{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:06:34Z","timestamp":1788944794539,"version":"build-2803163510"},"reference-count":34,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Adult granulosa cell tumors (AGCTs) of the ovary are rare sex cord-stromal malignancies characterized by an indolent clinical course and a persistent risk of late recurrence. Although adjuvant chemotherapy is considered for selected patients with higher-risk disease, the optimal platinum-based regimen remains uncertain because comparative evidence is limited. This study compared disease-free survival (DFS), treatment delivery, and toxicity between bleomycin\u2013etoposide\u2013cisplatin\/etoposide\u2013cisplatin (BEP\/EP) and carboplatin\u2013paclitaxel (CP) in the postoperative adjuvant setting. Methods: This retrospective, multicenter, nonrandomized comparative cohort study included 58 patients with AGCTs who underwent primary surgery and received adjuvant platinum-based chemotherapy at five tertiary oncology centers in T\u00fcrkiye between 2010 and 2024. Patients received BEP\/EP or CP according to institutional practice and physician discretion. The primary endpoint was disease-free survival (DFS), while secondary endpoints included treatment delivery and treatment-related toxicity. Results: A total of 58 patients were included, with 26 receiving BEP\/EP and 32 receiving CP. Patients treated with CP were older, whereas fertility-sparing surgery was more common in the BEP\/EP group. After a median follow-up of 75.5 months, 14 recurrences were observed; when deaths without prior recurrence were included according to the prespecified DFS definition, a total of 19 DFS events occurred. Median DFS was 77.2 months in the BEP\/EP group and 126.2 months in the CP group. The estimated 5-year DFS rates were 75.5% and 83.5%, respectively, with no statistically significant difference between treatment groups (log-rank p = 0.296). In an exploratory multivariable Cox model restricted to age and treatment regimen, increasing age was associated with a higher risk of a DFS event (adjusted HR 1.046 per year, 95% CI 1.011\u20131.082; p = 0.010), whereas CP versus BEP\/EP was not significantly associated with DFS (adjusted HR 0.426, 95% CI 0.167\u20131.083; p = 0.073). Treatment completion rates were numerically higher with CP (84.4% vs. 69.2%; p = 0.17). Peripheral neuropathy occurred more frequently with CP (p = 0.007), whereas nephrotoxicity occurred only in the BEP\/EP group (p = 0.014). Pulmonary toxicity was observed only with bleomycin-containing treatment, and one patient developed secondary acute myeloid leukemia following BEP. Conclusions: No statistically significant difference in DFS was detected between BEP\/EP and CP, while distinct toxicity patterns were observed. Given the retrospective design, limited sample size, and potential for treatment-selection bias and residual confounding, these findings should be considered exploratory and should not be interpreted as evidence of equivalent efficacy between the regimens.<\/jats:p>","DOI":"10.3390\/cancers18182910","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:05:43Z","timestamp":1788941143000},"page":"2910","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Outcomes and Toxicity of Cisplatin\u2013Etoposide-Based Regimens and Carboplatin\u2013Paclitaxel as Adjuvant Chemotherapy for Ovarian Adult Granulosa Cell Tumors: A Multicenter Retrospective Cohort Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Asl\u0131","family":"Ge\u00e7gel","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Ege University Faculty of Medicine, 35100 Izmir, 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Burak","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hacettepe University Faculty of Medicine, 06230 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Seval Ay","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kartal Dr. Lutfi Kirdar City Hospital, 34865 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Tuba 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Cancers, 14.","DOI":"10.3390\/cancers14122998"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/18\/2910\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:15:00Z","timestamp":1788941700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/18\/2910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":34,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["cancers18182910"],"URL":"https:\/\/doi.org\/10.3390\/cancers18182910","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]}}}