{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T09:40:05Z","timestamp":1786527605510,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K11856"],"award-info":[{"award-number":["24K11856"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Surgical site infection (SSI) is a common complication after colorectal cancer (CRC) surgery. We evaluated routinely available perioperative biomarkers for early prediction of superficial SSI after curative CRC surgery. Methods: This retrospective study included 488 patients undergoing elective curative CRC resection. Preoperative and postoperative day (POD) 1 laboratory parameters were evaluated using receiver operating characteristic curve analysis and multivariable logistic regression. Results: Superficial SSI developed in 66 patients (13.5%). In the perioperative multivariable association model, preoperative serum albumin \u2264 3.70 g\/dL (odds ratio [OR], 1.918; 95% confidence interval [CI], 1.066\u20133.449; p = 0.030) and WBC count \u2265 6.30 \u00d7 103\/\u00b5L (OR, 1.970; 95% CI, 1.123\u20133.458; p = 0.018) were independently associated with superficial SSI. On POD1, serum albumin \u2264 2.80 g\/dL (OR, 3.447; 95% CI, 1.993\u20135.963; p &lt; 0.001) and WBC count \u2265 10.50 \u00d7 103\/\u00b5L (OR, 2.822; 95% CI, 1.600\u20134.976; p &lt; 0.001) remained independently associated with SSI. Although lower POD1 lymphocyte-to-monocyte ratio was associated with SSI in univariable analysis, it was not significant after adjustment. A combined model incorporating dichotomized preoperative and POD1 albumin and WBC counts showed modest discrimination (AUC, 0.731; 95% CI, 0.663\u20130.800), with 47.0% sensitivity and 89.3% specificity. Conclusions: Perioperative albumin and WBC counts were independently associated with superficial SSI. POD1 assessment may aid early risk stratification; however, the modest performance indicates that these biomarkers should complement rather than replace clinical surveillance. Prospective external validation is required.<\/jats:p>","DOI":"10.3390\/cancers18162596","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T09:11:36Z","timestamp":1786525896000},"page":"2596","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Serum Albumin and White Blood Cell Count for Early Postoperative Risk Stratification of Superficial Surgical Site Infection After Colorectal Cancer Surgery"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3719-6425","authenticated-orcid":false,"given":"Chihiro","family":"Kosugi","sequence":"first","affiliation":[{"name":"Department of Surgery, Teikyo University Chiba Medical Center, Ichihara 299-0111, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohiko","family":"Shuto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Teikyo University Chiba Medical Center, Ichihara 299-0111, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8946-3471","authenticated-orcid":false,"given":"Mikito","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Surgery, Teikyo University Chiba Medical Center, Ichihara 299-0111, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Teikyo University Chiba Medical Center, Ichihara 299-0111, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Surgery, Teikyo University Chiba Medical Center, Ichihara 299-0111, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Surgery, Teikyo University Chiba Medical Center, Ichihara 299-0111, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Teikyo University Chiba Medical Center, Ichihara 299-0111, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","unstructured":"Foundation for Promotion of Cancer Research (2023). 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