{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:37:20Z","timestamp":1785429440411,"version":"3.56.0"},"reference-count":32,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health and Welfare","award":["RS-2025-02223506"],"award-info":[{"award-number":["RS-2025-02223506"]}]},{"award":["RS-2025-02223506"],"award-info":[{"award-number":["RS-2025-02223506"]}],"id":[{"id":"https:\/\/ror.org\/00vxgjw72","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00341570"],"award-info":[{"award-number":["RS-2024-00341570"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RS-2024-00341570"],"award-info":[{"award-number":["RS-2024-00341570"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Korea has undergone rapid epidemiological transitions in cancer incidence over the past two decades. Using a 25-year nationwide dataset (1999\u20132023), we characterize long-term trends for 61 cancer types, examine inter-cancer correlations, and forecast incidence to 2028. Methods: Annual incidence counts, crude rates, and age-standardized incidence rates (ASIRs) stratified by sex were obtained from the Korea Central Cancer Registry (KCCR) via the Korean Statistical Information Service (KOSIS). Annual percent change (APC) was estimated using log-linear regression. Pearson correlation coefficients were computed among cancer-specific ASIRs, with false-discovery-rate (FDR) correction for multiple comparisons. Multiple and hierarchical regression evaluated the statistical association of individual cancer types with the overall cancer rate, and variance inflation factors (VIFs) were used to quantify multicollinearity. Time series forecasting used damped Holt\u2013Winters exponential smoothing; forecast accuracy was assessed with rolling-origin cross-validation (RMSE, MAE, MAPE) and benchmarked against ARIMA. A sensitivity analysis excluding the pandemic years (2020\u20132021) tested the robustness of trend estimates. Five-year prevalence data (2007\u20132023) were analyzed from the KCCR prevalence module. Results: Total cancer incidence increased from 101,854 in 1999 to 288,613 in 2023, a 183% increase. The overall ASIR rose from 402.7 to 522.9 per 100,000 (2020 standard population). The three fastest-growing cancers were thyroid (APC +7.56%, p &lt; 0.001), prostate (+6.98%, p &lt; 0.001), and breast (+5.03%, p &lt; 0.001). Stomach (APC \u22122.20%) and liver (\u22122.90%) cancers showed significant declines. Hierarchical regression showed that adding thyroid, breast, and prostate to lung and stomach increased explained variance from R2 = 0.449 to 0.997; however, high VIF values (up to ~263) indicate substantial multicollinearity and compositional dependence, so these coefficients should not be read as independent causal contributions. Holt\u2013Winters and ARIMA produced comparable accuracy (mean MAPE 4.6% vs. 4.7%). The five-year cancer prevalence pool reached 1,035,107 in 2023. Forecasting projects a total incidence of approximately 319,000 by 2028. Conclusions: Korean cancer epidemiology is undergoing a transition from infection-related cancers toward hormone-sensitive and screening-detectable malignancies. These findings support strategic resource allocation for high-growth cancers while maintaining vigilance over rising pancreatic and other emerging cancers.<\/jats:p>","DOI":"10.3390\/cancers18142341","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:44:02Z","timestamp":1784544242000},"page":"2341","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological Trends, Inter-Cancer Correlations, and Incidence Projections for 61 Cancer Types in Korea, 1999\u20132028: A Nationwide Population-Based Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2428-2677","authenticated-orcid":false,"given":"Hyeran","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Pathology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8701-4282","authenticated-orcid":false,"given":"Minsun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: An overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.4143\/crt.2025.264","article-title":"Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2022","volume":"57","author":"Park","year":"2025","journal-title":"Cancer Res. Treat."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.4143\/crt.2025.263","article-title":"Prediction of cancer incidence and mortality in Korea, 2025","volume":"57","author":"Jung","year":"2025","journal-title":"Cancer Res. Treat."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4143\/crt.2022.128","article-title":"Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2019","volume":"54","author":"Kang","year":"2022","journal-title":"Cancer Res. Treat."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4143\/crt.2024.253","article-title":"Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2021","volume":"56","author":"Park","year":"2024","journal-title":"Cancer Res. Treat."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4143\/crt.2016.089","article-title":"Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2013","volume":"48","author":"Oh","year":"2016","journal-title":"Cancer Res. Treat."},{"key":"ref_10","unstructured":"Korean Statistical Information Service (KOSIS) (2025). Cancer Statistics: 61 Cancer Types by Sex, 1999\u20132023, Statistics Korea. Available online: https:\/\/kosis.kr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4143\/crt.2005.37.6.325","article-title":"Nationwide cancer incidence in Korea, 1999\u20132001; first result using the national cancer incidence database","volume":"37","author":"Shin","year":"2005","journal-title":"Cancer Res. Treat."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4143\/crt.2026.298","article-title":"Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2023","volume":"58","author":"Jung","year":"2026","journal-title":"Cancer Res. Treat."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z","article-title":"Permutation tests for joinpoint regression with applications to cancer rates","volume":"19","author":"Kim","year":"2000","journal-title":"Stat. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2307\/2087176","article-title":"Ecological correlations and the behavior of individuals","volume":"15","author":"Robinson","year":"1950","journal-title":"Am. Sociol. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s11135-006-9018-6","article-title":"A caution regarding rules of thumb for variance inflation factors","volume":"41","year":"2007","journal-title":"Qual. Quant."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ijforecast.2003.09.015","article-title":"Forecasting seasonals and trends by exponentially weighted moving averages","volume":"20","author":"Holt","year":"2004","journal-title":"Int. J. Forecast."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1287\/mnsc.6.3.324","article-title":"Forecasting sales by exponentially weighted moving averages","volume":"6","author":"Winters","year":"1960","journal-title":"Manag. Sci."},{"key":"ref_18","unstructured":"Hyndman, R.J., and Athanasopoulos, G. (2021). Forecasting: Principles and Practice, OTexts. [3rd ed.]. Available online: https:\/\/otexts.com\/fpp3\/."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ijforecast.2006.03.001","article-title":"Another look at measures of forecast accuracy","volume":"22","author":"Hyndman","year":"2006","journal-title":"Int. J. Forecast."},{"key":"ref_20","unstructured":"Box, G.E.P., Jenkins, G.M., Reinsel, G.C., and Ljung, G.M. (2015). Time Series Analysis: Forecasting and Control, Wiley. [5th ed.]."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v027.i03","article-title":"Automatic time series forecasting: The forecast package for R","volume":"27","author":"Hyndman","year":"2008","journal-title":"J. Stat. Softw."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"11380","DOI":"10.1038\/s41598-022-15778-3","article-title":"Impact of COVID-19 on cancer screening in South Korea","volume":"12","author":"Suh","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1056\/NEJMp1409841","article-title":"Korea\u2019s thyroid-cancer \u2018epidemic\u2019\u2014Screening and overdiagnosis","volume":"371","author":"Ahn","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4048\/jbc.2023.26.e27","article-title":"Breast cancer statistics in Korea, 2019","volume":"26","author":"Kang","year":"2023","journal-title":"J. Breast Cancer"},{"key":"ref_25","first-page":"1497","article-title":"Ecological study for refrigerator use, salt, vegetable, and fruit intakes, and gastric cancer","volume":"22","author":"Park","year":"2011","journal-title":"Cancer Causes Control"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"160","DOI":"10.5230\/jgc.2022.22.e21","article-title":"Epidemiology of gastric cancer in Korea: Trends in incidence and survival based on Korea Central Cancer Registry data (1999\u20132019)","volume":"22","author":"Park","year":"2022","journal-title":"J. Gastric Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1053\/j.gastro.2017.01.029","article-title":"Effectiveness of the Korean National Cancer Screening Program in reducing gastric cancer mortality","volume":"152","author":"Jun","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1056\/NEJMp1604412","article-title":"Worldwide thyroid-cancer epidemic? The increasing impact of overdiagnosis","volume":"375","author":"Vaccarella","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14740\/wjon1166","article-title":"Epidemiology of pancreatic cancer: Global trends, etiology and risk factors","volume":"10","author":"Rawla","year":"2019","journal-title":"World J. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4143\/crt.2012.44.1.11","article-title":"Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2009","volume":"44","author":"Jung","year":"2012","journal-title":"Cancer Res. Treat."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Lim, Y.X., Lim, Z.L., Ho, P.J., and Li, J. (2022). Breast cancer in Asia: Incidence, mortality, early detection, mammography programs, and risk-based screening initiatives. Cancers, 14.","DOI":"10.20944\/preprints202208.0105.v1"},{"key":"ref_32","first-page":"524","article-title":"Breast cancer statistics, 2022","volume":"72","author":"Giaquinto","year":"2022","journal-title":"CA Cancer J. Clin."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/14\/2341\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:25:51Z","timestamp":1784694351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/14\/2341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":32,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["cancers18142341"],"URL":"https:\/\/doi.org\/10.3390\/cancers18142341","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]}}}