{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:01:01Z","timestamp":1792789261894,"version":"4.5.0"},"reference-count":48,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Scientific and Technical Research Council of Argentina","award":["PIP 2021 #2414"],"award-info":[{"award-number":["PIP 2021 #2414"]}],"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Honorio Bigand Foundation"},{"name":"Florencio Fiorini Foundation"},{"name":"Williams Foundation","id":[{"id":"https:\/\/ror.org\/03799m784","id-type":"ROR","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03799m784","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Ren\u00e9 Bar\u00f3n Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Adipose tissue (AT) has emerged as a metabolically active component of the breast tumor microenvironment that contributes to breast cancer (BC) progression. Adipocytes release adipokines and lipids that influence tumor growth; however, the specific lipolytic proteins involved in these interactions remain poorly characterized. Methods: In this study, we analyzed the expression of perilipin 1, adipose triglyceride lipase (ATGL), and hormone-sensitive lipase (HSL) by Western blot and immunofluorescence in adipose tissue explants from BC patients and healthy donors, evaluating their associations with clinicopathological features related to BC prognosis. Results: We found that perilipin 1 expression was increased in AT from patients with aggressive tumor characteristics, including advanced stage, premenopausal status, and obesity. In contrast, ATGL and HSL levels were reduced in specific patient subgroups, particularly in obese and postmenopausal patients and in tumor-adjacent AT from invasive lobular carcinoma. Conclusions: Together, these findings indicate that the expression of proteins involved in the regulation of lipolysis is influenced by both tumor proximity and clinicopathological characteristics, suggesting alterations in the molecular machinery governing lipid droplet regulation and lipid mobilization within tumor-associated AT. The observed associations identify perilipin 1, ATGL, and HSL as potential candidate markers of tumor-associated AT alterations and provide further insight into tumor\u2013adipocyte interactions in BC. Despite the exploratory nature of this study, the observed associations provide a basis for further investigation into their potential biological and clinical relevance in BC.<\/jats:p>","DOI":"10.3390\/cancers18183001","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:50:27Z","timestamp":1789566627000},"page":"3001","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered Lipolytic Protein Expression in Tumor-Associated Adipose Tissue Correlates with Aggressive Breast Cancer Features"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4918-9740","authenticated-orcid":false,"given":"Priscila","family":"Pagnotta","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Vuelta de Obligado 2490, Buenos Aires 1428, Argentina"},{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Avenida Intendente Cantilo, Buenos Aires 1428, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Tom\u00e1s","family":"Gonz\u00e1lez-Garello","sequence":"additional","affiliation":[{"name":"Instituto de C\u00e1lculo (IC), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Avenida Intendente Cantilo, Buenos Aires 1428, 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Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Natalia","family":"Santiso","sequence":"additional","affiliation":[{"name":"Complejo M\u00e9dico Policial Churruca-Visca, Uspallata 3400, Buenos Aires 1437, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Anabela","family":"Ursino","sequence":"additional","affiliation":[{"name":"Complejo M\u00e9dico Policial Churruca-Visca, Uspallata 3400, Buenos Aires 1437, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Celeste","family":"Frascarolli","sequence":"additional","affiliation":[{"name":"Complejo M\u00e9dico Policial Churruca-Visca, Uspallata 3400, Buenos Aires 1437, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Alicia","family":"Amato","sequence":"additional","affiliation":[{"name":"Complejo M\u00e9dico Policial Churruca-Visca, Uspallata 3400, Buenos Aires 1437, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Rub\u00e9n","family":"Dreszman","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Microcirug\u00eda, Bulnes 1813, Buenos Aires 1425, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Camila","family":"Ramos Quintana","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Vuelta de Obligado 2490, Buenos Aires 1428, 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