{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:08:38Z","timestamp":1790824118568,"version":"4.1.0"},"reference-count":151,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01CA265981"],"award-info":[{"award-number":["1R01CA265981"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Pediatric malignancies are often closely linked to developmental cell states, differentiation trajectories, and restricted developmental windows. This relationship is especially evident in neural-crest-derived tumors, where malignant cells may retain, remodel, or reacquire glycosylation programs that normally regulate embryonic migration and lineage maturation. Using a pediatric developmental perspective, we consider tumor-associated sialylation as potentially reflecting retention of the developmental cell-of-origin glycome, reacquisition during malignant cell state plasticity, or cancer-specific remodeling. Neuroblastoma provides the strongest evidence linking these mechanisms to tumor biology and therapy. Polysialylated NCAM can support migratory and plastic phenotypes, ganglioside biosynthesis is coupled to adrenergic-mesenchymal cell state through cell state-dependent regulation of glycosyltransferases including ST8SIA1, and the developmentally enriched ganglioside GD2 creates an actionable therapeutic vulnerability. Selected neural-crest-derived tumors that also occur outside childhood are included as they may help distinguish lineage-associated mechanisms from features specific to pediatric malignancy. We examine sialoglycan-Siglec immune regulation, emerging glycan-directed therapies, and approaches for resolving sialylation across developmental and malignant cell states. This framework argues that pediatric neural-crest-derived tumors do not simply recapitulate embryonic glycosylation but selectively retain, remodel, or reacquire developmental sialylation programs that can influence plasticity, migration, immune evasion, and therapeutic response.<\/jats:p>","DOI":"10.3390\/cancers18183023","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:41:35Z","timestamp":1789645295000},"page":"3023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Developmental Sialylation in Neuroblastoma and Neural-Crest-Derived Tumors"],"prefix":"10.3390","volume":"18","author":[{"given":"Laxmi","family":"Swami","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA"},{"name":"Department of Bioscience and Biotechnology, Banasthali Vidyapith, Banasthali 304022, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Banasthali Vidyapith, Banasthali 304022, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0500-4636","authenticated-orcid":false,"given":"Pracheta","family":"Janmeda","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Banasthali Vidyapith, Banasthali 304022, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punarvi","family":"Mandadapu","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fauzia","family":"Jamal","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0191-0259","authenticated-orcid":false,"given":"Pradeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5172-2116","authenticated-orcid":false,"given":"Karin M.","family":"Hardiman","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3952-1017","authenticated-orcid":false,"given":"Laura L.","family":"Stafman","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/B978-0-12-380916-2.00004-8","article-title":"The connections between neural crest development and neuroblastoma","volume":"94","author":"Jiang","year":"2011","journal-title":"Curr. 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