{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:52:26Z","timestamp":1791550346356,"version":"4.3.4"},"reference-count":107,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Decision-making in advanced cancer care is intertwined with diagnostic profiling, prognostic communication, supportive care, and anticancer treatment selection. An author-developed D-S-T \u00d7 B\/C\/E conceptual mapping scaffold\u2014three decision\/action domains (Diagnosis, Supportive care, Therapy) and three evaluative dimensions (Biological, Clinical, Existential)\u2014was used to organise the literature, to identify coverage gaps and recurring framework categories, and, as a secondary conceptual synthesis objective, to derive a candidate integrative framework. Methods: The review was conducted according to the Joanna Briggs Institute (JBI) methodology for scoping reviews, pre-registered on OSF, and reported per PRISMA-ScR. PubMed was searched on 21 June 2026, and the final evidence set was derived solely from this search. Eligible records concerning adults with advanced cancer were dual-screened and charted using a structured form. Results: Eighty-two records (2010\u20132026) were included. Under the strict D-S-T \u00d7 B\/C\/E matrix, Supportive care showed the highest joint coverage, particularly S \u00d7 C (59\/82, 72.0%), whereas D \u00d7 B and D \u00d7 E were the least represented cells (13\/82 each, 15.9%). Eight recurring framework categories were inductively derived from the charted framework descriptors, led by early integrated palliative care (30\/82) and prognosis-informed shared decision-making (27\/82). Twenty-two records met an emergence-candidate screen defined at the synthesis stage, of which three received the maximum cross-axis coupling score of 6\/6 from both reviewers. Conclusions: The advanced-cancer decision-framework literature clusters around a small number of architectures with uneven D-S-T \u00d7 B\/C\/E coverage. Diagnosis-centred frameworks coupled with biological or existential dimensions were relatively under-represented within our mapping and represent priority targets for future primary research; the proposed Adaptive framework provides one structure in which this research could be conducted.<\/jats:p>","DOI":"10.3390\/cancers18193245","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:02:06Z","timestamp":1791547326000},"page":"3245","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping Integrative Decision-Making Frameworks in Advanced Cancer Care: A Scoping Review of Diagnostic, Supportive-Care, and Therapeutic Integration"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2642-8665","authenticated-orcid":false,"given":"Kazuyuki","family":"Murase","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1 W-16, Chuo-ku, Sapporo 060-8543, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-0512","authenticated-orcid":false,"given":"Yusuke","family":"Sugama","sequence":"additional","affiliation":[{"name":"Higashi Sapporo Hospital, 3-3-7-35 Higashi Sapporo, Shiroishi-ku, Sapporo 003-8585, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Arihara","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1 W-16, Chuo-ku, Sapporo 060-8543, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1393-9442","authenticated-orcid":false,"given":"Kohichi","family":"Takada","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1 W-16, Chuo-ku, Sapporo 060-8543, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8420-1608","authenticated-orcid":false,"given":"Kunihiko","family":"Ishitani","sequence":"additional","affiliation":[{"name":"Higashi Sapporo Hospital, 3-3-7-35 Higashi Sapporo, Shiroishi-ku, Sapporo 003-8585, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e70391","DOI":"10.1002\/cncr.70391","article-title":"Aligning precision oncology with person-centeredness: A call for a new definition","volume":"132","author":"Kearney","year":"2026","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jpainsymman.2016.10.370","article-title":"The Edmonton Symptom Assessment System 25 years later: Past, present, and future developments","volume":"53","author":"Hui","year":"2017","journal-title":"J. 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