{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:31:42Z","timestamp":1785403902323,"version":"3.56.0"},"reference-count":41,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020046","name":"DKMS Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020046","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03bp30y45","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Hematologic malignancies (HMs) represent a growing global health burden, and HSCT remains a cornerstone of treatment for many HMs. Despite improvements in survival, transplantation-related physical deconditioning is a persistent clinical challenge, and evidence supporting structured inpatient exercise interventions is scarce. Objectives: To evaluate the effects of a self-directed aerobic exercise program on a cycle ergometer in inpatients under isolation precautions related to HSCT. Methods: In this single-center prospective, non-randomized controlled interventional study, 73 patients were enrolled in an intervention group (n = 43) performing daily aerobic exercise on a cycle ergometer, or a control group (n = 30) receiving standard care. Physical performance was assessed at baseline and at discharge using the 6-min walk test (6 MWT), Timed Up and Go test (TUG), and 30-s chair stand test (30 s-CST). Results: Significant group-by-time interactions were observed for the TUG (F(1,71) = 10.35; p = 0.001; \u03b7p2 = 0.13) and the 30 s-CST (F(1,71) = 21.61; p &lt; 0.0001; \u03b7p2 = 0.23). No significant interaction was detected for the 6 MWT (F(1,71) = 2.01; p = 0.16; \u03b7p2 = 0.03), although the decline in walking distance was smaller in the intervention group than in the control group (\u22124.1% vs. \u221210.5%). Post hoc analyses demonstrated significant within-group deterioration only in the control group. Conclusions: Self-directed aerobic exercise during inpatient isolation may mitigate physical deconditioning in HSCT recipients, supporting its integration into routine care.<\/jats:p>","DOI":"10.3390\/cancers18152421","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:55:41Z","timestamp":1785225341000},"page":"2421","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Self-Rehabilitation on Physical Fitness in Adults with Hematological Malignancies (HMs) Undergoing Hematopoietic Stem Cell Transplantation (HSCT)"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6724-1888","authenticated-orcid":false,"given":"Micha\u0142","family":"Chmielewski","sequence":"first","affiliation":[{"name":"Active Recovery, Non-Profit Foundation, 53-019 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-3180","authenticated-orcid":false,"given":"Agnieszka","family":"Szeremet","sequence":"additional","affiliation":[{"name":"Department and Clinic of Hematology, Cellular Therapies and Internal Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6984-2116","authenticated-orcid":false,"given":"Paula","family":"Jab\u0142onowska-Babij","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Nursing and Midwifery, Wroclaw Medical University, 51-618 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-296X","authenticated-orcid":false,"given":"Maciej","family":"Majcherek","sequence":"additional","affiliation":[{"name":"Department and Clinic of Hematology, Cellular Therapies and Internal Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-0182","authenticated-orcid":false,"given":"Anna","family":"Czy\u017c","sequence":"additional","affiliation":[{"name":"Department and Clinic of Hematology, Cellular Therapies and Internal Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-3535","authenticated-orcid":false,"given":"Tomasz","family":"Wr\u00f3bel","sequence":"additional","affiliation":[{"name":"Department and Clinic of Hematology, Cellular Therapies and Internal Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7668-001X","authenticated-orcid":false,"given":"Iwona","family":"Malicka","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40164-025-00684-x","article-title":"Global burden and trends of hematologic malignancies based on Global Cancer Observatory 2022 and Global Burden of Disease 2021","volume":"14","author":"Pan","year":"2025","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"103193","DOI":"10.1016\/j.eclinm.2025.103193","article-title":"Global landscape and trends in lifetime risks of haematologic malignancies in 185 countries: Population-based estimates from GLOBOCAN 2022","volume":"83","author":"Sun","year":"2025","journal-title":"eClinicalMedicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41408-023-00853-3","article-title":"Global burden of hematologic malignancies and evolution patterns over the past 30 years","volume":"13","author":"Zhang","year":"2023","journal-title":"Blood Cancer J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41375-023-01852-w","article-title":"Survival in hematological malignancies in the Nordic countries through a half century with correlation to treatment","volume":"37","author":"Hemminki","year":"2023","journal-title":"Leukemia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41571-023-00754-1","article-title":"Long-term outcomes following CAR T cell therapy: What we know so far","volume":"20","author":"Cappell","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Jarden, M., Lindholm, S.T., Kaldan, G., Gr\u00f8nset, C., Larsen, R.F., Larsen, A.T.S., Engedal, M.S., Mikkelsen, M.K., Nielsen, D., and Vinther, A. (2024). Limited Evidence for the Benefits of Exercise in Older Adults with Hematological Malignancies: A Systematic Review and Meta-Analysis. Cancers, 16.","DOI":"10.3390\/cancers16172962"},{"key":"ref_7","first-page":"7111","article-title":"The effect of exercise and nutrition interventions on physical functioning in patients undergoing haematopoietic stem cell transplantation: A systematic review and meta-analysis","volume":"29","author":"Prins","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_8","first-page":"1160","article-title":"Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: Systematic review and meta-analysis","volume":"33","year":"2025","journal-title":"Support. Care Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41409-025-02524-2","article-title":"The 2023 EBMT report on hematopoietic cell transplantation and cellular therapies. Increased use of allogeneic HCT for myeloid malignancies and of CAR-T at the expense of autologous HCT","volume":"60","author":"Passweg","year":"2025","journal-title":"Bone Marrow Transplant."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/joim.12854","article-title":"Trends in patient outcome over the past two decades following allogeneic stem cell transplantation for acute myeloid leukaemia: An ALWP\/EBMT analysis","volume":"285","author":"Canaani","year":"2018","journal-title":"J. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1158\/1078-0432.CCR-23-3673","article-title":"Improvements in Posttransplant Outcomes Over Two Decades in Older Patients with Acute Myeloid Leukemia in the EBMT ALWP Study","volume":"30","author":"Bazarbachi","year":"2024","journal-title":"Clin. Cancer Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1002\/ajh.27422","article-title":"Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management","volume":"99","author":"Rajkumar","year":"2024","journal-title":"Am. J. Hematol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1182\/blood-2009-06-229369","article-title":"Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: A report from the Bone Marrow Transplant Survivor Study","volume":"116","author":"Sun","year":"2010","journal-title":"Blood"},{"key":"ref_14","first-page":"349","article-title":"International Recommendations for Screening and Preventative Practices for Long-Term Survivors of Transplantation and Cellular Therapy: A 2023 Update","volume":"30","author":"Rotz","year":"2024","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chmielewski, M., Szeremet, A., Stefa\u0144ska, M., Jab\u0142onowska-Babij, P., Majcherek, M., Czy\u017c, A., Wr\u00f3bel, T., and Malicka, I. (2024). Decreased Physical Activity and Endurance Capacity in Patients Qualified for Haematopoietic Stem Cell Transplantation (HSCT). J. Clin. Med., 14.","DOI":"10.3390\/jcm14010186"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/j.bbmt.2019.12.237","article-title":"Prevalence and Biobehavioral Predictors of Early and Long-Term Fatigue Following Hematopoietic Stem Cell Transplantation","volume":"26","author":"Costanzo","year":"2020","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_17","first-page":"200.e1","article-title":"Fatigue in Hematopoietic Cell Transplantation Survivors: Correlates, Care Team Communication, and Patient-Identified Mitigation Strategies","volume":"29","author":"Ullrich","year":"2022","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_18","first-page":"5871","article-title":"Pain, Fatigue, Nausea, and Vomiting as the Predictors of Anxiety in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study","volume":"30","author":"Pasyar","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.hemonc.2018.12.003","article-title":"Physical therapy pathway and protocol for patients undergoing hematopoietic stem cell transplantation","volume":"12","author":"Mohammed","year":"2019","journal-title":"Hematol. Stem Cell Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jaccao.2021.01.008","article-title":"Role of Physical Activity and Cardiac Rehabilitation in Patients Undergoing Hematopoietic Stem Cell Transplantation","volume":"3","author":"Mohananey","year":"2021","journal-title":"JACC CardioOncol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Morales-Rodriguez, E., P\u00e9rez-Bilbao, T., Juan, A.F.S., and Calvo, J.L. (2022). Effects of Exercise Programs on Physical Factors and Safety in Adult Patients with Cancer and Haematopoietic Stem Cell Transplantation: A Systematic Review. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031288"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00108-022-01450-5","article-title":"K\u00f6rperliche Aktivit\u00e4t und Bewegungstherapie in der Onkologie","volume":"64","author":"Zoth","year":"2023","journal-title":"Die Inn. Med."},{"key":"ref_23","first-page":"335","article-title":"Safety and feasibility of exercise interventions in patients with hematological cancer undergoing chemotherapy: A systematic review","volume":"31","author":"Bloch","year":"2023","journal-title":"Support. Care Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Potiaumpai, M., Caru, M., Mineishi, S., Naik, S., Zemel, B.S., and Schmitz, K.H. (2024). IMPROVE-BMT: A Pilot Randomized Controlled Trial of Prehabilitation Exercise for Adult Hematopoietic Stem Cell Transplant Recipients. J. Clin. Med., 13.","DOI":"10.3390\/jcm13072052"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.leukres.2012.05.016","article-title":"A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy","volume":"36","author":"Alibhai","year":"2012","journal-title":"Leuk. Res."},{"key":"ref_26","first-page":"497","article-title":"Exercise capacity prior to major cancer surgery: A cross-sectional observational study of the validity of the 6-minute walk and 30-second sit-to-stand tests","volume":"20","author":"Butson","year":"2024","journal-title":"Asia-Pac. J. Clin. Oncol."},{"key":"ref_27","first-page":"8251","article-title":"Thirty-second sit-to-stand test as an alternative for estimating peak oxygen uptake and 6-min walking distance in women with breast cancer: A cross-sectional study","volume":"30","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0735-1097(00)01054-8","article-title":"Age-predicted maximal heart rate revisited","volume":"37","author":"Tanaka","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/bmj.310.6973.170","article-title":"Multiple significance tests: The Bonferroni method","volume":"310","author":"Bland","year":"1995","journal-title":"BMJ"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"18672","DOI":"10.1038\/s41598-022-21547-z","article-title":"Clinical associations and prognostic implications of 6-minute walk test in rheumatoid arthritis","volume":"12","author":"Ferreira","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.2522\/ptj.20150376","article-title":"Use of Six-Minute Walk Test to Measure Functional Capacity After Liver Transplantation","volume":"96","author":"VanWagner","year":"2016","journal-title":"Phys. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1249\/MSS.0000000000002474","article-title":"Multidirectional Walking in Hematopoietic Stem Cell Transplant Patients","volume":"53","author":"Potiaumpai","year":"2020","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_33","first-page":"100","article-title":"Effect of Aerobic Exercise on Functional Capacity and Interleukin6 Level Post Allogeneic Hematopoietic Stem Cell Transplantation: A Ran-domized Controlled Trial","volume":"22","author":"Borham","year":"2022","journal-title":"Fizjoterapia Pol."},{"key":"ref_34","first-page":"S263","article-title":"Cardiac Rehabilitation in Patients With Lymphoma Undergoing Autologous Hematopoietic Stem Cell Transplantation: A Cardio-oncology Pilot Project","volume":"34","author":"Rothe","year":"2018","journal-title":"Can. J. Cardiol."},{"key":"ref_35","first-page":"1046","article-title":"Exercise for physical fitness, fatigue and quality of life of patients undergoing hematopoietic stem cell transplantation: A meta-analysis of randomized controlled trials","volume":"48","author":"Liang","year":"2018","journal-title":"Ultrasound Med. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"pzab130","DOI":"10.1093\/ptj\/pzab130","article-title":"People With Hematological Malignancies Treated With Bone Marrow Transplantation Have Improved Function, Quality of Life, and Fatigue Following Exercise Intervention: A Systematic Review and Meta-Analysis","volume":"101","author":"Abo","year":"2021","journal-title":"Phys. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.apmr.2014.02.016","article-title":"Health-related physical fitness measures: Reference values and reference equations for use in clinical practice","volume":"95","author":"Tveter","year":"2014","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/2150131916659282","article-title":"Timed Up and Go (TUG) Test: Normative reference values for ages 20 to 59 years and relationships with physical and mental health risk factors","volume":"8","author":"Kear","year":"2017","journal-title":"J. Prim. Care Community Health"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.gaitpost.2015.07.011","article-title":"Balance function in patients who had undergone allogeneic hematopoietic stem cell transplantation","volume":"42","author":"Morishita","year":"2015","journal-title":"Gait Posture"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1743-0003-10-86","article-title":"An evaluation of the 30-s chair stand test in older adults: Frailty detection based on kinematic parameters from a single inertial unit","volume":"10","author":"Millor","year":"2013","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/NCC.0b013e3181fb3686","article-title":"Strength Training Following Hematopoietic Stem Cell Transplantation","volume":"34","author":"Hacker","year":"2011","journal-title":"Cancer Nurs."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/15\/2421\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:24:44Z","timestamp":1785385484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/15\/2421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":41,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["cancers18152421"],"URL":"https:\/\/doi.org\/10.3390\/cancers18152421","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}