{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:54:08Z","timestamp":1791881648672,"version":"4.3.4"},"reference-count":58,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background and Objectives: Anxiety is highly prevalent among breast cancer patients and significantly impairs quality of life. Although both conventional physical exercise (PE) and mind\u2013body interventions (MBE) are used in supportive care, their relative efficacy remains unclear. This systematic review and meta-analysis compared the effects of PE and MBE on anxiety in breast cancer patients. Materials and Methods: PubMed, Web of Science, Embase, PsycINFO, and CINAHL were systematically searched through April 2026 for controlled trials comparing structured PE or MBE with control conditions. Effect sizes were pooled as standardized mean differences (SMDs; Hedges\u2019 g) using a random-effects model with restricted maximum likelihood estimation and modified Hartung\u2013Knapp inference. Subgroup analyses and univariable meta-regressions explored potential moderators. Results: Twenty-four reports (N = 2197) represented 25 independent trials; 22 estimates from 21 reports entered the meta-analysis, and three reports were synthesized narratively. Interventions significantly reduced anxiety on average (SMD = \u22120.58, 95% CI [\u22121.01, \u22120.15], p = 0.011), with substantial heterogeneity (I2 = 85.0%) and a 95% prediction interval of \u22122.38 to 1.22. Both PE (SMD = \u22120.67) and MBE (SMD = \u22120.46) favored intervention numerically, although both subgroup confidence intervals included no effect, with no significant difference between modalities (p = 0.697). A larger, yet non-significant, effect was observed during active treatment (SMD = \u22120.84, 95% CI [\u22121.68, 0.01]) compared with survivorship (SMD = \u22120.34, 95% CI [\u22120.62, \u22120.07]); the between-phase comparison was inconclusive (p = 0.291). The comparison across diagnostic stages was also inconclusive (p = 0.366). None of the seven continuous moderators met the multiplicity-adjusted significance threshold. Conclusions: Current findings suggest an average reduction in anxiety following physical and mind\u2013body interventions in breast cancer patients. However, no statistically significant differences were observed between intervention modalities or treatment stages. Very low certainty, substantial heterogeneity and indirect subgroup comparisons limit confidence in the size and consistency of benefit. Overall, individualized interventions may have a role in oncology care, but these findings do not establish superiority, equivalence or differential efficacy between modalities or treatment phases.<\/jats:p>","DOI":"10.3390\/cancers18193244","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:16:52Z","timestamp":1791472612000},"page":"3244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of Physical and Mind\u2013Body Exercise on Anxiety Among Patients with Breast Cancer: A Systematic Review and Meta-Analysis of Controlled Trials"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-2844","authenticated-orcid":false,"given":"Mesut","family":"S\u00fcleymano\u011fullar\u0131","sequence":"first","affiliation":[{"name":"Division of Physical Education and Sport, Department of Physical Education and Sport, Faculty of Sport Sciences, A\u011fr\u0131 Ibrahim \u00c7e\u00e7en University, 04100 A\u011fr\u0131, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemre Didem","family":"Eyip\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, Faculty of Sport Sciences, Gaziantep University, 27310 Gaziantep, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1659-2157","authenticated-orcid":false,"given":"Zarife","family":"Pancar","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, Faculty of Sport Sciences, Gaziantep University, 27310 Gaziantep, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4031-1412","authenticated-orcid":false,"given":"Valentina","family":"Stefanica","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, Faculty of Sciences, Physical Education and Informatics, National University of Science and Technology Politehnica Bucharest, Pitesti University Center, 110040 Pitesti, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Luigi","family":"Bragazzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Saarland University, 66123 Saarbr\u00fccken, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2214-4667","authenticated-orcid":false,"given":"Halil \u0130brahim","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Department of Physical Education of Sports Teaching, Faculty of Sports Sciences, Atat\u00fcrk University, 25240 Erzurum, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"ref_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.breast.2022.08.010","article-title":"Current and future burden of breast cancer: Global statistics for 2020 and 2040","volume":"66","author":"Arnold","year":"2022","journal-title":"Breast"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cpet.2018.02.006","article-title":"Overview of Breast Cancer Therapy","volume":"13","author":"Moo","year":"2018","journal-title":"PET Clin."},{"key":"ref_5","first-page":"438","article-title":"Breast cancer statistics, 2019","volume":"69","author":"DeSantis","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/bmj.38343.670868.D3","article-title":"Depression and anxiety in women with early breast cancer: Five year observational cohort study","volume":"330","author":"Burgess","year":"2005","journal-title":"BMJ"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s12282-019-01031-9","article-title":"Prevalence of anxiety among breast cancer patients: A systematic review and meta-analysis","volume":"27","author":"Hashemi","year":"2020","journal-title":"Breast Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"18673","DOI":"10.1038\/s41598-022-22971-x","article-title":"Impact of hormone therapy side effects on health-related quality of life, distress, and well-being of breast cancer survivors","volume":"12","author":"Andreu","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","article-title":"Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable","volume":"51","author":"Campbell","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_10","first-page":"194","article-title":"Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment","volume":"67","author":"Greenlee","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/1055-9965.EPI-11-0634","article-title":"Exercise effects on depressive symptoms in cancer survivors: A systematic review and meta-analysis","volume":"21","author":"Craft","year":"2012","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e000271","DOI":"10.1136\/esmoopen-2017-000271","article-title":"Effects of physical activity on depressive symptoms during breast cancer survivorship: A meta-analysis of randomised control trials","volume":"2","author":"Patsou","year":"2017","journal-title":"ESMO Open"},{"key":"ref_13","first-page":"CD010802","article-title":"Yoga for improving health-related quality of life, mental health and cancer-related symptoms in women diagnosed with breast cancer","volume":"1","author":"Cramer","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"102743","DOI":"10.1016\/j.ctim.2021.102743","article-title":"Qigong for women with breast cancer: An updated systematic review and meta-analysis","volume":"60","author":"Meng","year":"2021","journal-title":"Complement. Ther. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e6370","DOI":"10.1002\/pon.6370","article-title":"Effects of exercise interventions on quality of life in patients with breast cancer: A systematic review and network meta-analysis","volume":"33","author":"Han","year":"2024","journal-title":"Psychooncology"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Li, L., He, Y., Yang, X., and Liu, Y. (2025). The impact of mind-body exercise on female breast cancer patients-a systematic review and meta-analysis of randomized controlled trials. Front. Public Health, 13.","DOI":"10.3389\/fpubh.2025.1641075"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e70671","DOI":"10.1002\/cam4.70671","article-title":"Effects of Exercise on Depression and Anxiety in Breast Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"14","author":"Zhang","year":"2025","journal-title":"Cancer Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Jose, D., and Cacodcar, J.A. (2025). Effectiveness of a Relaxation Technique on Reducing Anxiety, Depression, and Fatigue among Women with Breast Cancer in Goa: A Randomized Controlled Trial. medRxiv.","DOI":"10.64898\/2025.12.17.25342348"},{"key":"ref_20","first-page":"233","article-title":"Effect of Multimodal Exercise on Cancer-Related Fatigue in Patients Undergoing Simultaneous Radiotherapy and Chemotherapy: A Randomized Trial in Patients with Breast Cancer","volume":"29","author":"Zhang","year":"2023","journal-title":"Altern. Ther. Health Med."},{"key":"ref_21","first-page":"34","article-title":"Comparing the Effectiveness of Exercise and Music Therapy on Anxiety and Depression in Patients with Breast Cancer","volume":"9","author":"Shehab","year":"2022","journal-title":"Int. J. Body Mind Cult."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/jrsm.11","article-title":"Outlier and influence diagnostics for meta-analysis","volume":"1","author":"Viechtbauer","year":"2010","journal-title":"Res. Synth. Methods"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1037\/a0016619","article-title":"Meta-analytic interval estimation for standardized and unstandardized mean differences","volume":"14","author":"Bonett","year":"2009","journal-title":"Psychol. Methods"},{"key":"ref_24","unstructured":"Hedges, L.V., and Olkin, I. (1985). Statistical Methods in Meta-Analysis, Academic Press."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/pon.1525","article-title":"Exercise and quality of life during and after treatment for breast cancer: Results of two randomized controlled trials","volume":"18","author":"Cadmus","year":"2009","journal-title":"Psychooncology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e70348","DOI":"10.1002\/pon.70348","article-title":"Effects of Individualized High-Intensity Online Concurrent Exercise Guided by Autonomic Modulation on the Mental Health and Quality of Life of Breast Cancer Survivors","volume":"34","author":"Nieto","year":"2025","journal-title":"Psychooncology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Travier, N., Velthuis, M.J., Steins Bisschop, C.N., van den Buijs, B., Monninkhof, E.M., Backx, F., Los, M., Erdkamp, F., Bloemendal, H.J., and Rodenhuis, C. (2015). Effects of an 18-week exercise program started early during breast cancer treatment: A randomised controlled trial. BMC Med., 13.","DOI":"10.1186\/s12916-015-0362-z"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1002\/pon.4254","article-title":"Effects of a multicomponent physical activity behavior change intervention on fatigue, anxiety, and depressive symptomatology in breast cancer survivors: Randomized trial","volume":"26","author":"Rogers","year":"2017","journal-title":"Psychooncology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ejon.2019.01.007","article-title":"The health effects of Baduanjin exercise (a type of Qigong exercise) in breast cancer survivors: A randomized, controlled, single-blinded trial","volume":"39","author":"Ying","year":"2019","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1002\/sim.1221","article-title":"A graphical method for exploring heterogeneity in meta-analyses: Application to a meta-analysis of 65 trials","volume":"21","author":"Baujat","year":"2002","journal-title":"Stat. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1037\/0033-2909.86.3.638","article-title":"The file drawer problem and tolerance for null results","volume":"86","author":"Rosenthal","year":"1979","journal-title":"Psychol. Bull."},{"key":"ref_35","first-page":"157","article-title":"A fail-safe N for effect size in meta-analysis","volume":"8","author":"Orwin","year":"1983","journal-title":"J. Educ. Stat."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"Duval","year":"2000","journal-title":"Biometrics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0895-4356(98)00131-0","article-title":"The Delphi list: A criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus","volume":"51","author":"Verhagen","year":"1998","journal-title":"J. Clin. Epidemiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.apmr.2017.08.485","article-title":"Methodologic Quality and Statistical Reporting of Physical Therapy Randomized Controlled Trials Relevant to Musculoskeletal Conditions","volume":"99","author":"Gonzalez","year":"2018","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: An emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.jbmt.2025.03.004","article-title":"What are the effects of free dance and dance therapy on self-esteem, anxiety, body image and depressive symptoms of women undergoing breast cancer surgery? A randomized clinical trial","volume":"42","author":"Gil","year":"2025","journal-title":"J. Bodyw. Mov. Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"102014","DOI":"10.1016\/j.ctcp.2025.102014","article-title":"Randomized controlled trial testing Tai Chi Easy\/Qigong and Sham Qigong on breast cancer survivors\u2019 fatigue and associated symptoms","volume":"61","author":"Larkey","year":"2025","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s10549-026-07923-7","article-title":"Effect of a supervised intermittent exercise program on insomnia in breast cancer patients undergoing chemotherapy","volume":"216","author":"Drozd","year":"2026","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_43","first-page":"620619","article-title":"Effectiveness of core stability exercises and recovery myofascial release massage on fatigue in breast cancer survivors: A randomized controlled clinical trial","volume":"2012","year":"2012","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.clbc.2022.07.009","article-title":"Motor Exercises Effect on Improving Shoulders Functioning, Functional Ability, Quality of Life, Depression and Anxiety For Women With Breast Cancer","volume":"22","author":"Charati","year":"2022","journal-title":"Clin. Breast Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/cncr.29330","article-title":"Yoga and meditation for menopausal symptoms in breast cancer survivors-A randomized controlled trial","volume":"121","author":"Cramer","year":"2015","journal-title":"Cancer"},{"key":"ref_46","first-page":"1139","article-title":"Effects of a self-managed home-based walking intervention on psychosocial health outcomes for breast cancer patients receiving chemotherapy: A randomised controlled trial","volume":"24","author":"Gokal","year":"2016","journal-title":"Support. Care Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jpainsymman.2015.12.332","article-title":"Effects of a Short-Term Dance Movement Therapy Program on Symptoms and Stress in Patients With Breast Cancer Undergoing Radiotherapy: A Randomized, Controlled, Single-Blind Trial","volume":"51","author":"Ho","year":"2016","journal-title":"J. Pain Symptom Manag."},{"key":"ref_48","first-page":"5281","article-title":"Pre-post analysis of a social capital-based exercise adherence intervention for breast cancer survivors with moderate fatigue: A randomized controlled trial","volume":"28","author":"Kim","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1007\/s00432-022-04167-y","article-title":"Effect of mindfulness yoga on anxiety and depression in early breast cancer patients received adjuvant chemotherapy: A randomized clinical trial","volume":"148","author":"Liu","year":"2022","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000327813","article-title":"Effects of a physical exercise rehabilitation group program on anxiety, depression, body image, and health-related quality of life among breast cancer patients","volume":"34","author":"Mehnert","year":"2011","journal-title":"Onkologie"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1519\/JSC.0000000000003817","article-title":"Resistance Training, Fatigue, Quality of Life, Anxiety in Breast Cancer Survivors","volume":"35","author":"Moraes","year":"2021","journal-title":"J. Strength Cond. Res."},{"key":"ref_52","first-page":"541","article-title":"The psychological and physical benefits of the supervised individual exercise program during radiotherapy in breast cancer patients: A randomized study","volume":"29","author":"Ozkan","year":"2022","journal-title":"Med. J. Suleyman Demirel Univ."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/0973-6131.36789","article-title":"Influence of yoga on mood states, distress, quality of life and immune outcomes in early stage breast cancer patients undergoing surgery","volume":"1","author":"Rao","year":"2008","journal-title":"Int. J. Yoga"},{"key":"ref_54","first-page":"6079","article-title":"Effects of Baduanjin exercise on cognitive function and cancer-related symptoms in women with breast cancer receiving chemotherapy: A randomized controlled trial","volume":"30","author":"Wei","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2023314","DOI":"10.1080\/20008198.2021.2023314","article-title":"Effectiveness of a nurse-led Mindfulness-based Tai Chi Chuan (MTCC) program on Posttraumatic Growth and perceived stress and anxiety of breast cancer survivors","volume":"13","author":"Zhang","year":"2022","journal-title":"Eur. J. Psychotraumatol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez-V\u00e9lez, R., Zambom-Ferraresi, F., Garc\u00eda-Hermoso, A., Kievisiene, J., Rauckiene-Michealsson, A., and Agostinis-Sobrinho, C. (2021). Evidence-Based Exercise Recommendations to Improve Mental Wellbeing in Women with Breast Cancer During Active Treatment: A Systematic Review and Meta-Analysis. Cancers, 13.","DOI":"10.3390\/cancers13020264"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Li, W., You, F., Wang, Q., Shen, Y., Wang, J., and Guo, J. (2023). Effects of Tai Chi Chuan training on the QoL and psychological well-being in female patients with breast cancer: A systematic review of randomized controlled trials. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1143674"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"295","DOI":"10.7326\/0003-4819-148-4-200802190-00008","article-title":"Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: Explanation and elaboration","volume":"148","author":"Boutron","year":"2008","journal-title":"Ann. Intern. Med."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/19\/3244\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:29:44Z","timestamp":1791880184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/19\/3244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":58,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["cancers18193244"],"URL":"https:\/\/doi.org\/10.3390\/cancers18193244","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]}}}