{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:10:15Z","timestamp":1788775815221,"version":"build-2803163510"},"reference-count":66,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Focused ultrasound (FUS) is an emerging and evolving minimally invasive therapeutic platform that is helping to redefine the management of malignant diseases. Clinical translation is advancing rapidly, with several completed and ongoing clinical trials demonstrating the safety, feasibility, and early efficacy of FUS in the treatment of cancer. This manuscript provides a synthesis of some of the available clinical data and device platforms being used and evaluates the results from completed and active clinical trials for cancers involving four different solid organs. To stay within the editorial parameters of the invited article, this review will not provide a meta-analysis of clinical trials data and\/or the literature but rather highlight some of the currently available clinical evidence and FUS technologies that have been used in the treatment of cancers of the brain, liver, prostate gland, and breast.<\/jats:p>","DOI":"10.3390\/cancers18172890","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:23:37Z","timestamp":1788773017000},"page":"2890","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Focused Ultrasound Therapies for Brain, Liver, Prostate, and Breast Cancer Applications: Clinical Evidence and Future Directions"],"prefix":"10.3390","volume":"18","author":[{"given":"Nassib Abou","family":"Heidar","sequence":"first","affiliation":[{"name":"Department of Urology, University of Virginia Health, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2952-6834","authenticated-orcid":false,"given":"Daniel","family":"Sheeran","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, University of Virginia Health, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divine","family":"Nwafor","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Virginia Health, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9987-7563","authenticated-orcid":false,"given":"Olivia C.","family":"Sears","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Virginia Health, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Moosa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Virginia Health, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn T.","family":"Dengel","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Virginia Health, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Greene","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Virginia Health, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-1590","authenticated-orcid":false,"given":"Alan H.","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, University of Virginia Health, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. 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