disease. These biomarkers may warrant further investigation into devising future patient-tolerant strategies that selectively activate ferroptosis in HPV-negative HNSCC.<\/jats:p>","DOI":"10.3390\/cancers18142320","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T02:32:08Z","timestamp":1784514728000},"page":"2320","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ferroptosis Biomarkers in HPV-Negative Head and Neck Squamous Cell Carcinoma"],"prefix":"10.3390","volume":"18","author":[{"given":"Sarah M.","family":"Parks","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2405-376X","authenticated-orcid":false,"given":"Werner J.","family":"Geldenhuys","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA"},{"name":"Graduate Program in Cancer Cell Biology, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Weed","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USA"},{"name":"Graduate Program in Cancer Cell Biology, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Barsouk, A., Aluru, J.S., Rawla, P., Saginala, K., and Barsouk, A. (2023). Epidemiology, Risk Factors, and Prevention of Head and Neck Squamous Cell Carcinoma. Med. Sci., 11.","DOI":"10.3390\/medsci11020042"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1056\/NEJMra1715715","article-title":"Head and Neck Cancer","volume":"382","author":"Chow","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1001\/jama.2025.21733","article-title":"Head and Neck Cancer: A Review","volume":"335","author":"Dunn","year":"2026","journal-title":"JAMA"},{"key":"ref_5","first-page":"956","article-title":"Cantonese-style salted fish as a cause of nasopharyngeal carcinoma: Report of a case-control study in Hong Kong","volume":"46","author":"Yu","year":"1986","journal-title":"Cancer Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1158\/1078-0432.CCR-09-0784","article-title":"Human papillomavirus in head and neck cancer: Its role in pathogenesis and clinical implications","volume":"15","author":"Chung","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.6004\/jnccn.2022.0016","article-title":"NCCN Guidelines\u00ae Insights: Head and Neck Cancers, Version 1.2022","volume":"20","author":"Caudell","year":"2022","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1470-2045(10)70017-6","article-title":"HPV-associated head and neck cancer: A virus-related cancer epidemic","volume":"11","author":"Marur","year":"2010","journal-title":"Lancet Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Powell, S.F., Vu, L., Spanos, W.C., and Pyeon, D. (2021). The Key Differences between Human Papillomavirus-Positive and -Negative Head and Neck Cancers: Biological and Clinical Implications. Cancers, 13.","DOI":"10.3390\/cancers13205206"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nature14129","article-title":"Comprehensive genomic characterization of head and neck squamous cell carcinomas","volume":"517","year":"2015","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Anderson, G., Ebadi, M., Vo, K., Novak, J., Govindarajan, A., and Amini, A. (2021). An Updated Review on Head and Neck Cancer Treatment with Radiation Therapy. Cancers, 13.","DOI":"10.3390\/cancers13194912"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1056\/NEJMoa0802656","article-title":"Platinum-based chemotherapy plus cetuximab in head and neck cancer","volume":"359","author":"Vermorken","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMoa1602252","article-title":"Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck","volume":"375","author":"Ferris","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1056\/NEJMoa2415434","article-title":"Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer","volume":"393","author":"Uppaluri","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Gao, W., Xia, Z., Zhou, T., and Dong, Y. (2025). Adverse event profile of five anti head and neck squamous cell carcinoma drugs: A descriptive analysis from WHO-VigiAccess. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1602276"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1158\/1078-0432.CCR-16-0323","article-title":"Subtypes of HPV-Positive Head and Neck Cancers Are Associated with HPV Characteristics, Copy Number Alterations, PIK3CA Mutation, and Pathway Signatures","volume":"22","author":"Zhang","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1158\/0008-5472.CAN-23-3594","article-title":"Integrative Multiomics Analyses Identify Molecular Subtypes of Head and Neck Squamous Cell Carcinoma with Distinct Therapeutic Vulnerabilities","volume":"84","author":"Diao","year":"2024","journal-title":"Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Iftikhar, N., Viswanadhapalli, S., Pratap, U.P., and Vadlamudi, R.K. (2026). Ferroptosis in Breast Cancer: Molecular Insights and Therapeutic Strategies. Front. Biosci. (Landmark Ed.), 31.","DOI":"10.31083\/FBL50950"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1089\/ars.2009.2513","article-title":"Redox control of the cell cycle in health and disease","volume":"11","author":"Sarsour","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/ars.2007.1957","article-title":"Redox regulation of cell survival","volume":"10","author":"Trachootham","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41392-023-01332-8","article-title":"Hypoxic microenvironment in cancer: Molecular mechanisms and therapeutic interventions","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12943-023-01801-2","article-title":"Molecular mechanisms of tumor resistance to radiotherapy","volume":"22","author":"Wu","year":"2023","journal-title":"Mol. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Teng, Y., Gao, L., Makitie, A.A., Florek, E., Czarnywojtek, A., Saba, N.F., and Ferlito, A. (2023). Iron, Ferroptosis, and Head and Neck Cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015127"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"708974","DOI":"10.5402\/2012\/708974","article-title":"Hypoxia in head and neck squamous cell carcinoma","volume":"2012","author":"Li","year":"2012","journal-title":"ISRN Otolaryngol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Lee, J., and Roh, J.-L. (2026). Inducing Ferroptosis to Enhance Radiotherapy in Head and Neck Cancer: Mechanisms, Radiosensitization Strategies, and Normal Tissue Considerations. Cells, 15.","DOI":"10.3390\/cells15090812"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Chen, X., Comish, P.B., Tang, D., and Kang, R. (2021). Characteristics and Biomarkers of Ferroptosis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.637162"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s11033-026-11828-5","article-title":"Role of ferroptosis on immunotherapy in breast cancer","volume":"53","author":"Deng","year":"2026","journal-title":"Mol. Biol. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"108096","DOI":"10.1016\/j.phrs.2026.108096","article-title":"Purinosomes and mitochondria: Dynamic interactomes at the crossroads of metabolism, cell structure, and disease","volume":"224","author":"Mancini","year":"2026","journal-title":"Pharmacol. Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Endale, H.T., Tesfaye, W., and Mengstie, T.A. (2023). ROS induced lipid peroxidation and their role in ferroptosis. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1226044"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Bucarey, J.L., Casas, M., and Espinosa, A. (2026). Mitochondrial Iron Handling and Lipid Peroxidation as Drivers of Ferroptosis. Int. J. Mol. Sci., 27.","DOI":"10.20944\/preprints202602.0439.v1"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1080\/15548627.2023.2218764","article-title":"GPX4 in cell death, autophagy, and disease","volume":"19","author":"Xie","year":"2023","journal-title":"Autophagy"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.molonc.2012.01.010","article-title":"Cancer biomarkers","volume":"6","author":"Henry","year":"2012","journal-title":"Mol. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Qoronfleh, M.W., and Al-Dewik, N. (2025). Cancer Biomarkers: Reflection on Recent Progress, Emerging Innovations, and the Clinical Horizon. Cancers, 17.","DOI":"10.3390\/cancers17182981"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1111\/jcmm.14511","article-title":"Molecular mechanisms of ferroptosis and its role in cancer therapy","volume":"23","author":"Xu","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41419-023-05930-w","article-title":"Ferroptosis as a potential target for cancer therapy","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.cell.2024.02.041","article-title":"Cancer biomarkers: Emerging trends and clinical implications for personalized treatment","volume":"187","author":"Passaro","year":"2024","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.gendis.2020.09.005","article-title":"Ferroptosis: An emerging therapeutic opportunity for cancer","volume":"9","author":"Wang","year":"2022","journal-title":"Genes Dis."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Yang, J., and Gu, Z. (2024). Ferroptosis in head and neck squamous cell carcinoma: From pathogenesis to treatment. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1283465"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"215854","DOI":"10.1016\/j.canlet.2022.215854","article-title":"Induction of ferroptosis in head and neck cancer: A novel bridgehead for fighting cancer resilience","volume":"546","author":"Lee","year":"2022","journal-title":"Cancer Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3892\/br.2024.1839","article-title":"Advances in ferroptosis in head and neck cancer","volume":"21","author":"Wang","year":"2024","journal-title":"Biomed. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Pan, J., Zhang, Y., Zhao, B., Shao, W., and Chen, X. (2025). Current perspectives and trend of ferroptosis in head and neck cancer: A bibliometric analysis. Front. Oral Health, 6.","DOI":"10.3389\/froh.2025.1601962"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3892\/ijmm.2025.5625","article-title":"Ferroptosis and head and neck cancer: Mechanisms and therapeutic perspectives","volume":"56","author":"Kang","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10735-025-10381-y","article-title":"Research progress on ferroptosis in head and neck squamous cell carcinoma","volume":"56","author":"Qiu","year":"2025","journal-title":"J. Mol. Histol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.bbrc.2020.09.134","article-title":"SLC7A11 as a biomarker and therapeutic target in HPV-positive head and neck Squamous Cell Carcinoma","volume":"533","author":"Hemon","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2582906","DOI":"10.1080\/07853890.2025.2582906","article-title":"Metabolic cell deaths in head and neck cancer: Mechanisms, therapeutic potential, and challenges","volume":"57","author":"Wang","year":"2025","journal-title":"Ann. Med."},{"key":"ref_52","first-page":"20180047","article-title":"HPV, hypoxia and radiation response in head and neck cancer","volume":"92","author":"Gottgens","year":"2019","journal-title":"Br. J. Radiol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Wu, I.C., Chen, Y.C., Karmakar, R., Mukundan, A., Gabriel, G., Wang, C.C., and Wang, H.C. (2024). Advancements in Hyperspectral Imaging and Computer-Aided Diagnostic Methods for the Enhanced Detection and Diagnosis of Head and Neck Cancer. Biomedicines, 12.","DOI":"10.3390\/biomedicines12102315"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Halicek, M., Dormer, J.D., Little, J.V., Chen, A.Y., Myers, L., Sumer, B.D., and Fei, B. (2019). Hyperspectral Imaging of Head and Neck Squamous Cell Carcinoma for Cancer Margin Detection in Surgical Specimens from 102 Patients Using Deep Learning. Cancers, 11.","DOI":"10.3390\/cancers11091367"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"D572","DOI":"10.1093\/nar\/gkaf1119","article-title":"FerrDb V3: Expanding the manually curated resource for regulators and disease associations from ferroptosis to regulated cell death","volume":"54","author":"Zhou","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Hu, Z.W., Wen, Y.H., Ma, R.Q., Chen, L., Zeng, X.L., Wen, W.P., and Sun, W. (2021). Ferroptosis Driver SOCS1 and Suppressor FTH1 Independently Correlate with M1 and M2 Macrophage Infiltration in Head and Neck Squamous Cell Carcinoma. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.727762"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/1878-0261.13720","article-title":"Targeting ferroptosis for improved radiotherapy outcomes in HPV-negative head and neck squamous cell carcinoma","volume":"19","author":"Noh","year":"2025","journal-title":"Mol. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Shi, M., Du, J., Shi, J., Huang, Y., Zhao, Y., and Ma, L. (2022). Ferroptosis-related gene ATG5 is a novel prognostic biomarker in nasopharyngeal carcinoma and head and neck squamous cell carcinoma. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.1006535"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Jia, X., Tian, J., Fu, Y., Wang, Y., Yang, Y., Zhang, M., Yang, C., and Liu, Y. (2024). Identification of AURKA as a Biomarker Associated with Cuproptosis and Ferroptosis in HNSCC. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084372"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"102276","DOI":"10.1016\/j.redox.2022.102276","article-title":"Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer","volume":"51","author":"Lee","year":"2022","journal-title":"Redox Biol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Yang, L., Chen, Z., Liu, Y., Wang, X., Li, J., and Ye, Q. (2022). Immunization Combined with Ferroptosis Related Genes to Construct a New Prognostic Model for Head and Neck Squamous Cell Carcinoma. Cancers, 14.","DOI":"10.3390\/cancers14174099"},{"key":"ref_62","first-page":"4829","article-title":"Characterization of ferroptosis driver gene signature in head and neck squamous cell carcinoma (HNSC)","volume":"15","author":"Shaikh","year":"2023","journal-title":"Am. J. Transl. Res."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Griso, A.B., Acero-Riaguas, L., Castelo, B., Cebrian-Carretero, J.L., and Sastre-Perona, A. (2022). Mechanisms of Cisplatin Resistance in HPV Negative Head and Neck Squamous Cell Carcinomas. Cells, 11.","DOI":"10.3390\/cells11030561"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Chen, Z., Cai, H., Ye, W., Wu, J., Liu, J., Xie, Y., Feng, S., Jin, Y., Lv, Y., and Ye, H. (2024). TP63 transcriptionally regulates SLC7A5 to suppress ferroptosis in head and neck squamous cell carcinoma. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1445472"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Cavalieri, S., Nuzzolese, I., Lenoci, D., Lucchetta, M., Ficorilli, M., Orlandi, E., De Cecco, L., and Licitra, L. (2025). LAT1 expression in head and neck cancer: A prognostic biomarker with potential relevance for BNCT. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1678011"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"23745","DOI":"10.1074\/jbc.C700107200","article-title":"The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster","volume":"282","author":"Wiley","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"101592","DOI":"10.1016\/j.tranon.2022.101592","article-title":"The antitumor activity of a novel GCN2 inhibitor in head and neck squamous cell carcinoma cell lines","volume":"27","author":"Lee","year":"2023","journal-title":"Transl. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.redox.2016.12.010","article-title":"Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis","volume":"11","author":"Roh","year":"2017","journal-title":"Redox Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.freeradbiomed.2023.06.011","article-title":"Human papillomavirus-driven repression of NRF2 signalling confers chemo-radio sensitivity and predicts prognosis in head and neck squamous cell carcinoma","volume":"205","author":"Ramesh","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41419-025-07773-z","article-title":"AKR1C3 enhances radioresistance in esophageal adenocarcinoma via inhibiting ferroptosis through suppressing TRIM21-mediated ubiquitination of HSPA5","volume":"16","author":"Ju","year":"2025","journal-title":"Cell Death Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s13402-020-00571-z","article-title":"AKR1C3 is a biomarker and druggable target for oropharyngeal tumors","volume":"44","author":"Ostano","year":"2021","journal-title":"Cell. Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/bab.2710","article-title":"PRKAA2 Promotes Tumor Growth and Inhibits Ferroptosis through SLC7A11\/GSH\/GPX4 Pathway in Non-Small Cell Lung Cancer","volume":"72","author":"Wei","year":"2025","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_73","first-page":"72","article-title":"A prognostic model for human papillomavirus-negative head and neck squamous cell carcinoma based on a novel ferroptosis-related gene signature: Development, validation and elucidation of its relationship with the immune microenvironment","volume":"31","author":"Li","year":"2026","journal-title":"Oncol. Lett."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Hsu, T.N., Huang, C.M., Huang, C.S., Huang, M.S., Yeh, C.T., Chao, T.Y., and Bamodu, O.A. (2019). Targeting FAT1 Inhibits Carcinogenesis, Induces Oxidative Stress and Enhances Cisplatin Sensitivity through Deregulation of LRP5\/WNT2\/GSS Signaling Axis in Oral Squamous Cell Carcinoma. Cancers, 11.","DOI":"10.3390\/cancers11121883"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s13046-022-02461-8","article-title":"The diverse functions of FAT1 in cancer progression: Good, bad, or ugly?","volume":"41","author":"Chen","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1038\/s41388-025-03421-0","article-title":"PAR1 inhibition sensitizes HPV-negative HNSCC cells to ferroptosis through inhibition of the STAT3-mediated regulation of iron and lipid metabolic pathways","volume":"44","author":"Tian","year":"2025","journal-title":"Oncogene"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.7150\/ijbs.61441","article-title":"Multi-omics Analysis of Ferroptosis Regulation Patterns and Characterization of Tumor Microenvironment in Patients with Oral Squamous Cell Carcinoma","volume":"17","author":"Gu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13008-016-0023-4","article-title":"Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways","volume":"11","author":"Taylor","year":"2016","journal-title":"Cell Div."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Gameiro, S.F., Ghasemi, F., Barrett, J.W., Nichols, A.C., and Mymryk, J.S. (2019). High Level Expression of MHC-II in HPV+ Head and Neck Cancers Suggests that Tumor Epithelial Cells Serve an Important Role as Accessory Antigen Presenting Cells. Cancers, 11.","DOI":"10.3390\/cancers11081129"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/jop.13267","article-title":"Caveolin-1 promotes cancer progression via inhibiting ferroptosis in head and neck squamous cell carcinoma","volume":"51","author":"Lu","year":"2022","journal-title":"J. Oral. Pathol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s42003-025-07886-3","article-title":"Protein covariation networks for elucidating ferroptosis inducer mechanisms and potential synergistic drug targets","volume":"8","author":"Kunishige","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.oraloncology.2017.04.016","article-title":"Relevance of chromosomal band 11q13 in oral carcinogenesis: An update of current knowledge","volume":"72","author":"Ayen","year":"2017","journal-title":"Oral. Oncol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"22354","DOI":"10.1002\/cam4.6715","article-title":"TTC7B is a new prognostic biomarker in head and neck squamous cell carcinoma linked to immune infiltration and ferroptosis","volume":"12","author":"He","year":"2023","journal-title":"Cancer Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41419-024-06472-5","article-title":"TRIB3 promotes malignancy of head and neck squamous cell carcinoma via inhibiting ferroptosis","volume":"15","author":"Chen","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Lenoci, D., Serafini, M.S., Lucchetta, M., Cavalieri, S., Brakenhoff, R.H., Hoebers, F., Scheckenbach, K., Poli, T., Licitra, L., and De Cecco, L. (2025). Ferroptosis-Related Gene Signatures: Prognostic Role in HPV-Positive Oropharyngeal Squamous Cell Carcinoma. Cancers, 17.","DOI":"10.3390\/cancers17030530"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3892\/or.2023.8693","article-title":"SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1","volume":"51","author":"Xu","year":"2024","journal-title":"Oncol. Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1021\/bi961830l","article-title":"Dinuclear center of ferritin: Studies of iron binding and oxidation show differences in the two iron sites","volume":"36","author":"Treffry","year":"1997","journal-title":"Biochemistry"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e16493","DOI":"10.7717\/peerj.16493","article-title":"FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma","volume":"11","author":"Liao","year":"2023","journal-title":"PeerJ"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e3669","DOI":"10.1002\/jgm.3669","article-title":"Baicalin induces ferroptosis in oral squamous cell carcinoma by suppressing the activity of FTH1","volume":"26","author":"Wen","year":"2024","journal-title":"J. Gene Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3892\/etm.2022.11449","article-title":"Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: A key therapeutic target and biomarker in head and neck squamous cell carcinoma","volume":"24","author":"Mao","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3892\/ijmm.2023.5248","article-title":"Advances in the study of regulators of ferroptosis in head and neck squamous cell carcinoma","volume":"51","author":"Yang","year":"2023","journal-title":"Int. J. Mol. Med."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Lenarduzzi, M., Hui, A.B., Yue, S., Ito, E., Shi, W., Williams, J., Bruce, J., Sakemura-Nakatsugawa, N., Xu, W., and Schimmer, A. (2013). Hemochromatosis enhances tumor progression via upregulation of intracellular iron in head and neck cancer. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0074075"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1111\/cas.15006","article-title":"Amino acid transporters as emerging therapeutic targets in cancer","volume":"112","author":"Saito","year":"2021","journal-title":"Cancer Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s12276-025-01436-x","article-title":"Transferrin receptors","volume":"57","author":"Guo","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature14601","article-title":"Regulation of mitochondrial morphology and function by stearoylation of TFR1","volume":"525","author":"Senyilmaz","year":"2015","journal-title":"Nature"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/j.celrep.2020.02.049","article-title":"Transferrin Receptor Is a Specific Ferroptosis Marker","volume":"30","author":"Feng","year":"2020","journal-title":"Cell Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41389-025-00595-w","article-title":"Iron and metabolic rewiring in cancer","volume":"15","author":"Ciscar","year":"2026","journal-title":"Oncogenesis"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/BJ20120625","article-title":"TfR1 interacts with the IKK complex and is involved in IKK-NF-kappaB signalling","volume":"449","author":"Kenneth","year":"2013","journal-title":"Biochem. J."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"a041545","DOI":"10.1101\/cshperspect.a041545","article-title":"Iron, Copper, and Selenium: Cancer\u2019s Thing for Redox Bling","volume":"14","author":"Terzi","year":"2024","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Candelaria, P.V., Leoh, L.S., Penichet, M.L., and Daniels-Wells, T.R. (2021). Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Agents. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.607692"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Ye, X., Zhou, X.J., and Zhang, H. (2018). Exploring the Role of Autophagy-Related Gene 5 (ATG5) Yields Important Insights Into Autophagy in Autoimmune\/Autoinflammatory Diseases. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02334"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.3390\/curroncol29050247","article-title":"Immune Checkpoint Inhibitors in Cancer Therapy","volume":"29","author":"Shiravand","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e10308","DOI":"10.7554\/eLife.10308","article-title":"Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis","volume":"4","author":"Mancias","year":"2015","journal-title":"eLife"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e70000","DOI":"10.1002\/adbi.202400832","article-title":"Oncogenic miR-182-5p Targets NCOA4 to Disrupt the NCOA4-FTH1 Axis-Mediated Ferroptosis in Head and Neck Squamous Cell Carcinoma","volume":"9","author":"Wen","year":"2025","journal-title":"Adv. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bbrc.2009.01.136","article-title":"Poly(C)-binding proteins as transcriptional regulators of gene expression","volume":"380","author":"Choi","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"23356","DOI":"10.1038\/s41598-021-02642-z","article-title":"PCBP1 regulates the transcription and alternative splicing of metastasis-related genes and pathways in hepatocellular carcinoma","volume":"11","author":"Huang","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1126\/science.1157643","article-title":"A cytosolic iron chaperone that delivers iron to ferritin","volume":"320","author":"Shi","year":"2008","journal-title":"Science"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e2104666118","DOI":"10.1073\/pnas.2104666118","article-title":"The iron chaperone and nucleic acid-binding activities of poly(rC)-binding protein 1 are separable and independently essential","volume":"118","author":"Patel","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/hep.31328","article-title":"Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver from Lipid Peroxidation and Steatosis","volume":"73","author":"Protchenko","year":"2021","journal-title":"Hepatology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13046-018-0840-1","article-title":"PCBP1 depletion promotes tumorigenesis through attenuation of p27(Kip1) mRNA stability and translation","volume":"37","author":"Shi","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1186\/s12967-022-03552-y","article-title":"The RNA-binding protein PCBP1 represses lung adenocarcinoma progression by stabilizing DKK1 mRNA and subsequently downregulating beta-catenin","volume":"20","author":"Zheng","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ccr.2010.04.028","article-title":"PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase","volume":"18","author":"Wang","year":"2010","journal-title":"Cancer Cell"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.7150\/ijbs.33103","article-title":"PCBP1 inhibits the expression of oncogenic STAT3 isoform by targeting alternative splicing of STAT3 exon 23","volume":"15","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Jyotsana, N., Ta, K.T., and DelGiorno, K.E. (2022). The Role of Cystine\/Glutamate Antiporter SLC7A11\/xCT in the Pathophysiology of Cancer. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.858462"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s40880-017-0255-y","article-title":"Systematic analyses of glutamine and glutamate metabolisms across different cancer types","volume":"36","author":"Tian","year":"2017","journal-title":"Chin. J. Cancer"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12935-021-02366-0","article-title":"Induction and application of ferroptosis in cancer therapy","volume":"22","author":"Nie","year":"2022","journal-title":"Cancer Cell Int."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.canlet.2016.07.035","article-title":"Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer","volume":"381","author":"Roh","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"101952","DOI":"10.1016\/j.molmet.2024.101952","article-title":"Amino acid transporters within the solute carrier superfamily: Underappreciated proteins and novel opportunities for cancer therapy","volume":"84","author":"Hushmandi","year":"2024","journal-title":"Mol. Metab."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Lee, J., Seo, Y., and Roh, J.L. (2025). Emerging Therapeutic Strategies Targeting GPX4-Mediated Ferroptosis in Head and Neck Cancer. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26136452"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"217697","DOI":"10.1016\/j.canlet.2025.217697","article-title":"Glutathione metabolism in ferroptosis and cancer therapy","volume":"621","author":"Xue","year":"2025","journal-title":"Cancer Lett."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and Transferrin Regulate Ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Battaglia, A.M., Chirillo, R., Aversa, I., Sacco, A., Costanzo, F., and Biamonte, F. (2020). Ferroptosis and Cancer: Mitochondria Meet the \u201cIron Maiden\u201d Cell Death. Cells, 9.","DOI":"10.3390\/cells9061505"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e202500969","DOI":"10.1002\/cmdc.202500969","article-title":"Medicinal Chemistry Review of the NEET Protein Family","volume":"21","author":"Geldenhuys","year":"2026","journal-title":"ChemMedChem"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"E252","DOI":"10.1152\/ajpendo.00424.2003","article-title":"Identification of a novel mitochondrial protein (\u201cmitoNEET\u201d) cross-linked specifically by a thiazolidinedione photoprobe","volume":"286","author":"Colca","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1073\/pnas.0701078104","article-title":"MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity","volume":"104","author":"Wiley","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.bbrc.2016.08.034","article-title":"CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation","volume":"478","author":"Yuan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.freeradbiomed.2021.09.003","article-title":"Loss of the redox mitochondrial protein mitoNEET leads to mitochondrial dysfunction in B-cell acute lymphoblastic leukemia","volume":"175","author":"Geldenhuys","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_128","unstructured":"Kent, C., Liang, Z., Vontz, G., Li, C., Ding, H., and Shen, Q. (2026). The Oncogenic Role of MitoNEET in Breast Cancer. Proceedings of the San Antonio Breast Cancer Symposium 2025, San Antonio, TX, USA, 9\u201312 December 2025, ACCR."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e97027","DOI":"10.7554\/eLife.97027","article-title":"Iron-sulfur cluster loss in mitochondrial CISD1 mediates PINK1 loss-of-function phenotypes","volume":"13","author":"Bitar","year":"2024","journal-title":"eLife"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"354","DOI":"10.5483\/BMBRep.2022.55.7.040","article-title":"Inhibition of mitoNEET induces Pink1-Parkin-mediated mitophagy","volume":"55","author":"Lee","year":"2022","journal-title":"BMB Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"101677","DOI":"10.1016\/j.gendis.2025.101677","article-title":"Exploring CISD1 as a multifaceted biomarker in cancer: Implications for diagnosis, prognosis, and immunotherapeutic response","volume":"12","author":"Li","year":"2025","journal-title":"Genes. Dis."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e202200358","DOI":"10.1002\/asia.202200358","article-title":"Highly Conjugated Two-dimensional Covalent Organic Frameworks for Efficient Iodine Uptake","volume":"17","author":"Zhou","year":"2022","journal-title":"Chem. Asian J."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3713929","DOI":"10.1155\/2022\/3713929","article-title":"Relationships of Ferroptosis and Pyroptosis-Related Genes with Clinical Prognosis and Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma","volume":"2022","author":"Yu","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s42003-018-0212-6","article-title":"Golgi stress mediates redox imbalance and ferroptosis in human cells","volume":"1","author":"Alborzinia","year":"2018","journal-title":"Commun. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"E6806","DOI":"10.1073\/pnas.1607152113","article-title":"Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses","volume":"113","author":"Ou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41573-025-01145-0","article-title":"Thirty years of NRF2: Advances and therapeutic challenges","volume":"24","author":"Zhang","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1128\/MCB.24.16.7130-7139.2004","article-title":"Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2","volume":"24","author":"Kobayashi","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.1128\/MCB.23.22.8137-8151.2003","article-title":"Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress","volume":"23","author":"Zhang","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb2021","article-title":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1","volume":"12","author":"Komatsu","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_141","first-page":"41","article-title":"NFE2L2 and ferroptosis resistance in cancer therapy","volume":"7","author":"Tang","year":"2024","journal-title":"Cancer Drug Resist."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41389-024-00536-z","article-title":"NRF2 signaling plays an essential role in cancer progression through the NRF2-GPX2-NOTCH3 axis in head and neck squamous cell carcinoma","volume":"13","author":"Jin","year":"2024","journal-title":"Oncogenesis"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.1158\/1078-0432.CCR-25-0112","article-title":"Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed Antitumor Immunity in Head and Neck Squamous Cell Carcinoma","volume":"31","author":"Patel","year":"2025","journal-title":"Clin. Cancer Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.semcancer.2021.06.003","article-title":"Targeting NRF2 to treat cancer","volume":"76","author":"Sivinski","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Sadu Murari, L.S., Kunkel, S., Shetty, A., Bents, A., Bhandary, A., and Rivera-Mulia, J.C. (2025). p63: A Master Regulator at the Crossroads Between Development, Senescence, Aging, and Cancer. Cells, 14.","DOI":"10.3390\/cells14010043"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/1878-0261.12473","article-title":"DeltaNp63 in squamous cell carcinoma: Defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment","volume":"13","author":"Gatti","year":"2019","journal-title":"Mol. Oncol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1038\/s41388-023-02859-4","article-title":"p63: A crucial player in epithelial stemness regulation","volume":"42","author":"Li","year":"2023","journal-title":"Oncogene"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/carcin\/bgh148","article-title":"p63: Molecular complexity in development and cancer","volume":"25","author":"Westfall","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.humpath.2004.12.003","article-title":"p63 overexpression associates with poor prognosis in head and neck squamous cell carcinoma","volume":"36","author":"Santarelli","year":"2005","journal-title":"Hum. Pathol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ccell.2016.12.001","article-title":"ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis","volume":"31","author":"Saladi","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.1073\/pnas.97.10.5462","article-title":"AIS is an oncogene amplified in squamous cell carcinoma","volume":"97","author":"Hibi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ccr.2005.12.013","article-title":"p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis","volume":"9","author":"Rocco","year":"2006","journal-title":"Cancer Cell"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1158\/1541-7786.MCR-18-1355","article-title":"Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling","volume":"17","author":"Lakshmanachetty","year":"2019","journal-title":"Mol. Cancer Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/s41419-025-07938-w","article-title":"TP63 as a modulator of ferroptosis in TP53 mutations glioblastoma","volume":"16","author":"Cai","year":"2025","journal-title":"Cell Death Dis."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"30","DOI":"10.21037\/cco-2025-aw-151","article-title":"TP63 drives TKI resistance in EGFR-mutant lung cancer via ferroptosis inhibition","volume":"15","author":"Li","year":"2026","journal-title":"Chin. Clin. Oncol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/s41388-025-03277-4","article-title":"Targeting aldehyde dehydrogenase ALDH3A1 increases ferroptosis vulnerability in squamous cancer","volume":"44","author":"Kong","year":"2025","journal-title":"Oncogene"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1210\/er.2018-00089","article-title":"Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes","volume":"40","author":"Penning","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Li, M., Zhang, L., Yu, J., Wang, X., Cheng, L., Ma, Z., Chen, X., Wang, L., and Goh, B.C. (2024). AKR1C3 in carcinomas: From multifaceted roles to therapeutic strategies. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1378292"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/mc.23527","article-title":"AKR1C3 suppresses ferroptosis in hepatocellular carcinoma through regulation of YAP\/SLC7A11 signaling pathway","volume":"62","author":"Chen","year":"2023","journal-title":"Mol. Carcinog."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/01.RES.0000256090.42690.05","article-title":"AMP-activated protein kinase in metabolic control and insulin signaling","volume":"100","author":"Towler","year":"2007","journal-title":"Circ. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1073\/pnas.0308061100","article-title":"The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress","volume":"101","author":"Shaw","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","article-title":"The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"106791","DOI":"10.1016\/j.isci.2023.106791","article-title":"Loss of AMPKalpha2 promotes melanoma tumor growth and brain metastasis","volume":"26","author":"Yuan","year":"2023","journal-title":"iScience"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.21037\/jgo-23-110","article-title":"Anti-ferroptotic PRKAA2 serves as a potential diagnostic and prognostic marker for hepatoblastoma","volume":"14","author":"Xie","year":"2023","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"e24722","DOI":"10.1002\/jcla.24722","article-title":"Exploration of a predictive model based on genes associated with fatty acid metabolism and clinical treatment for head and neck squamous cell carcinoma","volume":"36","author":"Yuan","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"11507","DOI":"10.18632\/oncotarget.3432","article-title":"AMPK-mediated energy homeostasis and associated metabolic effects on cancer cell response and resistance to cetuximab","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0014-4827(02)00098-8","article-title":"Epidermal growth factor receptor: Mechanisms of activation and signalling","volume":"284","author":"Jorissen","year":"2003","journal-title":"Exp. Cell Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"6168","DOI":"10.18632\/oncotarget.27249","article-title":"Differential gene expression analysis of HNSCC tumors deciphered tobacco dependent and independent molecular signatures","volume":"10","author":"Shaikh","year":"2019","journal-title":"Oncotarget"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41419-024-07327-9","article-title":"Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma","volume":"16","author":"Wang","year":"2025","journal-title":"Cell Death Dis."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Liu, S., Yan, S., Zhu, J., Lu, R., Kang, C., Tang, K., Zeng, J., Ding, M., Guo, Z., and Lai, X. (2022). Combination RSL3 Treatment Sensitizes Ferroptosis- and EGFR-Inhibition-Resistant HNSCCs to Cetuximab. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169014"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Jehl, A., Conrad, O., Burgy, M., Foppolo, S., Vauchelles, R., Ronzani, C., Etienne-Selloum, N., Chenard, M.P., Danic, A., and Dourlhes, T. (2023). Blocking EREG\/GPX4 Sensitizes Head and Neck Cancer to Cetuximab through Ferroptosis Induction. Cells, 12.","DOI":"10.3390\/cells12050733"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3892\/or.2024.8739","article-title":"Cetuximab chemotherapy resistance: Insight into the homeostatic evolution of head and neck cancer","volume":"51","author":"Diniz","year":"2024","journal-title":"Oncol. Rep."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"e02313","DOI":"10.7554\/eLife.02313","article-title":"A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype","volume":"3","author":"Serra","year":"2014","journal-title":"eLife"},{"key":"ref_174","first-page":"1182","article-title":"Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells","volume":"10","author":"Ye","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"e20212166","DOI":"10.1084\/jem.20212166","article-title":"Iron out KRAS-driven cancer","volume":"219","author":"Lei","year":"2022","journal-title":"J. Exp. Med."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccell.2026.01.001","article-title":"Emerging landscape of KRAS inhibitors in cancer treatment","volume":"44","author":"Riedl","year":"2026","journal-title":"Cancer Cell"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41417-025-00902-y","article-title":"Regulation of nucleotide excision repair by wild-type HRAS signaling in head and neck cancer","volume":"32","author":"Hoxhallari","year":"2025","journal-title":"Cancer Gene Ther."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"105538","DOI":"10.1016\/j.esmoop.2025.105538","article-title":"The immunologic landscape of HRAS-mutant head and neck squamous-cell carcinoma","volume":"10","author":"Economopoulou","year":"2025","journal-title":"ESMO Open"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41580-018-0015-0","article-title":"The functions and regulation of the PTEN tumour suppressor: New modes and prospects","volume":"19","author":"Lee","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1038\/onc.2008.247","article-title":"The PTEN-PI3K pathway: Of feedbacks and cross-talks","volume":"27","author":"Carracedo","year":"2008","journal-title":"Oncogene"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.oraloncology.2019.02.026","article-title":"PTEN loss is associated with resistance to cetuximab in patients with head and neck squamous cell carcinoma","volume":"91","author":"Eze","year":"2019","journal-title":"Oral Oncol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1593\/neo.121024","article-title":"PTEN deficiency contributes to the development and progression of head and neck cancer","volume":"15","author":"Squarize","year":"2013","journal-title":"Neoplasia"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13045-022-01392-3","article-title":"Targeting cell death pathways for cancer therapy: Recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research","volume":"15","author":"Tong","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1038\/s41416-020-0834-6","article-title":"Emerging role of PTEN loss in evasion of the immune response to tumours","volume":"122","author":"Vidotto","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00018-012-1073-7","article-title":"Aurora A kinase (AURKA) in normal and pathological cell division","volume":"70","author":"Nikonova","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s40364-024-00651-4","article-title":"The significant others of aurora kinase a in cancer: Combination is the key","volume":"12","author":"Nikhil","year":"2024","journal-title":"Biomark. Res."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Fan, X., Ou, Y., Liu, H., Zhan, L., Zhu, X., Cheng, M., Li, Q., Yin, D., and Liao, L. (2021). A Ferroptosis-Related Prognostic Signature Based on Antitumor Immunity and Tumor Protein p53 Mutation Exploration for Guiding Treatment in Patients with Head and Neck Squamous Cell Carcinoma. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.732211"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"e28365","DOI":"10.1016\/j.heliyon.2024.e28365","article-title":"AURKA knockdown inhibits esophageal squamous cell carcinoma progression through ferroptosis","volume":"10","author":"Mi","year":"2024","journal-title":"Heliyon"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Huang, Y., Liu, G., Liang, Z., and Zhang, J. (2025). AURKA Suppresses Ferroptosis via the KEAP1\/NRF2\/HO-1 Axis in EGFR-Mutant Lung Adenocarcinoma. Front. Biosci. (Landmark Ed.), 30.","DOI":"10.31083\/FBL41293"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"103137","DOI":"10.1016\/j.redox.2024.103137","article-title":"Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis","volume":"72","author":"Ye","year":"2024","journal-title":"Redox Biol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3892\/ol.2021.12659","article-title":"Role of FAT1 in health and disease","volume":"21","author":"Peng","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"217089","DOI":"10.1016\/j.canlet.2024.217089","article-title":"A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death","volume":"598","author":"Allevato","year":"2024","journal-title":"Cancer Lett."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"107334","DOI":"10.18632\/oncotarget.21015","article-title":"Protease-activated receptor-1 (PAR-1): A promising molecular target for cancer","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Song, X., Si, Q., Qi, R., Liu, W., Li, M., Guo, M., Wei, L., and Yao, Z. (2021). Indoleamine 2,3-Dioxygenase 1: A Promising Therapeutic Target in Malignant Tumor. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.800630"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3892\/or.2022.8308","article-title":"IFNgamma enhances ferroptosis by increasing JAK-STAT pathway activation to suppress SLCA711 expression in adrenocortical carcinoma","volume":"47","author":"Yu","year":"2022","journal-title":"Oncol. Rep."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.drup.2010.04.001","article-title":"Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches","volume":"13","author":"Lai","year":"2010","journal-title":"Drug Resist. Updates"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Ilangumaran, S., Gui, Y., Shukla, A., and Ramanathan, S. (2024). SOCS1 expression in cancer cells: Potential roles in promoting antitumor immunity. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1362224"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13045-019-0720-y","article-title":"Ferroptosis, a new form of cell death: Opportunities and challenges in cancer","volume":"12","author":"Mou","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"175097","DOI":"10.1016\/j.ejphar.2022.175097","article-title":"Role of TNFSF9 bidirectional signal transduction in antitumor immunotherapy","volume":"928","author":"Wu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.21037\/tcr-23-1791","article-title":"Identification of an immune-related signature as a prognostic classifier for patients with early-stage head and neck squamous cell carcinoma","volume":"13","author":"Wang","year":"2024","journal-title":"Transl. Cancer Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0092-8674(92)90143-Z","article-title":"Caveolin, a protein component of caveolae membrane coats","volume":"68","author":"Rothberg","year":"1992","journal-title":"Cell"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Dalton, C.M., Schlegel, C., and Hunter, C.J. (2023). Caveolin-1: A Review of Intracellular Functions, Tissue-Specific Roles, and Epithelial Tight Junction Regulation. Biology, 12.","DOI":"10.3390\/biology12111402"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/j.1582-4934.2008.00331.x","article-title":"Caveolin-1: An ambiguous partner in cell signalling and cancer","volume":"12","author":"Quest","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.freeradbiomed.2014.04.029","article-title":"Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species","volume":"73","author":"Chen","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"C494","DOI":"10.1152\/ajpcell.00458.2004","article-title":"Caveolin-1 in oncogenic transformation, cancer, and metastasis","volume":"288","author":"Williams","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s10555-008-9160-9","article-title":"Caveolin-1 in tumor progression: The good, the bad and the ugly","volume":"27","author":"Goetz","year":"2008","journal-title":"Cancer Metastasis Rev."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-020-02792-4","article-title":"Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response","volume":"11","author":"Diaz","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1038\/s41417-024-00821-4","article-title":"Caveolin-1 knockout mitigates breast cancer metastasis to the lungs via integrin alpha3 dysregulation in 4T1-induced syngeneic breast cancer model","volume":"31","author":"Singh","year":"2024","journal-title":"Cancer Gene Ther."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/pcan.2009.29","article-title":"The role of caveolin-1 in prostate cancer: Clinical implications","volume":"13","author":"Thompson","year":"2010","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/jcmm.12030","article-title":"Caveolin-1 as a promoter of tumour spreading: When, how, where and why","volume":"17","author":"Senetta","year":"2013","journal-title":"J. Cell. Mol. Med."},{"key":"ref_211","first-page":"521","article-title":"Caveolin-1: An essential modulator of cancer cell radio-and chemoresistance","volume":"1","author":"Hehlgans","year":"2011","journal-title":"Am. J. Cancer Res."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1007\/s12094-024-03724-w","article-title":"Caveolin-1 modulates cisplatin sensitivity in oral squamous cell carcinoma through ferroptosis","volume":"27","author":"Zhang","year":"2025","journal-title":"Clin. Transl. Oncol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"e151982","DOI":"10.1172\/jci.insight.151982","article-title":"Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer","volume":"6","author":"Bouhaddou","year":"2021","journal-title":"JCI Insight"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/sj.bjc.6604735","article-title":"Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma","volume":"99","author":"Zhang","year":"2008","journal-title":"Br. J. Cancer"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/S0960-9822(02)01035-7","article-title":"Interaction of cortactin and N-WASp with Arp2\/3 complex","volume":"12","author":"Weaver","year":"2002","journal-title":"Curr. Biol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/cm.20296","article-title":"Cortactin branches out: Roles in regulating protrusive actin dynamics","volume":"65","author":"Ammer","year":"2008","journal-title":"Cell Motil. Cytoskelet."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/path.2462","article-title":"Distinctive clinicopathological associations of amplification of the cortactin gene at 11q13 in head and neck squamous cell carcinomas","volume":"217","author":"Rodrigo","year":"2009","journal-title":"J. Pathol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4161\/cam.5.2.14773","article-title":"Cortactin: A multifunctional regulator of cellular invasiveness","volume":"5","author":"Kirkbride","year":"2011","journal-title":"Cell Adhes. Migr."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1128\/MCB.23.6.2162-2170.2003","article-title":"Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis","volume":"23","author":"Cao","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.devcel.2007.07.014","article-title":"HDAC6-pack: Cortactin acetylation joins the brew","volume":"13","author":"Luxton","year":"2007","journal-title":"Dev. Cell"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb3271","article-title":"The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane","volume":"18","author":"Baskin","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/jcbfm.2012.24","article-title":"TTC7B emerges as a novel risk factor for ischemic stroke through the convergence of several genome-wide approaches","volume":"32","author":"Krug","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.biochi.2016.02.005","article-title":"Tripping on TRIB3 at the junction of health, metabolic dysfunction and cancer","volume":"124","author":"Mondal","year":"2016","journal-title":"Biochimie"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"109581","DOI":"10.1016\/j.intimp.2022.109581","article-title":"The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer","volume":"114","author":"Arif","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/carcin\/bgae042","article-title":"Diverse functions of Tribbles homolog 3 in cancers and its potential as a therapeutic target","volume":"45","author":"Lei","year":"2024","journal-title":"Carcinogenesis"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"105977","DOI":"10.1016\/j.archoralbio.2024.105977","article-title":"TRIB3 promotes the growth of oral squamous cell carcinoma by regulating JNK\/JUN-mediated aerobic glycolysis","volume":"164","author":"Meng","year":"2024","journal-title":"Arch. Oral Biol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3892\/or.2025.8947","article-title":"SENP1: A perspective from immune cells to disease","volume":"54","author":"Feng","year":"2025","journal-title":"Oncol. Rep."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"17651","DOI":"10.18632\/oncotarget.13283","article-title":"SENP1 regulates PTEN stability to dictate prostate cancer development","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.18632\/aging.102700","article-title":"SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T","volume":"12","author":"Tao","year":"2020","journal-title":"Aging"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"10983","DOI":"10.1073\/pnas.1802932115","article-title":"SUMO protease SENP1 deSUMOylates and stabilizes c-Myc","volume":"115","author":"Sun","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Lin, M., Zhang, M., Yi, B., Chen, J., Wen, S., Chen, R., Chen, T., and Li, Z. (2024). Emerging role of SENP1 in tumorigenesis and cancer therapy. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1354323"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.csbj.2015.03.001","article-title":"Advances in the development of SUMO specific protease (SENP) inhibitors","volume":"13","author":"Kumar","year":"2015","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Krupa, R., and Wozniak, K. (2025). Naturally Derived SENP1 Inhibitors with Anticancer Activity. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262211210"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/s41556-024-01425-8","article-title":"Exploiting ferroptosis vulnerabilities in cancer","volume":"26","author":"Nakamura","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41420-024-02037-9","article-title":"Ferroptosis: A double-edged sword","volume":"10","author":"Wang","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10565-025-10025-7","article-title":"Lipotoxicity, lipid peroxidation and ferroptosis: A dilemma in cancer therapy","volume":"41","author":"Ma","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12943-024-01999-9","article-title":"Ferroptotic therapy in cancer: Benefits, side effects, and risks","volume":"23","author":"Diao","year":"2024","journal-title":"Mol. Cancer"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jacbts.2023.10.009","article-title":"Molecular Mechanisms and Therapeutic Targeting of Ferroptosis in Doxorubicin-Induced Cardiotoxicity","volume":"9","author":"Wu","year":"2024","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.trecan.2024.01.002","article-title":"Adverse effects of ferroptotic therapy: Mechanisms and management","volume":"10","author":"Liu","year":"2024","journal-title":"Trends Cancer"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"27185","DOI":"10.18632\/oncotarget.8448","article-title":"The degree of intratumor mutational heterogeneity varies by primary tumor sub-site","volume":"7","author":"Ledgerwood","year":"2016","journal-title":"Oncotarget"},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Mroz, E.A., Tward, A.D., Hammon, R.J., Ren, Y., and Rocco, J.W. (2015). Intra-tumor genetic heterogeneity and mortality in head and neck cancer: Analysis of data from the Cancer Genome Atlas. PLoS Med., 12.","DOI":"10.1371\/journal.pmed.1001786"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"107208","DOI":"10.1016\/j.oraloncology.2025.107208","article-title":"Evolution of testing for the diagnosis of human papillomavirus (HPV) status in head and neck squamous cell carcinoma: Where from and where to?","volume":"162","author":"Khan","year":"2025","journal-title":"Oral Oncol."},{"key":"ref_243","first-page":"202523","article-title":"Ferroptosis surveillance: Insights from in vivo contexts","volume":"2","author":"Vaughan","year":"2026","journal-title":"Ferroptosis Oxidative Stress"},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Singh, M., Arora, H.L., Naik, R., Joshi, S., Sonawane, K., Sharma, N.K., and Sinha, B.K. (2025). Ferroptosis in Cancer: Mechanism and Therapeutic Potential. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26083852"}],"updated-by":[{"DOI":"10.3390\/cancers18162604","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000}}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/14\/2320\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:20:49Z","timestamp":1786969249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/14\/2320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":244,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["cancers18142320"],"URL":"https:\/\/doi.org\/10.3390\/cancers18142320","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]}}}