{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:14:33Z","timestamp":1788527673075,"version":"build-2803163510"},"reference-count":62,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Comorbidity is an important determinant of treatment selection and in-hospital complications in patients with head and neck cancer (HNC) and thyroid cancer (TC), yet population-based evidence on this relationship remains limited. Methods: We analyzed nationwide Diagnosis-Related Groups (DRG) data from 1,552,028 inpatient HNC and TC treatments of patients aged \u226530 years in Germany between 2005 and 2021. The aim was to characterize the association of comorbidity and severe treatment-related procedure-coded inpatient events (IEs) with gender, age, tumor subsite, and treatment type. Results: The largest proportion of treatments occurred in patients aged 60\u201369 years (33.5%). The most frequent tumor subsites were the oropharynx, thyroid gland, oral cavity, larynx, and hypopharynx, with 35.52, 33.84, 33.60, 26.12, and 15.76 treatments per 100,000 population per year, respectively. Overall, 38% of cases had a Charlson Comorbidity Index (CCI) \u2265 1, with the highest mean CCI observed for C14 (other sites of the lip, oral cavity and pharynx) and C12 (piriform sinus). IEs requiring additional in-hospital treatment occurred in 19.3% of cases. After adjustment for age, tumor location, and treatment type, men had a lower risk of IEs than women (OR 0.929; CI 0.919\u20130.939; p &lt; 0.001). Increasing comorbidity was associated with a higher IE risk, reaching a plateau at CCI \u2265 4 (OR 2.135; CI 2.029\u20132.246; p &lt; 0.001). IE risk was high during chemotherapy\/immunotherapy (OR 29.527; CI 28.897\u201330.170; p &lt; 0.001), followed by surgery (OR 3.465; CI 3.433\u20133.498; p &lt; 0.001), whereas radiotherapy showed the lowest risk (OR 1.339; CI 1.313\u20131.366; p &lt; 0.001). Conclusions: These findings highlight substantial heterogeneity in comorbidity and IE risk among patients with HNC or TC.<\/jats:p>","DOI":"10.3390\/cancers18172860","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:20:19Z","timestamp":1788524419000},"page":"2860","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Comorbidity on Severe Procedure-Coded Inpatient Events in Head and Neck Cancer and Thyroid Cancer Hospitalizations in Germany: A Nationwide DRG Analysis, 2005\u20132021"],"prefix":"10.3390","volume":"18","author":[{"given":"Lisa-Marie","family":"M\u00fcller-Anderski","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Jena University Hospital, D-07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4822-907X","authenticated-orcid":false,"given":"Mussab","family":"Kouka","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Jena University Hospital, D-07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Peter","family":"Schlattmann","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Computer Sciences and Data Sciences, Jena University Hospital, D-07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-0784","authenticated-orcid":false,"given":"Orlando","family":"Guntinas-Lichius","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Jena University Hospital, D-07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00005537-200004000-00011","article-title":"Importance of comorbidity in head and neck cancer","volume":"110","author":"Piccirillo","year":"2000","journal-title":"Laryngoscope"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1365-2265.2006.02492.x","article-title":"Comorbidity in newly diagnosed thyroid cancer patients: A population-based study on prevalence and the impact on treatment and survival","volume":"64","author":"Kuijpens","year":"2006","journal-title":"Clin. Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1002\/cam4.882","article-title":"Role of comorbidity on outcome of head and neck cancer: A population-based study in Thuringia, Germany","volume":"5","author":"Goellnitz","year":"2016","journal-title":"Cancer Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"104561","DOI":"10.1016\/j.oraloncology.2019.104561","article-title":"Comorbidity in head and neck cancer: Is it associated with therapeutic delay, post-treatment mortality and survival in a population-based study?","volume":"102","author":"Stordeur","year":"2020","journal-title":"Oral Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jgo.2018.06.003","article-title":"Impact of age, comorbidity, and WHO performance status on delay of treatment in patients undergoing fast-track work-up for head and neck cancer","volume":"10","author":"Carlsen","year":"2019","journal-title":"J. Geriatr. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.oraloncology.2010.03.013","article-title":"Complications of head and neck cancer surgery\u2013Prevention and management","volume":"46","author":"Kerawala","year":"2010","journal-title":"Oral Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/odi.12710","article-title":"Oral complications at 6 months after radiation therapy for head and neck cancer","volume":"23","author":"Lalla","year":"2017","journal-title":"Oral Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.currproblcancer.2016.06.001","article-title":"Toxicities associated with head and neck cancer treatment and oncology-related clinical trials","volume":"40","author":"Villa","year":"2016","journal-title":"Curr. Probl. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.oraloncology.2010.07.008","article-title":"Comorbidity in head and neck cancer: A critical appraisal and recommendations for practice","volume":"46","author":"Paleri","year":"2010","journal-title":"Oral Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1002\/cncr.29262","article-title":"Treatment-related toxicities in older adults with head and neck cancer: A population-based analysis","volume":"121","author":"Baxi","year":"2015","journal-title":"Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/0284186X.2012.742964","article-title":"The impact of comorbidity on outcome in 12 623 Danish head and neck cancer patients: A population based study from the DAHANCA database","volume":"52","author":"Boje","year":"2013","journal-title":"Acta Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jcrc.2004.09.007","article-title":"A systematic review of the Charlson comorbidity index using Canadian administrative databases: A perspective on risk adjustment in critical care research","volume":"20","author":"Needham","year":"2005","journal-title":"J. Crit. Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.23838\/pfm.2024.00191","article-title":"The use of Charlson comorbidity index for observational studies using administrative data in Korea","volume":"9","author":"Shin","year":"2025","journal-title":"Precis. Future Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/bjs5.50173","article-title":"Nationwide in-hospital mortality following colonic cancer resection according to hospital volume in Germany","volume":"3","author":"Diers","year":"2019","journal-title":"BJS Open"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Hermanns, I., Ziadat, R., Schlattmann, P., and Guntinas-Lichius, O. (2021). Trends in treatment of head and neck cancer in Germany: A diagnosis-related-groups-based nationwide analysis, 2005\u20132018. Cancers, 13.","DOI":"10.3390\/cancers13236060"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1387860","DOI":"10.1155\/2022\/1387860","article-title":"Mortality during In-Hospital Treatment for Head and Neck Cancer in Germany: A Diagnosis-Related Group-Based Nationwide Analysis, 2005\u20132018","volume":"2022","author":"Hermanns","year":"2022","journal-title":"J. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kouka, M., Hermanns, I., Schlattmann, P., and Guntinas-Lichius, O. (2023). The Association between Patient\u2019s Age and Head and Neck Cancer Treatment Decision\u2014A Population-Based Diagnoses-Related Group-Based Nationwide Study in Germany. Cancers, 15.","DOI":"10.3390\/cancers15061780"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1370\/afm.983","article-title":"Defining comorbidity: Implications for understanding health and health services","volume":"7","author":"Valderas","year":"2009","journal-title":"Ann. Fam. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/1475-6773.12398","article-title":"Disease-Specific Trends of Comorbidity Coding and Implications for Risk Adjustment in Hospital Administrative Data","volume":"51","author":"Nimptsch","year":"2016","journal-title":"Health Serv. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e016184","DOI":"10.1136\/bmjopen-2017-016184","article-title":"Hospital volume and mortality for 25 types of inpatient treatment in German hospitals: Observational study using complete national data from 2009 to 2014","volume":"7","author":"Nimptsch","year":"2017","journal-title":"BMJ Open"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","article-title":"Validation of a combined comorbidity index","volume":"47","author":"Charlson","year":"1994","journal-title":"J. Clin. Epidemiol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Stausberg, J., and Hagn, S. (2015). New Morbidity and Comorbidity Scores based on the Structure of the ICD-10. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0143365"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.juro.2007.01.037","article-title":"Analysis of complications following partial and total nephrectomy for renal cancer in a population based sample","volume":"177","author":"Joudi","year":"2007","journal-title":"J. Urol."},{"key":"ref_24","unstructured":"B\u00fcchel, C. (2012). Chirurgische Versorgung Prim\u00e4r Maligner Tumoren der Niere und des Nierenbeckens Anhand der DRG-Statistik der Jahre 2005 und 2006. [Ph.D. Thesis, Medical Faculty, Martin-Luther-University Halle-Wittenberg]."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","article-title":"Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data","volume":"43","author":"Quan","year":"2005","journal-title":"Med. Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/0194599818796163","article-title":"Prevalence of Comorbidities among Older Head and Neck Cancer Survivors in the United States","volume":"160","author":"Eytan","year":"2019","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1097\/JS9.0000000000001528","article-title":"The impact of surgical timing on outcome in acute appendicitis in adults: A retrospective observational population-based cohort study","volume":"110","author":"Uttinger","year":"2024","journal-title":"Int. J. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1001\/jama.291.20.2441","article-title":"Prognostic importance of comorbidity in a hospital-based cancer registry","volume":"291","author":"Piccirillo","year":"2004","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11912-006-0047-z","article-title":"Comorbidity in patients with cancer of the head and neck: Prevalence and impact on treatment and prognosis","volume":"8","author":"Piccirillo","year":"2006","journal-title":"Curr. Oncol. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.radonc.2013.07.005","article-title":"Impact of comorbidity on treatment outcome in head and neck squamous cell carcinoma\u2014A systematic review","volume":"110","author":"Boje","year":"2014","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.radonc.2013.11.009","article-title":"Evaluation of comorbidity in 9388 head and neck cancer patients: A national cohort study from the DAHANCA database","volume":"110","author":"Boje","year":"2014","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1007\/s00405-015-3836-x","article-title":"Cardiac comorbidity in head and neck cancer patients and its influence on cancer treatment selection and mortality: A prospective cohort study","volume":"273","author":"Simeoni","year":"2016","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1007\/s12325-025-03314-4","article-title":"Global Incidence and Mortality of Myocardial Infarction in Multi-Modality Head and Neck Cancer Treatment: A Systematic Review and Meta-analysis","volume":"42","author":"Asarkar","year":"2025","journal-title":"Adv. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1055\/a-1528-0513","article-title":"Increasing Use of Anticoagulants in Germany and Its Impact on Hospitalization for Tooth Extraction","volume":"42","author":"Santosa","year":"2022","journal-title":"Hamostaseologie"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s11606-025-09395-9","article-title":"Diagnosis Documentation Done Right: Cross-Specialty Standard for the Diagnosis Section in German Discharge Summaries\u2014A Mixed-Methods Study","volume":"40","author":"Frings","year":"2025","journal-title":"J. Gen. Intern. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Glombitza, L., Ballmaier, J., Kouka, M., Bitter, T., and Guntinas-Lichius, O. (2025). Clavien-Dindo classification for assessment of complications after 1465 unselected otorhinolaryngology and head and neck surgeries in a university hospital: A retrospective observational study. BMC Surg., 25.","DOI":"10.1186\/s12893-025-02970-1"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/08941939.2017.1420837","article-title":"The Clavien-Dindo Classification in Pancreatic Surgery: A Clinical and Economic Validation","volume":"32","author":"Bartel","year":"2019","journal-title":"J. Invest. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Tzedakis, S., Romengas, L., Berzan, D., Ronde-Roupie, C., Jeddou, H., Dhote, A., De Ponthaud, C., Lazzati, A., Guilloux, A., and Dokmak, S. (Ann. Surg., 2026). Deriving Clavien\u2013Dindo Classification from Administrative Data: Development and External Validation in Hepatobiliary Surgery, Ann. Surg., Online ahead of print.","DOI":"10.1097\/SLA.0000000000007105"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.ejso.2021.12.006","article-title":"Mortality, complications and failure to rescue after surgery for esophageal, gastric, pancreatic and liver cancer patients based on minimum caseloads set by the German Cancer Society","volume":"48","author":"Uttinger","year":"2021","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Uttinger, K.L., Riedmeier, M., Reibetanz, J., Meyer, T., Germer, C.T., Fassnacht, M., Wiegering, A., and Wiegering, V. (2022). Adrenalectomies in children and adolescents in Germany\u2014A diagnose related groups based analysis from 2009\u20132017. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.914449"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/hed.20374","article-title":"Cardiovascular and respiratory complications after major head and neck surgery","volume":"28","author":"Buitelaar","year":"2006","journal-title":"Head Neck"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1007\/s00405-016-4164-5","article-title":"Incidence and predictors of 30-day cardiovascular complications in patients undergoing head and neck cancer surgery","volume":"273","author":"Haapio","year":"2016","journal-title":"Eur. Arch. Oto-Rhino-Laryngol. Off. J. Eur. Fed. Oto-Rhino-Laryngol. Soc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1038\/s41598-021-83665-4","article-title":"The incidence of myocardial infarction and stroke in head and neck cancer patients","volume":"11","author":"Kwon","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ohn.1249","article-title":"Stroke Risk in Head and Neck Cancer: A Meta-analysis of Reconstructed Individual Patient Survival Data","volume":"173","author":"Liew","year":"2025","journal-title":"Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_46","first-page":"820","article-title":"The Effects of Minimum Caseload Requirements on Management and Outcome in Abdominal Aortic Aneurysm Repair","volume":"117","author":"Trenner","year":"2020","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1213\/ANE.0000000000005082","article-title":"Invasiveness of Treatment Is Gender Dependent in Intensive Care: Results from a Retrospective Analysis of 26,711 Cases","volume":"132","author":"Blecha","year":"2021","journal-title":"Anesth. Analg."},{"key":"ref_48","first-page":"624","article-title":"Population-Based Analysis of Sex-Dependent Risk Factors for Mortality in Thoracic Surgery for Lung Cancer","volume":"101","author":"Baum","year":"2022","journal-title":"Respir. Int. Rev. Thorac. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"NP62","DOI":"10.1177\/0145561319856006","article-title":"Head and Neck Cancer Complications in the Geriatric Population Based on Hospital Case Volume","volume":"100","author":"Rubin","year":"2021","journal-title":"Ear Nose Throat J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1177\/0194599816654689","article-title":"Quality Indicators for Head and Neck Oncologic Surgery: Academic versus Nonacademic Outcomes","volume":"155","author":"Puram","year":"2016","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_51","first-page":"100835","article-title":"Acute toxicities in proton therapy for head and neck cancer\u2014A matched analysis of the DAHANCA 35 feasibility study","volume":"48","author":"Friborg","year":"2024","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s10147-021-01949-1","article-title":"Real-world safety and effectiveness of nivolumab for recurrent or metastatic head and neck cancer in Japan: A post-marketing surveillance","volume":"26","author":"Tahara","year":"2021","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1210\/jc.2017-00255","article-title":"Population-Based Assessment of Complications Following Surgery for Thyroid Cancer","volume":"102","author":"Papaleontiou","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"838614","DOI":"10.5402\/2012\/838614","article-title":"Predictors of hypocalcemia after thyroidectomy: Results from the nationwide inpatient sample","volume":"2012","author":"Baldassarre","year":"2012","journal-title":"ISRN Surg."},{"key":"ref_55","first-page":"76","article-title":"Reliability of DRG Routine Data to Analyse Treatment Outcome and Complications of Thyroid Surgery. A Critical Analysis of Data of Patient Records Compared to Administrative Data","volume":"146","author":"Sahm","year":"2021","journal-title":"Zentralbl. Chir."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s10198-023-01645-z","article-title":"Country-level effects of diagnosis-related groups: Evidence from Germany\u2019s comprehensive reform of hospital payments","volume":"25","author":"Messerle","year":"2024","journal-title":"Eur. J. Health Econ. HEPAC Health Econ. Prev. Care"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Ruud Kj\u00e6r, E.K., Jensen, J.S., Jakobsen, K.K., Lelkaitis, G., Wessel, I., von Buchwald, C., and Gr\u00f8nh\u00f8j, C. (2020). The Impact of Comorbidity on Survival in Patients with Head and Neck Squamous Cell Carcinoma: A Nationwide Case-Control Study Spanning 35 Years. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.617184"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1007\/s12325-023-02527-9","article-title":"Artificial Intelligence in Head and Neck Cancer: A Systematic Review of Systematic Reviews","volume":"40","author":"Alabi","year":"2023","journal-title":"Adv. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41598-025-29295-6","article-title":"Machine learning for survival outcome in head and neck squamous cell carcinoma: A multicenter validation study","volume":"16","author":"Alabi","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"27640","DOI":"10.1038\/s41598-026-55741-0","article-title":"Early and late mortality among patients with T1\u2013T3 head and neck squamous cell carcinoma: A machine learning analysis using a SEER population-based cohort study","volume":"16","author":"Alabi","year":"2026","journal-title":"Sci. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Liu, X., Fang, C., Wu, C., Yu, J., and Zhao, Q. (2021). DRG grouping by machine learning: From expert-oriented to data-based method. BMC Med. Inform. Decis. Mak., 21.","DOI":"10.1186\/s12911-021-01676-7"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Benchimol, E.I., Smeeth, L., Guttmann, A., Harron, K., Moher, D., Petersen, I., S\u00f8rensen, H.T., von Elm, E., Langan, S.M., and RECORD Working Committee (2015). The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement. PLoS Med., 12.","DOI":"10.1371\/journal.pmed.1001885"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/17\/2860\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:26:04Z","timestamp":1788524764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/17\/2860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":62,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["cancers18172860"],"URL":"https:\/\/doi.org\/10.3390\/cancers18172860","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]}}}