{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:03:24Z","timestamp":1790697804702,"version":"4.1.0"},"reference-count":53,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32260162"],"award-info":[{"award-number":["32260162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["32260162"],"award-info":[{"award-number":["32260162"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010857","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20242BAB25499"],"award-info":[{"award-number":["20242BAB25499"]}],"id":[{"id":"10.13039\/501100010857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Our previous study identified ZBTB1 as a novel tumor suppressor in estrogen receptor-positive (ER+) breast cancer. Moreover, The Cancer Genome Atlas (TCGA) data analysis showed a much lower level of ZBTB1 in triple-negative breast cancer than in ER+ breast cancer. Triple negative breast cancer (TNBC) lacks effective targeted therapies and largely depends on chemotherapy, while chemotherapy resistance remains a major clinical challenge. This study aimed to explore the role of ZBTB1 in TNBC progression and chemotherapy resistance. Methods: We performed clinical survival analysis, in vitro and in vivo functional experiments, mass spectrometry screening, and mechanistic validation in TNBC and Adriamycin-resistant TNBC cells. Results: We found that ZBTB1 protein is downregulated in TNBC and this downregulation correlates with shorter patient survival. ZBTB1 regulates glycolysis and chemotherapy resistance in TNBC cells. Mechanistically, ZBTB1 interacts with c-Myc and suppresses its transcriptional activity in MDA-MB-231 and MDA-MB-453 but not in Adriamycin-resistant cells (MDA-MB-231\/ADR and MDA-MB-453\/ADR). LncRNA SAP30L-AS1 is required for maintaining the ZBTB1\u2013c-Myc interaction in TNBC cells. SAP30L-AS1 is significantly depleted in Adriamycin-resistant cells, which disrupts the binding between ZBTB1 and c-Myc. Functional validation revealed that SAP30L-AS1 modulates glycolysis and chemotherapy resistance in TNBC cells in a ZBTB1-dependent manner. Conclusions: Collectively, our data indicate the key role of ZBTB1 in TNBC and ZBTB1 may serve as a novel approach for TNBC treatments.<\/jats:p>","DOI":"10.3390\/cancers18193156","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:14:37Z","timestamp":1790694877000},"page":"3156","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ZBTB1 Regulates Glycolysis and Chemotherapy Resistance Through Interacting with c-Myc in Triple Negative Breast Cancer"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6330-170X","authenticated-orcid":false,"given":"Na","family":"Qian","sequence":"first","affiliation":[{"name":"The Center for Translational Medicine, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Songyao","family":"Sun","sequence":"additional","affiliation":[{"name":"The Center for Translational Medicine, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Cong","family":"Ouyang","sequence":"additional","affiliation":[{"name":"The Center for Translational Medicine, Yichun University, Yichun 336000, China"},{"name":"The Department of Biochemistry, School of Basic Medical Sciences, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Wenlong","family":"Xie","sequence":"additional","affiliation":[{"name":"The Center for Translational Medicine, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Shuhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang 330029, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Huizheng","family":"Xie","sequence":"additional","affiliation":[{"name":"The Center for Translational Medicine, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Songyu","family":"Li","sequence":"additional","affiliation":[{"name":"The Center for Translational Medicine, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[{"name":"The Center for Translational Medicine, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Yumeng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Center for Translational Medicine, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Zihua","family":"Li","sequence":"additional","affiliation":[{"name":"The Center for Translational Medicine, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[{"name":"The Center for Applied Mathematics, School of Artificial Intelligence and Information Engineering, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"software","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6061-8977","authenticated-orcid":false,"given":"Kuaiying","family":"Wu","sequence":"additional","affiliation":[{"name":"The Center for Translational Medicine, Yichun University, Yichun 336000, 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(2024). Recent Developments in Combination Immunotherapy with Other Therapies and Nanoparticle-Based Therapy for Triple-Negative Breast Cancer (TNBC). Cancers, 16.","DOI":"10.20944\/preprints202404.1833.v1"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.omtn.2021.06.017","article-title":"Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer","volume":"26","author":"Tian","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"107205","DOI":"10.1016\/j.phrs.2024.107205","article-title":"Epigenetic modulations in triple-negative breast cancer: Therapeutic implications for tumor microenvironment","volume":"204","author":"Zhou","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Crintea, A., Bocsan, C.I., Jianu, E.M., Sovrea, A.S., Munteanu, C., Kubelac, M.P., Craciun, A.M., and Silaghi, C.N. (2026). Overcoming Chemotherapy Resistance in Triple-Negative Breast Cancer with Nanocarrier-Delivered siRNA Therapeutics. J. Clin. Med., 15.","DOI":"10.3390\/jcm15062311"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Juan, C., and Peng, Y. (2025). The Molecular Landscape and Utility of Multiomic Analyses in Triple-Negative Breast Cancer: Further Subtyping and Exploring Novel Biomarkers and Therapeutic Targets. Cancers, 17.","DOI":"10.20944\/preprints202510.0714.v1"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2217\/epi-2023-0430","article-title":"The regulation of microRNAs on chemoresistance in triple-negative breast cancer: A recent update","volume":"16","author":"Yan","year":"2024","journal-title":"Epigenomics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cpt.2023.06.002","article-title":"Efficacy and safety of first-line treatment for metastatic triple-negative breast cancer: A network meta-analysis","volume":"2","author":"Shi","year":"2024","journal-title":"Cancer Pathog. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Previtali, A., Guardamagna, I., Calandra, S., Shakarami, M., Lonati, L., Riani, C., Semerano, R., Baiocco, G., Maggi, M., and Scotti, C. (2026). Emerging Protein Targets in Triple-Negative Breast Cancer: Beyond Conventional Therapy. Cancers, 18.","DOI":"10.20944\/preprints202601.0915.v1"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Taglialatela, I., Ruffilli, B., Conte, B., D\u2019Avanzo, F., Rossi, V., Nardin, S., and Gennari, A. (2025). Updating the Role of Carboplatin Added to Neoadjuvant Chemotherapy in Early Triple-Negative Breast Cancer: A Meta-Analysis. Cancers, 17.","DOI":"10.3390\/cancers17243961"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/s41598-023-28355-z","article-title":"CENPF knockdown inhibits adriamycin chemoresistance in triple-negative breast cancer via the Rb-E2F1 axis","volume":"13","author":"Wang","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.breast.2017.06.023","article-title":"Mechanisms of resistance of chemotherapy in early-stage triple negative breast cancer (TNBC)","volume":"34","author":"Wein","year":"2017","journal-title":"Breast"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Nedeljkovic, M., and Damjanovic, A. (2019). Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer-How We Can Rise to the Challenge. Cells, 8.","DOI":"10.3390\/cells8090957"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wang, Z., Sun, X., Li, Z., Yu, H., Li, W., and Xu, Y. (2024). Metabolic reprogramming in esophageal squamous cell carcinoma. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1423629"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ccr.2008.05.005","article-title":"Tumor cell metabolism: Cancer\u2019s Achilles\u2019 heel","volume":"13","author":"Kroemer","year":"2008","journal-title":"Cancer Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41568-026-00908-0","article-title":"Decoding cancer across scales with metabolomics","volume":"26","author":"Rowles","year":"2026","journal-title":"Nat. Rev. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kollmar, J., Xu, J., Gonzalves, D., Baur, J.A., Li, L.Z., Tchou, J., and Xu, H.N. (2024). Differential Mitochondrial Redox Responses to the Inhibition of NAD(+) Salvage Pathway of Triple Negative Breast Cancer Cells. Cancers, 17.","DOI":"10.3390\/cancers17010007"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: The metabolic requirements of cell proliferation","volume":"324","author":"Cantley","year":"2009","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1476-4598-12-152","article-title":"Tumor glycolysis as a target for cancer therapy: Progress and prospects","volume":"12","author":"Geschwind","year":"2013","journal-title":"Mol. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1085\/jgp.8.6.519","article-title":"The Metabolism of Tumors in the Body","volume":"8","author":"Warburg","year":"1927","journal-title":"J. Gen. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1126\/science.124.3215.267","article-title":"On respiratory impairment in cancer cells","volume":"124","author":"Weinhouse","year":"1956","journal-title":"Science"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41419-026-08521-7","article-title":"Deubiquitinase UCH-L1 confers paclitaxel resistance via stabilizing PKM2 to promote glycolysis in triple-negative breast cancer","volume":"17","author":"Chen","year":"2026","journal-title":"Cell Death Dis."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Doddapaneni, R., Tucker, J.D., Lu, P.J., and Lu, Q.L. (2023). Metabolic Reprogramming by Ribitol Expands the Therapeutic Window of BETi JQ1 against Breast Cancer. Cancers, 15.","DOI":"10.3390\/cancers15174356"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1476-4598-9-33","article-title":"Warburg effect in chemosensitivity: Targeting lactate dehydrogenase\u2014A re-sensitizes taxol-resistant cancer cells to taxol","volume":"9","author":"Zhou","year":"2010","journal-title":"Mol. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.bbadis.2018.01.002","article-title":"Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects","volume":"1864","author":"Guha","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Liu, S., Li, Y., Yuan, M., Song, Q., and Liu, M. (2022). Correlation between the Warburg effect and progression of triple-negative breast cancer. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1060495"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1186\/s13058-014-0434-6","article-title":"Mitochondrial dysfunction in some triple-negative breast cancer cell lines: Role of mTOR pathway and therapeutic potential","volume":"16","author":"Pelicano","year":"2014","journal-title":"Breast Cancer Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.breast.2016.08.014","article-title":"High expressions of LDHA and AMPK as prognostic biomarkers for breast cancer","volume":"30","author":"Huang","year":"2016","journal-title":"Breast"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/ptr.70112","article-title":"A Natural LDHA Allosteric Inhibitor Geraniin Suppresses Triple-Negative Breast Cancer Cell Growth","volume":"40","author":"Yu","year":"2026","journal-title":"Phytother. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14824","DOI":"10.1021\/jacs.5c04233","article-title":"Inhibiting Glycolysis and Disrupting the Mitochondrial HK2-VDAC1 Protein-Protein Interaction Using a Bifunctional Lonidamine-Conjugated Metal Probe for Combating Triple-Negative Breast Cancer","volume":"147","author":"Wang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.21037\/tcr.2019.01.37","article-title":"Downregulation of hexokinase 2 improves radiosensitivity of breast cancer","volume":"8","author":"Zhang","year":"2019","journal-title":"Transl. Cancer Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1084\/jem.20112084","article-title":"ZBTB1 is a determinant of lymphoid development","volume":"209","author":"Siggs","year":"2012","journal-title":"J. Exp. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.4049\/jimmunol.1600013","article-title":"Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors","volume":"197","author":"Cao","year":"2016","journal-title":"J. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.4049\/jimmunol.1200623","article-title":"Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development","volume":"189","author":"Punwani","year":"2012","journal-title":"J. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"58768","DOI":"10.18632\/oncotarget.11356","article-title":"Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1111\/jcmm.13663","article-title":"Reciprocal suppression between Zbtb1 expression and IL-7Ralpha signalling during T-cell development","volume":"22","author":"Cao","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"102506","DOI":"10.1016\/j.jbc.2022.102506","article-title":"Transcription factor Zbtb1 interacts with bridging factor Lmo2 and maintains the T-lineage differentiation capacity of lymphoid progenitor cells","volume":"298","author":"Koizumi","year":"2022","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"14140","DOI":"10.1074\/jbc.RA119.010759","article-title":"A novel tumor suppressor ZBTB1 regulates tamoxifen resistance and aerobic glycolysis through suppressing HER2 expression in breast cancer","volume":"295","author":"Zhang","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1038\/onc.2014.430","article-title":"MiR-873 regulates ERalpha transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells","volume":"34","author":"Cui","year":"2015","journal-title":"Oncogene"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"115845","DOI":"10.1016\/j.taap.2021.115845","article-title":"The mechanism underlying arsenic-induced PD-L1 upregulation in transformed BEAS-2B cells","volume":"435","author":"Wang","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.tcb.2017.11.008","article-title":"Long Noncoding RNA in Cancer: Wiring Signaling Circuitry","volume":"28","author":"Lin","year":"2018","journal-title":"Trends Cell Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e23122","DOI":"10.1002\/jcla.23122","article-title":"A long non-coding RNA LNBC3 facilitates non-small cell lung cancer progression by stabilizing BCL6","volume":"34","author":"Shen","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","article-title":"UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses","volume":"19","author":"Chandrashekar","year":"2017","journal-title":"Neoplasia"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"152026","DOI":"10.1016\/j.bbrc.2025.152026","article-title":"The ZBTB family in cardiac development and diseases","volume":"771","author":"Xiang","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Ghasemi, N., Azizi, H., Razavi-Amoli, S.K., and Skutella, T. (2024). The Role of Plzf in Spermatogonial Stem Cell Maintenance and Differentiation: Mapping the Transcriptional Dynamics and Key Interactions. Cells, 13.","DOI":"10.3390\/cells13231930"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Cheng, Z.Y., He, T.T., Gao, X.M., Zhao, Y., and Wang, J. (2021). ZBTB Transcription Factors: Key Regulators of the Development, Differentiation and Effector Function of T Cells. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.713294"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Zhu, C., Chen, G., Zhao, Y., Gao, X.M., and Wang, J. (2018). Regulation of the Development and Function of B Cells by ZBTB Transcription Factors. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00580"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molcel.2014.02.017","article-title":"Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis","volume":"54","author":"Kim","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1073\/pnas.1501555112","article-title":"Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP","volume":"112","author":"Shen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"108258","DOI":"10.1016\/j.isci.2023.108258","article-title":"RBFOX2 regulated EYA3 isoforms partner with SIX4 or ZBTB1 to control transcription during myogenesis","volume":"26","author":"Wiedner","year":"2023","journal-title":"iScience"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Fallah, Y., Brundage, J., Allegakoen, P., and Shajahan-Haq, A.N. (2017). MYC-Driven Pathways in Breast Cancer Subtypes. Biomolecules, 7.","DOI":"10.3390\/biom7030053"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1158\/2159-8290.CD-22-0649","article-title":"MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer","volume":"14","author":"Meena","year":"2024","journal-title":"Cancer Discov."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.clbc.2022.11.006","article-title":"USP22 Contributes to Chemoresistance, Stemness, and EMT Phenotype of Triple-Negative Breast Cancer Cells by egulating the Warburg Effect via c-Myc Deubiquitination","volume":"23","author":"Li","year":"2023","journal-title":"Clin. Breast Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.gene.2018.12.047","article-title":"Long non-coding RNA SAP30L-AS1 promotes prostate cancer growth through repressing SAP30L","volume":"690","author":"Qin","year":"2019","journal-title":"Gene"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/19\/3156\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:20:22Z","timestamp":1790695222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/19\/3156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":53,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["cancers18193156"],"URL":"https:\/\/doi.org\/10.3390\/cancers18193156","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]}}}