{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:54:03Z","timestamp":1792450443547,"version":"4.5.0"},"reference-count":44,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Research, Innovation and Digitalization","award":["760009\/30.12.2022, code CF 14\/16.11.2022"],"award-info":[{"award-number":["760009\/30.12.2022, code CF 14\/16.11.2022"]}]},{"name":"University of Medicine and Pharmacy of Craiova"},{"id":[{"id":"https:\/\/ror.org\/031d5vw30","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Colorectal cancer (CRC) remains a major contributor to the global oncological burden, with marked disparities in mortality and survival between Western and Eastern European countries. Romania continues to report unfavorable CRC outcomes, driven by delayed diagnosis, limited screening uptake, and heterogeneous care pathways. This study aimed to assess the 15-year institutional description of colorectal cancer case-mix in South-West Oltenia, Romania, using real-world data from a high-volume oncology referral center. Methods: We conducted a retrospective observational study including 3497 patients with newly diagnosed CRC registered between 2011 and 2025. Sociodemographic characteristics, tumor localization, stage at diagnosis, and histopathological grade were analyzed. Temporal patterns were assessed across three five-year intervals. Results: The institutional CRC case volume increased, with 434 cases recorded in 2011\u20132015, 1015 in 2016\u20132020, and 2048 in 2021\u20132025. Male patients accounted for 60.5% and urban residents for 60.3% of cases. Early-onset CRC was identified in 12.0% of patients, with no significant temporal trend. Rectosigmoid junction\/rectal cancers represented the largest anatomical group, followed by left-sided cancers, with stable distribution across periods. Advanced stage disease was frequent, with 77.1% of patients diagnosed in stage III\u2013IV, increasing from 67.7% to 82.0% across study intervals (p &lt; 0.001). Histopathological grade changed significantly (p &lt; 0.001), due to a progressive increase in unspecified grade, from 16.1% to 45.5%. Conclusions: Colorectal cancer represents a substantial institutional workload at this regional referral center, emphasizing the need for strengthened early detection strategies, optimized referral system, improved diagnostic access, and standardized pathological reporting practices.<\/jats:p>","DOI":"10.3390\/cancers18162615","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T17:01:35Z","timestamp":1786640495000},"page":"2615","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Colorectal Cancer Burden and Trends in South-West Oltenia, Romania: A 15-Year Real-World Study from a Regional Referral Cancer Center"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-9624","authenticated-orcid":false,"given":"Tradian Ciprian","family":"Berisha","sequence":"first","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania"},{"name":"Sf. Nectarie Oncology Center, 200347 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin","family":"Burada","sequence":"additional","affiliation":[{"name":"Human Genomics Laboratory, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"Regional Center of Medical Genetics Dolj, Emergency Clinical County Hospital Craiova, 200642 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5847-6480","authenticated-orcid":false,"given":"Mihai Gabriel","family":"Cucu","sequence":"additional","affiliation":[{"name":"Human Genomics Laboratory, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"Regional Center of Medical Genetics Dolj, Emergency Clinical County Hospital Craiova, 200642 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Maria","family":"Ciurea","sequence":"additional","affiliation":[{"name":"Sf. Nectarie Oncology Center, 200347 Craiova, Romania"},{"name":"Department of Oncology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina Maria","family":"Mehedinteanu","sequence":"additional","affiliation":[{"name":"Sf. Nectarie Oncology Center, 200347 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puiu Olivian","family":"Stovicek","sequence":"additional","affiliation":[{"name":"Sf. Nectarie Oncology Center, 200347 Craiova, Romania"},{"name":"Department of Pharmacology, Faculty of Nursing, T\u00e2rgu Jiu Subsidiary, \u201cTitu Maiorescu\u201d University, 040441 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona Adriana","family":"Schenker","sequence":"additional","affiliation":[{"name":"Sf. Nectarie Oncology Center, 200347 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schenker","sequence":"additional","affiliation":[{"name":"Sf. Nectarie Oncology Center, 200347 Craiova, Romania"},{"name":"Department of Oncology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5471-4717","authenticated-orcid":false,"given":"Monica-Laura","family":"Cara","sequence":"additional","affiliation":[{"name":"Sf. Nectarie Oncology Center, 200347 Craiova, Romania"},{"name":"Department of Public Health, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA A Cancer J. 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