{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T04:42:06Z","timestamp":1786250526588,"version":"build-2736575974"},"reference-count":77,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008308","name":"City of Hope Comprehensive Cancer Center","doi-asserted-by":"crossref","award":["NIH P30CA033572"],"award-info":[{"award-number":["NIH P30CA033572"]}],"id":[{"id":"10.13039\/100008308","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008308","name":"City of Hope Comprehensive Cancer Center","doi-asserted-by":"crossref","award":["NIH R01CA166161"],"award-info":[{"award-number":["NIH R01CA166161"]}],"id":[{"id":"10.13039\/100008308","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008308","name":"City of Hope Comprehensive Cancer Center","doi-asserted-by":"crossref","award":["R21NS074392"],"award-info":[{"award-number":["R21NS074392"]}],"id":[{"id":"10.13039\/100008308","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008308","name":"City of Hope Comprehensive Cancer Center","doi-asserted-by":"crossref","award":["R21AI105057"],"award-info":[{"award-number":["R21AI105057"]}],"id":[{"id":"10.13039\/100008308","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008308","name":"City of Hope Comprehensive Cancer Center","doi-asserted-by":"crossref","award":["R01HL112638"],"award-info":[{"award-number":["R01HL112638"]}],"id":[{"id":"10.13039\/100008308","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Rotary Coins for Alzheimer\u2019s Research Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Somatic stem cells, as well as cancer stem cells, exist in two basic \u201cstates\u201d, quiescent versus activated. The regulation of the balance between quiescence and activation is critical to tissue homeostasis and repair after injury. Additionally, after being activated, the decision to divide symmetrically or asymmetrically is critical. Aberrant regulation of stem cell quiescence and mode of mitotic division is associated with aging and diseases of aging including cancer, fibrosis, sarcopenia and neurodegeneration. Based on over 25 years of chemical genetic and genetic investigation, we discuss the differential roles of the two Kat3 coactivators (Kat3A\/CREBBP\/CBP and Kat3B\/EP300\/p300) in regulating stem cell quiescence and the mode of division of activated stem cells. The ability to pharmacologically regulate differential Kat3 coactivator usage has important implications to ameliorate the aging process as well as to eliminate quiescent cancer stem cells, which are the cause of disease relapse and metastasis.<\/jats:p>","DOI":"10.3390\/cancers18162542","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T10:12:01Z","timestamp":1786097521000},"page":"2542","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Somatic Stem Cells: Control of Quiescence Versus Activation in Aging and Cancer"],"prefix":"10.3390","volume":"18","author":[{"given":"Daniel","family":"Yi","sequence":"first","affiliation":[{"name":"Cancer Biology and Molecular Medicine, Beckman Research Institute, Duarte, CA 91010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1220-4644","authenticated-orcid":false,"given":"Michael","family":"Kahn","sequence":"additional","affiliation":[{"name":"Cancer Biology and Molecular Medicine, Beckman Research Institute, Duarte, CA 91010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Higuchi, Y., Teo, J.-L., Yi, D., and Kahn, M. (2025). Safely targeting cancer, the wound that never heals, utilizing CBP\/\u03b2-catenin antagonists. Cancers, 17.","DOI":"10.3390\/cancers17091503"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ceb.2013.01.004","article-title":"Wnt signaling in stem and cancer stem cells","volume":"25","author":"Holland","year":"2013","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/14728222.2021.1992386","article-title":"Taking the road less traveled\u2014The therapeutic potential of CBP\/\u03b2-catenin antagonists","volume":"25","author":"Kahn","year":"2021","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1073\/pnas.1000834107","article-title":"Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion","volume":"107","author":"Beerman","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature05091","article-title":"Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing","volume":"443","author":"Molofsky","year":"2006","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nature03260","article-title":"Rejuvenation of aged progenitor cells by exposure to a young systemic environment","volume":"433","author":"Conboy","year":"2005","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1126\/science.1099593","article-title":"Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche","volume":"307","author":"Nishimura","year":"2005","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/B978-0-12-416022-4.00014-7","article-title":"Cellular mechanisms of somatic stem cell aging","volume":"Volume 107","author":"Jung","year":"2014","journal-title":"Current Topics in Developmental Biology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.stem.2025.06.004","article-title":"Hallmarks of stem cell aging","volume":"32","author":"Rando","year":"2025","journal-title":"Cell Stem Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10565-016-9318-0","article-title":"Kat3 coactivators in somatic stem cells and cancer stem cells: Biological roles, evolution, and pharmacologic manipulation","volume":"32","author":"Thomas","year":"2016","journal-title":"Cell Biol. Toxicol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102630","DOI":"10.1016\/j.ceb.2026.102630","article-title":"Ageing influences tumour\u2013niche interactions: Implications for metastatic dormancy, reawakening and recurrence","volume":"100","author":"Mackie","year":"2026","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","article-title":"Stem cells, cancer, and cancer stem cells","volume":"414","author":"Reya","year":"2001","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature03319","article-title":"Wnt signalling in stem cells and cancer","volume":"434","author":"Reya","year":"2005","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/s41467-020-14700-7","article-title":"Inhibiting WNT and NOTCH in Renal Cancer Stem Cells and the Implications for Human Patients","volume":"11","author":"Fendler","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41568-026-00928-w","article-title":"The sleeping threat: Targeting cancer dormancy to transform metastasis therapy","volume":"26","author":"Guo","year":"2026","journal-title":"Nat. Rev. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.tcb.2019.05.002","article-title":"Quiescence: Good and bad of stem cell aging","volume":"29","author":"Tumpel","year":"2019","journal-title":"Trends Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41514-024-00166-0","article-title":"Aging insights from heterochronic parabiosis models","volume":"10","year":"2024","journal-title":"npj Aging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.tins.2024.07.004","article-title":"Tools to study neural and glioma stem cell quiescence","volume":"47","author":"Friess","year":"2024","journal-title":"Trends Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/255197a0","article-title":"Mutation selection and the natural history of cancer","volume":"255","author":"Cairns","year":"1975","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0092-8674(78)90274-X","article-title":"The segregation of DNA in epithelial stem cells","volume":"15","author":"Potten","year":"1978","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.neuron.2013.10.037","article-title":"Neural Stem Cells: Generating and Regenerating the Brain","volume":"80","author":"Gage","year":"2013","journal-title":"Neuron"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Lukaszewicz, A.I., Nguyen, C., Melendez, E., Lin, D.P., Teo, J.-L., Lai, K.K.Y., Huttner, W.B., Shi, S.-H., and Kahn, M. (2019). The Mode of Stem Cell Division Is Dependent on the Differential Interaction of \u03b2-Catenin with the Kat3 Coactivators CBP or p300. Cancers, 11.","DOI":"10.3390\/cancers11070962"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.cell.2007.06.017","article-title":"Immortal strands? Give me a break","volume":"129","author":"Lansdorp","year":"2007","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.cell.2007.06.019","article-title":"The immortal strand hypothesis: Segregation and reconstruction","volume":"129","author":"Rando","year":"2007","journal-title":"Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cell.2009.06.048","article-title":"The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells","volume":"138","author":"Cicalese","year":"2009","journal-title":"Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.stem.2010.09.015","article-title":"mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion","volume":"7","author":"Lee","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Park, D.S., Akuffo, A.A., Muench, D.E., Grimes, H.L., Epling-Burnette, P.K., Maini, P.K., Anderson, A.R.A., and Bonsall, M.B. (2019). Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation. PLoS Comput. Biol., 15.","DOI":"10.1371\/journal.pcbi.1006913"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13619-024-00188-9","article-title":"Asymmetric division of stem cells and its cancer relevance","volume":"13","author":"Chao","year":"2024","journal-title":"Cell Regen."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.chembiol.2021.09.001","article-title":"DNA template strand segregation in developing zebrafish","volume":"28","author":"Glasauer","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e201910084","DOI":"10.1083\/jcb.201910084","article-title":"Asymmetric assembly of centromeres epigenetically regulates stem cell fate","volume":"219","author":"Dattoli","year":"2020","journal-title":"J. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ceb.2020.08.003","article-title":"Asymmetric inheritance of epigenetic states in asymmetrically dividing stem cells","volume":"67","author":"Zion","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Shlyakhtina, Y., Moran, K.L., and Portal, M.M. (2019). Asymmetric inheritance of cell fate determinants: Focus on RNA. Non-Coding RNA, 5.","DOI":"10.3390\/ncrna5020038"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1073\/pnas.0803027105","article-title":"Asymmetric mitosis: Unequal segregation of proteins destined for degradation","volume":"105","author":"Fuentealba","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.it.2025.04.008","article-title":"Restraining the killers: Regulation of T cell quiescence","volume":"46","author":"Lumnitzer","year":"2025","journal-title":"Trends Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/jama.289.2.179","article-title":"Mortality associated with influenza and respiratory syncytial virus in the United States","volume":"289","author":"Thompson","year":"2003","journal-title":"JAMA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/s43587-024-00644-w","article-title":"Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19","volume":"4","author":"Dallan","year":"2024","journal-title":"Nat. Aging"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.exger.2006.11.017","article-title":"Aging and CD8+ T cell immunity to respiratory virus infections","volume":"42","author":"Ely","year":"2007","journal-title":"Exp. Gerontol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1038\/s41467-024-45984-8","article-title":"Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice","volume":"15","author":"Durand","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.it.2015.09.004","article-title":"Asymmetric cell division in T lymphocyte fate diversification","volume":"36","author":"Arsenio","year":"2015","journal-title":"Trends Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41577-019-0180-1","article-title":"Mechanisms underlying T cell ageing","volume":"19","author":"Goronzy","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.1111\/febs.15770","article-title":"Hallmarks of the aging T-cell system","volume":"288","author":"Zhang","year":"2021","journal-title":"FEBS J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.15283\/ijsc.2012.5.1.39","article-title":"Evolution of energy metabolism, stem cells and cancer stem cells: How the Warburg and Barker hypotheses might be linked","volume":"5","author":"Trosko","year":"2012","journal-title":"Int. J. Stem Cells"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"D377","DOI":"10.1093\/nar\/gks1118","article-title":"PANTHER in 2013: Modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees","volume":"41","author":"Mi","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0092-8674(94)90127-9","article-title":"E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators","volume":"77","author":"Arany","year":"1994","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41573-024-01080-6","article-title":"Targeting lysine acetylation readers and writers","volume":"24","author":"Zhou","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1101\/gad.14.3.272","article-title":"Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP","volume":"14","author":"Kung","year":"2000","journal-title":"Genes Dev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng829","article-title":"Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice","volume":"30","author":"Yamauchi","year":"2002","journal-title":"Nat. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1093\/emboj\/cdg473","article-title":"Differential role of p300 and CBP acetyltransferase during myogenesis: P300 acts upstream of MyoD and Myf5","volume":"22","author":"Roth","year":"2003","journal-title":"EMBO J."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kahn, M. (2023). A Metabolic Smorgasbord Drives and Sustains CSC Heterogeneity. Cancers, 15.","DOI":"10.3390\/cancers15020343"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Hu, X., Ono, M., Chimge, N.-O., Chosa, K., Nguyen, C., Melendez, E., Lou, C.-H., Lim, P., Termini, J., and Lai, K.K.Y. (2021). Differential Kat3 Usage Orchestrates the Integration of Cellular Metabolism with Differentiation. Cancers, 13.","DOI":"10.3390\/cancers13235884"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1399-3011.2004.00126.x","article-title":"The Coactivator LXXLL Nuclear Receptor Recognition Motif","volume":"63","author":"Savkur","year":"2004","journal-title":"J. Pept. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1073\/pnas.94.4.1074","article-title":"Nuclear integration of JAK\/STAT and Ras\/AP-1 signaling by CBP and p300","volume":"94","author":"Horvai","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41586-026-10169-4","article-title":"Human hippocampal neurogenesis in adulthood, ageing and Alzheimer\u2019s disease","volume":"652","author":"Disouky","year":"2026","journal-title":"Nature"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"12171","DOI":"10.1073\/pnas.0504600102","article-title":"Specific inhibition of CBP\/\u03b2-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation","volume":"102","author":"Teo","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e170823219875","DOI":"10.2174\/1874467217666230817092415","article-title":"Differential Kat3 Coactivator Usage Regulates Brain Metabolism and Neuronal Differentiation","volume":"17","author":"Poku","year":"2024","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2147\/TACG.S273525","article-title":"Mutations involved in premature-ageing syndromes","volume":"14","year":"2021","journal-title":"Appl. Clin. Genet."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Ma, J., Li, P., Jiang, Y., Yang, X., Luo, Y., Tao, L., Guo, X., and Gao, B. (2024). The association between dietary nutrient intake and acceleration of aging: Evidence from NHANES. Nutrients, 16.","DOI":"10.3390\/nu16111635"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","article-title":"Inflammation and aging: Signaling pathways and intervention therapies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"9076485","DOI":"10.1155\/2018\/9076485","article-title":"Cellular senescence and inflammaging in age-related diseases","volume":"2018","author":"Olivieri","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1126\/science.aaf9011","article-title":"Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention","volume":"355","author":"Tomasetti","year":"2017","journal-title":"Science"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Zhou, Y., He, Z., Li, T., Choppavarapu, L., Hu, X., Cao, R., Leone, G.W., Kahn, M., and Jin, V.X. (2024). 3D Chromatin Alteration by Disrupting \u03b2-Catenin\/CBP Interaction Is Enriched with Insulin Signaling in Pancreatic Cancer. Cancers, 16.","DOI":"10.3390\/cancers16122202"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.molcel.2021.03.008","article-title":"Enhancers are activated by p300\/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release","volume":"81","author":"Narita","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2013.09.053","article-title":"Super-Enhancers in the Control of Cell Identity and Disease","volume":"155","author":"Hnisz","year":"2013","journal-title":"Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1200\/jco.2013.31.15_suppl.2501","article-title":"A phase I first-in-human study of PRI-724 in patients (pts) with advanced solid tumors","volume":"31","author":"Ning","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ebiom.2017.08.016","article-title":"Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP\/\u03b2-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial","volume":"23","author":"Kimura","year":"2017","journal-title":"eBioMedicine"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev-pathol-052016-100256","article-title":"Circulating tumor cells: Fluid surrogates of solid tumors","volume":"12","author":"Thiele","year":"2017","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"14309","DOI":"10.1073\/pnas.1001520107","article-title":"Inhibition of Wnt\/\u03b2-catenin\/CREB binding protein (CBP) signaling reverses pulmonary fibrosis","volume":"107","author":"Henderson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1074\/jbc.M115.706416","article-title":"p300\/\u03b2-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a\/Protein Kinase C (PKC)","volume":"291","author":"Rieger","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12964-018-0222-5","article-title":"Inhibition of CREB binding protein\u2013\u03b2-catenin signaling downregulates CD133 expression and activates PP2A\u2013PTEN signaling in tumor-initiating liver cancer cells","volume":"16","author":"Tang","year":"2018","journal-title":"Cell Commun. Signal."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13046-017-0595-0","article-title":"ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population","volume":"36","author":"Liu","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exphem.2017.04.010","article-title":"CBP\/catenin antagonists: Targeting LSCs\u2019 Achilles heel","volume":"52","author":"Kim","year":"2017","journal-title":"Exp. Hematol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1038\/emboj.2013.127","article-title":"Wnt\/\u03b2-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours","volume":"32","author":"Wend","year":"2013","journal-title":"EMBO J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1158\/2159-8290.CD-24-0263","article-title":"Survivin Promotes Stem Cell Competence for Skin Cancer Initiation","volume":"15","author":"Canato","year":"2025","journal-title":"Cancer Discov."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.tcb.2014.04.001","article-title":"Surviving change: The metabolic journey of hematopoietic stem cells","volume":"24","author":"Kohli","year":"2014","journal-title":"Trends Cell Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1016\/j.molcel.2022.09.005","article-title":"p300\/CBP sustains Polycomb silencing by non-enzymatic functions","volume":"82","author":"Hunt","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"E744","DOI":"10.1073\/pnas.1515465113","article-title":"Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain","volume":"113","author":"Tie","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","first-page":"e290523217409","article-title":"E7386 is not a Specific CBP\/\u03b2-Catenin Antagonist","volume":"17","author":"Higuchi","year":"2024","journal-title":"Curr. Mol. Pharmacol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/16\/2542\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T04:22:58Z","timestamp":1786249378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/16\/2542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":77,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["cancers18162542"],"URL":"https:\/\/doi.org\/10.3390\/cancers18162542","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]}}}