{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:33:35Z","timestamp":1785407615608,"version":"3.56.0"},"reference-count":49,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention & Research Institute of Texas","doi-asserted-by":"crossref","award":["RP260461"],"award-info":[{"award-number":["RP260461"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention & Research Institute of Texas","doi-asserted-by":"crossref","award":["RP260816"],"award-info":[{"award-number":["RP260816"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"crossref"}]},{"award":["RP260461"],"award-info":[{"award-number":["RP260461"]}],"id":[{"id":"https:\/\/ror.org\/0003xa228","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RP260816"],"award-info":[{"award-number":["RP260816"]}],"id":[{"id":"https:\/\/ror.org\/0003xa228","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","award":["1R01CA283330"],"award-info":[{"award-number":["1R01CA283330"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Introduction:\u00a0Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm that can arise across a wide range of anatomical locations, most commonly within the thoracic cavity, including the pleura. Surgical resection and radiotherapy are often first-line treatments for SFT. However, tumors that are not amenable to these conventional approaches require systemic therapy, for which effective options remain limited. In 2013, the NAB2::STAT6 fusion gene was discovered as the critical oncogenic driver of SFT. Nevertheless, the underlying molecular mechanisms by which the NAB2::STAT6 fusion event drives cancer progression remain largely unknown, primarily due to the lack of proper SFT and control cell models. Aims: To address this challenge, we used the SFT patient-derived cell line, INT-SFT, and performed short hairpin RNA (shRNA)-mediated downregulation to interrogate fusion-associated effects. Results: Phenotypic assays confirmed the oncogenic effects of the NAB2::STAT6 fusion transcript. Next, using transcriptomic and proteomic analyses, we identified genes and proteins regulated by the NAB2::STAT6 fusion and delineated its effects on key signaling pathways. Conclusions: Taken together, our SFT cell models, derived from the same genetic and clinical background but with different expression levels of the fusion transcript, represent a valuable resource for studying etiology and exploring novel therapeutics for SFTs.<\/jats:p>","DOI":"10.3390\/cancers18152385","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:36:13Z","timestamp":1784878573000},"page":"2385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Construction and Characterization of Paired Patient-Derived Cell Models for Solitary Fibrous Tumors (SFTs)"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7605-5330","authenticated-orcid":false,"given":"Farhan","family":"Vahdat Azad","sequence":"first","affiliation":[{"name":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5015-0559","authenticated-orcid":false,"given":"Paulina I.","family":"Trevino","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Kappagantu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maliha","family":"Mehjabin","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Balla","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-7448","authenticated-orcid":false,"given":"Clark A.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Bleris","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA"},{"name":"Department of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA"},{"name":"Center for Systems Biology, University of Texas at Dallas, Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA"},{"name":"Center for Systems Biology, University of Texas at Dallas, Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13000-021-01095-2","article-title":"The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior","volume":"16","author":"Tariq","year":"2021","journal-title":"Diagn. 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