{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T04:41:54Z","timestamp":1786250514198,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/01g9ty582","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Long-term mortality trends for melanoma and non-melanoma skin cancer (NMSC) in Hungary have not been comprehensively assessed. Methods: We conducted a retrospective nationwide study of deaths registered in Hungary between 1980 and 2020 among individuals aged 35 years or older, where melanoma (ICD-10 C43) or NMSC (ICD-10 C44) was recorded as the primary cause of death. Annual crude death rates (CDRs; overall and age-specific 35\u201364 and \u226565 years) and age-standardised death rates (ASDRs) per 100,000 population were calculated by sex. Trends were analysed using Joinpoint regression. Results: Overall, 18,857 skin cancer deaths, including 12,026 melanoma and 6831 NMSC deaths, were identified. Melanoma mortality was consistently higher in men. Among men, melanoma ASDR increased until 1994 and then stabilised, while crude mortality among older men continued to increase. Among women, the ASDR of melanoma increased until 1994 and subsequently declined. Crude mortality decreased after 2005 in women aged 35\u201364 years. Although NMSC mortality was lower than melanoma mortality, NMSC accounted for 36.2% of skin cancer deaths. In both sexes, NMSC mortality was concentrated in adults \u2265 65 years. In older women, crude NMSC mortality increased again after the mid-2000s, whereas ASDR remained broadly stable. Conclusions: Melanoma mortality trends in Hungary partially stabilised or improved after the mid-1990s, particularly in age-standardised analyses, but mortality remained high among older adults, especially among men. NMSC represented a substantial proportion of skin cancer deaths, with the burden concentrated in adults \u2265 65 years, supporting the inclusion of NMSC in routine mortality surveillance and disease burden assessments.<\/jats:p>","DOI":"10.3390\/cancers18162533","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T08:01:36Z","timestamp":1786089696000},"page":"2533","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Trends of Melanoma and Non-Melanoma Skin Cancer Mortality Rates in Hungary Between 1980 and 2020"],"prefix":"10.3390","volume":"18","author":[{"given":"\u00c1gnes","family":"Stier","sequence":"first","affiliation":[{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9166-7374","authenticated-orcid":false,"given":"Anna","family":"P\u00e1ldy","sequence":"additional","affiliation":[{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Department of Environmental Health Laboratory, National Center for Public Health and Pharmacy, 1097 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"ref_1","first-page":"788","article-title":"Incidence Trends of Nonmelanoma Skin Cancer in Germany from 1998 to 2010","volume":"13","author":"Rudolph","year":"2015","journal-title":"JDDG J. Dtsch. Dermatol. Ges."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1684\/ejd.2018.3248","article-title":"Do Cancer Registries Play a Role in Determining the Incidence of Non-Melanoma Skin Cancers?","volume":"28","author":"Lyra","year":"2018","journal-title":"Eur. J. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jdin.2020.10.013","article-title":"The Global Burden of Skin Cancer: A Longitudinal Analysis from the Global Burden of Disease Study, 1990\u20132017","volume":"2","author":"Urban","year":"2021","journal-title":"JAAD Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.jid.2017.04.020","article-title":"Incidence, Mortality, and Trends of Nonmelanoma Skin Cancer in Germany","volume":"137","author":"Leiter","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.12688\/f1000research.2-107.v1","article-title":"An Estimation of the Prevalence of Nonmelanoma Skin Cancer in the U.S","volume":"2","author":"Perera","year":"2013","journal-title":"F1000Research"},{"key":"ref_6","unstructured":"European Academy of Dermatology (New Study Finds, 2023). Non-Melanoma Skin Cancer Killing More People than Melanoma, New Study Finds."},{"key":"ref_7","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_8","unstructured":"OECD (2021). State of the Health in the EU, Hungary\u2014Country Health Profile, OECD."},{"key":"ref_9","first-page":"94","article-title":"A Melan\u00f3ma Hazai Morbidit\u00e1si \u00c9s Mortalit\u00e1si Helyzete a XXI. Sz\u00e1zad Els\u0151 K\u00e9t \u00c9vtized\u00e9ben [Hungarian Situation of Melanoma Incidence and Mortality in the First Two Decades of 21st Century]","volume":"66","author":"Parrag","year":"2022","journal-title":"Magy. Onkol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"V\u00e1rnai, M., Kiss, Z., Gyulai, R., Ol\u00e1h, J., Holl\u00f3, P., Emri, G., Csejtei, A., Kenessey, I., Benedek, A., and Pol\u00e1nyi, Z. (2021). Improving Quality Indicator of Melanoma Management\u2014Change of Melanoma Mortality-to-Incidence Rate Ratio Based on a Hungarian Nationwide Retrospective Study. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.745550"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Gub\u00e1n, R., Parrag, P., Kisp\u00e1l, M.T., Czirbesz, K., Danyi, T., Kenessey, I., and Liszkay, G. (2025). Characterization of Melanoma in Hungary Based on a Retrospective Single-Center Study Between 2001 and 2018. Cancers, 17.","DOI":"10.3390\/cancers17132171"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Koczkodaj, P., Sulkowska, U., Didkowska, J., Rutkowski, P., and Ma\u0144czuk, M. (2023). Melanoma Mortality Trends in 28 European Countries: A Retrospective Analysis for the Years 1960\u20132020. Cancers, 15.","DOI":"10.3390\/cancers15051514"},{"key":"ref_13","unstructured":"Stier, A., and P\u00e1ldy, A. (2021). Temporal Changes in Skin Cancer Epidemiology in Hungary (2001\u20132015). Ann. Dip. Metod. Model. L\u2019Econ. Territ. Finanz., 125\u2013146."},{"key":"ref_14","unstructured":"K\u00f6zponti Statisztikai Hivatal [Hungarian Central Statistical Office] (2024). Ter\u00fcleti Atlasz\u2014J\u00e1r\u00e1sok [Regional Atlas\u2014Districts]."},{"key":"ref_15","unstructured":"Pace, M., Lanzieri, G., Glickman, M., Grande, E., Zupanic, T., Wojtyniak, B., Gissler, M., Cayotte, E., and Agafitei, L. (2013). Revision of the European Standard Population, Publications Office of the European Union."},{"key":"ref_16","unstructured":"National Cancer Institute (2024, June 02). Division of Cancer Control and Population Sciences Joinpoint Trend Analysis Software, Available online: https:\/\/surveillance.cancer.gov\/joinpoint\/."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Papp, B.T., Toplenszky, K., \u00d3csai, H., Cs\u00e1nyi, I., Kem\u00e9ny, L., Gyulai, R., Ol\u00e1h, J., and Baltas, E. (2025). Ten Years of Euromelanoma in Hungary: Nationwide Trends and Risk Factors for Skin Cancer in Central\u2013Eastern Europe. Cancers, 17.","DOI":"10.3390\/cancers17233749"},{"key":"ref_18","unstructured":"International Agency for Research on Cancer (IARC) (2012). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Volume 100D, Radiation, International Agency for Research on Cancer (IARC)."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/jamadermatol.2022.0160","article-title":"Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040","volume":"158","author":"Arnold","year":"2022","journal-title":"JAMA Dermatol."},{"key":"ref_20","unstructured":"International Agency for Research on Cancer (2026, May 04). Cancer Today: Data Visualization (GLOBOCAN 2022) [Online Database]. Global Cancer Observatory. Available online: https:\/\/gco.iarc.who.int\/today\/en\/dataviz\/pie?mode=population&group_populations=0."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Stier, \u00c1., Kenessey, I., and P\u00e1ldy, A. (2026). Long-Term Changes in Melanoma Epidemiology in Hungary: Who Are the High-Risk Groups, and Where Should We Concentrate Prevention Programs?. BMC Public Health, 26.","DOI":"10.1186\/s12889-026-26713-w"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s12672-026-04769-9","article-title":"Global Regional and National Burden of Nonmelanoma Skin Cancer from 1990 to 2021 Based on the Global Burden of Disease 2021 Study","volume":"17","author":"Dai","year":"2026","journal-title":"Discov. Oncol."},{"key":"ref_23","unstructured":"(2026, April 29). Hungarian Central Statistical Office N\u00e9pess\u00e9g Kor\u00e9v \u00c9s Nem Szerint, Janu\u00e1r 1. (1980\u2013)* [Population According to Age and Sex, from 1. January 1980] (STADAT Table I_wdsd009). Available online: https:\/\/www.ksh.hu\/docs\/hun\/xstadat\/xstadat_eves\/i_wdsd009.html."},{"key":"ref_24","unstructured":"(2026, April 29). Hungarian Central Statistical Office N\u00e9pess\u00e9g, N\u00e9pmozgalom [Population, Vital Statistics] (Table H_wdsd001b). Available online: https:\/\/www.ksh.hu\/docs\/hun\/xstadat\/xstadat_hosszu\/h_wdsd001b.html."},{"key":"ref_25","unstructured":"Monostori, J., \u0150ri, P., and Sp\u00e9der, Z. (2015). Mortality, Demographic Portrait of Hungary 2015."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s11113-010-9192-z","article-title":"The State Socialist Mortality Syndrome","volume":"30","author":"Carlson","year":"2011","journal-title":"Popul. Res. Policy Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1556\/MOnkol.52.2008.1.4","article-title":"European and national tasks of oncology [Eur\u00f3pai \u00c9s Hazai Kih\u00edv\u00e1sok Az Onkol\u00f3gi\u00e1ban]","volume":"52","year":"2008","journal-title":"Magy. Onkol."},{"key":"ref_28","unstructured":"Organisation for Economic Co-Operation and Development (OECD), and European Commission (2025). Hungary Country Cancer Profile 2025. European Cancer Inequalities Registry, OECD Publishing."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"\u00c1d\u00e1ny, R., Juh\u00e1sz, A., Nagy, C., Burkali, B., Pik\u00f3, P., McKee, M., and Oroszi, B. (2024). Discrepancies between the Spatial Distribution of Cancer Incidence and Mortality as an Indicator of Unmet Needs in Cancer Prevention and\/or Treatment in Hungary. Cancers, 16.","DOI":"10.3390\/cancers16162917"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1023\/A:1011504122300","article-title":"Choice and Solidarity: The Health Sector in Eastern Europe and Proposals for Reform","volume":"1","author":"Kornai","year":"2001","journal-title":"Int. J. Health Care Finance Econ."},{"key":"ref_31","unstructured":"Szel\u00e9nyi, I. (1998). Theories of the New Class, University of Minnesota Press."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Koumaki, D., Evangelou, G., Gregoriou, S., Kouloumvakou, S., Manios, A., Katoulis, A., Zacharopoulos, G., Chernyshov, P., Papadakis, M., and Kassotakis, D. (2024). Skin Cancer Knowledge, Sun Exposure, Photoprotection Behavior, and Perceived Barriers Associated with Skin Cancer Types in a Greek Cohort: A Cross-Sectional Study on the Island of Crete. Cancers, 16.","DOI":"10.3390\/cancers16244226"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Wunderlich, K., Suppa, M., Gandini, S., Lipski, J., White, J.M., and Del Marmol, V. (2024). Risk Factors and Innovations in Risk Assessment for Melanoma, Basal Cell Carcinoma, and Squamous Cell Carcinoma. Cancers, 16.","DOI":"10.3390\/cancers16051016"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.pathol.2022.12.345","article-title":"Diagnostic Error, Uncertainty, and Overdiagnosis in Melanoma","volume":"55","author":"Elder","year":"2023","journal-title":"Pathology"},{"key":"ref_35","first-page":"102306","article-title":"Evaluation of Data Quality at the Hungarian National Cancer Registry, 2000\u20132019","volume":"82","author":"Mery","year":"2022","journal-title":"Cancer Epidemiol."},{"key":"ref_36","unstructured":"W\u00e9ber, A., Szatm\u00e1ri, I., Dobozi, M., Nagy, P., Dank, M., and Kenessey, I. (2026, January 19\u201321). Hungarian Trends in the Incidence of Non-Melanoma Skin Cancer and the Impact of COVID Pandemic. Proceedings of the IARC 60th Anniversary, Lyon, France."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13555-016-0165-y","article-title":"Skin Cancer: Epidemiology, Disease Burden, Pathophysiology, Diagnosis, and Therapeutic Approaches","volume":"7","author":"Apalla","year":"2017","journal-title":"Dermatol. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1001\/jamadermatol.2020.3678","article-title":"Underestimation of Cutaneous Squamous Cell Carcinoma Incidence, Even in Cancer Registries","volume":"156","author":"Wehner","year":"2020","journal-title":"JAMA Dermatol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/16\/2533\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T04:13:18Z","timestamp":1786248798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/16\/2533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":38,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["cancers18162533"],"URL":"https:\/\/doi.org\/10.3390\/cancers18162533","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]}}}