{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:17:28Z","timestamp":1785406648922,"version":"3.56.0"},"reference-count":58,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union\u2019s Horizon TNA-MSCA-DN","doi-asserted-by":"publisher","award":["101169068"],"award-info":[{"award-number":["101169068"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"award":["101169068"],"award-info":[{"award-number":["101169068"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Research, Technology and Space","doi-asserted-by":"crossref","award":["01KD2101A"],"award-info":[{"award-number":["01KD2101A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Research, Technology and Space","doi-asserted-by":"crossref","award":["01KD2104A"],"award-info":[{"award-number":["01KD2104A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]},{"award":["01KD2101A"],"award-info":[{"award-number":["01KD2101A"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"publisher"}]},{"award":["01KD2104A"],"award-info":[{"award-number":["01KD2104A"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Colorectal cancer (CRC) is complicated by cachexia, a wasting syndrome with muscle and fat loss that worsens survival and treatment outcomes. Evidence suggests that the gut microbiome may contribute to CRC cachexia, but its role remains unclear. This systematic review synthesizes evidence to identify microbial signatures linked to cachexia hallmarks in CRC. Methods: The protocol was pre-registered with PROSPERO and followed PRISMA guidelines. PubMed, Web of Science, and Scopus were searched for studies on CRC patients and preclinical models with cachexia. Eligible studies compared microbiota composition between cachectic and non-cachectic groups to identify alterations linked to cachexia progression. Study quality was assessed using the Newcastle\u2013Ottawa Scale and CAMARADES checklist. Results: Of 2456 records, 15 studies met inclusion criteria, including 13 preclinical studies and 2 clinical studies. Study quality was moderate for preclinical studies and high for clinical cohort studies. Murine CRC cachexia models showed reduced alpha diversity and beta diversity shifts. Butyrate-producing taxa were depleted, whereas Enterobacteriaceae and other pathobionts were enriched. Some microbial changes were independent of food intake and linked to inflammation, metabolic dysregulation, and muscle wasting. Clinical evidence was limited to two reports from the same cohort, in which higher pre-surgical abundance of Fusobacterium nucleatum and lower Porphyromonas and Actinomyces spp. were associated with cachexia onset. Conclusions: Current evidence suggests an association between CRC-associated cachexia and gut microbiome alterations, but causality, directionality, and clinical relevance remain uncertain.<\/jats:p>","DOI":"10.3390\/cancers18152387","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:38:41Z","timestamp":1784889521000},"page":"2387","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Association Between Gut Microbiome and Cachexia in Colorectal Cancer: A Systematic Review"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2982-9045","authenticated-orcid":false,"given":"Mariem","family":"Hachani","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology of Early Cancer Detection, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"},{"name":"Medical Faculty Heidelberg, Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5683-6315","authenticated-orcid":false,"given":"Tafirenyika","family":"Gwenzi","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology of Early Cancer Detection, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-4521","authenticated-orcid":false,"given":"Ben","family":"Sch\u00f6ttker","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology of Early Cancer Detection, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Puschhof","sequence":"additional","affiliation":[{"name":"Junior Research Group Epithelium Microbiome Interactions, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Stein-Th\u00f6ringer","sequence":"additional","affiliation":[{"name":"Internal Medicine I, Translational Microbiome Research Group, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Panagiotou","sequence":"additional","affiliation":[{"name":"Microbiome Dynamics, Leibniz Institute for Natural Product Research and Infection Biology\u2014Hans Kn\u00f6ll Institute, 07745 Jena, Germany"},{"name":"Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, 07743 Jena, Germany"},{"name":"Department of Medicine, State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China"},{"name":"Faculty of Biological Sciences, Friedrich Schiller University, 07743 Jena, Germany"},{"name":"Jena University Hospital, Friedrich Schiller University, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-1572","authenticated-orcid":false,"given":"Hermann","family":"Brenner","sequence":"additional","affiliation":[{"name":"Cancer Prevention Graduate School, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8307-3197","authenticated-orcid":false,"given":"Michael","family":"Hoffmeister","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology of Early Cancer Detection, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet"},{"key":"ref_2","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kasprzak, A. (2021). The Role of Tumor Microenvironment Cells in Colorectal Cancer (CRC) Cachexia. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041565"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"van de Haterd, B., Verboven, K., Vandenabeele, F., and Agten, A. (2022). The Role of Skeletal Muscle Mitochondria in Colorectal Cancer Related Cachexia: Friends or Foes?. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314833"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1200\/JCO.20.00611","article-title":"Management of Cancer Cachexia: ASCO Guideline","volume":"38","author":"Roeland","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1080\/01635581.2025.2492126","article-title":"The Prevalence and Prognostic Impact of Cancer Cachexia on Overall Survival in Patients with Gastrointestinal Cancer: A Meta-Analysis","volume":"77","author":"Zhang","year":"2025","journal-title":"Nutr. Cancer"},{"key":"ref_7","first-page":"482","article-title":"Understanding the gut microbiota in cancer cachexia","volume":"26","author":"Rocha","year":"2023","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Roy, S., Alizadeh Bahmani, A.H., Davids, M., Herrema, H., and Nieuwdorp, M. (2025). Modulating the Gut-Muscle Axis: Increasing SCFA-Producing Gut Microbiota Commensals and Decreasing Endotoxin Production to Mitigate Cancer Cachexia. Microorganisms, 13.","DOI":"10.3390\/microorganisms13061356"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1002\/jcsm.12804","article-title":"Gut microbiota and short-chain fatty acid alterations in cachectic cancer patients","volume":"12","author":"Ubachs","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ionescu, V.A., Diaconu, C.C., Gheorghe, G., Mihai, M.M., Diaconu, C.C., Bostan, M., and Bleotu, C. (2025). Gut Microbiota and Colorectal Cancer: A Balance Between Risk and Protection. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26083733"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Vacante, M., Ciuni, R., Basile, F., and Biondi, A. (2020). Gut Microbiota and Colorectal Cancer Development: A Closer Look to the Adenoma-Carcinoma Sequence. Biomedicines, 8.","DOI":"10.3390\/biomedicines8110489"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e155101","DOI":"10.1172\/JCI155101","article-title":"Colorectal cancer: The facts in the case of the microbiota","volume":"132","author":"Clay","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.ccell.2021.08.006","article-title":"Microbiome and cancer","volume":"39","author":"Cullin","year":"2021","journal-title":"Cancer Cell"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Cao, Q., Yang, M., and Chen, M. (2025). Metabolic interactions: How gut microbial metabolites influence colorectal cancer. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1611698"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Tong, Y., and Lou, X. (2025). Interplay between bile acids, gut microbiota, and the tumor immune microenvironment: Mechanistic insights and therapeutic strategies. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1638352"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12263-025-00791-8","article-title":"Gut microbiota in cancer cachexia: A new frontier for research and therapy","volume":"20","author":"Ardis","year":"2025","journal-title":"Genes Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Dong, X., Yang, J., He, L., Fang, H., Wang, L., Zhu, J., Xu, J., Song, K., and Xuan, Z. (2026). The Barrier-Microbiota-Inflammation Axis in Colorectal Cancer: Mechanisms and Emerging Diagnostic & Therapeutic Strategies. Cancers, 18.","DOI":"10.3390\/cancers18040576"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00262-025-04118-9","article-title":"Gut modulation to regulate NF-\u03baB in colorectal and gastric cancer therapy and inflammation","volume":"74","author":"Kearns","year":"2025","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1186\/s40001-025-02734-w","article-title":"NF-\u03baB and apoptosis: Colorectal cancer progression and novel strategies for treatment","volume":"30","author":"Sadati","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_21","first-page":"e54893","article-title":"The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia","volume":"117","author":"Bonetto","year":"2016","journal-title":"J. Vis. Exp."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1002\/jcsm.12449","article-title":"Cancer cachexia induces morphological and inflammatory changes in the intestinal mucosa","volume":"10","author":"Costa","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/01.mcg.0000436437.83015.17","article-title":"Bacterial translocation contributes to cachexia and its possible pathway in patients with colon cancer","volume":"48","author":"Jiang","year":"2014","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Alsholi, D.M., Yacoub, G.S., Rehman, A.U., Ullah, H., Khan, A.I., Deng, T., Siddiqui, N.Z., Alioui, Y., Farooqui, N.A., and Elkharti, M. (2023). Lactobacillus rhamnosus Attenuates Cisplatin-Induced Intestinal Mucositis in Mice via Modulating the Gut Microbiota and Improving Intestinal Inflammation. Pathogens, 12.","DOI":"10.3390\/pathogens12111340"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"12552","DOI":"10.1038\/s41598-017-12644-5","article-title":"Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in Apc(Min\/+) mice","volume":"7","author":"Huang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Wang, J.L., Chen, Y.S., Huang, K.C., Yeh, C.H., Chen, M.C., Wu, L.S., and Chiu, Y.H. (2024). Resistant Starch-Encapsulated Probiotics Attenuate Colorectal Cancer Cachexia and 5-Fluorouracil-Induced Microbial Dysbiosis. Biomedicines, 12.","DOI":"10.3390\/biomedicines12071450"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1111\/cas.15306","article-title":"Water-soluble dietary fiber alleviates cancer-induced muscle wasting through changes in gut microenvironment in mice","volume":"113","author":"Sakakida","year":"2022","journal-title":"Cancer Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"11803","DOI":"10.18632\/oncotarget.7730","article-title":"Beneficial bacteria inhibit cachexia","volume":"7","author":"Varian","year":"2016","journal-title":"Oncotarget"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1038\/ismej.2015.209","article-title":"Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia","volume":"10","author":"Bindels","year":"2016","journal-title":"ISME J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"18224","DOI":"10.18632\/oncotarget.24804","article-title":"Increased gut permeability in cancer cachexia: Mechanisms and clinical relevance","volume":"9","author":"Bindels","year":"2018","journal-title":"Oncotarget"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"12321","DOI":"10.1038\/s41598-018-30569-5","article-title":"Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction","volume":"8","author":"Brossel","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jcsm.12684","article-title":"Multi-compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice","volume":"12","author":"Thibaut","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2449586","DOI":"10.1080\/19490976.2025.2449586","article-title":"The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia","volume":"17","author":"Thibaut","year":"2025","journal-title":"Gut Microbes"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Pekkala, S., Keskitalo, A., Kettunen, E., Lensu, S., Nyk\u00e4nen, N., Kuopio, T., Ritvos, O., Hentil\u00e4, J., Nissinen, T.A., and Hulmi, J.J. (2019). Blocking Activin Receptor Ligands Is Not Sufficient to Rescue Cancer-Associated Gut Microbiota\u2014A Role for Gut Microbial Flagellin in Colorectal Cancer and Cachexia?. Cancers, 11.","DOI":"10.3390\/cancers11111799"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/jcsm.12798","article-title":"Bile acid metabolism dysregulation associates with cancer cachexia: Roles of liver and gut microbiome","volume":"12","author":"Feng","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"106332","DOI":"10.1016\/j.micpath.2023.106332","article-title":"Unraveling the gut microbiota and short-chain fatty acids characteristics and associations in a cancer cachexia mouse model","volume":"183","author":"Liu","year":"2023","journal-title":"Microb. Pathog."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"111001","DOI":"10.1016\/j.intimp.2023.111001","article-title":"The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization","volume":"124","author":"Liu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s41065-025-00541-1","article-title":"Qingxie Fuzheng granules attenuate cancer cachexia by restoring gut microbiota homeostasis and suppressing IL-6\/NF-\u03baB signaling in colorectal adenocarcinoma","volume":"162","author":"Jin","year":"2025","journal-title":"Hereditas"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/bit.28972","article-title":"Engineered Lactobacillus rhamnosus Producing 3-Hydroxybutyrate: A Dual-Action Therapeutic Strategy for Colon Cancer Cachexia","volume":"122","author":"Qiu","year":"2025","journal-title":"Biotechnol. Bioeng."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.21037\/jgo-2025-720","article-title":"Colon cancer cachexia remodels gut microbiota and metabolite profiles in a murine model","volume":"17","author":"Zou","year":"2026","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"109248","DOI":"10.1016\/j.jnutbio.2022.109248","article-title":"\u03b2-Carotene suppresses cancer cachexia by regulating the adipose tissue metabolism and gut microbiota dysregulation","volume":"114","author":"Kim","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e70431","DOI":"10.1002\/cam4.70431","article-title":"Fusobacterium nucleatum Abundance is Associated with Cachexia in Colorectal Cancer Patients: The ColoCare Study","volume":"13","author":"Ilozumba","year":"2024","journal-title":"Cancer Med."},{"key":"ref_43","first-page":"1795","article-title":"Pre-surgery gut microbial diversity and abundance are associated with post-surgery onset of cachexia in colorectal cancer patients: The ColoCare Study","volume":"36","author":"Ilozumba","year":"2025","journal-title":"Cancer Causes Control"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"C310","DOI":"10.1152\/ajpcell.00317.2024","article-title":"Exploring heterogeneity: A dive into preclinical models of cancer cachexia","volume":"327","author":"Morena","year":"2024","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.celrep.2019.07.016","article-title":"Modeling Human Cancer-induced Cachexia","volume":"28","author":"Talbert","year":"2019","journal-title":"Cell Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1093\/ajcn\/nqz029","article-title":"Associations between usual diet and gut microbiota composition: Results from the Milieu Int\u00e9rieur cross-sectional study","volume":"109","author":"Partula","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1042\/BST0390989","article-title":"Old and new findings on lipopolysaccharide-binding protein: A soluble pattern-recognition molecule","volume":"39","author":"Schumann","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1126\/science.aam9949","article-title":"Microbiota-activated PPAR-\u03b3 signaling inhibits dysbiotic Enterobacteriaceae expansion","volume":"357","author":"Byndloss","year":"2017","journal-title":"Science"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/bph.15693","article-title":"Butyrate ameliorates skeletal muscle atrophy in diabetic nephropathy by enhancing gut barrier function and FFA2-mediated PI3K\/Akt\/mTOR signals","volume":"179","author":"Tang","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mib.2018.07.003","article-title":"Low diversity gut microbiota dysbiosis: Drivers, functional implications and recovery","volume":"44","author":"Kriss","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s11274-025-04617-y","article-title":"Multi-omics integration reveals gut Microbiome and Short-chain fatty acid profiles in gastric cancer cachexia patients and their clinical significance","volume":"41","author":"Liu","year":"2025","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Yang, C., You, L., Li, X., Kwok, L.Y., and Chen, Y. (2024). Inflammation, Gut Microbiota, and Metabolomic Shifts in Colorectal Cancer: Insights from Human and Mouse Models. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252011189"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1038\/s44318-025-00542-w","article-title":"Fusobacterium nucleatum interacts with cancer-associated fibroblasts to promote colorectal cancer","volume":"44","author":"Karta","year":"2025","journal-title":"EMBO J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jare.2023.04.002","article-title":"Fusobacterium nucleatum outer membrane vesicles activate autophagy to promote oral cancer metastasis","volume":"56","author":"Chen","year":"2024","journal-title":"J. Adv. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/apt.70252","article-title":"Systematic Review: The Relationship Between the Faecal Microbiome and Colorectal Neoplasia in Shotgun Metagenomic Studies","volume":"62","author":"Manning","year":"2025","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41416-022-01740-7","article-title":"A systematic review of microbial markers for risk prediction of colorectal neoplasia","volume":"126","author":"Yu","year":"2022","journal-title":"Br. J. Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Herlo, L.F., Salcudean, A., Sirli, R., Iurciuc, S., Herlo, A., Nelson-Twakor, A., Alexandrescu, L., and Dumache, R. (2024). Gut Microbiota Signatures in Colorectal Cancer as a Potential Diagnostic Biomarker in the Future: A Systematic Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147937"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1038\/s41396-021-00998-8","article-title":"Distinct composition and metabolic functions of human gut microbiota are associated with cachexia in lung cancer patients","volume":"15","author":"Ni","year":"2021","journal-title":"ISME J."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/15\/2387\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T04:20:18Z","timestamp":1785039618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/15\/2387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":58,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["cancers18152387"],"URL":"https:\/\/doi.org\/10.3390\/cancers18152387","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]}}}