{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T08:49:12Z","timestamp":1775033352619,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The mechanisms of response to radiation exposure are conserved in plants and animals. The DNA damage response (DDR) pathways are the predominant molecular pathways activated upon exposure to radiation, both in plants and animals. The conserved features of DDR in plants and animals might facilitate interdisciplinary studies that cross traditional boundaries between animal and plant biology in order to expand the collection of biomarkers currently used for radiation exposure monitoring (REM) in environmental and biomedical settings. Genes implicated in trans-kingdom conserved DDR networks often triggered by ionizing radiation (IR) and UV light are deposited into biological databases. In this study, we have applied an innovative approach utilizing data pertinent to plant and human genes from publicly available databases towards the design of a \u2018plant radiation biodosimeter\u2019, that is, a plant and DDR gene-based platform that could serve as a REM reliable biomarker for assessing environmental radiation exposure and associated risk. From our analysis, in addition to REM biomarkers, a significant number of genes, both in human and Arabidopsis thaliana, not yet characterized as DDR, are suggested as possible DNA repair players. Last but not least, we provide an example on the applicability of an Arabidopsis thaliana\u2014based plant system monitoring the role of cancer-related DNA repair genes BRCA1, BARD1 and PARP1 in processing DNA lesions.<\/jats:p>","DOI":"10.3390\/cancers9060065","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T10:53:09Z","timestamp":1496746389000},"page":"65","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Bridging Plant and Human Radiation Response and DNA Repair through an In Silico Approach"],"prefix":"10.3390","volume":"9","author":[{"given":"Zacharenia","family":"Nikitaki","sequence":"first","affiliation":[{"name":"DNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Iroon Polytechniou 9, 15780 Zografou, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasia","family":"Pavlopoulou","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Biomedical Informatics, University of Thessaly, Papasiopoulou 2-4, 35100 Lamia, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Hol\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Experimental Botany ASCR, Na Karlovce 1, 16000 Praha, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Don\u00e0","sequence":"additional","affiliation":[{"name":"Gregor Mendel Institute (GMI) Austrian Academy of Science, Vienna Biocenter (VBC), Dr. Bohr Gasse 3, 1030 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-8712","authenticated-orcid":false,"given":"Ioannis","family":"Michalopoulos","sequence":"additional","affiliation":[{"name":"Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma","family":"Balestrazzi","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology \u2018Lazzaro Spallanzani\u2019, via Ferrata 1, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Angelis","sequence":"additional","affiliation":[{"name":"Institute of Experimental Botany ASCR, Na Karlovce 1, 16000 Praha, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5971-0010","authenticated-orcid":false,"given":"Alexandros","family":"Georgakilas","sequence":"additional","affiliation":[{"name":"DNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Iroon Polytechniou 9, 15780 Zografou, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1001\/jama.2015.10387","article-title":"The DNA damage response--Self-awareness for DNA: The 2015 albert lasker basic medical research award","volume":"314","author":"Elledge","year":"2015","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nrc3342","article-title":"The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance","volume":"12","author":"Bouwman","year":"2012","journal-title":"Nat. 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