{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:49:14Z","timestamp":1790660954924,"version":"4.1.0"},"reference-count":28,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Introduction: Melanoma is a chronic disease that significantly affects patients\u2019 daily functioning and emotional well-being. Beyond its somatic burden, it often leads to substantial changes in quality of life (QoL). This study aimed to assess illness acceptance among melanoma patients and examine its associations with selected clinical characteristics (disease stage, pruritus and time since diagnosis), psychological distress (depression and anxiety) and QoL. Materials and Methods: A cross-sectional study was conducted between June 2025 and February 2026 at two tertiary oncology centers in Poland. Initially, 191 consecutive melanoma patients were recruited, of whom 162 (58.6% men; mean age 59.8 \u00b1 13.7 years) were included in the final analysis (response rate: 84.8%). Participants completed validated questionnaires assessing illness acceptance (Acceptance of Illness Scale (AIS)), depression (PHQ-9, HADS-D), anxiety (GAD-7, HADS-A), and QoL (DLQI). Statistical analyses were performed, with p &lt; 0.05 considered statistically significant. Results: The mean AIS score was 13.28 \u00b1 7.50 points, indicating a remarkably low level of illness acceptance. In the multivariable linear regression analysis, greater depressive symptoms (HADS-D: \u03b2 = \u22121.16, 95% CI \u22121.79 to \u22120.54; p &lt; 0.001) and more advanced melanoma stage (\u03b2 = \u22121.52, 95% CI \u22122.92 to \u22120.12; p = 0.034) were independently associated with lower illness acceptance. In addition, illness acceptance showed significant correlations with depressive symptoms, anxiety symptoms, and dermatology-related QoL, whereas no significant associations were observed with most evaluated demographic and clinical variables. Conclusions: Patients with melanoma demonstrated remarkably low illness acceptance. Depressive symptoms and more advanced melanoma stage were independently associated with lower illness acceptance. These findings support the integration of psychological assessment into comprehensive melanoma care.<\/jats:p>","DOI":"10.3390\/cancers18162558","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:20:03Z","timestamp":1786324803000},"page":"2558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Illness Acceptance Among Adults with Melanoma: A Prospective Observational Cross-Sectional Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Paulina","family":"Piesch","sequence":"first","affiliation":[{"name":"Students\u2019 Research Group of Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, 50-377 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Kr\u0119\u017cel","sequence":"additional","affiliation":[{"name":"Students\u2019 Research Group of Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, 50-377 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Adamska","sequence":"additional","affiliation":[{"name":"Students\u2019 Research Group of Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, 50-377 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Bu\u0142awa","sequence":"additional","affiliation":[{"name":"Students\u2019 Research Group of Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, 50-377 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Hrynczyszyn","sequence":"additional","affiliation":[{"name":"Students\u2019 Research Group of Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, 50-377 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalina","family":"\u015awietlicka","sequence":"additional","affiliation":[{"name":"Students\u2019 Research Group of Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, 50-377 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4843-4073","authenticated-orcid":false,"given":"Marta","family":"Szepietowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Jagiellonian University Medical College, 31-503 Cracow, Poland"},{"name":"Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, 31-530 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr K.","family":"Krajewski","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, 50-377 Wroclaw, Poland"},{"name":"Department of Dermato-Venereology, 4th Military Hospital, 50-981 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-4945","authenticated-orcid":false,"given":"Gra\u017cyna","family":"Kami\u0144ska-Winciorek","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Haematology-Oncology, Skin Cancer and Melanoma Team, Maria Sklodowska-Curie National Research Institute of Oncology, 44-102 Gliwice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Zi\u0119tek","sequence":"additional","affiliation":[{"name":"Lower Silesian Oncology, Pulmonology and Hematology Center, 53-413 Wroclaw, Poland"},{"name":"Department of Oncology, Faculty of Medicine, Wroclaw Medical University, 53-413 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Matusiak","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, 50-377 Wroclaw, Poland"},{"name":"Department of Dermato-Venereology, 4th Military Hospital, 50-981 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0766-6342","authenticated-orcid":false,"given":"Jacek C.","family":"Szepietowski","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, 50-377 Wroclaw, Poland"},{"name":"Department of Dermato-Venereology, 4th Military Hospital, 50-981 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5996","DOI":"10.1038\/s41598-025-90485-3","article-title":"Global, regional, and national trends in the burden of melanoma and non-melanoma skin cancer: Insights from the global burden of disease study 1990\u20132021","volume":"15","author":"Zhou","year":"2025","journal-title":"Sci. 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