{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:59:42Z","timestamp":1792789182575,"version":"4.5.0"},"reference-count":184,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Minist\u00e8re Fran\u00e7ais de l\u2019Enseignement Sup\u00e9rieur et de la Recherche"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","award":["U1209"],"award-info":[{"award-number":["U1209"]}],"id":[{"id":"https:\/\/ror.org\/02vjkv261","id-type":"ROR","asserted-by":"crossref"}]},{"award":["U1209"],"award-info":[{"award-number":["U1209"]}],"id":[{"id":"https:\/\/ror.org\/02vjkv261","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Centre National de La Recherche Scientifique","award":["UMR5309"],"award-info":[{"award-number":["UMR5309"]}],"id":[{"id":"https:\/\/ror.org\/02feahw73","id-type":"ROR","asserted-by":"crossref"}]},{"award":["UMR5309"],"award-info":[{"award-number":["UMR5309"]}],"id":[{"id":"https:\/\/ror.org\/02feahw73","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012952","name":"Universit\u00e9 Grenoble Alpes","doi-asserted-by":"publisher","award":["IRGA2024"],"award-info":[{"award-number":["IRGA2024"]}],"id":[{"id":"10.13039\/100012952","id-type":"DOI","asserted-by":"publisher"}]},{"award":["IRGA2024"],"award-info":[{"award-number":["IRGA2024"]}],"id":[{"id":"https:\/\/ror.org\/02rx3b187","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Fondation ARC","award":["ARCPJA2022050005024"],"award-info":[{"award-number":["ARCPJA2022050005024"]}]},{"name":"Ligue Contre le Cancer","id":[{"id":"https:\/\/ror.org\/00rkrv905","id-type":"ROR","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00rkrv905","id-type":"ROR","asserted-by":"publisher"}]},{"name":"ESPOIR Is\u00e8re Contre Le Cancer"},{"name":"GEFLUC-Grenoble"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Lung cancer is the leading cause of cancer death worldwide. However, the molecular mechanisms involved in its development and response to therapies remain poorly understood. Previous studies have unraveled the pro- or anti-tumoral roles of circular RNAs (circRNAs) in numerous cancers. These mostly non-coding RNAs consist of a single-strand RNA forming a stable closed loop. CircRNA expression is often dysregulated in cancers, including lung cancer. An increasing number of studies have been published describing the role of circRNAs in lung tumor progression and\/or resistance to therapies. Most of these studies have focused on how circRNAs impact cancer cells in a cell-autonomous manner, but less is known about the role of tumoral circRNAs in the crosstalk between cancer cells and cells from the tumor microenvironment (TME). In this review, focusing on non-small cell lung cancer (NSCLC), we provide a comprehensive and up-to-date analysis of the current knowledge in this emerging field. We highlight key molecular mechanisms by which tumor-derived circRNAs reshape the NSCLC tumor immune microenvironment. We also discuss recent findings showing their contributions to most NSCLC hallmarks, including those newly described in 2022, as well as their involvement in NSCLC\u2019s escape from therapies. All these studies clearly open avenues for translational applications of circRNAs in NSCLC, as either potential biomarkers or therapeutic targets, although current limitations clearly need to be overcome to translate circRNAs into the clinic.<\/jats:p>","DOI":"10.3390\/cancers18182989","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:58:59Z","timestamp":1789545539000},"page":"2989","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circular RNAs in NSCLC: Their Role in Tumorigenesis, Tumor Microenvironment Reshaping, and Response to Therapies"],"prefix":"10.3390","volume":"18","author":[{"given":"Lea","family":"Cerato","sequence":"first","affiliation":[{"name":"University Grenoble Alpes, INSERM U1209, CNRS UMR5309, Team RNA Splicing, Cell Signaling and Response to Therapies, Institute For Advanced Biosciences, F38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9594-6584","authenticated-orcid":false,"given":"Florence","family":"de Fraipont","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, INSERM U1209, CNRS UMR5309, Team RNA Splicing, Cell Signaling and Response to Therapies, Institute For Advanced Biosciences, F38000 Grenoble, France"},{"name":"Medical Unit of Molecular Genetic (Hereditary Diseases and Oncology), Grenoble-Alpes University Hospital, F38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7311-3810","authenticated-orcid":false,"given":"Beatrice","family":"Eymin","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, INSERM U1209, CNRS UMR5309, Team RNA Splicing, Cell Signaling and Response to Therapies, Institute For Advanced Biosciences, F38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Caba, L., Florea, L., Gug, C., Dimitriu, D.C., and Gorduza, E.V. (2021). Circular RNA\u2014Is the Circle Perfect?. Biomolecules, 11.","DOI":"10.3390\/biom11121755"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1073\/pnas.73.11.3852","article-title":"Viroids Are Single-Stranded Covalently Closed Circular RNA Molecules Existing as Highly Base-Paired Rod-like Structures","volume":"73","author":"Sanger","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0092-8674(91)90244-S","article-title":"Scrambled Exons","volume":"64","author":"Nigro","year":"1991","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"108739","DOI":"10.1016\/j.biotechadv.2025.108739","article-title":"Circular RNAs in Microalgae: Uncovering Their Biological Significance","volume":"86","author":"Dehghani","year":"2026","journal-title":"Biotechnol. Adv."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"132800","DOI":"10.1016\/j.ijbiomac.2024.132800","article-title":"CircRNA: An Emerging Star in Plant Research: A Review","volume":"272","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zucko, D., and Boris-Lawrie, K. (2020). Circular RNAs Are Regulators of Diverse Animal Transcriptomes: One Health Perspective. Front. Genet., 11.","DOI":"10.3389\/fgene.2020.00999"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s41061-025-00505-z","article-title":"Circular RNA, A Molecule with Potential Chemistry and Applications in RNA-Based Cancer Therapeutics: An Insight into Recent Advances","volume":"383","author":"Shafaghat","year":"2025","journal-title":"Top. Curr. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1038\/s41388-023-02780-w","article-title":"Going Circular: History, Present, and Future of circRNAs in Cancer","volume":"42","author":"Pisignano","year":"2023","journal-title":"Oncogene"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1038\/s41467-025-58070-4","article-title":"A Functional Screen Uncovers Circular RNAs Regulating Excitatory Synaptogenesis in Hippocampal Neurons","volume":"16","author":"Kelly","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/bph.16434","article-title":"Circular RNA Regulatory Role in Pathological Cardiac Remodelling","volume":"182","author":"Bibi","year":"2025","journal-title":"Br. J. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"109042","DOI":"10.1016\/j.jdiacomp.2025.109042","article-title":"The Role of circRNA in Insulin Resistance and Its Progression Induced by Adipose Inflammation","volume":"39","author":"Liu","year":"2025","journal-title":"J. Diabetes Complicat."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e70079","DOI":"10.1002\/mco2.70079","article-title":"Circular RNAs in Cancer","volume":"6","author":"Guo","year":"2025","journal-title":"MedComm"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12672-025-01743-9","article-title":"Circular RNAs in Cancer: Roles, Mechanisms, and Therapeutic Potential across Colorectal, Gastric, Liver, and Lung Carcinomas","volume":"16","author":"Malviya","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"117027","DOI":"10.1016\/j.biopha.2024.117027","article-title":"New Insights into the Potential of Exosomal Circular RNAs in Mediating Cancer Chemotherapy Resistance and Their Clinical Applications","volume":"177","author":"Li","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"DeSouza, N.R., Nielsen, K.J., Jarboe, T., Carnazza, M., Quaranto, D., Kopec, K., Suriano, R., Islam, H.K., Tiwari, R.K., and Geliebter, J. (2024). Dysregulated Expression Patterns of Circular RNAs in Cancer: Uncovering Molecular Mechanisms and Biomarker Potential. Biomolecules, 14.","DOI":"10.3390\/biom14040384"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ncrna.2022.11.002","article-title":"Circular RNAs as Biomarkers for Lung Cancer","volume":"8","author":"Sufianov","year":"2023","journal-title":"Non-Coding RNA Res."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Chen, H.-H., Zhang, T.-N., Wu, Q.-J., Huang, X.-M., and Zhao, Y.-H. (2021). Circular RNAs in Lung Cancer: Recent Advances and Future Perspectives. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.664290"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"115260","DOI":"10.1016\/j.biopha.2023.115260","article-title":"CircRNAs and Lung Cancer: Insight into Their Roles in Metastasis","volume":"166","author":"Ning","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"15365","DOI":"10.1007\/s00432-023-05317-6","article-title":"Hsa_circ_0041150 Serves as a Novel Biomarker for Monitoring Chemotherapy Resistance in Small Cell Lung Cancer Patients Treated with a First-Line Chemotherapy Regimen","volume":"149","author":"Zhang","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12943-022-01595-9","article-title":"CircVAPA Promotes Small Cell Lung Cancer Progression by Modulating the miR-377-3p and miR-494-3p\/IGF1R\/AKT Axis","volume":"21","author":"Hua","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41568-022-00541-7","article-title":"RNA Splicing Dysregulation and the Hallmarks of Cancer","volume":"23","author":"Bradley","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.tig.2025.11.001","article-title":"Features and Biomedical Relevance of Circular RNA Biogenesis","volume":"42","author":"Wang","year":"2026","journal-title":"Trends Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41568-024-00721-7","article-title":"Circular RNA in Cancer","volume":"24","author":"Conn","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/s12276-024-01220-3","article-title":"Molecular Mechanisms of Circular RNA Translation","volume":"56","author":"Hwang","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Guria, A., Sharma, P., Natesan, S., and Pandi, G. (2020). Circular RNAs\u2014The Road Less Traveled. Front. Mol. Biosci., 6.","DOI":"10.3389\/fmolb.2019.00146"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"975","DOI":"10.7150\/ijms.71840","article-title":"Advances in Circular RNA and Its Applications","volume":"19","author":"Zhao","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1016\/j.jmb.2015.02.018","article-title":"Exon Skipping Is Correlated with Exon Circularization","volume":"427","author":"Kelly","year":"2015","journal-title":"J. Mol. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Qiu, Y., Chen, Y., Agbede, O., Eshaghi, E., and Peng, C. (2022). Circular RNAs in Epithelial Ovarian Cancer: From Biomarkers to Therapeutic Targets. Cancers, 14.","DOI":"10.3390\/cancers14225711"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s11658-024-00606-5","article-title":"CircR-Loop: A Novel RNA:DNA Interaction on Genome Instability","volume":"29","author":"Su","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jhep.2021.08.027","article-title":"Circular RNA ACTN4 Promotes Intrahepatic Cholangiocarcinoma Progression by Recruiting YBX1 to Initiate FZD7 Transcription","volume":"76","author":"Chen","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.molcel.2021.11.032","article-title":"Circular RNA ZNF609\/CKAP5 mRNA Interaction Regulates Microtubule Dynamics and Tumorigenicity","volume":"82","author":"Rossi","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zhang, D., Ma, Y., Naz, M., Ahmed, N., Zhang, L., Zhou, J.-J., Yang, D., and Chen, Z. (2024). Advances in CircRNAs in the Past Decade: Review of CircRNAs Biogenesis, Regulatory Mechanisms, and Functions in Plants. Genes, 15.","DOI":"10.3390\/genes15070958"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1038\/s41467-026-71822-0","article-title":"The History and Function of a Circular RNA","volume":"17","author":"Scoyni","year":"2026","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1038\/emboj.2011.359","article-title":"miRNA-dependent Gene Silencing Involving Ago2-mediated Cleavage of a Circular Antisense RNA","volume":"30","author":"Hansen","year":"2011","journal-title":"EMBO J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/s41592-022-01487-2","article-title":"Best Practice Standards for circRNA Research","volume":"19","author":"Nielsen","year":"2022","journal-title":"Nat. Methods"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrg.2016.20","article-title":"Endogenous microRNA Sponges: Evidence and Controversy","volume":"17","author":"Thomson","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1038\/s41467-020-18355-2","article-title":"Spatial Expression Analyses of the Putative Oncogene ciRS-7 in Cancer Reshape the microRNA Sponge Theory","volume":"11","author":"Kristensen","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.molcel.2014.08.019","article-title":"circRNA Biogenesis Competes with Pre-mRNA Splicing","volume":"56","author":"Meyer","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"100003","DOI":"10.1016\/j.gmg.2024.100003","article-title":"Research Progress of Circular RNA FOXO3 in Diseases (Review)","volume":"12","author":"Zhao","year":"2024","journal-title":"Glob. Med. Genet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12943-019-1046-7","article-title":"Circular RNA circRHOT1 Promotes Hepatocellular Carcinoma Progression by Initiation of NR2F6 Expression","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1111\/jcmm.17751","article-title":"Newly Discovered Mechanisms That Mediate Tumorigenesis and Tumour Progression: CircRNA-encoded Proteins","volume":"27","author":"Wu","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1038\/s41467-018-05096-6","article-title":"Engineering Circular RNA for Potent and Stable Translation in Eukaryotic Cells","volume":"9","author":"Wesselhoeft","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12943-021-01484-7","article-title":"Expanding Uncapped Translation and Emerging Function of Circular RNA in Carcinomas and Noncarcinomas","volume":"21","author":"Wang","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"101347","DOI":"10.1016\/j.gendis.2024.101347","article-title":"Coding Circular RNA in Human Cancer","volume":"12","author":"Lin","year":"2024","journal-title":"Genes Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e008402","DOI":"10.1136\/jitc-2023-008402","article-title":"Circular RNA as a Source of Neoantigens for Cancer Vaccines","volume":"12","author":"Ren","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Xia, J., Li, S., Ren, B., and Zhang, P. (2023). Circular RNAs as a Potential Source of Neoepitopes in Cancer. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1098523"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"104861","DOI":"10.1016\/j.yexmp.2023.104861","article-title":"The Biogenesis, Biological Functions and Modification of Circular RNAs","volume":"131","author":"Liu","year":"2023","journal-title":"Exp. Mol. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"gkae1167","DOI":"10.1093\/nar\/gkae1167","article-title":"Translation of Circular RNAs","volume":"53","author":"Margvelani","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41422-020-0279-8","article-title":"m6A-Dependent Biogenesis of Circular RNAs in Male Germ Cells","volume":"30","author":"Tang","year":"2020","journal-title":"Cell Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/neuonc\/noaa279","article-title":"Rolling-Translated EGFR Variants Sustain EGFR Signaling and Promote Glioblastoma Tumorigenicity","volume":"23","author":"Liu","year":"2020","journal-title":"Neuro Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12943-021-01448-x","article-title":"Cancer Cell-Derived Exosomal circUSP7 Induces CD8+ T Cell Dysfunction and Anti-PD1 Resistance by Regulating the miR-934\/SHP2 Axis in NSCLC","volume":"20","author":"Chen","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Yang, K., Zhang, J., and Bao, C. (2021). Exosomal circEIF3K from Cancer-Associated Fibroblast Promotes Colorectal Cancer (CRC) Progression via miR-214\/PD-L1 Axis. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-08669-9"},{"key":"ref_54","unstructured":"(2026, June 26). L\u2019Institut National du Cancer. Homepage. Available online: https:\/\/en-www.cancer.fr\/professionnels-de-sante\/statistiques-et-chiffres-sur-les-cancers\/epidemiologie-des-cancers\/cancer-du-poumon."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1111\/febs.14132","article-title":"Hsa_circ_0013958: A Circular RNA and Potential Novel Biomarker for Lung Adenocarcinoma","volume":"284","author":"Zhu","year":"2017","journal-title":"FEBS J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41417-020-00209-0","article-title":"circRACGAP1 Promotes Non-Small Cell Lung Cancer Proliferation by Regulating miR-144-5p\/CDKL1 Signaling Pathway","volume":"28","author":"Lu","year":"2021","journal-title":"Cancer Gene Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1579490","DOI":"10.1155\/2016\/1579490","article-title":"Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt\/\u03b2-Catenin Pathway","volume":"2016","author":"Wan","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1128\/MCB.00251-12","article-title":"The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein","volume":"32","author":"Wei","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/1759-7714.14926","article-title":"Exosomal ERBB2IP Contributes to Tumor Growth via Elevating PSAT1 Expression in Non-small Cell Lung Carcinoma","volume":"14","author":"Peng","year":"2023","journal-title":"Thorac. Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41420-025-02565-y","article-title":"Circular RNA circLIMK1-005 Promotes the Progression of Lung Adenocarcinoma by Interacting with RPA1 Protein to Activate CDK4 Signaling","volume":"11","author":"Yang","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.biopha.2018.12.007","article-title":"Circular RNA PVT1 Acts as a Competing Endogenous RNA for miR-497 in Promoting Non-Small Cell Lung Cancer Progression","volume":"111","author":"Qin","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.bbrc.2018.11.176","article-title":"CircPUM1 Promotes the Malignant Behavior of Lung Adenocarcinoma by Regulating miR-326","volume":"508","author":"Chen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_63","first-page":"1387","article-title":"A Novel Circular RNA Hsa_circ_0020123 Exerts Oncogenic Properties through Suppression of miR-144 in Non-Small Cell Lung Cancer","volume":"8","author":"Qu","year":"2018","journal-title":"Am. J. Cancer Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.3892\/mmr.2017.7319","article-title":"Interferon Regulatory Factor 4 (IRF4) Is Overexpressed in Human Non-small Cell Lung Cancer (NSCLC) and Activates the Notch Signaling Pathway","volume":"16","author":"Qian","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"392","DOI":"10.4149\/neo_2022_211013N1449","article-title":"Circ_0020123 Regulates Autophagy, Glycolysis, and Malignancy by Upregulating IRF4 through Eliminating miR-193a-3p-Mediated Suppression of IRF4 in Non-Small Cell Lung Cancer","volume":"69","author":"Yang","year":"2022","journal-title":"Neo"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1111\/1759-7714.14408","article-title":"Circ_0020123 Plays an Oncogenic Role in Non-Small Cell Lung Cancer Depending on the Regulation of miR-512-3p\/CORO1C","volume":"13","author":"Zhang","year":"2022","journal-title":"Thorac. Cancer"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12943-018-0889-7","article-title":"Circular RNA Hsa_circ_0008305 (circPTK2) Inhibits TGF-\u03b2-Induced Epithelial-Mesenchymal Transition and Metastasis by Controlling TIF1\u03b3 in Non-Small Cell Lung Cancer","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"149060","DOI":"10.1016\/j.gene.2024.149060","article-title":"CircRNA Regulates Lung Cancer Metastasis","volume":"935","author":"Li","year":"2025","journal-title":"Gene"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/kjm2.12662","article-title":"Circular RNA circDLG1 (Has_circ_0068706) Functions as an Oncogene in Nonsmall Cell Lung Cancer through Regulating AKT\/mTOR Signaling and Direct Binding to miR-144","volume":"39","author":"Chen","year":"2023","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e3325","DOI":"10.1002\/jgm.3325","article-title":"CircVAPA Exerts Oncogenic Property in Non-Small Cell Lung Cancer by the miR-876-5p\/WNT5A Axis","volume":"23","author":"Zhao","year":"2021","journal-title":"J. Gene Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1158\/0008-5472.CAN-21-1473","article-title":"Oncogenic circRNA C190 Promotes Non\u2013Small Cell Lung Cancer via Modulation of the EGFR\/ERK Pathway","volume":"82","author":"Ishola","year":"2022","journal-title":"Cancer Res."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Chelakkot, C., Chelakkot, V.S., Shin, Y., and Song, K. (2023). Modulating Glycolysis to Improve Cancer Therapy. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032606"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/s41419-019-2127-7","article-title":"CircRNA-ENO1 Promoted Glycolysis and Tumor Progression in Lung Adenocarcinoma through Upregulating Its Host Gene ENO1","volume":"10","author":"Zhou","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s40001-025-02359-z","article-title":"circZNF707 Promoted Glycolysis and Tumor Progression through miR-668-3p-PFKM Axis in NSCLC","volume":"30","author":"Chen","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.omtn.2020.11.012","article-title":"circDCUN1D4 Suppresses Tumor Metastasis and Glycolysis in Lung Adenocarcinoma by Stabilizing TXNIP Expression","volume":"23","author":"Liang","year":"2021","journal-title":"Mol. Ther.\u2014Nucleic Acids"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1016\/j.biocel.2012.08.022","article-title":"Cancer Stem Cells","volume":"44","author":"Yu","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41419-021-04095-8","article-title":"Hsa_circ_0003222 Accelerates Stemness and Progression of Non-Small Cell Lung Cancer by Sponging miR-527","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12943-023-01811-0","article-title":"Enhancement of TKI Sensitivity in Lung Adenocarcinoma through m6A-Dependent Translational Repression of Wnt Signaling by Circ-FBXW7","volume":"22","author":"Li","year":"2023","journal-title":"Mol. Cancer"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e24811","DOI":"10.1016\/j.heliyon.2024.e24811","article-title":"Exploring the Interplay between Methylation Patterns and Non-Coding RNAs in Non-Small Cell Lung Cancer: Implications for Pathogenesis and Therapeutic Targets","volume":"10","author":"Yang","year":"2024","journal-title":"Heliyon"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s12033-022-00594-x","article-title":"CircTFF1 Promotes Proliferation, Migration and Invasion of Lung Cancer Cells by Facilitating Methylation of BCL6B Promoter via miR-29c-3p\/DNMT3A Axis","volume":"65","author":"Zhao","year":"2023","journal-title":"Mol. Biotechnol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/jcmm.15997","article-title":"G Protein-Coupled Oestrogen Receptor Promotes Cell Growth of Non-Small Cell Lung Cancer Cells via YAP1\/QKI\/circNOTCH1\/m6A Methylated NOTCH1 Signalling","volume":"25","author":"Shen","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"6711","DOI":"10.1080\/21655979.2022.2025707","article-title":"Circular RNA Hsa_circ_0077837 Is Upregulated in Non-Small Cell Lung Cancer to Downregulate Phosphatase and Tensin Homolog through Methylation","volume":"13","author":"Li","year":"2022","journal-title":"Bioengineered"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.biopha.2017.12.015","article-title":"Emerging Roles of Circular RNA Hsa_circ_0000064 in the Proliferation and Metastasis of Lung Cancer","volume":"96","author":"Luo","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"14413","DOI":"10.1038\/s41598-020-71484-y","article-title":"VEGF-A Splice Variants Bind VEGFRs with Differential Affinities","volume":"10","author":"Mamer","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"114367","DOI":"10.1016\/j.ecoenv.2022.114367","article-title":"CircCDR1as Mediates PM2.5-Induced Lung Cancer Progression by Binding to SRSF1","volume":"249","author":"Xu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"19019","DOI":"10.1002\/jcb.29225","article-title":"Circular RNA circPIP5K1A Promotes Non-Small Cell Lung Cancer Proliferation and Metastasis through miR-600\/HIF-1\u03b1 Regulation","volume":"120","author":"Chi","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.coi.2013.03.004","article-title":"From the Immune Contexture to the Immunoscore: The Role of Prognostic and Predictive Immune Markers in Cancer","volume":"25","author":"Angell","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Zou, Y., Zheng, S., Deng, X., Yang, A., Xie, X., Tang, H., and Xie, X. (2019). The Role of Circular RNA CDR1as\/ciRS-7 in Regulating Tumor Microenvironment: A Pan-Cancer Analysis. Biomolecules, 9.","DOI":"10.3390\/biom9090429"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bbrc.2022.10.043","article-title":"circRNA-Mediated Upregulation of HOXC9 Is Correlated with Poor Outcome and Immune Microenvironment Infiltrates in LUAD","volume":"635","author":"Liu","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Peng, D., Liang, M., Li, L., Yang, H., Fang, D., Chen, L., and Guan, B. (2024). Circ_BBS9 as an Early Diagnostic Biomarker for Lung Adenocarcinoma: Direct Interaction with IFIT3 in the Modulation of Tumor Immune Microenvironment. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1344954"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41467-020-20527-z","article-title":"circNDUFB2 Inhibits Non-Small Cell Lung Cancer Progression via Destabilizing IGF2BPs and Activating Anti-Tumor Immunity","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s42003-025-08108-6","article-title":"Tumor Cell-Intrinsic Circular RNA circFNDC3B Attenuates CD8+ T Cells Infiltration in Non-Small Cell Lung Cancer","volume":"8","author":"Wei","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1158\/0008-5472.CAN-24-1484","article-title":"The circRNA cEMSY Induces Immunogenic Cell Death and Boosts Immunotherapy Efficacy in Lung Adenocarcinoma","volume":"85","author":"Zhang","year":"2025","journal-title":"Cancer Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41419-023-05647-w","article-title":"Regulation of the Tumor Immune Microenvironment by Cancer-Derived Circular RNAs","volume":"14","author":"Guan","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Yang, J., Jia, Y., Wang, B., Yang, S., Du, K., Luo, Y., Li, Y., and Zhu, B. (2021). Circular RNA CHST15 Sponges miR-155-5p and miR-194-5p to Promote the Immune Escape of Lung Cancer Cells Mediated by PD-L1. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.595609"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41419-020-2230-9","article-title":"circRNA-002178 Act as a ceRNA to Promote PDL1\/PD1 Expression in Lung Adenocarcinoma","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1093\/hmg\/ddac155","article-title":"Immunomodulatory Functions of the Circ_001678\/miRNA-326\/ZEB1 Axis in Non-Small Cell Lung Cancer via the Regulation of PD-1\/PD-L1 Pathway","volume":"31","author":"Tian","year":"2022","journal-title":"Hum. Mol. Genet."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Luo, Y.-H., Yang, Y.-P., Chien, C.-S., Yarmishyn, A.A., Adekunle Ishola, A., Chien, Y., Chen, Y.-M., Tsai, P.-H., Lin, T.-W., and Wang, M.-L. (2021). Circular RNA Hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010064"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00262-022-03235-z","article-title":"Circ-HSP90A Expedites Cell Growth, Stemness, and Immune Evasion in Non-Small Cell Lung Cancer by Regulating STAT3 Signaling and PD-1\/PD-L1 Checkpoint","volume":"72","author":"Lei","year":"2023","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12943-021-01398-4","article-title":"N6-Methyladenosine-Modified circIGF2BP3 Inhibits CD8+ T-Cell Responses to Facilitate Tumor Immune Evasion by Promoting the Deubiquitination of PD-L1 in Non-Small Cell Lung Cancer","volume":"20","author":"Liu","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/tox.23768","article-title":"Hsa_circ_0003528 Promotes Cell Malignant Transformation and Immune Escape via Increasing Oncogene PDL1 through Sponging miR-511-3p in Non-Small Cell Lung Cancer","volume":"38","author":"Wang","year":"2023","journal-title":"Environ. Toxicol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"13929","DOI":"10.1080\/21655979.2022.2080386","article-title":"Circ_0092012 Knockdown Restrains Non-Small Cell Lung Cancer Progression by Inhibiting Cell Malignant Phenotype and Immune Escape through microRNA-635\/Programmed Death Ligand 1 Axis","volume":"13","author":"Yan","year":"2022","journal-title":"Bioengineered"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3892\/ijmm.2017.2852","article-title":"Microarray Analysis of Circular RNA Expression Patterns in Polarized Macrophages","volume":"39","author":"Zhang","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"15455","DOI":"10.1038\/s41598-021-94671-x","article-title":"Kras-Driven Intratumoral Heterogeneity Triggers Infiltration of M2 Polarized Macrophages via the circHIPK3\/PTK2 Immunosuppressive Circuit","volume":"11","author":"Katopodi","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.omto.2022.01.012","article-title":"Exosomal circSHKBP1 Participates in Non-Small Cell Lung Cancer Progression through PKM2-Mediated Glycolysis","volume":"24","author":"Chen","year":"2022","journal-title":"Mol. Ther. Oncolytics"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s13046-022-02505-z","article-title":"Exosomal circZNF451 Restrains Anti-PD1 Treatment in Lung Adenocarcinoma via Polarizing Macrophages by Complexing with TRIM56 and FXR1","volume":"41","author":"Gao","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2309857","DOI":"10.1002\/advs.202309857","article-title":"Hypoxic Exosomal circPLEKHM1-Mediated Crosstalk between Tumor Cells and Macrophages Drives Lung Cancer Metastasis","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/1759-7714.15182","article-title":"Tumor-related Exosomal Circ_0001715 Promotes Lung Adenocarcinoma Cell Proliferation and Metastasis via Enhancing M2 Macrophage Polarization by Regulating Triggering Receptor Expressed on Myeloid Cells-2","volume":"15","author":"Chen","year":"2023","journal-title":"Thorac. Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/s13046-023-02916-6","article-title":"Circular RNA circATP9A Promotes Non-Small Cell Lung Cancer Progression by Interacting with HuR and by Promoting Extracellular Vesicles-Mediated Macrophage M2 Polarization","volume":"42","author":"Yao","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhang, G., Liu, Y., Chen, R., Zhao, D., McAlister, V., Mele, T., Liu, K., and Zheng, X. (2018). GDF15 Regulates Malat-1 Circular RNA and Inactivates NF\u03baB Signaling Leading to Immune Tolerogenic DCs for Preventing Alloimmune Rejection in Heart Transplantation. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02407"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/j.ymthe.2020.07.001","article-title":"Circular RNA circSnx5 Controls Immunogenicity of Dendritic Cells through the miR-544\/SOCS1 Axis and PU.1 Activity Regulation","volume":"28","author":"Chen","year":"2020","journal-title":"Mol. Ther."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"59.17","DOI":"10.4049\/jimmunol.202.Supp.59.17","article-title":"Knockdown of Circular RNA FSCN1 Impairs Dendritic Cell Immune Function through Regulating the NFKB and Foxo3 Signaling Pathways","volume":"202","author":"Zheng","year":"2019","journal-title":"J. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"164.24","DOI":"10.4049\/jimmunol.204.Supp.164.24","article-title":"Circular RNA AEBP2 Modulates Dendritic Cells by the hnRNP\/pP65 Signaling Pathway","volume":"204","author":"Zhou","year":"2020","journal-title":"J. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Mu, Q., Lv, Y., Luo, C., Liu, X., Huang, C., Xiu, Y., and Tang, L. (2021). Research Progress on the Functions and Mechanism of circRNA in Cisplatin Resistance in Tumors. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.709324"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"153639","DOI":"10.1016\/j.prp.2021.153639","article-title":"CiRS-7\/CDR1as; An Oncogenic Circular RNA as a Potential Cancer Biomarker","volume":"227","author":"Rahmati","year":"2021","journal-title":"Pathol.\u2014Res. Pract."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"11215","DOI":"10.1038\/ncomms11215","article-title":"Circular RNA Profiling Reveals an Abundant circHIPK3 That Regulates Cell Growth by Sponging Multiple miRNAs","volume":"7","author":"Zheng","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12935-020-1162-x","article-title":"Circ_0072083 Interference Enhances Growth-Inhibiting Effects of Cisplatin in Non-Small-Cell Lung Cancer Cells via miR-545-3p\/CBLL1 Axis","volume":"20","author":"Li","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1111\/1759-7714.13527","article-title":"Circ_0007385 Served as Competing Endogenous RNA for miR-519d-3p to Suppress Malignant Behaviors and Cisplatin Resistance of Non-Small Cell Lung Cancer Cells","volume":"11","author":"Ye","year":"2020","journal-title":"Thorac. Cancer"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12931-021-01840-7","article-title":"Circ_PIP5K1A Regulates Cisplatin Resistance and Malignant Progression in Non-Small Cell Lung Cancer Cells and Xenograft Murine Model via Depending on miR-493-5p\/ROCK1 Axis","volume":"22","author":"Feng","year":"2021","journal-title":"Respir. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1111\/1759-7714.14941","article-title":"Circ_0010235 Confers Cisplatin Resistance in Lung Cancer by Upregulating E2F7 through Absorbing miR-379-5p","volume":"14","author":"Wang","year":"2023","journal-title":"Thorac. Cancer"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1002\/cbin.11401","article-title":"Circular RNA Hsa_circ_0085131 Is Involved in Cisplatin-Resistance of Non-Small-Cell Lung Cancer Cells by Regulating Autophagy","volume":"44","author":"Kong","year":"2020","journal-title":"Cell Biol. Int."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3233\/CBM-201705","article-title":"CircRNA_100565 Contributes to Cisplatin Resistance of NSCLC Cells by Regulating Proliferation, Apoptosis and Autophagy via miR-337-3p\/ADAM28 Axis","volume":"30","author":"Zhong","year":"2021","journal-title":"Cancer Biomark."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1111\/1759-7714.13993","article-title":"Circular RNA circLDB2 Functions as a Competing Endogenous RNA to Suppress Development and Promote Cisplatin Sensitivity in Non-Squamous Non-Small Cell Lung Cancer","volume":"12","author":"Wang","year":"2021","journal-title":"Thorac. Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"0963689720961070","DOI":"10.1177\/0963689720961070","article-title":"Circ_0000079 Decoys the RNA-Binding Protein FXR1 to Interrupt Formation of the FXR1\/PRCKI Complex and Decline Their Mediated Cell Invasion and Drug Resistance in NSCLC","volume":"29","author":"Chen","year":"2020","journal-title":"Cell Transplant."},{"key":"ref_125","first-page":"3997045","article-title":"circHUWE1 Exerts an Oncogenic Role in Inducing DDP-Resistant NSCLC Progression Depending on the Regulation of miR-34a-5p\/TNFAIP8","volume":"2021","author":"Yang","year":"2021","journal-title":"Int. J. Genom."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"110294","DOI":"10.1016\/j.ygeno.2022.110294","article-title":"Circ_0004015 Silencing Represses Cisplatin Chemoresistance and Tumor Progression by Reducing KLF8 in a miR-198-Dependent Manner in Non-Small Cell Lung Cancer","volume":"114","author":"Li","year":"2022","journal-title":"Genomics"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.bbrc.2018.11.157","article-title":"Circular RNA Hsa_circ_0004015 Regulates the Proliferation, Invasion, and TKI Drug Resistance of Non-Small Cell Lung Cancer by miR-1183\/PDPK1 Signaling Pathway","volume":"508","author":"Zhou","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/1759-7714.14787","article-title":"Circ_0110498 Facilitates the Cisplatin Resistance of Non-Small Cell Lung Cancer by Mediating the miR-1287-5p\/RBBP4 Axis","volume":"14","author":"Hao","year":"2023","journal-title":"Thorac. Cancer"},{"key":"ref_129","first-page":"293","article-title":"Circular RNAcirc_0076305 Promotes Cisplatin (DDP) Resistance of Non-Small Cell Lung Cancer Cells by Regulating ABCC1 Through miR-186-5p","volume":"38","author":"Wang","year":"2023","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3892\/etm.2021.10366","article-title":"circRNA_103615 Contributes to Tumor Progression and Cisplatin Resistance in NSCLC by Regulating ABCB1","volume":"22","author":"Liang","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1080\/10717544.2022.2057617","article-title":"Exosome-Transmitted circVMP1 Facilitates the Progression and Cisplatin Resistance of Non-Small Cell Lung Cancer by Targeting miR-524-5p-METTL3\/SOX2 Axis","volume":"29","author":"Xie","year":"2022","journal-title":"Drug Deliv."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Huang, M.-S., Liu, J.-Y., Xia, X.-B., Liu, Y.-Z., Li, X., Yin, J.-Y., Peng, J.-B., Wu, L., Zhang, W., and Zhou, H.-H. (2019). Hsa_circ_0001946 Inhibits Lung Cancer Progression and Mediates Cisplatin Sensitivity in Non-Small Cell Lung Cancer via the Nucleotide Excision Repair Signaling Pathway. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00508"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"13264","DOI":"10.18632\/aging.203011","article-title":"Tumor-Derived Exosomal circRNA_102481 Contributes to EGFR-TKIs Resistance via the miR-30a-5p\/ROR1 Axis in Non-Small Cell Lung Cancer","volume":"13","author":"Yang","year":"2021","journal-title":"Aging"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.omtn.2020.07.027","article-title":"circSETD3 Contributes to Acquired Resistance to Gefitinib in Non-Small-Cell Lung Cancer by Targeting the miR-520h\/ABCG2 Pathway","volume":"21","author":"Huang","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.2147\/OTT.S243214","article-title":"A Novel Serum Exosomes-Based Biomarker Hsa_circ_0002130 Facilitates Osimertinib-Resistance in Non-Small Cell Lung Cancer by Sponging miR-498","volume":"13","author":"Ma","year":"2020","journal-title":"Onco Targets Ther."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.2147\/CMAR.S555993","article-title":"The Intricate Web of MicroRNAs in Modulating EGFR-TKI Resistance in Non-Small Cell Lung Cancer: A Comprehensive Review","volume":"17","author":"Xu","year":"2025","journal-title":"Cancer Manag. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"201007","DOI":"10.1016\/j.omton.2025.201007","article-title":"CircSPINT2 Confers Sensitivity to Osimertinib via Hsa-miR-1296-3p\/RBP1 Axis and Inhibits NSCLC Progression","volume":"33","author":"Verusingam","year":"2025","journal-title":"Mol. Ther. Oncol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s13577-021-00628-7","article-title":"F-circEA1 Regulates Cell Proliferation and Apoptosis through ALK Downstream Signaling Pathway in Non-Small Cell Lung Cancer","volume":"35","author":"Huo","year":"2022","journal-title":"Hum. Cell"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"111571","DOI":"10.1016\/j.cellsig.2024.111571","article-title":"Fusion circRNA F-circEA1 Facilitates EML4-ALK1 Positive Lung Adenocarcinoma Progression through the miR-4673\/SMAD4\/ADAR1 Axis","volume":"127","author":"Huo","year":"2025","journal-title":"Cell. Signal."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12943-019-1111-2","article-title":"Circular RNA circFGFR1 Promotes Progression and Anti-PD-1 Resistance by Sponging miR-381-3p in Non-Small Cell Lung Cancer Cells","volume":"18","author":"Zhang","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"24560","DOI":"10.18632\/aging.203576","article-title":"Circular RNA CELF1 Drives Immunosuppression and Anti-PD1 Therapy Resistance in Non-Small Cell Lung Cancer via the miR-491-5p\/EGFR Axis","volume":"13","author":"Ge","year":"2021","journal-title":"Aging"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12943-022-01586-w","article-title":"The Circular RNA circHMGB2 Drives Immunosuppression and Anti-PD-1 Resistance in Lung Adenocarcinomas and Squamous Cell Carcinomas via the miR-181a-5p\/CARM1 Axis","volume":"21","author":"Zhang","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41698-025-01102-5","article-title":"Diagnostic and Prognostic Roles of Circulating EVs circ_PPAPDC1A in ICIs Resistance in NSCLC","volume":"9","author":"Zou","year":"2025","journal-title":"npj Precis. Oncol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12935-021-01791-5","article-title":"Circ-ANXA7 Facilitates Lung Adenocarcinoma Progression via miR-331\/LAD1 Axis","volume":"21","author":"Wang","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12943-019-1061-8","article-title":"RNA-Seq Profiling of Circular RNA in Human Lung Adenocarcinoma and Squamous Cell Carcinoma","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.biopha.2018.03.084","article-title":"Increased Expression of circRNA_102231 in Lung Cancer and Its Clinical Significance","volume":"102","author":"Zong","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1080\/15384101.2018.1515553","article-title":"CircRNA Hsa_circ_100395 Regulates miR-1228\/TCF21 Pathway to Inhibit Lung Cancer Progression","volume":"17","author":"Chen","year":"2018","journal-title":"Cell Cycle"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1111\/1759-7714.14942","article-title":"A Novel Molecular Mechanism Mediated by circCCDC134 Regulates Non-small Cell Lung Cancer Progression","volume":"14","author":"Tong","year":"2023","journal-title":"Thorac. Cancer"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1002\/cam4.1514","article-title":"A Novel Plasma Circular RNA circFARSA Is a Potential Biomarker for Non-Small Cell Lung Cancer","volume":"7","author":"Hang","year":"2018","journal-title":"Cancer Med."},{"key":"ref_150","first-page":"100412","article-title":"Tumor-Derived Exosomal circFARSA Mediates M2 Macrophage Polarization via the PTEN\/PI3K\/AKT Pathway to Promote Non-Small Cell Lung Cancer Metastasis","volume":"28","author":"Chen","year":"2021","journal-title":"Cancer Treat. Res. Commun."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.jmoldx.2020.05.011","article-title":"Identification of Three Circular RNA Cargoes in Serum Exosomes as Diagnostic Biomarkers of Non\u2013Small-Cell Lung Cancer in the Chinese Population","volume":"22","author":"Xian","year":"2020","journal-title":"J. Mol. Diagn."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.clinbiochem.2022.01.005","article-title":"Serum Exosomal Hsa_circ_0069313 Has a Potential to Diagnose More Aggressive Non-Small Cell Lung Cancer","volume":"102","author":"Chen","year":"2022","journal-title":"Clin. Biochem."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s12967-024-05215-6","article-title":"Exosome-Transported Circ_0061407 and Circ_0008103 Play a Tumour-Repressive Role and Show Diagnostic Value in Non-Small-Cell Lung Cancer","volume":"22","author":"Chen","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1002\/1878-0261.13182","article-title":"Digital Multiplexed Analysis of Circular RNAs in FFPE and Fresh Non-small Cell Lung Cancer Specimens","volume":"16","author":"Giannoukakos","year":"2022","journal-title":"Mol. Oncol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1080\/17520363.2025.2542115","article-title":"Plasma-Derived circALG8 and circCAMTA1 as a Panel for Early Diagnosis of Non-Small Cell Lung Cancer","volume":"19","author":"Sheng","year":"2025","journal-title":"Biomark. Med."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"D\u2019Ambrosi, S., Giannoukakos, S., Antunes-Ferreira, M., Pedraz-Valdunciel, C., Bracht, J.W.P., Potie, N., Gimenez-Capitan, A., Hackenberg, M., Fernandez Hilario, A., and Molina-Vila, M.A. (2023). Combinatorial Blood Platelets-Derived circRNA and mRNA Signature for Early-Stage Lung Cancer Detection. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054881"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/1759-7714.13097","article-title":"CBLL1 Is Highly Expressed in Non-small Cell Lung Cancer and Promotes Cell Proliferation and Invasion","volume":"10","author":"Hui","year":"2019","journal-title":"Thorac. Cancer"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1051\/jbio:2005024","article-title":"L\u2019autophagie: Un m\u00e9canisme de survie et de mort cellulaire","volume":"199","author":"Codogno","year":"2005","journal-title":"J. Soc. Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"e70090","DOI":"10.1002\/cam4.70090","article-title":"RBBP4: A Novel Diagnostic and Prognostic Biomarker for Non-small-cell Lung Cancer Correlated with Autophagic Cell Death","volume":"13","author":"Zhan","year":"2024","journal-title":"Cancer Med."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Zhu, X., Han, J., Lan, H., Lin, Q., Wang, Y., and Sun, X. (2020). A Novel Circular RNA hsa_circRNA_103809\/miR-377-3p\/GOT1 Pathway Regulates Cisplatin-Resistance in Non-Small Cell Lung Cancer (NSCLC). BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07680-w"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12935-020-01390-w","article-title":"CircRNA CDR1as\/miR-641\/HOXA9 Pathway Regulated Stemness Contributes to Cisplatin Resistance in Non-Small Cell Lung Cancer (NSCLC)","volume":"20","author":"Zhao","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"44917","DOI":"10.18632\/oncotarget.16570","article-title":"The Dark Side of SOX2: Cancer\u2014A Comprehensive Overview","volume":"8","author":"Wuebben","year":"2017","journal-title":"Oncotarget"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/cas.15177","article-title":"Hsa_circ_0005576 Promotes Osimertinib Resistance through the miR-512-5p\/IGF1R Axis in Lung Adenocarcinoma Cells","volume":"113","author":"Liu","year":"2022","journal-title":"Cancer Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/nm1201-1339","article-title":"Stromal-Derived Factor-1 in Human Tumors Recruits and Alters the Function of Plasmacytoid Precursor Dendritic Cells","volume":"7","author":"Zou","year":"2001","journal-title":"Nat. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"123066","DOI":"10.1016\/j.talanta.2021.123066","article-title":"Circular RNA Detection Methods: A Minireview","volume":"238","author":"Mi","year":"2022","journal-title":"Talanta"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nbt.2890","article-title":"Detecting and Characterizing Circular RNAs","volume":"32","author":"Jeck","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/2211-5463.12397","article-title":"Profiling Expression of Coding Genes, Long Noncoding RNA, and Circular RNA in Lung Adenocarcinoma by Ribosomal RNA-Depleted RNA Sequencing","volume":"8","author":"Ding","year":"2018","journal-title":"FEBS Open Bio"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Ahsan, S., Win, T.T., Aye, S.N., and Than, N.N. (2024). The Role of Circular RNAs (circRNAs) as a Prognostic Factor in Lung Cancer: A Meta-Analysis. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12704-w"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Hofman, P. (2024). Liquid and Tissue Biopsies for Lung Cancer: Algorithms and Perspectives. Cancers, 16.","DOI":"10.3390\/cancers16193340"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.gpb.2022.11.003","article-title":"Machine Learning for Lung Cancer Diagnosis, Treatment, and Prognosis","volume":"20","author":"Li","year":"2022","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/cr.2015.82","article-title":"Circular RNA Is Enriched and Stable in Exosomes: A Promising Biomarker for Cancer Diagnosis","volume":"25","author":"Li","year":"2015","journal-title":"Cell Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"e371","DOI":"10.1016\/j.clon.2024.07.004","article-title":"Overview of the Role of Liquid Biopsy in Non-Small Cell Lung Cancer (NSCLC)","volume":"36","author":"Ospina","year":"2024","journal-title":"Clin. Oncol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"e667","DOI":"10.1002\/mco2.667","article-title":"Circular RNA-based Neoantigen Vaccine for Hepatocellular Carcinoma Immunotherapy","volume":"5","author":"Wang","year":"2024","journal-title":"MedComm"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e23866","DOI":"10.1002\/jcla.23866","article-title":"Translation Role of circRNAs in Cancers","volume":"35","author":"Lu","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/15384047.2018.1523848","article-title":"Research Progress of Circular RNAs in Lung Cancer","volume":"20","author":"Ma","year":"2019","journal-title":"Cancer Biol. Ther."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12943-019-1113-0","article-title":"Circular RNAs in the Tumour Microenvironment","volume":"19","author":"Ma","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12935-020-01301-z","article-title":"Circular RNA and Tumor Microenvironment","volume":"20","author":"Song","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12943-019-1125-9","article-title":"Roles of circRNAs in the Tumour Microenvironment","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Fang, Z., Jiang, C., and Li, S. (2021). The Potential Regulatory Roles of Circular RNAs in Tumor Immunology and Immunotherapy. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.617583"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40364-020-00204-5","article-title":"The Emerging Landscape of Circular RNAs in Immunity: Breakthroughs and Challenges","volume":"8","author":"Li","year":"2020","journal-title":"Biomark. Res."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00262-024-03924-x","article-title":"CircRNA-Loaded DC Vaccine in Combination with Low-Dose Gemcitabine Induced Potent Anti-Tumor Immunity in Pancreatic Cancer Model","volume":"74","author":"Cai","year":"2025","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3892\/mmr.2025.13662","article-title":"CircRNA in Non-small Cell Lung Cancer: Potential Biomarkers and Therapeutic Targets (Review)","volume":"32","author":"Wu","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12943-020-01298-z","article-title":"Circular RNAs in Body Fluids as Cancer Biomarkers: The New Frontier of Liquid Biopsies","volume":"20","author":"Wang","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.canlet.2020.08.013","article-title":"CircRNAs in Lung Cancer\u2014Biogenesis, Function and Clinical Implication","volume":"492","author":"Wang","year":"2020","journal-title":"Cancer Lett."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/18\/2989\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:12:46Z","timestamp":1789704766000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/18\/2989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":184,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["cancers18182989"],"URL":"https:\/\/doi.org\/10.3390\/cancers18182989","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]}}}