{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:46:42Z","timestamp":1785833202066,"version":"3.56.0"},"reference-count":114,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Skull base plasmacytomas are rare plasma cell neoplasms arising from the clivus, sphenoid bone, and petrous apex, presenting with cranial neuropathies and bearing a high risk of progression to multiple myeloma. Optimal management remains poorly defined due to their rarity. Objective: The objectives of this study are to comprehensively characterize the clinical presentation, management strategies, and outcomes of skull base plasmacytomas and identify evolving trends in the literature. Methods: A systematic search of PubMed, EMBASE, Web of Science, and Cochrane databases was conducted, yielding 92 studies (18 case series and 74 case reports) encompassing 118 patients. Data on the demographics, symptoms, imaging, histopathology, treatment, and outcomes were extracted and analyzed. Results: The median patient age was 56 years; visual disturbances (66.1%) and headache (54.2%) were the most common presenting symptoms. The middle and posterior cranial fossae were most frequently involved, and cranial nerve VI was most affected (65.7%). Surgical resection was performed in 63.6% of cases with a gross total resection in 36%. At a median follow-up of 12 months (calculated across the entire cohort of 118 patients, including the 29 who presented with a prior diagnosis of multiple myeloma), 81.4% were alive, with symptom resolution at 38.1% or improvement at 26.2%. Recurrence occurred in 19.4% of patients, and multiple myeloma developed in 25.8% of patients without a prior diagnosis. Multiple myeloma status was the only independent predictor of survival on multivariate analysis (OR = 10.14, 95% CI: 1.63\u201363.04, p = 0.013). Conclusions: Skull base plasmacytomas show consistent clinical patterns but variable management strategies. Surgery is increasingly utilized; yet, its survival benefit remains unclear. Prospective multicenter studies with standardized outcome reporting and molecular profiling are needed to optimize individualized care.<\/jats:p>","DOI":"10.3390\/cancers18152495","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:02:19Z","timestamp":1785830539000},"page":"2495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Skull-Base Plasmacytomas: A Systematic Review on Therapeutic Trends"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5943-0828","authenticated-orcid":false,"given":"Francisco","family":"Call-Orellana","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-7022","authenticated-orcid":false,"given":"Kishore","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"College of Medicine, Texas A&M Health Science Center, Houston, TX 77807, USA"},{"name":"Department of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3173-7361","authenticated-orcid":false,"given":"Hanyu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Houpt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9964-1149","authenticated-orcid":false,"given":"Tushar Kanti","family":"Bhadra","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, National Institute of Cardiovascular Diseases, Dhaka 1207, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3846-6557","authenticated-orcid":false,"given":"Georgios","family":"Toumbas","sequence":"additional","affiliation":[{"name":"Clinical School of Medicine, University of Cambridge, Cambridge CB2 0SP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beste","family":"G\u00fclsuna","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Zuccato","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayiotis","family":"Pelargos","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Basit","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4234-340X","authenticated-orcid":false,"given":"Hakeem J.","family":"Shakir","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Siyag, A., Soni, T.P., Gupta, A.K., Sharma, L.M., Jakhotia, N., and Sharma, S. (2018). Plasmacytoma of the Skull-base: A Rare Tumor. Cureus, 10.","DOI":"10.7759\/cureus.2073"},{"key":"ref_2","first-page":"61","article-title":"Plasmacytoma of the Skull Base: A Meta-Analysis","volume":"77","author":"Amit","year":"2016","journal-title":"J. Neurol. Surg. Part B Skull Base"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1016\/j.radcr.2023.08.027","article-title":"Solitary plasmacytoma of the skull base: A case report and literature review","volume":"18","author":"Mansouri","year":"2023","journal-title":"Radiol. Case Rep."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Elsabah, H., Ghasoub, R., Soliman, D.S., Ibrahim, F., Aldapt, M.B., Taha, R.Y., Al Azawi, S., Mudawi, D., Moustafa, A., and Elomri, H. (2024). Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes. Cancer Rep., 7.","DOI":"10.1002\/cnr2.2106"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11060-019-03089-z","article-title":"Clinical features, radiological profiles, and surgical outcomes of primary intracranial solitary plasmacytomas: A report of 17 cases and a pooled analysis of individual patient data","volume":"142","author":"Ma","year":"2019","journal-title":"J. Neurooncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1055\/s-2002-31570-1","article-title":"Plasma Cell Tumors of the Skull Base: Four Case Reports and Literature Review","volume":"12","author":"Wein","year":"2002","journal-title":"Skull Base"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/s41588-024-01853-0","article-title":"Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes","volume":"56","author":"Skerget","year":"2024","journal-title":"Nat. Genet."},{"key":"ref_9","unstructured":"OCEBM Levels of Evidence Working Group (2011). The Oxford 2011 Levels of Evidence, Oxford Centre for Evidence-Based Medicine. Available online: https:\/\/www.cebm.ox.ac.uk\/resources\/levels-of-evidence\/ocebm-levels-of-evidence."},{"key":"ref_10","unstructured":"Aromataris, E., and Munn, Z. (2017). Chapter 7: Systematic reviews of etiology and risk. Joanna Briggs Institute Reviewer\u2019s Manual, The Joanna Briggs Institute."},{"key":"ref_11","first-page":"2127","article-title":"Methodological quality of case series studies: An introduction to the JBI critical appraisal tool","volume":"18","author":"Munn","year":"2020","journal-title":"JBI Evid. Synth."},{"key":"ref_12","first-page":"259","article-title":"The Multiple Oral Presentations of Multiple Myeloma","volume":"22","author":"Cardoso","year":"2014","journal-title":"Support. Care Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.25259\/SNI_812_2021","article-title":"Solitary bone plasmacytoma as posterior fossa cranial neoplasia, presentation of two clinical cases","volume":"13","author":"Andaluz","year":"2022","journal-title":"Surg. Neurol. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e978","DOI":"10.1016\/j.wneu.2018.10.183","article-title":"Differential Diagnosis and Treatment Modality of Parasellar Plasmacytoma: Clinical Series and Literature Review","volume":"122","author":"Jin","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11102-017-0799-5","article-title":"Sellar and clival plasmacytomas: Case series of 5 patients with systematic review of 65 published cases","volume":"20","author":"Lee","year":"2017","journal-title":"Pituitary"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5005\/jp-journals-10003-1134","article-title":"Extramedullary Plasmacytoma of Head and Neck Region: Report of Six Cases with Different Localizations","volume":"5","author":"Midilli","year":"2013","journal-title":"Int. J. Otorhinolaryngol. Clin."},{"key":"ref_17","first-page":"171","article-title":"Plasma cell tumor of the clivus: Report of two cases","volume":"80","year":"2012","journal-title":"Cir. Cir."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1743-7563.2010.01327.x","article-title":"Cranial nerve palsy in multiple myeloma and solitary plasmacytoma","volume":"6","author":"Kashyap","year":"2010","journal-title":"Asia-Pac. J. Clin. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1200\/JCO.2005.06.011","article-title":"Plasma Cell Problems","volume":"23","author":"Duet","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.surneu.2005.02.014","article-title":"Plasma cell tumors of the skull","volume":"64","author":"Singh","year":"2005","journal-title":"Surg. Neurol."},{"key":"ref_21","first-page":"365","article-title":"Metastatic lesions involving the sella: Report of three cases and review of the literature","volume":"52","author":"Weilbaecher","year":"2004","journal-title":"Neurol. India"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF02482189","article-title":"Plasma cell myeloma of the skull base: Report of two cases","volume":"21","author":"Higurashi","year":"2004","journal-title":"Brain Tumor Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00041327-200312000-00006","article-title":"Solitary Intracranial Extra-osseous Plasmacytoma Presenting with Ophthalmic Signs","volume":"23","author":"Brannan","year":"2003","journal-title":"J. Neuroophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s003300050192","article-title":"Solitary plasmacytomas of the occipital bone: A report of two cases","volume":"7","author":"Okamoto","year":"1997","journal-title":"Eur. Radiol."},{"key":"ref_25","first-page":"174","article-title":"Solitary intracranial plasmacytoma of the skull base","volume":"31","author":"Prasad","year":"1994","journal-title":"Indian. J. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1177\/019459989310900517","article-title":"Extramedullary plasmacytomas of the head and neck","volume":"109","author":"Wax","year":"1993","journal-title":"Otolaryngol. Neck Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1227\/00006123-199112000-00017","article-title":"Plasmacytoma of the Skull: Case Reports","volume":"29","author":"Branca","year":"1991","journal-title":"Neurosurgery"},{"key":"ref_28","first-page":"1039","article-title":"Association between Intracranial Plasmacytoma and Multiple Myeloma: Clinicopathological Outcome Study","volume":"49","author":"Schwartz","year":"2001","journal-title":"Neurosurgery"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3171\/jns.1995.83.2.0218","article-title":"Management of intracranial plasmacytoma","volume":"83","author":"Bindal","year":"1995","journal-title":"J. Neurosurg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11102-006-8281-9","article-title":"Intrasellar plasmacytoma presenting as a non-functional invasive pituitary macro-adenoma: Case report & literature review","volume":"9","author":"Sinnott","year":"2006","journal-title":"Pituitary"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Sevindik, B., Uysal, E., Ugras, S., Sevindik, B., Uysal, E., and Ugras, S. (2024). A Rare Tumor Causing Optic and Oculomotor Nerve Compression: Clivus Plasmacytoma Case Report. Cureus, 16.","DOI":"10.7759\/cureus.62447"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.25259\/SNI_915_2023","article-title":"Combined endoscopic transorbital and transnasal approach for the management of a solitary plasmacytoma of the sphenoid bone: A case report and literature review","volume":"15","author":"Olivas","year":"2024","journal-title":"Surg. Neurol. Int."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Shamas, T., Reynolds, C.D., Garcia, R.R., Doescher, R., Fuchs, D., and Rogers, S.N. (2024). Markedly T2-Hypointense Clival Plasmacytoma With Light Chain Deposition Disease: A Case Report. Cureus, 16.","DOI":"10.7759\/cureus.76289"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.25259\/SNI_964_2023","article-title":"Multiple myeloma extramedullary relapse at the sellar and suprasellar region after autologous stem cell transplantation","volume":"15","year":"2024","journal-title":"Surg. Neurol. Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.4102\/sajr.v28i1.2883","article-title":"Multiple myeloma in a young female presenting as an aggressive skull-base tumour","volume":"28","author":"Lesar","year":"2024","journal-title":"S. Afr. J. Radiol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Huang, T.R., Lin, C.S., and Chen, H.C. (2024). Solitary Bone Plasmacytoma of the Skull Base With an Unusual Presentation. Ear Nose Throat J., 01455613241249039.","DOI":"10.1177\/01455613241249039"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"rjae199","DOI":"10.1093\/jscr\/rjae199","article-title":"Sphenoid plasmacytoma as initial presentation of multiple myeloma\u2014Case report","volume":"2024","author":"Chadli","year":"2024","journal-title":"J. Surg. Case Rep."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Shah, C.P., Chamlagain, R., Shah, S., Paudel, S., Sah, S.K., Koirala, B., Pandit, K., Sitaula, S., and Shrestha, A. (2023). Multiple myeloma with plasmacytoma of the clivus bone presenting with multiple cranial nerve III, IV, and VI palsy: A diagnostic dilemma. Clin. Case Rep., 11.","DOI":"10.1002\/ccr3.6958"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Bin Waqar, S.H., Rehan, A., Salahi, N., Zhonghua, L., and McFarlane, I. (2022). An Exceptional Case of Diplopia and Ptosis: Extramedullary Plasmacytoma of the Clivus With Multiple Myeloma. Cureus, 14.","DOI":"10.7759\/cureus.23219"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Silverman, R.F., Hanson, L., Salahi, N., Li, Z., Boruk, M., and Hodgson, N.M. (2022). Case Report: Cavernous Sinus Syndrome as the Initial Presentation of Multiple Myeloma. Front. Ophthalmol., 2.","DOI":"10.3389\/fopht.2022.849343"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Khilji, H., Silver, C., Morrar, D., Chhabra, A.M., Mandel, S., Langer, D.J., Shani, D., and Ellis, J.A. (2022). Complete Resolution of Skull Base Solitary Plasmacytoma Using Proton-Beam Radiotherapy: A Case Report. Cureus, 14.","DOI":"10.7759\/cureus.23130"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Sharifi, S., and Asadi, M. (2022). Extramedullary plasmacytoma of the sphenoid sinus presenting with visual loss: A case report. Clin. Case Rep., 10.","DOI":"10.1002\/ccr3.5758"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s41984-022-00144-2","article-title":"Proptosis secondary to a solitary plasmacytoma of the sphenoid bone: A case report on a rare skull base tumour","volume":"37","author":"Knight","year":"2022","journal-title":"Egypt. J. Neurosurg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1308\/rcsann.2020.0088","article-title":"A rare cause of diplopia: Solitary extramedullary plasmacytoma of the skull base","volume":"103","author":"Bonduelle","year":"2021","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1097\/WNO.0000000000000939","article-title":"Nonsecretory Recurrence of Multiple Myeloma Presenting as Sixth Nerve Palsy Secondary to Clival Plasmacytoma","volume":"41","author":"Kaufman","year":"2021","journal-title":"J. Neuroophthalmol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"0300060520914817","DOI":"10.1177\/0300060520914817","article-title":"Solitary plasmacytoma of the occipital bone: A case report","volume":"48","author":"Wang","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"ref_47","first-page":"94","article-title":"Solitary Skull Base Plasmacytoma with Sella Turcica Extension","volume":"13","author":"Aoi","year":"2018","journal-title":"Int. J. Gerontol."},{"key":"ref_48","first-page":"358","article-title":"Sphenoidal Plasmacytoma Associated with Multiple Myeloma Mimicking Meningeal Tumor in a Geriatric Patient","volume":"13","author":"Pan","year":"2019","journal-title":"Int. J. Gerontol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ibekwe, E., Horsley, N.B., Jiang, L., Achenjang, N.-S., Anudu, A., Akhtar, Z., Chornenka, K.G., Monohan, G.P., and Chornenkyy, Y.G. (2018). Abducens Nerve Palsy as Initial Presentation of Multiple Myeloma and Intracranial Plasmacytoma. J. Clin. Med., 7.","DOI":"10.3390\/jcm7090253"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Wu, P.W., Lee, T.J., Chen, J.R., and Huang, C.C. (2017). An unusual presentation of multiple myeloma with unilateral sudden vision loss: A case report. Medicine, 96.","DOI":"10.1097\/MD.0000000000007277"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"573","DOI":"10.4103\/1793-5482.148788","article-title":"Plasmacytoma of the clivus","volume":"12","author":"Amita","year":"2017","journal-title":"Asian J. Neurosurg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4103\/1793-5482.144193","article-title":"Solitary plasmacytoma of temporal bone: A rare case report","volume":"12","author":"Kumar","year":"2017","journal-title":"Asian J. Neurosurg."},{"key":"ref_53","first-page":"57","article-title":"Multiple Myeloma Revealed by a Sphenoid Plasmocytoma: Case Report and Literature Review","volume":"3","author":"Kadiri","year":"2016","journal-title":"Integr. J. Med. Sci."},{"key":"ref_54","first-page":"160031","article-title":"The solitary sellar plasmacytoma: A diagnostic challenge","volume":"2016","author":"Soejbjerg","year":"2016","journal-title":"Endocrinol. Diabetes Metab. Case Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1055\/s-0035-1554930","article-title":"Plasmacytoma of the Clivus Presenting as Bilateral Sixth Nerve Palsy","volume":"76","author":"Kalwani","year":"2015","journal-title":"J. Neurol. Surg. Rep."},{"key":"ref_56","first-page":"272","article-title":"Cyberknife radiosurgery for cranial plasma cell tumor","volume":"24","author":"Alafaci","year":"2014","journal-title":"Turk. Neurosurg."},{"key":"ref_57","first-page":"526","article-title":"Gradenigo\u2019s syndrome as first presentation of solitary osseous plasmacytoma of the petrous apex","volume":"17","author":"Khalatbari","year":"2014","journal-title":"Arch. Iran. Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Jiang, C.Z., Lin, Q.S., Wu, X.Y., Wang, C.Y., and Kang, D.Z. (2014). Sellar Solitary Plasmacytoma Progressing to Multiple Myeloma: A Case Report and Literature Review. Medicine, 93.","DOI":"10.1097\/MD.0000000000000058"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jcms.2012.06.006","article-title":"A case of extramedullary plasmacytoma in the sphenoid sinus with unilateral loss of vision","volume":"41","author":"Tarkan","year":"2013","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jocn.2011.07.009","article-title":"Intrasellar plasmacytoma: An illustrative case and literature review","volume":"19","author":"Khan","year":"2012","journal-title":"J. Clin. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"232","DOI":"10.7156\/najms.2012.054232","article-title":"Solitary Intracranial Plasmacytoma Located in the Clivus: A Diagnostic and Theraputic Challenge","volume":"5","author":"Liu","year":"2012","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1177\/147323001003800535","article-title":"Solitary Intracranial Plasmacytoma Located in the Spheno-Clival Region Mimicking Chordoma: A Case Report","volume":"38","author":"Liu","year":"2010","journal-title":"J. Int. Med. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"E505","DOI":"10.1227\/01.NEU.0000371985.32844.B7","article-title":"Immunoglobulin D Multiple Myeloma Involving the Sella Manifesting as Oculomotor Palsy: Case Report","volume":"67","author":"Fukai","year":"2010","journal-title":"Neurosurgery"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3340\/jkns.2009.46.2.156","article-title":"Endoscopic Endonasal Transsphenoidal Resection of Solitary Extramedullary Plasmacytoma in the Sphenoid Sinus with Destruction of Skull Base","volume":"46","author":"Park","year":"2009","journal-title":"J. Korean Neurosurg. Soc."},{"key":"ref_65","first-page":"bcr0820080804","article-title":"Extramedullary plasmacytoma masquerading as Tolosa\u2013Hunt syndrome: A case report","volume":"2009","author":"Ko","year":"2009","journal-title":"Case Rep."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Rahmah, N., Brotoarianto, H., Andor, E., Kusnarto, G., Muttaqin, Z., and Hongo, K. (2009). Dural plasmacytoma mimicking meningioma in a young patient with multiple myeloma. Biomed. Imaging Interv. J., 5.","DOI":"10.2349\/biij.5.2.e5"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"9110","DOI":"10.1186\/1757-1626-2-9110","article-title":"Multiple myeloma presenting as an intracranial plasmacytoma: A case report","volume":"2","author":"Terada","year":"2009","journal-title":"Cases J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"9154","DOI":"10.1186\/1757-1626-2-9154","article-title":"Primary plasmacytoma of the cranial vault: A case report","volume":"2","author":"Zigouris","year":"2009","journal-title":"Cases J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s11060-008-9558-9","article-title":"Extramedullary plasmacytoma presented as a non-functional invasive pituitary macro-adenoma","volume":"88","author":"Pitini","year":"2008","journal-title":"J. Neurooncol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00701-008-0012-8","article-title":"Intrasellar plasmacytoma: An unusual presentation of multiple myeloma","volume":"150","author":"Yaman","year":"2008","journal-title":"Acta Neurochir."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.surneu.2007.10.020","article-title":"Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: A case report","volume":"70","author":"Yamaguchi","year":"2008","journal-title":"Surg. Neurol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/014556130708600910","article-title":"Recurrence of Isolated Multiple Myeloma in the Skull Base: A Case Report and Review of the Literature","volume":"86","author":"Husein","year":"2007","journal-title":"Ear Nose Throat J."},{"key":"ref_73","first-page":"568","article-title":"Plasmacytoma of the clivus: A case report","volume":"49","author":"Goyal","year":"2006","journal-title":"Indian J. Pathol. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1552-6569.2006.00062.x","article-title":"Cyberknife Radiosurgery for Basal Skull Plasmacytoma","volume":"16","author":"Wong","year":"2006","journal-title":"J. Neuroimaging"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.surneu.2003.12.013","article-title":"Gamma knife radiosurgery for cavernous sinus plasmacytoma in a patient with breast cancer history","volume":"63","author":"Peker","year":"2005","journal-title":"Surg. Neurol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1080\/00016480410017224","article-title":"Solitary extramedullary plasmacytoma arising in the pterygoid fossa","volume":"124","author":"Halefoglu","year":"2004","journal-title":"Acta Otolaryngol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11102-005-1758-0","article-title":"Plasmacytoma: An unusual cause of a pituitary mass lesion. A case report and a review of the literature","volume":"7","author":"McLaughlin","year":"2004","journal-title":"Pituitary"},{"key":"ref_78","unstructured":"Hon, C., Au, W.Y., and Shek, T.W. (2003). Isolated sphenoid plasmacytoma presenting as painful ophthalmoplegia. Haematologica, 88."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1080\/1042819021000015998","article-title":"Cavernous Sinus Involvement by Extramedullary Plasmacytoma of the Sphenoid Sinus","volume":"43","author":"Ampil","year":"2002","journal-title":"Leuk. Lymphoma"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/ajh.10077","article-title":"Unusual presentation of multiple myeloma with unilateral visual loss and numb chin syndrome in a young adult","volume":"70","author":"Hogan","year":"2002","journal-title":"Am. J. Hematol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1080\/000164801317166772","article-title":"Plasmacytoma of the Temporal Bone: Management with a Combination of Surgery and Radiotherapy","volume":"121","author":"Yetiser","year":"2001","journal-title":"Acta Otolaryngol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1017\/S0022215100143464","article-title":"Solitary plasmacytoma of the skull base presenting with unilateral sensorineural hearing loss","volume":"113","author":"Delap","year":"1999","journal-title":"J. Laryngol. Otol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4158\/EP.4.6.382","article-title":"An Unusual Sellar Mass\u2014Solitary Plasmacytoma","volume":"4","author":"Mandagere","year":"1998","journal-title":"Endocr. Pract."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0196-0709(98)90130-2","article-title":"Plasmacytoma of the temporal bone","volume":"19","author":"Chiang","year":"1998","journal-title":"Am. J. Otolaryngol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s002340050325","article-title":"Intracranial plasmacytoma: A case report","volume":"38","author":"Kinnunen","year":"1996","journal-title":"Neuroradiology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/(SICI)1097-0347(199707)19:4<347::AID-HED14>3.0.CO;2-6","article-title":"Sphenoid sinus localization of multiple myeloma revealing evolution from benign gammopathy","volume":"19","author":"Bachmeyer","year":"1997","journal-title":"Head. Neck"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1177\/000348949210100807","article-title":"Solitary Plasmacytoma of the Skull Base","volume":"101","author":"Brookes","year":"1992","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/0090-3019(92)90010-K","article-title":"Solitary plasmacytoma of the sphenoid sinus involving the pituitary fossa: A case report and review of the literature","volume":"37","author":"Losa","year":"1992","journal-title":"Surg. Neurol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF02915418","article-title":"Multiple myeloma presenting as a sellar plasmacytoma and mimicking a pituitary tumor: Report of a case and a review of the literature","volume":"1","author":"Dhanani","year":"1990","journal-title":"Endocr. Pathol."},{"key":"ref_90","first-page":"331","article-title":"Parasellar syndrome caused by plasma cell leukemia","volume":"24","author":"Bellan","year":"1989","journal-title":"Can. J. Ophthalmol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0730-4862(86)90109-5","article-title":"Multiple myeloma mimicking pituitary adenoma","volume":"10","author":"Bitterman","year":"1986","journal-title":"Comput. Radiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/pgmj.61.716.513","article-title":"Pituitary function with a solitary intrasellar plasmacytoma","volume":"61","author":"Evans","year":"1985","journal-title":"Postgrad. Med. J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1288\/00005537-198311000-00016","article-title":"An igd extramedullary plasmacytoma involving the sphenoid sinus at onset: An immunohistochemical study","volume":"93","author":"Humphrey","year":"1983","journal-title":"Laryngoscope"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1002\/1097-0142(19830615)51:12<2226::AID-CNCR2820511213>3.0.CO;2-Q","article-title":"Solitary intracranial plasmacytoma","volume":"51","author":"Mancardi","year":"1983","journal-title":"Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/archneur.1982.00510130059017","article-title":"Intracranial Solitary Extraskeletal Plasmacytoma Resembling Meningioma","volume":"39","author":"Atweh","year":"1982","journal-title":"Arch. Neurol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3171\/jns.1980.52.6.0857","article-title":"Plasmacytoma of the clivus presenting with an unusual combination of symptoms","volume":"52","author":"Vera","year":"1980","journal-title":"J. Neurosurg."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0009-9260(71)80023-5","article-title":"Plasmacytoma of the skull base","volume":"22","author":"Toland","year":"1971","journal-title":"Clin. Radiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3171\/jns.1971.35.2.0223","article-title":"Solitary posterior fossa plasmacytoma: Case report","volume":"35","author":"Someren","year":"1971","journal-title":"J. Neurosurg."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1212\/WNL.16.6.615","article-title":"Cerebral plasmacytoma with myeloma protein in the cerebrospinal fluid","volume":"16","author":"Weiner","year":"1966","journal-title":"Neurology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3171\/jns.1960.17.5.0929","article-title":"Solitary Plasmacytoma of Petrous Bone","volume":"17","author":"Rovit","year":"1960","journal-title":"J. Neurosurg."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1017\/S0022215100041359","article-title":"Plasmacytoma of the Petrous Temporal Bone and Base of Skull","volume":"50","author":"Cappell","year":"1935","journal-title":"J. Laryngol. Otol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e841","DOI":"10.1016\/j.wneu.2023.04.032","article-title":"Primary Skull Base Chordomas: A Clinicopathological Analysis of 94 Patients","volume":"175","author":"Zhao","year":"2023","journal-title":"World Neurosurg."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jocn.2018.06.022","article-title":"Preoperative embolization of skull base meningiomas: A systematic review","volume":"59","author":"Ilyas","year":"2019","journal-title":"J. Clin. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10143-018-0976-7","article-title":"Meningiomas: Skull base versus non-skull base","volume":"42","author":"Meling","year":"2019","journal-title":"Neurosurg. Rev."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.rpor.2015.12.008","article-title":"Imaging of skull base tumours","volume":"21","author":"Thust","year":"2016","journal-title":"Rep. Pract. Oncol. Radiother."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s00701-013-1845-3","article-title":"Solitary clival plasmocytomas: Misleading clinical and radiological features of a rare pathology with a specific biological behaviour","volume":"155","author":"Gagliardi","year":"2013","journal-title":"Acta Neurochir."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.wneu.2013.01.010","article-title":"Clinical Characteristics, Immunohistochemistry, and Outcomes of 77 Patients with Skull Base Chordomas","volume":"81","author":"Ouyang","year":"2014","journal-title":"World Neurosurg."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e520","DOI":"10.1016\/j.wneu.2018.11.201","article-title":"Meningiomas Display a Specific Immunoexpression Pattern in a Rostrocaudal Gradient: An Analysis of 366 Patients","volume":"123","author":"Sav","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1746-1596-6-123","article-title":"Extraosseous (extramedullary) plasmacytomas: A clinicopathologic and immunophenotypic study of 32 Chinese cases","volume":"6","author":"Zuo","year":"2011","journal-title":"Diagn. Pathol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.3892\/mmr.2015.3976","article-title":"Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas","volume":"12","author":"Wang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1365-2141.2004.04834.x","article-title":"Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma","volume":"124","author":"Soutar","year":"2004","journal-title":"Br. J. Haematol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ijrobp.2005.06.039","article-title":"Outcomes and patterns of failure in solitary plasmacytoma: A multicenter Rare Cancer Network study of 258 patients","volume":"64","author":"Ozsahin","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Elsayad, K., Oertel, M., K\u00f6nig, L., H\u00fcske, S., Le Ray, E., Meheissen, M.A., Elsaid, A.A., Elfaham, E., Debus, J., and Kirova, Y. (2020). Maximizing the clinical benefit of radiotherapy in solitary plasmacytoma: An international multicenter analysis. Cancers, 12.","DOI":"10.3390\/cancers12030676"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/15\/2495\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:22:07Z","timestamp":1785831727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/15\/2495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":114,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["cancers18152495"],"URL":"https:\/\/doi.org\/10.3390\/cancers18152495","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]}}}