{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:17:50Z","timestamp":1788455870080,"version":"build-2803163510"},"reference-count":240,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Advances in lung cancer treatment have progressively improved survival across all disease stages. Some patients now achieve long-term survival, while others may remain on treatment for several years, particularly with immune checkpoint inhibitors and selected tyrosine kinase inhibitors. These advances have increased recognition of the survivorship needs of patients with lung cancer, including persistent symptoms, treatment-related toxicities, and social, psychological, and caregiver-related concerns. The integration of palliative care has also become increasingly relevant, reflecting a shift in the traditional care paradigm by extending supportive approaches beyond the end-of-life setting to patients living long-term with active disease. However, evidence and care models addressing lung cancer survivorship remain fragmented and focus predominantly on patients treated with curative intent. This narrative review provides a comprehensive overview of survivorship in lung cancer, from screening and early-stage to locally advanced and metastatic disease, while also examining more cross-cutting physical, psychological and social domains. Greater recognition and systematic assessment of these needs is essential to develop structured, coordinated, and personalized survivorship pathways for the growing and clinically heterogeneous population of individuals living with and beyond lung cancer.<\/jats:p>","DOI":"10.3390\/cancers18172856","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:21:21Z","timestamp":1788452481000},"page":"2856","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lung Cancer Survivorship: Challenges and Care Needs"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9608-4840","authenticated-orcid":false,"given":"Massimiliano","family":"Cani","sequence":"first","affiliation":[{"name":"Department of Oncology, University of Turin, 10043 Orbassano, Italy"},{"name":"Gustave Roussy Cancer Center, Paris-Saclay University, 94800 Villejuif, 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Target. Ther."},{"key":"ref_3","first-page":"e70043","article-title":"Cancer statistics, 2026","volume":"76","author":"Siegel","year":"2026","journal-title":"CA Cancer J. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1200\/JCO.21.00174","article-title":"Five-Year Outcomes with Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer with PD-L1 Tumor Proportion Score \u2265 50%","volume":"39","author":"Reck","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.annonc.2026.05.692","article-title":"Lorlatinib versus crizotinib as first-line treatment for advanced ALK-positive non-small-cell lung cancer: 7-year update from the phase III CROWN study","volume":"37","author":"Shaw","year":"2026","journal-title":"Ann. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e70039","DOI":"10.1002\/cncr.70039","article-title":"Defining concepts in cancer survivorship","volume":"131","author":"Mollica","year":"2025","journal-title":"Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e433298","DOI":"10.1200\/EDBK_433298","article-title":"Survivorship in Advanced Lung Cancer: Understanding a New Landscape and Opportunities","volume":"44","author":"Presley","year":"2024","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1200\/OP.23.00716","article-title":"Survivorship Care for People Affected by Advanced or Metastatic Cancer: MASCC-ASCO Standards and Practice Recommendations","volume":"20","author":"Hart","year":"2024","journal-title":"JCO Oncol. Pract."},{"key":"ref_9","unstructured":"(2026, June 09). IASLC Language Guide. Available online: https:\/\/www.iaslc.org\/IASLCLanguageGuide."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/09691413221117685","article-title":"The prevalence of comorbidity in the lung cancer screening population: A systematic review and meta-analysis","volume":"30","author":"Almatrafi","year":"2023","journal-title":"J. Med. Screen."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"ezaf329","DOI":"10.1183\/13993003.00156-2025","article-title":"European Respiratory Society and European Society of Thoracic Surgeons clinical practice guideline on fitness for curative intent treatment of lung cancer","volume":"66","author":"Brunelli","year":"2025","journal-title":"Eur. Respir. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41571-020-00432-6","article-title":"Lung cancer LDCT screening and mortality reduction\u2014Evidence, pitfalls and future perspectives","volume":"18","author":"Oudkerk","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Revel, M.P., Goo, J.M., Vliegenthart, R., Silva, M., and Snoeckx, A. (2026). Smoking-Related Comorbidities Detected Through Low-Dose CT Imaging Lung Cancer Screening: Current Evidence and Future Directions. Chest.","DOI":"10.1016\/j.chest.2026.05.028"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"National Lung Screening Trial Research Team, Aberle, D.R., Adams, A.M., Berg, C.D., Black, W.C., Clapp, J.D., Fagerstrom, R.M., Gareen, I.F., Gatsonis, C., and Marcus, P.M. (2011). Reduced lung-cancer mortality with low-dose computed tomographic screening. N. Engl. J. Med., 365, 395\u2013409.","DOI":"10.1056\/NEJMoa1102873"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1911793","article-title":"Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial","volume":"382","author":"Scholten","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.annonc.2025.08.003","article-title":"Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"36","author":"Zer","year":"2025","journal-title":"Ann. Oncol."},{"key":"ref_17","first-page":"50","article-title":"Screening for lung cancer: 2023 guideline update from the American Cancer Society","volume":"74","author":"Wolf","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1038\/s41591-026-04292-y","article-title":"Implementation of the NHS England Lung Cancer Screening Programme over 5 years","volume":"32","author":"Lee","year":"2026","journal-title":"Nat. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.jtho.2024.07.014","article-title":"Second Primary Lung Cancer\u2014An Emerging Issue in Lung Cancer Survivors","volume":"19","author":"Jensen","year":"2024","journal-title":"J. Thorac. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e2535000","DOI":"10.1001\/jamanetworkopen.2025.35000","article-title":"Lung Cancer Screening in Cancer Survivors vs. Those without a History of Cancer","volume":"8","author":"Rivera","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"j347","DOI":"10.1136\/bmj.j347","article-title":"Exposure to low dose computed tomography for lung cancer screening and risk of cancer: Secondary analysis of trial data and risk-benefit analysis","volume":"356","author":"Rampinelli","year":"2017","journal-title":"BMJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.crad.2023.01.006","article-title":"Ultra-low-dose CT lung screening with artificial intelligence iterative reconstruction: Evaluation via automatic nodule-detection software","volume":"78","author":"Yang","year":"2023","journal-title":"Clin. Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1148\/radiol.210551","article-title":"Deep Learning Reconstruction Shows Better Lung Nodule Detection for Ultra-Low-Dose Chest CT","volume":"303","author":"Jiang","year":"2022","journal-title":"Radiology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1007\/s00330-016-4228-3","article-title":"Low-dose computed tomography for lung cancer screening: Comparison of performance between annual and biennial screen","volume":"26","author":"Sverzellati","year":"2016","journal-title":"Eur. Radiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.annonc.2022.01.008","article-title":"Baseline computed tomography screening and blood microRNA predict lung cancer risk and define adequate intervals in the BioMILD trial","volume":"33","author":"Pastorino","year":"2022","journal-title":"Ann. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1001\/jama.2026.8044","article-title":"Biomarker-Based Eligibility for Lung Cancer Screening: Validation of the Protein-Based INTEGRAL-Risk Model","volume":"336","author":"Zahed","year":"2026","journal-title":"JAMA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11764-013-0278-6","article-title":"Screening for new primary cancers in cancer survivors compared to non-cancer controls: A systematic review and meta-analysis","volume":"7","author":"Corkum","year":"2013","journal-title":"J. Cancer Surviv."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.annonc.2023.07.001","article-title":"Overall survival with adjuvant atezolizumab after chemotherapy in resected stage II-IIIA non-small-cell lung cancer (IMpower010): A randomised, multicentre, open-label, phase III trial","volume":"34","author":"Felip","year":"2023","journal-title":"Ann. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1056\/NEJMoa2304594","article-title":"Overall Survival with Osimertinib in Resected EGFR-Mutated NSCLC","volume":"389","author":"Tsuboi","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1056\/NEJMoa2310532","article-title":"Alectinib in Resected ALK-Positive Non-Small-Cell Lung Cancer","volume":"390","author":"Wu","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1056\/NEJMoa2202170","article-title":"Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer","volume":"386","author":"Forde","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1056\/NEJMoa2302983","article-title":"Perioperative Pembrolizumab for Early-Stage Non-Small-Cell Lung Cancer","volume":"389","author":"Wakelee","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1056\/NEJMoa2304875","article-title":"Perioperative Durvalumab for Resectable Non-Small-Cell Lung Cancer","volume":"389","author":"Heymach","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/107327481402100106","article-title":"Survivorship issues for patients with lung cancer","volume":"21","author":"Pozo","year":"2014","journal-title":"Cancer Control"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.chest.2021.12.634","article-title":"The Impact of Persistent Smoking After Surgery on Long-term Outcomes After Stage I Non-small Cell Lung Cancer Resection","volume":"161","author":"Heiden","year":"2022","journal-title":"Chest"},{"key":"ref_36","first-page":"1383","article-title":"The influence of comorbid chronic diseases and physical activity on quality of life in lung cancer survivors","volume":"23","author":"Wang","year":"2015","journal-title":"Support. Care Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/JTO.0b013e3182398e82","article-title":"Predictors of postoperative quality of life after surgery for lung cancer","volume":"7","author":"Moller","year":"2012","journal-title":"J. Thorac. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Menna, C., Rendina, E.A., and D\u2019Andrilli, A. (2022). Parenchymal Sparing Surgery for Lung Cancer: Focus on Pulmonary Artery Reconstruction. Cancers, 14.","DOI":"10.3390\/cancers14194782"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S1470-2045(16)00173-X","article-title":"Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: A randomised controlled trial","volume":"17","author":"Bendixen","year":"2016","journal-title":"Lancet Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Travis, L.B., Fossa, S.D., Sesso, H.D., Frisina, R.D., Herrmann, D.N., Beard, C.J., Feldman, D.R., Pagliaro, L.C., Miller, R.C., and Vaughn, D.J. (2014). Chemotherapy-induced peripheral neurotoxicity and ototoxicity: New paradigms for translational genomics. J. Natl. Cancer Inst., 106.","DOI":"10.1093\/jnci\/dju044"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ni, Y., Lei, J., Huang, W., Wang, J., Guo, H., Lv, F., Kang, S., Lan, K., and Jiang, T. (2023). Systematic review of the perioperative immunotherapy in patients with non-small cell lung cancer: Evidence mapping and synthesis. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1092663"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e008591","DOI":"10.1136\/jitc-2023-008591","article-title":"Chronic immune-related adverse events arising from immune checkpoint inhibitors: An update","volume":"12","author":"Fletcher","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1056\/NEJMoa1709937","article-title":"Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer","volume":"377","author":"Antonia","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1200\/JCO.21.01308","article-title":"Five-Year Survival Outcomes From the PACIFIC Trial: Durvalumab After Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer","volume":"40","author":"Spigel","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1056\/NEJMoa2402614","article-title":"Osimertinib after Chemoradiotherapy in Stage III EGFR-Mutated NSCLC","volume":"391","author":"Lu","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1001\/jamaoncol.2016.4280","article-title":"Comparison of Concurrent Use of Thoracic Radiation with Either Carboplatin-Paclitaxel or Cisplatin-Etoposide for Patients with Stage III Non-Small-Cell Lung Cancer: A Systematic Review","volume":"3","author":"Steuer","year":"2017","journal-title":"JAMA Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zheng, Q., Min, S., and Zhou, Y. (2022). A network meta-analysis for efficacies and toxicities of different concurrent chemoradiotherapy regimens in the treatment of locally advanced non-small cell lung cancer. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-09717-8"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13014-020-01654-9","article-title":"Radiation-induced lung toxicity\u2013cellular and molecular mechanisms of pathogenesis, management, and literature review","volume":"15","author":"Kasmann","year":"2020","journal-title":"Radiat. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.ijrobp.2021.12.150","article-title":"Real-World Safety and Efficacy of Consolidation Durvalumab After Chemoradiation Therapy for Stage III Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis","volume":"112","author":"Wang","year":"2022","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.ijrobp.2024.01.217","article-title":"Pneumonitis Risk After Chemoradiotherapy with and without Immunotherapy in Patients with Locally Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis","volume":"119","author":"Han","year":"2024","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"115266","DOI":"10.1016\/j.ejca.2025.115266","article-title":"Efficacy and safety of immune checkpoint inhibition combined with concurrent chemoradiotherapy in patients with stage III unresectable non-small cell lung cancer: A systematic review and meta-analysis","volume":"218","author":"Acker","year":"2025","journal-title":"Eur. J. Cancer"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1001\/jamaoncol.2024.1841","article-title":"Long-Term Prospective Outcomes of Intensity Modulated Radiotherapy for Locally Advanced Lung Cancer: A Secondary Analysis of a Randomized Clinical Trial","volume":"10","author":"Chun","year":"2024","journal-title":"JAMA Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/S1470-2045(25)00515-7","article-title":"Pirfenidone for grade 2 and grade 3 radiation-induced lung injury: A multicentre, open-label, randomised, phase 2 trial","volume":"26","author":"Hou","year":"2025","journal-title":"Lancet Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e027288","DOI":"10.1161\/JAHA.122.027288","article-title":"Cardiac Adverse Events Associated with Chemo-Radiation Versus Chemotherapy for Resectable Stage III Non-Small-Cell Lung Cancer: A Surveillance, Epidemiology and End Results-Medicare Study","volume":"11","author":"Herbach","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e021686","DOI":"10.1161\/JAHA.121.021686","article-title":"Radiation-Induced Cardiovascular Disease: Review of an Underrecognized Pathology","volume":"10","author":"Eisenberg","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"107531","DOI":"10.1016\/j.lungcan.2024.107531","article-title":"The impact of pre-treatment smoking status on survival after chemoradiotherapy for locally advanced non-small-cell lung cancer","volume":"190","author":"Wallace","year":"2024","journal-title":"Lung Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","article-title":"2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.annonc.2022.12.009","article-title":"Oncogene-addicted metastatic non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"34","author":"Hendriks","year":"2023","journal-title":"Ann. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.tranon.2018.08.010","article-title":"Short-Term Responders of Non-Small Cell Lung Cancer Patients to EGFR Tyrosine Kinase Inhibitors Display High Prevalence of TP53 Mutations and Primary Resistance Mechanisms","volume":"11","author":"Xu","year":"2018","journal-title":"Transl. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Shalata, W., Zolnoorian, J., Migliozzi, G., Jama, A.A., Dudnik, Y., Cohen, A.Y., Meirovitz, A., and Yakobson, A. (2023). Long-Lasting Therapeutic Response following Treatment with Pembrolizumab in Patients with Non-Small Cell Lung Cancer: A Real-World Experience. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065938"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1056\/NEJMoa2510308","article-title":"Survival with Osimertinib plus Chemotherapy in EGFR-Mutated Advanced NSCLC","volume":"394","author":"Janne","year":"2026","journal-title":"N. Engl. J. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1056\/NEJMoa2503001","article-title":"Overall Survival with Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC","volume":"393","author":"Yang","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.jtho.2025.07.117","article-title":"Enhanced Versus Standard Dermatologic Management with Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC: The COCOON Global Randomized Controlled Trial","volume":"20","author":"Cho","year":"2025","journal-title":"J. Thorac. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1200\/JCO.24.01001","article-title":"Subcutaneous Versus Intravenous Amivantamab, Both in Combination with Lazertinib, in Refractory Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer: Primary Results From the Phase III PALOMA-3 Study","volume":"42","author":"Leighl","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"S573","DOI":"10.1016\/j.jtho.2025.09.1080","article-title":"P3.18.65 Trial in Progress\u2014RAsolve 301: A Phase 3 Study of Daraxonrasib (RMC-6236) Vs. Docetaxel in in Patients with Previously Treated RAS Mutant NSCLC","volume":"20","author":"Skoulidis","year":"2025","journal-title":"J. Thorac. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/S1556-0864(25)00201-1","article-title":"6MO: Safety and clinical activity of daraxonrasib (RMC-6236) in RAS mutant non-small cell lung cancer (NSCLC)","volume":"20","author":"Punekar","year":"2025","journal-title":"J. Thorac. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1200\/JCO.24.00581","article-title":"Lorlatinib Versus Crizotinib in Patients with Advanced ALK-Positive Non-Small Cell Lung Cancer: 5-Year Outcomes From the Phase III CROWN Study","volume":"42","author":"Solomon","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Cadranel, J., Corre, R., Roget, P., Wingler, M., Alliaume, S., Bausson, P., Capdevielle, L., Mendes, J., Mogenet, A., and Mennecier, B. (2026). Living with ALK fusion-positive NSCLC: A French nationwide survey of the psychosocial impact among patients, caregivers and healthcare professionals. JTO Clin. Res. Rep., 101038.","DOI":"10.1016\/j.jtocrr.2026.101038"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"108936","DOI":"10.1016\/j.lungcan.2026.108936","article-title":"Osimertinib dose-reduction and survival in 1L EGFR-mutated metastatic non-small cell lung cancer (mNSCLC)","volume":"213","author":"Barsouk","year":"2026","journal-title":"Lung Cancer"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"107535","DOI":"10.1016\/j.lungcan.2024.107535","article-title":"A pragmatic guide for management of adverse events associated with lorlatinib","volume":"191","author":"Liu","year":"2024","journal-title":"Lung Cancer"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.annonc.2022.12.013","article-title":"Non-oncogene-addicted metastatic non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"34","author":"Hendriks","year":"2023","journal-title":"Ann. Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1200\/JCO.21.01497","article-title":"First-Line Immunotherapy for Non-Small-Cell Lung Cancer","volume":"40","author":"Reck","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e581","DOI":"10.1200\/OP.22.00560","article-title":"Increasing Racial and Ethnic Equity, Diversity, and Inclusion in Cancer Treatment Trials: Evaluation of an ASCO-Association of Community Cancer Centers Site Self-Assessment","volume":"19","author":"Guerra","year":"2023","journal-title":"JCO Oncol. Pract."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"S402","DOI":"10.1016\/j.jtho.2024.09.730","article-title":"P4.11E.17 Clinical Outcomes and Immunotherapy Retreatment in Patients with Metastatic NSCLC Who Complete at Least Two Years of Immune Checkpoint Blockade","volume":"19","author":"Ricciuti","year":"2024","journal-title":"J. Thorac. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1001\/jamaoncol.2023.1891","article-title":"Association Between Duration of Immunotherapy and Overall Survival in Advanced Non-Small Cell Lung Cancer","volume":"9","author":"Sun","year":"2023","journal-title":"JAMA Oncol."},{"key":"ref_76","first-page":"100970","article-title":"Impact of pembrolizumab treatment duration on overall survival and prognostic factors in advanced non-small cell lung cancer: A nationwide retrospective cohort study","volume":"43","author":"Rousseau","year":"2024","journal-title":"Lancet Reg. Health\u2013Eur."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"116579","DOI":"10.1016\/j.ejca.2026.116579","article-title":"Real-world outcomes of immunotherapy discontinuation at two years in advanced non-small cell lung cancer: Final results of the I-STOP study","volume":"237","author":"Gemelli","year":"2026","journal-title":"Eur. J. Cancer"},{"key":"ref_78","first-page":"100851","article-title":"Late Immune-Related Adverse Events After At Least Two Years of Immune Checkpoint Inhibitor Therapy: Incidence and Association with Survival in Patients with Advanced NSCLC","volume":"6","author":"Elghawy","year":"2025","journal-title":"JTO Clin. Res. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(24)02722-3","article-title":"Ivonescimab versus pembrolizumab for PD-L1-positive non-small cell lung cancer (HARMONi-2): A randomised, double-blind, phase 3 study in China","volume":"405","author":"Xiong","year":"2025","journal-title":"Lancet"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/jama.2024.10613","article-title":"Ivonescimab Plus Chemotherapy in Non-Small Cell Lung Cancer with EGFR Variant: A Randomized Clinical Trial","volume":"332","author":"Investigators","year":"2024","journal-title":"JAMA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1056\/NEJMoa2502099","article-title":"Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy","volume":"393","author":"Mountzios","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.annonc.2023.07.006","article-title":"Randomized open-label controlled study of cancer vaccine OSE2101 versus chemotherapy in HLA-A2-positive patients with advanced non-small-cell lung cancer with resistance to immunotherapy: ATALANTE-1","volume":"34","author":"Besse","year":"2023","journal-title":"Ann. Oncol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1056\/NEJMoa1809064","article-title":"First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer","volume":"379","author":"Horn","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0140-6736(19)32222-6","article-title":"Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): A randomised, controlled, open-label, phase 3 trial","volume":"394","author":"Dvorkin","year":"2019","journal-title":"Lancet"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/S0140-6736(25)01011-6","article-title":"Efficacy and safety of first-line maintenance therapy with lurbinectedin plus atezolizumab in extensive-stage small-cell lung cancer (IMforte): A randomised, multicentre, open-label, phase 3 trial","volume":"405","author":"Borghaei","year":"2025","journal-title":"Lancet"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.annonc.2021.03.207","article-title":"Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(\u2606)","volume":"32","author":"Dingemans","year":"2021","journal-title":"Ann. Oncol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1056\/NEJMoa2404873","article-title":"Durvalumab after Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer","volume":"391","author":"Cheng","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1200\/JCO-25-00221","article-title":"Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients with Small Cell Lung Cancer: Randomized Phase II\/III Trial NRG-CC003","volume":"43","author":"Gondi","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jtho.2021.12.005","article-title":"Quitting Smoking At or Around Diagnosis Improves the Overall Survival of Lung Cancer Patients: A Systematic Review and Meta-Analysis","volume":"17","author":"Caini","year":"2022","journal-title":"J. Thorac. Oncol."},{"key":"ref_90","unstructured":"(2026, July 26). WHO Clinical Treatment Guideline for Tobacco Cessation in Adults [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK604665\/."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1158\/1055-9965.EPI-15-0257","article-title":"Systematic Review of Tobacco Use after Lung or Head\/Neck Cancer Diagnosis: Results and Recommendations for Future Research","volume":"24","author":"Burris","year":"2015","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1001\/jamaoncol.2024.4890","article-title":"Survival Outcomes of an Early Intervention Smoking Cessation Treatment After a Cancer Diagnosis","volume":"10","author":"Cinciripini","year":"2024","journal-title":"JAMA Oncol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"100025","DOI":"10.1016\/j.pecinn.2022.100025","article-title":"Reducing stigma triggered by assessing smoking status among patients diagnosed with lung cancer: De-stigmatizing do and don\u2019t lessons learned from qualitative interviews","volume":"1","author":"Ostroff","year":"2022","journal-title":"PEC Innov."},{"key":"ref_94","first-page":"CD010216","article-title":"Electronic cigarettes for smoking cessation","volume":"11","author":"Lindson","year":"2025","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_95","first-page":"CD013790","article-title":"Heated tobacco products for smoking cessation and reducing smoking prevalence","volume":"1","author":"Kock","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1200\/JCO.2011.38.5161","article-title":"American Society of Clinical Oncology provisional clinical opinion: The integration of palliative care into standard oncology care","volume":"30","author":"Smith","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1200\/JCO.21.01710","article-title":"Patient-Centered Palliative Care for Patients with Advanced Lung Cancer","volume":"40","author":"Temel","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Jordan, R.I., Allsop, M.J., ElMokhallalati, Y., Jackson, C.E., Edwards, H.L., Chapman, E.J., Deliens, L., and Bennett, M.I. (2020). Duration of palliative care before death in international routine practice: A systematic review and meta-analysis. BMC Med., 18.","DOI":"10.1186\/s12916-020-01829-x"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/jama.2024.10398","article-title":"Stepped Palliative Care for Patients with Advanced Lung Cancer: A Randomized Clinical Trial","volume":"332","author":"Temel","year":"2024","journal-title":"JAMA"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e098075","DOI":"10.1136\/bmjopen-2024-098075","article-title":"Blended palliative and survivorship care intervention (POISE) for patients with metastatic oncogene-driven non-small cell lung cancer: Study protocol for a pilot randomised controlled trial","volume":"15","author":"Richard","year":"2025","journal-title":"BMJ Open"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e1373","DOI":"10.1093\/oncolo\/oyae050","article-title":"Early Incorporation to Palliative Care (EPC) in Patients with Advanced Non-Small Cell Lung Cancer: The PACO Randomized Clinical Trial","volume":"29","author":"Allende","year":"2024","journal-title":"Oncologist"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1089\/jpm.2022.0544","article-title":"Improving Access and Timeliness of Early Palliative Care Specialist Assessment for Patients with Advanced Lung Cancer in a Rapid Assessment Clinic","volume":"26","author":"Robertson","year":"2023","journal-title":"J. Palliat. Med."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"(1998). Cancer care during the last phase of life. J. Clin. Oncol., 16, 1986\u20131996.","DOI":"10.1200\/JCO.1998.16.5.1986"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1089\/jpm.2023.0040","article-title":"Intersection of Palliative Care and Hospice Use Among Patients with Advanced Lung Cancer","volume":"26","author":"Hooker","year":"2023","journal-title":"J. Palliat. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1177\/10966218251393031","article-title":"Specialist Palliative Care Reduces the Need for Acute Health Care Services in Patients with Nonmalignant Pulmonary Diseases and Lung Cancer: A Nationwide Study","volume":"29","author":"Pihlaja","year":"2026","journal-title":"J. Palliat. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1200\/JCO.2012.43.6055","article-title":"Associations between end-of-life discussion characteristics and care received near death: A prospective cohort study","volume":"30","author":"Mack","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"204","DOI":"10.7326\/0003-4819-156-3-201202070-00008","article-title":"End-of-life care discussions among patients with advanced cancer: A cohort study","volume":"156","author":"Mack","year":"2012","journal-title":"Ann. Intern. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1200\/JCO.2015.63.6696","article-title":"Discussions of Life Expectancy and Changes in Illness Understanding in Patients with Advanced Cancer","volume":"34","author":"Epstein","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"107800","DOI":"10.1016\/j.lungcan.2024.107800","article-title":"Palliative care integration and end-of-life care intensity for patients with NSCLC","volume":"192","author":"Martin","year":"2024","journal-title":"Lung Cancer"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1200\/OP.21.00299","article-title":"Effect of Early Palliative Care on End-of-Life Health Care Costs: A Population-Based, Propensity Score-Matched Cohort Study","volume":"18","author":"Seow","year":"2022","journal-title":"JCO Oncol. Pract."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e2458576","DOI":"10.1001\/jamanetworkopen.2024.58576","article-title":"Algorithm-Based Palliative Care in Patients with Cancer: A Cluster Randomized Clinical Trial","volume":"8","author":"Parikh","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jpainsymman.2018.03.013","article-title":"Evaluating the Feasibility and Acceptability of a Telehealth Program in a Rural Palliative Care Population: TapCloud for Palliative Care","volume":"56","author":"Bonsignore","year":"2018","journal-title":"J. Pain Symptom Manag."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1177\/02692163211006317","article-title":"Web and mobile-based symptom management interventions for physical symptoms of people with advanced cancer: A systematic review and meta-analysis","volume":"35","author":"Saeidzadeh","year":"2021","journal-title":"Palliat. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1089\/jpm.2025.0066","article-title":"Pilot Feasibility Trial of a Supportive Care Digital Application for Patients with Advanced Nonsmall Cell Lung Cancer","volume":"28","author":"Boulanger","year":"2025","journal-title":"J. Palliat. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"8567","DOI":"10.1002\/cam4.5538","article-title":"Racial and ethnic inequities of palliative care use among advanced Non-Small cell lung cancer patients in the US","volume":"12","author":"Islam","year":"2023","journal-title":"Cancer Med."},{"key":"ref_116","first-page":"75","article-title":"Sex and Racial\/Ethnic Differences in End-of-Life Care in Decedents with Lung Cancer in Texas","volume":"29","author":"Serna","year":"2026","journal-title":"J. Palliat. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e2694","DOI":"10.1136\/spcare-2022-004038","article-title":"Extensive stage small cell lung cancer (ES-SCLC) and palliative care disparities: A national cancer database study","volume":"14","author":"Khullar","year":"2024","journal-title":"BMJ Support. Palliat. Care"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1001\/jamainternmed.2016.1548","article-title":"Association of Leisure-Time Physical Activity with Risk of 26 Types of Cancer in 1.44 Million Adults","volume":"176","author":"Moore","year":"2016","journal-title":"JAMA Intern. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1249\/MSS.0b013e31829a3b63","article-title":"Impact of resistance training in cancer survivors: A meta-analysis","volume":"45","author":"Strasser","year":"2013","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/bjsports-2015-094787","article-title":"Exercise improves quality of life in patients with cancer: A systematic review and meta-analysis of randomised controlled trials","volume":"50","author":"Gerritsen","year":"2016","journal-title":"Br. J. Sports Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.lungcan.2020.05.003","article-title":"Effects of an exercise intervention for patients with advanced inoperable lung cancer undergoing chemotherapy: A randomized clinical trial","volume":"145","author":"Quist","year":"2020","journal-title":"Lung Cancer"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1080\/0284186X.2023.2180660","article-title":"Sarcopenia and loss of muscle mass in patients with lung cancer undergoing chemotherapy treatment: A systematic review and meta-analysis","volume":"62","author":"Jensen","year":"2023","journal-title":"Acta Oncol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e582","DOI":"10.1016\/j.cllc.2025.07.005","article-title":"The Effect of Exercise on Quality of Life in Patients with Advanced Lung Cancer: A Secondary Analysis of a Randomized Controlled Trial","volume":"26","author":"Bloch","year":"2025","journal-title":"Clin. Lung Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11764-021-01153-0","article-title":"The effects of physical exercise in the palliative care phase for people with advanced cancer: A systematic review with meta-analysis","volume":"17","author":"Toohey","year":"2023","journal-title":"J. Cancer Surviv."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e70092","DOI":"10.1002\/jcsm.70092","article-title":"Association of Pre- and Postdiagnosis Physical Activity, Promotion and Maintenance with Lung Cancer Survival: A Nationwide Cohort Study","volume":"16","author":"Kim","year":"2025","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1200\/JCO.20.01336","article-title":"Prospective Cohort Study of Pre- and Postdiagnosis Physical Activity and Endometrial Cancer Survival","volume":"38","author":"Friedenreich","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12955-016-0461-3","article-title":"Impact of self-reported physical activity and health promotion behaviors on lung cancer survivorship","volume":"14","author":"Sloan","year":"2016","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_128","first-page":"230","article-title":"American Cancer Society nutrition and physical activity guideline for cancer survivors","volume":"72","author":"Rock","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1200\/JCO.22.00687","article-title":"Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline","volume":"40","author":"Ligibel","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1249\/MSS.0000000000002117","article-title":"American College of Sports Medicine Roundtable Report on Physical Activity, Sedentary Behavior, and Cancer Prevention and Control","volume":"51","author":"Patel","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s11764-021-01080-0","article-title":"Implementation barriers to integrating exercise as medicine in oncology: An ecological scoping review","volume":"16","author":"Kennedy","year":"2022","journal-title":"J. Cancer Surviv."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1007\/s00432-022-04232-6","article-title":"Willingness, preferences, barriers, and facilitators of a multimodal supportive care intervention including exercise, nutritional and psychological approach in patients with cancer: A cross-sectional study","volume":"149","author":"Avancini","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"103624","DOI":"10.1016\/j.esmoop.2024.103624","article-title":"A cross-sectional study evaluating the exercise discussion with oncologist during cancer consultation: The CONNECT study","volume":"9","author":"Avancini","year":"2024","journal-title":"ESMO Open"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1016\/j.clnu.2021.02.005","article-title":"ESPEN practical guideline: Clinical Nutrition in cancer","volume":"40","author":"Muscaritoli","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1002\/cncr.29488","article-title":"Diet quality of cancer survivors and noncancer individuals: Results from a national survey","volume":"121","author":"Zhang","year":"2015","journal-title":"Cancer"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: An international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41591-023-02232-8","article-title":"Body composition and lung cancer-associated cachexia in TRACERx","volume":"29","author":"Weiss","year":"2023","journal-title":"Nat. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pccm.2024.02.003","article-title":"Understanding cachexia and its impact on lung cancer and beyond","volume":"2","author":"Yue","year":"2024","journal-title":"Chin. Med. J. Pulm. Crit. Care Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1200\/JCO.21.01440","article-title":"Management of Immune-Related Adverse Events in Patients Treated with Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update","volume":"39","author":"Schneider","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1038\/s41591-024-03008-4","article-title":"Entrectinib in ROS1-positive advanced non-small cell lung cancer: The phase 2\/3 BFAST trial","volume":"30","author":"Peters","year":"2024","journal-title":"Nat. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e70198","DOI":"10.1111\/1759-7714.70198","article-title":"Impact of Long-Term Structured Exercise on Body Composition in an NTRK Fusion-Positive NSCLC Patient Treated with Entrectinib","volume":"16","author":"Avancini","year":"2025","journal-title":"Thorac. Cancer"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1634\/theoncologist.2018-0380","article-title":"Clinical Management of Adverse Events Associated with Lorlatinib","volume":"24","author":"Bauer","year":"2019","journal-title":"Oncologist"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Mantz, L., Mercaldo, N.D., Peterson, J., Abadi, P.T., Krueger, E.A., Fintelmann, F.J., and Dagogo-Jack, I. (2026). Weight Gain on Lorlatinib is Associated with Accumulation of Visceral Adipose Tissue. J. Thorac. Oncol., 104078.","DOI":"10.1016\/j.jtho.2026.104078"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.clnesp.2020.10.023","article-title":"A national survey of oncology survivors examining nutrition attitudes, problems and behaviours, and access to dietetic care throughout the cancer journey","volume":"41","author":"Sullivan","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/jhn.13111","article-title":"Sources of nutrition advice and desired nutrition guidance in oncology care: Patient\u2019s perspectives","volume":"36","author":"Keaver","year":"2023","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"102864","DOI":"10.1016\/j.eclinm.2024.102864","article-title":"Health inequalities in cancer care: A literature review of pathways to diagnosis in the United Kingdom","volume":"76","author":"Scott","year":"2024","journal-title":"EClinicalMedicine"},{"key":"ref_147","first-page":"290","article-title":"Dietitians\u2019 practices and perspectives of the delivery of nutritional care to cancer survivors in the primary care setting","volume":"33","author":"Ryding","year":"2025","journal-title":"Support. Care Cancer"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cllc.2014.08.004","article-title":"Long-term lung cancer survivors have permanently decreased quality of life after surgery","volume":"16","author":"Rauma","year":"2015","journal-title":"Clin. Lung Cancer"},{"key":"ref_149","first-page":"e13525","article-title":"Unmet supportive care needs associated with quality of life for people with lung cancer: A systematic review of the evidence 2007\u20132020","volume":"31","author":"Cochrane","year":"2022","journal-title":"Eur. J. Cancer Care"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.lungcan.2014.09.009","article-title":"Depression, anxiety and disease-related distress in couples affected by advanced lung cancer","volume":"86","author":"Haun","year":"2014","journal-title":"Lung Cancer"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.lungcan.2020.02.014","article-title":"Severe symptoms persist for Up to one year after diagnosis of stage I-III lung cancer: An analysis of province-wide patient reported outcomes","volume":"142","author":"Hirpara","year":"2020","journal-title":"Lung Cancer"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.lungcan.2016.08.002","article-title":"Scan-associated distress in lung cancer: Quantifying the impact of \u201cscanxiety\u201d","volume":"100","author":"Bauml","year":"2016","journal-title":"Lung Cancer"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Derry-Vick, H.M., Heathcote, L.C., Glesby, N., Stribling, J., Luebke, M., Epstein, A.S., and Prigerson, H.G. 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Natl. Compr. Cancer Netw."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1200\/JCO.23.00293","article-title":"Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update","volume":"41","author":"Andersen","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e69621","DOI":"10.2196\/69621","article-title":"Digital Health Interventions to Improve Mental Health in Patients with Cancer: Umbrella Review","volume":"27","author":"Zhong","year":"2025","journal-title":"J. Med. Internet Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.jsxm.2019.05.019","article-title":"Sexual Function in Patients Treated with Stereotactic Radiotherapy For Prostate Cancer: A Systematic Review of the Current Evidence","volume":"16","author":"Loi","year":"2019","journal-title":"J. Sex. Med."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Tramacere, F., Lancellotta, V., Casa, C., Fionda, B., Cornacchione, P., Mazzarella, C., De Vincenzo, R.P., Macchia, G., Ferioli, M., and Rovirosa, A. (2022). Assessment of Sexual Dysfunction in Cervical Cancer Patients after Different Treatment Modality: A Systematic Review. Medicina, 58.","DOI":"10.3390\/medicina58091223"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jsxm.2015.12.034","article-title":"Incidence and Prevalence of Sexual Dysfunction in Women and Men: A Consensus Statement from the Fourth International Consultation on Sexual Medicine 2015","volume":"13","author":"McCabe","year":"2016","journal-title":"J. Sex. Med."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Perz, J., Ussher, J.M., Gilbert, E., Australian, C., and Sexuality Study, T. (2014). Feeling well and talking about sex: Psycho-social predictors of sexual functioning after cancer. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-228"},{"key":"ref_163","first-page":"101001","article-title":"Multidisciplinary Approach to Sexual Dysfunction in Persons with Lung Cancer-Spanish Lung Cancer Group Expert Consensus Statement","volume":"7","author":"Losada","year":"2026","journal-title":"JTO Clin. Res. Rep."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1200\/JCO.2012.41.7915","article-title":"Sexuality in adult cancer survivors: Challenges and intervention","volume":"30","author":"Bober","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_165","first-page":"920","article-title":"Sexual health of patients with lung cancer: A systematic review","volume":"33","author":"Zanni","year":"2025","journal-title":"Support. Care Cancer"},{"key":"ref_166","first-page":"94","article-title":"The impact of thoracotomy on psychological and sexual function in men with lung cancer","volume":"17","author":"Bolat","year":"2019","journal-title":"Rev. Int. Androl."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Costa, M., Fernandes, C.L., Leite, J., Vilaca, M., Estevinho, F., and Magalhaes, H. (2025). Sexual Health of Patients in Treatment for Lung Cancer: An Undercover Concern for Patients and Oncologists. Curr. Oncol., 32.","DOI":"10.3390\/curroncol32020107"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"104539","DOI":"10.1016\/j.esmoop.2025.104539","article-title":"LUDICAS: Sexual dysfunction in patients with lung cancer, a multicenter cross-sectional study","volume":"10","author":"Aparisi","year":"2025","journal-title":"ESMO Open"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/pon.1787","article-title":"Communication about sexuality and intimacy in couples affected by lung cancer and their clinical-care providers","volume":"20","author":"Lindau","year":"2011","journal-title":"Psychooncology"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/cncr.35057","article-title":"Sexual Health Assessment in Women with Lung Cancer study: Sexual health assessment in women with lung cancer","volume":"130","author":"Florez","year":"2024","journal-title":"Cancer"},{"key":"ref_171","first-page":"1147","article-title":"Sexual dysfunction in patients with cancer, a challenge in oncology practice: Results of the CLARIFY project","volume":"26","author":"Maximiano","year":"2024","journal-title":"Clin. Transl. Oncol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1007\/s13187-019-01559-6","article-title":"Discussing Sexual Health in the Medical Oncologist\u2019s Practice: Exploring Current Practice and Challenges","volume":"35","author":"Krouwel","year":"2020","journal-title":"J. Cancer Educ."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1200\/JCO.2017.75.8995","article-title":"Interventions to Address Sexual Problems in People with Cancer: American Society of Clinical Oncology Clinical Practice Guideline Adaptation of Cancer Care Ontario Guideline","volume":"36","author":"Carter","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1002\/cncr.30263","article-title":"Sexuality after a cancer diagnosis: A population-based study","volume":"122","author":"Jackson","year":"2016","journal-title":"Cancer"},{"key":"ref_175","first-page":"CD006145","article-title":"Exercise for the management of cancer-related fatigue in adults","volume":"11","author":"Cramp","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1200\/JCO.24.00541","article-title":"Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update","volume":"42","author":"Bower","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Pang, K., Pan, D., Xu, H., Ma, Y., Wang, J., Xu, P., Wang, H., and Zang, G. (2022). Advances in physical diagnosis and treatment of male erectile dysfunction. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.1096741"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s11764-016-0585-9","article-title":"Vaginal and sexual health treatment strategies within a female sexual medicine program for cancer patients and survivors","volume":"11","author":"Carter","year":"2017","journal-title":"J. Cancer Surviv."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1200\/JCO-24-02782","article-title":"Fertility Preservation in People with Cancer: ASCO Guideline Update","volume":"43","author":"Su","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"e2444540","DOI":"10.1001\/jamanetworkopen.2024.44540","article-title":"Patient-Reported Discussions on Fertility Preservation Before Early-Onset Cancer Treatment","volume":"7","author":"Keller","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"100276","DOI":"10.1016\/j.esmoop.2021.100276","article-title":"Checkpoint inhibitors, fertility, pregnancy, and sexual life: A systematic review","volume":"6","author":"Garutti","year":"2021","journal-title":"ESMO Open"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1634\/theoncologist.2019-0837","article-title":"It Is Time to Talk about Fertility and Immunotherapy","volume":"25","author":"Duma","year":"2020","journal-title":"Oncologist"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s10815-021-02181-6","article-title":"Fertility considerations in targeted biologic therapy with tyrosine kinase inhibitors: A review","volume":"38","author":"Rambhatla","year":"2021","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.theriogenology.2017.05.014","article-title":"Reversible meiotic arrest of bovine oocytes by EGFR inhibition and follicular hemisections","volume":"99","author":"Duggavathi","year":"2017","journal-title":"Theriogenology"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"101308","DOI":"10.1016\/j.mam.2024.101308","article-title":"Impacts of cancer therapy on male fertility: Past and present","volume":"100","author":"Duffin","year":"2024","journal-title":"Mol. Asp. Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"e002220","DOI":"10.1136\/jitc-2020-002220","article-title":"Immune checkpoint inhibitor-related hypogonadism and infertility: A neglected issue in immuno-oncology","volume":"9","author":"Ozdemir","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"e432488","DOI":"10.1200\/EDBK_432488","article-title":"Tackling Non-Small Cell Lung Cancer in Young Adults: From Risk Factors and Genetic Susceptibility to Lung Cancer Profile and Outcomes","volume":"44","author":"Laguna","year":"2024","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"S317","DOI":"10.1016\/j.jtho.2024.09.569","article-title":"P3.03I.19 The International Pregnancy and Lung Cancer Registry at Dana-Farber Cancer Institute","volume":"19","author":"Florez","year":"2024","journal-title":"J. Thorac. Oncol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0140-6736(17)33326-3","article-title":"Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): Analysis of individual records for 37,513,025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries","volume":"391","author":"Allemani","year":"2018","journal-title":"Lancet"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/annonc\/mdu022","article-title":"Management of elderly patients with NSCLC; updated expert\u2019s opinion paper: EORTC Elderly Task Force, Lung Cancer Group and International Society for Geriatric Oncology","volume":"25","author":"Pallis","year":"2014","journal-title":"Ann. Oncol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"e2500276","DOI":"10.1200\/GO-25-00276","article-title":"Geriatric Assessment: ASCO Global Guideline","volume":"11","author":"Bergerot","year":"2025","journal-title":"JCO Glob. Oncol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1056\/NEJMra2301292","article-title":"Frailty in Older Adults","volume":"391","author":"Kim","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1200\/JCO.23.00933","article-title":"Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Systemic Cancer Therapy: ASCO Guideline Update","volume":"41","author":"Dale","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"39898","DOI":"10.1038\/s41598-025-20785-1","article-title":"Frailty as a predictor of mortality in lung cancer survivors: Evidence from a nationally representative cohort NHIS 1997\u20132018","volume":"15","author":"Wang","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Grogan, M., Hoyd, R., Benedict, J., Janse, S., Williams, N., Naughton, M., Burd, C.E., Paskett, E.D., Rosko, A., and Spakowicz, D.J. (2024). The FITNESS study: Longitudinal geriatric assessment, treatment toxicity, and biospecimen collection to assess functional disability among older adults with lung cancer. Front. Aging, 5.","DOI":"10.3389\/fragi.2024.1268232"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"104212","DOI":"10.1016\/j.critrevonc.2023.104212","article-title":"Antibody drug conjugates in older patients: State of the art","volume":"193","author":"Rached","year":"2024","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"102394","DOI":"10.1016\/j.ctrv.2022.102394","article-title":"The use of immunotherapy in older patients with advanced non-small cell lung cancer","volume":"106","author":"Tagliamento","year":"2022","journal-title":"Cancer Treat. Rev."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jinf.2014.10.008","article-title":"The association between infections and chemotherapy interruptions among cancer patients: Prospective cohort study","volume":"70","author":"Taha","year":"2015","journal-title":"J. Infect."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Schmedt, N., Heuer, O.D., Hackl, D., Sato, R., and Theilacker, C. (2019). Burden of community-acquired pneumonia, predisposing factors and health-care related costs in patients with cancer. BMC Health Serv. Res., 19.","DOI":"10.1186\/s12913-018-3861-8"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1200\/JCO.24.00032","article-title":"Vaccination of Adults with Cancer: ASCO Guideline","volume":"42","author":"Kamboj","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Leduc, C., Antoni, D., Charloux, A., Falcoz, P.E., and Quoix, E. (2017). Comorbidities in the management of patients with lung cancer. Eur. Respir. J., 49.","DOI":"10.1183\/13993003.01721-2016"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s40271-016-0204-x","article-title":"A Systematic Review of Financial Toxicity Among Cancer Survivors: We Can\u2019t Pay the Co-Pay","volume":"10","author":"Gordon","year":"2017","journal-title":"Patient"},{"key":"ref_203","first-page":"341","article-title":"Cancer diagnosis and treatment in working-age adults: Implications for employment, health insurance coverage, and financial hardship in the United States","volume":"74","author":"Yabroff","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"e1110","DOI":"10.1200\/OP.20.00723","article-title":"Unmet Care Needs and Financial Hardship in Patients With Metastatic Non-Small-Cell Lung Cancer on Immunotherapy or Chemoimmunotherapy in Clinical Practice","volume":"17","author":"McLouth","year":"2021","journal-title":"JCO Oncol. Pract."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"e246872","DOI":"10.1001\/jamanetworkopen.2024.6872","article-title":"Unmet Needs, Quality of Life, and Financial Toxicity Among Survivors of Lung Cancer","volume":"7","author":"Hsu","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_206","first-page":"437","article-title":"Navigating financial toxicity in patients with cancer: A multidisciplinary management approach","volume":"72","author":"Smith","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"152119","DOI":"10.1016\/j.soncn.2025.152119","article-title":"Financial Hardship Among Newly Diagnosed Patients with Lung Cancer and Their Caregivers: A Dyadic Analysis","volume":"42","author":"Jia","year":"2026","journal-title":"Semin. Oncol. Nurs."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/pon.3562","article-title":"Family caregivers\u2019 distress levels related to quality of life, burden, and preparedness","volume":"24","author":"Fujinami","year":"2015","journal-title":"Psychooncology"},{"key":"ref_209","first-page":"2371","article-title":"Longitudinal associations between caregiver burden and patient and spouse distress in couples coping with lung cancer","volume":"21","author":"Milbury","year":"2013","journal-title":"Support. Care Cancer"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Ullrich, A., Ascherfeld, L., Marx, G., Bokemeyer, C., Bergelt, C., and Oechsle, K. (2017). Quality of life, psychological burden, needs, and satisfaction during specialized inpatient palliative care in family caregivers of advanced cancer patients. BMC Palliat. Care, 16.","DOI":"10.1186\/s12904-017-0206-z"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Hirayama, K., Kuribara, T., and Oshikiri, M. (2023). Experiences of the older spousal caregivers of patients with cancer during palliative chemotherapy: A qualitative descriptive study. BMC Palliat. Care, 22.","DOI":"10.1186\/s12904-023-01313-2"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"c2581","DOI":"10.1136\/bmj.c2581","article-title":"Archetypal trajectories of social, psychological, and spiritual wellbeing and distress in family care givers of patients with lung cancer: Secondary analysis of serial qualitative interviews","volume":"340","author":"Murray","year":"2010","journal-title":"BMJ"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1007\/s11136-015-1028-1","article-title":"Caring for relatives with lung cancer in Europe: An evaluation of caregivers\u2019 experience","volume":"24","author":"Jassem","year":"2015","journal-title":"Qual. Life Res."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/pon.4529","article-title":"Impact of caregiver burden on mental health in bereaved caregivers of cancer patients: A systematic review","volume":"27","author":"Grosse","year":"2018","journal-title":"Psychooncology"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Tay, D.L., Dubose, K., Chipman, J., Ellington, L., Alnajar, M., Iacob, E., Stephens, C., and Ornstein, K.A. (2025). Risk of mental health conditions in bereavement: A population-based analysis of lung cancer spouses. Front. Public Health, 13.","DOI":"10.3389\/fpubh.2025.1539180"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Lei, F., Lee, E., Shin, J., and Lee, S.Y. (2023). Non-pharmacological interventions on anxiety and depression in lung cancer patients\u2019 informal caregivers: A systematic review and meta-analysis. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0282887"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/pon.5694","article-title":"Variables associated with distress amongst informal caregivers of people with lung cancer: A systematic review of the literature","volume":"30","author":"Cochrane","year":"2021","journal-title":"Psychooncology"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.pec.2020.05.009","article-title":"Online peer-to-peer support for persons affected by prostate cancer: A systematic review","volume":"103","author":"Ihrig","year":"2020","journal-title":"Patient Educ. Couns."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jtho.2020.10.017","article-title":"Lung Cancer Stigma Then and Now: Continued Challenges Amid a Landscape of Progress","volume":"16","author":"Hamann","year":"2021","journal-title":"J. Thorac. Oncol."},{"key":"ref_220","first-page":"553","article-title":"Identifying Barriers to Advocacy Among Patients with Lung Cancer: The Role of Stigma-Related Interpersonal Constraint","volume":"49","author":"Price","year":"2022","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jtho.2024.12.010","article-title":"Actionable NSCLC Mutation Identification by Comprehensive Genomic Profiling for Clinical Trial Enrollment: The European Program for the Routine Testing of Patients with Advanced Lung Cancer (EPROPA)","volume":"20","author":"Passiglia","year":"2025","journal-title":"J. Thorac. Oncol."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Pompili, C., Ungaro, A., Pateli-Bell, K., Shilo, S., Hennink, M., Diaz, Y., Vallone, S., Novello, S., and Montague, D. (2026). Patient Advocacy in Transforming Surgical Lung Cancer Care in Europe. Interdiscip. Cardiovasc. Thorac. Surg., 41.","DOI":"10.1093\/icvts\/ivag012"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/2374373517714451","article-title":"Live, Learn, Pass It on: A Patient Advocacy Engagement Project on the Lived Experience of Lung Cancer Survivors","volume":"4","author":"Dy","year":"2017","journal-title":"J. Patient Exp."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"e35969","DOI":"10.1002\/cncr.35969","article-title":"The American Cancer Society National Lung Cancer Roundtable strategic plan: Changing the lung cancer story: Addressing survivorship, stigma, and nihilism to facilitate transformation","volume":"131","author":"Studts","year":"2025","journal-title":"Cancer"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s10555-024-10187-6","article-title":"Healthcare disparities, screening, and molecular testing in the changing landscape of non-small cell lung cancer in the United States: A review","volume":"43","author":"Kurzrock","year":"2024","journal-title":"Cancer Metastasis Rev."},{"key":"ref_226","first-page":"308","article-title":"Cancer treatment and survivorship statistics, 2025","volume":"75","author":"Wagle","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s11764-021-01024-8","article-title":"Living with and beyond metastatic non-small cell lung cancer: The survivorship experience for people treated with immunotherapy or targeted therapy","volume":"15","author":"Heynemann","year":"2021","journal-title":"J. Cancer Surviv."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1200\/JCO.22.02212","article-title":"Evolving Landscape of Metastatic Cancer Survivorship: Reconsidering Clinical Care, Policy, and Research Priorities for the Modern Era","volume":"41","author":"Heynemann","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.7326\/M21-0252","article-title":"Postdiagnosis Smoking Cessation and Reduced Risk for Lung Cancer Progression and Mortality: A Prospective Cohort Study","volume":"174","author":"Sheikh","year":"2021","journal-title":"Ann. Intern. Med."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/jnci\/djab224","article-title":"The Survival Impact of Second Primary Lung Cancer in Patients with Lung Cancer","volume":"114","author":"Choi","year":"2022","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/HCR.0000000000000658","article-title":"Implementation and Effectiveness of a Veterans Affairs-Based Comprehensive Lung Cancer Survivorship Program","volume":"42","author":"Rabe","year":"2022","journal-title":"J. Cardiopulm. Rehabil. Prev."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.cllc.2024.09.008","article-title":"Implementation and Retrospective Examination of a Lung Cancer Survivorship Clinic in a Comprehensive Cancer Center","volume":"26","author":"Price","year":"2025","journal-title":"Clin. Lung Cancer"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"e2447325","DOI":"10.1001\/jamanetworkopen.2024.47325","article-title":"Home-Based Exercise and Self-Management After Lung Cancer Resection: A Randomized Clinical Trial","volume":"7","author":"Granger","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_234","first-page":"546","article-title":"Telemedicine-based inspiratory muscle training and walking promotion with lung cancer survivors following curative intent therapy: A parallel-group pilot randomized trial","volume":"31","author":"Ha","year":"2023","journal-title":"Support. Care Cancer"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.3390\/curroncol29060349","article-title":"A Narrative Review on the Collection and Use of Electronic Patient-Reported Outcomes in Cancer Survivorship Care with Emphasis on Symptom Monitoring","volume":"29","author":"Mols","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"e2200187","DOI":"10.1200\/CCI.22.00187","article-title":"Tenets for Implementing Electronic Patient-Reported Outcomes for Remote Symptom Monitoring During Cancer Treatment","volume":"7","author":"Basch","year":"2023","journal-title":"JCO Clin. Cancer Inform."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1158\/2159-8290.CD-17-0716","article-title":"Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling","volume":"7","author":"Chaudhuri","year":"2017","journal-title":"Cancer Discov."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.annonc.2022.05.520","article-title":"ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: A report from the ESMO Precision Medicine Working Group","volume":"33","author":"Pascual","year":"2022","journal-title":"Ann. Oncol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"e072322","DOI":"10.1136\/bmjopen-2023-072322","article-title":"Evaluation of Managing Cancer and Living Meaningfully (CALM) in people with advanced non-small cell lung cancer treated with immunotherapies or targeted therapies: Protocol for a single-arm, mixed-methods pilot study","volume":"13","author":"Lynch","year":"2023","journal-title":"BMJ Open"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1056\/NEJMoa1000678","article-title":"Early palliative care for patients with metastatic non-small-cell lung cancer","volume":"363","author":"Temel","year":"2010","journal-title":"N. Engl. J. 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