{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:54:01Z","timestamp":1790711641549,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2016,12,6]],"date-time":"2016-12-06T00:00:00Z","timestamp":1480982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 CA154562"],"award-info":[{"award-number":["R01 CA154562"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01 CA 87971"],"award-info":[{"award-number":["P01 CA 87971"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK PSRC","award":["EP\/K015338\/1"],"award-info":[{"award-number":["EP\/K015338\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Accurate photodynamic therapy (PDT) dosimetry is critical for the use of PDT in the treatment of malignant and nonmalignant localized diseases. A singlet oxygen explicit dosimetry (SOED) model has been developed for in vivo purposes. It involves the measurement of the key components in PDT\u2014light fluence (rate), photosensitizer concentration, and ground-state oxygen concentration ([3O2])\u2014to calculate the amount of reacted singlet oxygen ([1O2]rx), the main cytotoxic component in type II PDT. Experiments were performed in phantoms with the photosensitizer Photofrin and in solution using phosphorescence-based singlet oxygen luminescence dosimetry (SOLD) to validate the SOED model. Oxygen concentration and photosensitizer photobleaching versus time were measured during PDT, along with direct SOLD measurements of singlet oxygen and triplet state lifetime (\u03c4\u0394 and \u03c4t), for various photosensitizer concentrations to determine necessary photophysical parameters. SOLD-determined cumulative [1O2]rx was compared to SOED-calculated [1O2]rx for various photosensitizer concentrations to show a clear correlation between the two methods. This illustrates that explicit dosimetry can be used when phosphorescence-based dosimetry is not feasible. Using SOED modeling, we have also shown evidence that SOLD-measured [1O2]rx using a 523 nm pulsed laser can be used to correlate to singlet oxygen generated by a 630 nm laser during a clinical malignant pleural mesothelioma (MPM) PDT protocol by using a conversion formula.<\/jats:p>","DOI":"10.3390\/cancers8120109","type":"journal-article","created":{"date-parts":[[2016,12,6]],"date-time":"2016-12-06T10:07:17Z","timestamp":1481018837000},"page":"109","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["A Comparison of Singlet Oxygen Explicit Dosimetry (SOED) and Singlet Oxygen Luminescence Dosimetry (SOLD) for Photofrin-Mediated Photodynamic Therapy"],"prefix":"10.3390","volume":"8","author":[{"given":"Michele","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA"},{"name":"Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozhin","family":"Penjweini","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Gemmell","sequence":"additional","affiliation":[{"name":"Department of Electronic and Nanoscale Engineering, University of Glasgow, Glasgow G12 8LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Veilleux","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University of Toronto, ON M5G 1L7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aongus","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Institute of Photonics and Quantum Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Buller","sequence":"additional","affiliation":[{"name":"Institute of Photonics and Quantum Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hadfield","sequence":"additional","affiliation":[{"name":"Department of Electronic and Nanoscale Engineering, University of Glasgow, Glasgow G12 8LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Wilson","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University of Toronto, ON M5G 1L7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1118\/1.2937440","article-title":"The role of photodynamic therapy (PDT) Physics","volume":"35","author":"Zhu","year":"2008","journal-title":"Med. 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