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This exceptional microenvironment is highly permissive for phenotypic plasticity, enabling mesenchymal-to-epithelial (MET) and epithelial-to-mesenchymal (EMT) transitions. 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(2013). The Biology of Cancer, Garland Science.","DOI":"10.1201\/9780429258794"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2011.09.024","article-title":"Tumor Metastasis: Molecular Insights and Evolving Paradigms","volume":"147","author":"Valastyan","year":"2011","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrc1098","article-title":"The Pathogenesis of Cancer Metastasis: The \u2018Seed and Soil\u2019 Hypothesis Revisited","volume":"3","author":"Fidler","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0012-1606(84)90112-X","article-title":"Molecular Nature of the Calcium-Dependent Cell-Cell Adhesion System in Mouse Teratocarcinoma and Embryonic Cells Studied with a Monoclonal Antibody","volume":"101","author":"Suzuki","year":"1984","journal-title":"Dev. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1242\/dev.102.4.639","article-title":"The Cadherins: Cell-Cell Adhesion Molecules Controlling Animal Morphogenesis","volume":"102","author":"Takeichi","year":"1988","journal-title":"Development"},{"key":"ref_8","first-page":"3819","article-title":"N-Cadherin-Mediated Intercellular Interactions Promote Survival and Migration of Melanoma Cells","volume":"61","author":"Li","year":"2001","journal-title":"Cancer Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1517\/13543784.16.4.451","article-title":"N-Cadherin as a Therapeutic Target in Cancer","volume":"16","author":"Mariotti","year":"2007","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/1097-0177(200007)218:3<472::AID-DVDY1008>3.0.CO;2-#","article-title":"N-cadherin Mediates Pericytic-endothelial Interaction during Brain Angiogenesis in the Chicken","volume":"218","author":"Gerhardt","year":"2000","journal-title":"Dev. Dyn."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"20140039","DOI":"10.1098\/rstb.2014.0039","article-title":"N-Cadherin Antagonists as Oncology Therapeutics","volume":"370","author":"Blaschuk","year":"2015","journal-title":"Philos. Trans. R. Soc. Lond. B. Biol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Shibue, T., and Weinberg, R.A. (2017). EMT, CSCs, and Drug Resistance: The Mechanistic Link and Clinical Implications. Nat. Rev. Clin. Oncol.","DOI":"10.1038\/nrclinonc.2017.44"},{"key":"ref_13","unstructured":"American Cancer Society (2017). Cancer Facts & Figures 2017, American Cancer Society."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer Statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"ref_15","unstructured":"Howlader, N., Noone, A.M., Krapcho, M., Garshell, J., Miller, D., Altekruse, S.F., Kosary, C.L., Yu, M., Ruhl, J., and Tatalovich, Z. (2011). SEER Cancer Statistics Review, 1975\u20132008, National Cancer Institute."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.7150\/jca.7810","article-title":"Current Approaches and Challenges in Managing and Monitoring Treatment Response in Ovarian Cancer","volume":"5","author":"Marcus","year":"2014","journal-title":"J. Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10585-008-9171-5","article-title":"Phenotypic Plasticity of Neoplastic Ovarian Epithelium: Unique Cadherin Profiles in Tumor Progression","volume":"25","author":"Hudson","year":"2008","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian Cancer Development and Metastasis","volume":"177","author":"Lengyel","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ygyno.2008.11.032","article-title":"Multicellular Spheroids in Ovarian Cancer Metastases: Biology and Pathology","volume":"113","author":"Shield","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2008.12.003","article-title":"Dissemination of Intraperitoneal Ovarian Cancer: Discussion of Mechanisms and Demonstration of Lymphatic Spreading in Ovarian Cancer Model","volume":"72","author":"Feki","year":"2009","journal-title":"Crit. Rev. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2014.05.002","article-title":"Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread","volume":"26","author":"Pradeep","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.trsl.2016.03.016","article-title":"New Models of Hematogenous Ovarian Cancer Metastasis Demonstrate Preferential Spread to the Ovary and a Requirement for the Ovary for Abdominal Dissemination","volume":"175","author":"Coffman","year":"2016","journal-title":"Trans. Res."},{"key":"ref_23","first-page":"255","article-title":"Ovarian Surface Epithelium: Biology, Endocrinology, and Pathology","volume":"22","author":"Auersperg","year":"2001","journal-title":"Endocr. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/PGP.0b013e3181f45f3e","article-title":"The Origin of Ovarian Carcinomas: A Unifying Hypothesis","volume":"30","author":"Auersperg","year":"2011","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/oxfordjournals.humrep.a137398","article-title":"A Scanning Electron Microscopic Study of the Human Ovarian Surface Epithelium: Characterization of Two Cell Types","volume":"6","author":"Gillett","year":"1991","journal-title":"Hum. Reprod."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2741\/S401","article-title":"The Origin of Ovarian Cancers\u2014Hypotheses and Controversies","volume":"5","author":"Auersperg","year":"2013","journal-title":"Front. Biosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/pgp.0b013e31814b191f","article-title":"Serous Carcinogenesis in the Fallopian Tube: A Descriptive Classification","volume":"27","author":"Jarboe","year":"2008","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1200\/JCO.2008.16.4814","article-title":"Serous Tubal Intraepithelial Carcinoma: Its Potential Role in Primary Peritoneal Serous Carcinoma and Serous Cancer Prevention","volume":"26","author":"Carlson","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.pas.0000213335.40358.47","article-title":"Intraepithelial Carcinoma of the Fimbria and Pelvic Serous Carcinoma: Evidence for a Causal Relationship","volume":"31","author":"Kindelberger","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1097\/PAS.0b013e3181ef7b16","article-title":"Are all Pelvic (Nonuterine) Serous Carcinomas of Tubal Origin?","volume":"34","author":"Przybycin","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/PAS.0b013e3181868904","article-title":"Serous Tubal Intraepithelial Carcinoma and the Dominant Ovarian Mass: Clues to Serous Tumor Origin?","volume":"33","author":"Roh","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ygyno.2008.05.010","article-title":"Chromosomal Instability in Fallopian Tube Precursor Lesions of Serous Carcinoma and Frequent Monoclonality of Synchronous Ovarian and Fallopian Tube Mucosal Serous Carcinoma","volume":"110","author":"Salvador","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/his.12046","article-title":"Fallopian Tube Precursors of Ovarian Low-and High-grade Serous Neoplasms","volume":"62","author":"Vang","year":"2013","journal-title":"Histopathology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.critrevonc.2013.03.004","article-title":"Tu-be Or Not Tu-be: That is the Question\u2026 about Serous Ovarian Carcinogenesis","volume":"88","author":"Chene","year":"2013","journal-title":"Crit. Rev. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1158\/0008-5472.CAN-04-3931","article-title":"Stem and Progenitor-Like Cells Contribute to the Aggressive Behavior of Human Epithelial Ovarian Cancer","volume":"65","author":"Bapat","year":"2005","journal-title":"Cancer Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Bowen, N.J., Walker, L.D., Matyunina, L.V., Logani, S., Totten, K.A., Benigno, B.B., and McDonald, J.F. (2009). Gene Expression Profiling Supports the Hypothesis that Human Ovarian Surface Epithelia are Multipotent and Capable of Serving as Ovarian Cancer Initiating Cells. BMC Med. Genom., 2.","DOI":"10.1186\/1755-8794-2-71"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11154","DOI":"10.1073\/pnas.0603672103","article-title":"Ovarian Cancer Side Population Defines Cells with Stem Cell-Like Characteristics and Mullerian Inhibiting Substance Responsiveness","volume":"103","author":"Szotek","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nature11979","article-title":"Ovarian Surface Epithelium at the Junction Area Contains a Cancer-Prone Stem Cell Niche","volume":"495","author":"Hwang","year":"2013","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/PGP.0b013e3181f29d2a","article-title":"The Fallopian Tube-Peritoneal Junction: A Potential Site of Carcinogenesis","volume":"30","author":"Seidman","year":"2011","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1002\/stem.1207","article-title":"Stem-Like Epithelial Cells are Concentrated in the Distal End of the Fallopian Tube: A Site for Injury and Serous Cancer Initiation","volume":"30","author":"Paik","year":"2012","journal-title":"Stem Cells"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrm4056","article-title":"Ovary and Fimbrial Stem Cells: Biology, Niche and Cancer Origins","volume":"16","author":"Ng","year":"2015","journal-title":"Nat. Rev. Mol. Cell Boil."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Klymenko, Y., and Stack, M.S. (2013). Abstract B6: Cadherin Switching, Multicellular Aggregate Dynamics and Metastatic Success. Clin. Cancer Res., 19.","DOI":"10.1158\/1078-0432.OVCA13-B6"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.neo.2017.04.002","article-title":"Heterogeneous Cadherin Expression and Multi-Cellular Aggregate Dynamics in Ovarian Cancer Dissemination","volume":"19","author":"Klymenko","year":"2017","journal-title":"Neoplasia"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1159\/000326027","article-title":"Cadherin Expression in Ovarian Carcinoma and Malignant Mesothelioma Cell Effusions","volume":"50","author":"Sivertsen","year":"2006","journal-title":"Acta Cytol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Klymenko, Y., Kim, O., Loughran, E.A., Yang, J., Lombard, R., Alber, M., and Stack, M. (2017). Cadherin Composition and Multicellular Aggregate Dynamics in Organotypic Models of Epithelial Ovarian Cancer Intraperitoneal Metastasis. Oncogene.","DOI":"10.1038\/onc.2017.171"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.ymthe.2004.08.013","article-title":"Characterization of Intraperitoneal, Orthotopic, and Metastatic Xenograft Models of Human Ovarian Cancer","volume":"10","author":"Shaw","year":"2004","journal-title":"Mol. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1002\/cncr.21533","article-title":"2C4, a Monoclonal Antibody Against HER2, Disrupts the HER Kinase Signaling Pathway and Inhibits Ovarian Carcinoma Cell Growth","volume":"104","author":"Takai","year":"2005","journal-title":"Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0046-8177(98)90226-X","article-title":"MT1-MMP and MMP-2 mRNA Expression in Human Ovarian Tumors: Possible Implications for the Role of Desmoplastic Fibroblasts","volume":"29","author":"Afzal","year":"1998","journal-title":"Hum. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1158\/0008-5472.CAN-15-0706","article-title":"Obesity Contributes to Ovarian Cancer Metastatic Success through Increased Lipogenesis, Enhanced Vascularity, and Decreased Infiltration of M1 Macrophages","volume":"75","author":"Liu","year":"2015","journal-title":"Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ygyno.2015.05.040","article-title":"In Vivo Tumor Growth of High-Grade Serous Ovarian Cancer Cell Lines","volume":"138","author":"Mitra","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1040-8428(00)00077-9","article-title":"Spheroids and Cell Survival","volume":"36","author":"Bates","year":"2000","journal-title":"Crit. Rev. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1040-8428(00)00086-X","article-title":"Multicellular Resistance: A Paradigm for Clinical Resistance?","volume":"36","author":"Desoize","year":"2000","journal-title":"Crit. Rev. Oncol."},{"key":"ref_53","first-page":"4837","article-title":"Induction of Anoikis and Suppression of Human Ovarian Tumor Growth in Vivo by Down-Regulation of Bcl-X(L)","volume":"61","author":"Frankel","year":"2001","journal-title":"Cancer Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1158\/1535-7163.149.3.2","article-title":"Antiadhesive Antibodies Targeting E-Cadherin Sensitize Multicellular Tumor Spheroids to Chemotherapy in Vitro","volume":"3","author":"Green","year":"2004","journal-title":"Mol. Cancer. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.2451290","article-title":"Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model","volume":"240","author":"Sutherland","year":"1988","journal-title":"Science"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Latifi, A., Luwor, R.B., Bilandzic, M., Nazaretian, S., Stenvers, K., Pyman, J., Zhu, H., Thompson, E.W., Quinn, M.A., and Findlay, J.K. (2012). Isolation and Characterization of Tumor Cells from the Ascites of Ovarian Cancer Patients: Molecular Phenotype of Chemoresistant Ovarian Tumors. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046858"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1038\/onc.2014.136","article-title":"Epithelial\u2013mesenchymal Status Renders Differential Responses to Cisplatin in Ovarian Cancer","volume":"34","author":"Miow","year":"2015","journal-title":"Oncogene"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1210\/me.2004-0342","article-title":"Formation of E-Cadherin-Mediated Cell-Cell Adhesion Activates AKT and Mitogen Activated Protein Kinase Via Phosphatidylinositol 3 Kinase and Ligand-Independent Activation of Epidermal Growth Factor Receptor in Ovarian Cancer Cells","volume":"19","author":"Reddy","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"23467","DOI":"10.1074\/jbc.M110.199539","article-title":"Integrin Regulation of Beta-Catenin Signaling in Ovarian Carcinoma","volume":"286","author":"Burkhalter","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"501492","DOI":"10.1155\/2012\/501492","article-title":"Lysophosphatidic Acid Disrupts Junctional Integrity and Epithelial Cohesion in Ovarian Cancer Cells","volume":"2012","author":"Liu","year":"2012","journal-title":"J. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1432-0436.2007.00193.x","article-title":"The Morphogenic Function of E-cadherin-mediated Adherens Junctions in Epithelial Ovarian Carcinoma Formation and Progression","volume":"76","author":"Wu","year":"2008","journal-title":"Differentiation"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1158\/0008-5472.CAN-06-2808","article-title":"Engagement of Collagen-Binding Integrins Promotes Matrix Metalloproteinase-9-Dependent E-Cadherin Ectodomain Shedding in Ovarian Carcinoma Cells","volume":"67","author":"Symowicz","year":"2007","journal-title":"Cancer Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ygyno.2007.10.027","article-title":"Lysophosphatidic Acid (LPA) Promotes E-Cadherin Ectodomain Shedding and OVCA429 Cell Invasion in an uPA-Dependent Manner","volume":"108","author":"Gil","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/ijc.11168","article-title":"Upregulation of MMPs by Soluble E-cadherin in Human Lung Tumor Cells","volume":"105","author":"Gilles","year":"2003","journal-title":"Int. J. Cancer"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/emboj\/21.8.1948","article-title":"A Presenilin-1\/Gamma-Secretase Cleavage Releases the E-Cadherin Intracellular Domain and Regulates Disassembly of Adherens Junctions","volume":"21","author":"Marambaud","year":"2002","journal-title":"EMBO J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/modpathol.3800990","article-title":"Frequent Accumulation of Nuclear E-Cadherin and Alterations in the Wnt Signaling Pathway in Esophageal Squamous Cell Carcinomas","volume":"21","author":"Salahshor","year":"2008","journal-title":"Mod. Pathol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.2741\/4031","article-title":"Soluble E-Cadherin: More than a Symptom of Disease","volume":"17","author":"Grabowska","year":"2012","journal-title":"Front. Biosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbcan.2012.03.002","article-title":"E-Cadherin\u2019s Dark Side: Possible Role in Tumor Progression","volume":"1826","author":"Rodriguez","year":"2012","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Jolly, M.K., Boareto, M., Huang, B., Jia, D., Lu, M., Ben-Jacob, E., Onuchic, J.N., and Levine, H. (2015). Implications of the Hybrid Epithelial\/Mesenchymal Phenotype in Metastasis. Front. Oncol., 5.","DOI":"10.3389\/fonc.2015.00155"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/nm.3336","article-title":"The Epigenetics of Epithelial-Mesenchymal Plasticity in Cancer","volume":"19","author":"Tam","year":"2013","journal-title":"Nat. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e915","DOI":"10.1038\/cddis.2013.442","article-title":"An EMT Spectrum Defines an Anoikis-Resistant and Spheroidogenic Intermediate Mesenchymal State that is Sensitive to E-Cadherin Restoration by a Src-Kinase Inhibitor, Saracatinib (AZD0530)","volume":"4","author":"Huang","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"27067","DOI":"10.18632\/oncotarget.8166","article-title":"Stability of the Hybrid Epithelial\/Mesenchymal Phenotype","volume":"7","author":"Jolly","year":"2016","journal-title":"Oncotarget"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12307-011-0085-4","article-title":"Partial Mesenchymal to Epithelial Reverting Transition in Breast and Prostate Cancer Metastases","volume":"5","author":"Chao","year":"2012","journal-title":"Cancer Microenviron."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Hecht, I., Bar-El, Y., Balmer, F., Natan, S., Tsarfaty, I., Schweitzer, F., and Ben-Jacob, E. (2015). Tumor Invasion Optimization by Mesenchymal-Amoeboid Heterogeneity. Sci. Rep., 5.","DOI":"10.1038\/srep10622"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1083\/jcb.200909003","article-title":"Plasticity of Cell Migration: A Multiscale Tuning Model","volume":"188","author":"Friedl","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.molonc.2015.10.002","article-title":"Conversion to Stem-cell State in Response to Microenvironmental Cues is Regulated by Balance between Epithelial and Mesenchymal Features in Lung Cancer Cells","volume":"10","author":"Andriani","year":"2016","journal-title":"Mol. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/jcb.24896","article-title":"Progeny from Irradiated Colorectal Cancer Cells Acquire an EMT-Like Phenotype and Activate Wnt\/\u03b2-Catenin Pathway","volume":"115","author":"Bastos","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/ijc.21355","article-title":"Tamoxifen Resistance in MCF7 Cells Promotes EMT-like Behaviour and Involves Modulation of B-catenin Phosphorylation","volume":"118","author":"Hiscox","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1158\/1541-7786.MCR-12-0155-T","article-title":"Expression of Wnt3 Activates Wnt\/Beta-Catenin Pathway and Promotes EMT-Like Phenotype in Trastuzumab-Resistant HER2-Overexpressing Breast Cancer Cells","volume":"10","author":"Wu","year":"2012","journal-title":"Mol. Cancer. Res."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Grosse-Wilde, A., d\u2019H\u00e9rou\u00ebl, A.F., McIntosh, E., Ertaylan, G., Skupin, A., Kuestner, R.E., del Sol, A., Walters, K., and Huang, S. (2015). Stemness of the Hybrid Epithelial\/Mesenchymal State in Breast Cancer and its Association with Poor Survival. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126522"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Strauss, R., Li, Z., Liu, Y., Beyer, I., Persson, J., Sova, P., M\u00f6ller, T., Pesonen, S., Hemminki, A., and Hamerlik, P. (2011). Analysis of Epithelial and Mesenchymal Markers in Ovarian Cancer Reveals Phenotypic Heterogeneity and Plasticity. PLoS ONE, 6.","DOI":"10.1371\/annotation\/8c637352-3614-406c-89dc-e78d10fa069c"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1158\/0008-5472.CAN-14-3476","article-title":"Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis","volume":"75","author":"Ruscetti","year":"2015","journal-title":"Cancer Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc1143","article-title":"The Emerging Role of Lysophosphatidic Acid in Cancer","volume":"3","author":"Mills","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Mills, G.B., Eder, A., Fang, X., Hasegawa, Y., Mao, M., Lu, Y., Tanyi, J., Tabassam, F.H., Wiener, J., and Lapushin, R. (2002). Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer. Ovarian Cancer, Springer.","DOI":"10.1007\/978-1-4757-3587-1_12"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1001\/jama.287.23.3081","article-title":"Plasma Lysophosphatidic Acid Concentration and Ovarian Cancer","volume":"287","author":"Baker","year":"2002","journal-title":"JAMA"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1001\/jama.280.8.719","article-title":"Lysophosphatidic Acid as a Potential Biomarker for Ovarian and Other Gynecologic Cancers","volume":"280","author":"Xu","year":"1998","journal-title":"JAMA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1023\/A:1008217129273","article-title":"Malignant Effusions Contain Lysophosphatidic Acid (LPA)-Like Activity","volume":"9","author":"Westermann","year":"1998","journal-title":"Ann. Oncol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1158\/1055-9965.1185.13.7","article-title":"Lysophospholipids are Potential Biomarkers of Ovarian Cancer","volume":"13","author":"Sutphen","year":"2004","journal-title":"Cancer Epidemiol. Prev. Biomark."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1158\/0008-5472.CAN-05-1292","article-title":"Lysophosphatidic Acid is Constitutively Produced by Human Peritoneal Mesothelial Cells and Enhances Adhesion, Migration, and Invasion of Ovarian Cancer Cells","volume":"66","author":"Ren","year":"2006","journal-title":"Cancer Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1158\/1541-7786.MCR-06-0319","article-title":"Lysophosphatidic Acid Down-Regulates Stress Fibers and Up-Regulates Pro-Matrix Metalloproteinase-2 Activation in Ovarian Cancer Cells","volume":"5","author":"Do","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"ref_91","first-page":"3194","article-title":"Lysophosphatidic Acid Promotes Matrix Metalloproteinase (MMP) Activation and MMP-Dependent Invasion in Ovarian Cancer Cells","volume":"61","author":"Fishman","year":"2001","journal-title":"Cancer Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"22143","DOI":"10.1074\/jbc.M115.641092","article-title":"Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces Beta-Catenin-Mediated Transcription in Epithelial Ovarian Carcinoma","volume":"290","author":"Burkhalter","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1159\/000458744","article-title":"Lysophosphatidic Acid Promotes Epithelial to Mesenchymal Transition in Ovarian Cancer Cells by Repressing SIRT1","volume":"41","author":"Ray","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"37664","DOI":"10.18632\/oncotarget.9224","article-title":"Lysophosphatidic Acid Stimulates Epithelial to Mesenchymal Transition Marker Slug\/Snail2 in Ovarian Cancer Cells Via Galphai2, Src, and HIF1alpha Signaling Nexus","volume":"7","author":"Ha","year":"2016","journal-title":"Oncotarget"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.canlet.2009.09.017","article-title":"Epithelial\u2013mesenchymal Transition in Ovarian Cancer","volume":"291","author":"Vergara","year":"2010","journal-title":"Cancer Lett."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bbrc.2010.09.059","article-title":"TGF\u03b2 and EGF Synergistically Induce a More Invasive Phenotype of Epithelial Ovarian Cancer Cells","volume":"401","author":"Xu","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrm1835","article-title":"Complex Networks Orchestrate Epithelial\u2013mesenchymal Transitions","volume":"7","author":"Thiery","year":"2006","journal-title":"Nat. Rev. Mol. Cell Boil."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-Mesenchymal Transitions in Development and Disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"48193","DOI":"10.18632\/oncotarget.10194","article-title":"MT2-MMP Induces Proteolysis and Leads to EMT in Carcinomas","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1158\/0008-5472.CAN-07-5046","article-title":"Matrix Metalloproteinase 9 is a Mediator of Epidermal Growth Factor-Dependent E-Cadherin Loss in Ovarian Carcinoma Cells","volume":"68","author":"Dahl","year":"2008","journal-title":"Cancer Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"F43","DOI":"10.1152\/ajprenal.00179.2005","article-title":"Ischemia-Induced Cleavage of Cadherins in NRK Cells Requires MT1-MMP (MMP-14)","volume":"290","author":"Covington","year":"2006","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1083\/jcb.139.7.1861","article-title":"Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations that Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells","volume":"139","author":"Lochter","year":"1997","journal-title":"J. Cell Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1242\/jcs.114.1.111","article-title":"Release of an Invasion Promoter E-Cadherin Fragment by Matrilysin and Stromelysin-1","volume":"114","author":"Noe","year":"2001","journal-title":"J. Cell. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","article-title":"Matrix Metalloproteinases: Regulators of the Tumor Microenvironment","volume":"141","author":"Kessenbrock","year":"2010","journal-title":"Cell"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev.cellbio.24.110707.175315","article-title":"Navigating ECM Barriers at the Invasive Front: The Cancer Cell\u2013stroma Interface","volume":"25","author":"Rowe","year":"2009","journal-title":"Ann. Rev. Cell Dev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.matbio.2015.03.004","article-title":"Membrane-Type Matrix Metalloproteinases: Their Functions and Regulations","volume":"44","author":"Itoh","year":"2015","journal-title":"Matrix Biol."},{"key":"ref_107","first-page":"891","article-title":"Increased Invasion and Matrix Metalloproteinase-2 Expression by Snail-Induced Mesenchymal Transition in Squamous Cell Carcinomas","volume":"22","author":"Yokoyama","year":"2003","journal-title":"Int. J. Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0002-9440(10)65204-2","article-title":"B-Catenin Regulates the Expression of the Matrix Metalloproteinase-7 in Human Colorectal Cancer","volume":"155","author":"Brabletz","year":"1999","journal-title":"Am. J. Pathol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1128\/MCB.21.4.1370-1383.2001","article-title":"The PEA3 Subfamily of Ets Transcription Factors Synergizes with Beta-Catenin-LEF-1 to Activate Matrilysin Transcription in Intestinal Tumors","volume":"21","author":"Crawford","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1038\/sj.onc.1205755","article-title":"Identification of Membrane-Type Matrix Metalloproteinase-1 as a Target of the [Beta]-Catenin\/Tcf4 Complex in Human Colorectal Cancers","volume":"21","author":"Takahashi","year":"2002","journal-title":"Oncogene"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Turunen, S.P., Tatti-Bugaeva, O., and Lehti, K. (2017). Membrane-Type Matrix Metalloproteases as Diverse Effectors of Cancer Progression. Biochim. Biophys. Acta Mol. Cell Res.","DOI":"10.1016\/j.bbamcr.2017.04.002"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Gilles, C., Newgreen, D.F., Sato, H., and Thompson, E.W. (2005). Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition. Rise and Fall of Epithelial Phenotype, Springer.","DOI":"10.1007\/0-387-28671-3_20"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1200\/JCO.2009.23.5556","article-title":"Matrix Metalloproteinases as Novel Biomarker s and Potential Therapeutic Targets in Human Cancer","volume":"27","author":"Roy","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_114","first-page":"1108","article-title":"Analysis of Chemokines and Chemokine Receptor Expression in Ovarian Cancer Ascites","volume":"8","author":"Milliken","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"ref_115","first-page":"566","article-title":"Profiling of Cytokines in Human Epithelial Ovarian Cancer Ascites","volume":"2","author":"Matte","year":"2012","journal-title":"Am. J. Cancer Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1525-1438.2000.00003.x","article-title":"Cytokines IL-1\u03b2, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNF\u03b1 in Patients with Epithelial Ovarian Cancer and their Relationship to Treatment with Paclitaxel","volume":"10","author":"Penson","year":"2000","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrc3432","article-title":"Meeting the Challenge of Ascites in Ovarian Cancer: New Avenues for Therapy and Research","volume":"13","author":"Kipps","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s12094-014-1240-4","article-title":"Interleukin-8 Promotes Human Ovarian Cancer Cell Migration by Epithelial\u2013mesenchymal Transition Induction in Vitro","volume":"17","author":"Yin","year":"2015","journal-title":"Clin. Transl. Oncol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3892\/ijo.2015.3122","article-title":"Interleukin-6 Expression by Interactions between Gynecologic Cancer Cells and Human Mesenchymal Stem Cells Promotes Epithelial-Mesenchymal Transition","volume":"47","author":"So","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.canlet.2016.02.048","article-title":"Cancer Development, Chemoresistance, Epithelial to Mesenchymal Transition and Stem Cells: A Snapshot of IL-6 Mediated Involvement","volume":"375","author":"Bharti","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"9653","DOI":"10.1074\/jbc.M306662200","article-title":"Mechanisms for Lysophosphatidic Acid-Induced Cytokine Production in Ovarian Cancer Cells","volume":"279","author":"Fang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.18632\/oncotarget.3462","article-title":"CD133+ Ovarian Cancer Stem-Like Cells Promote Non-Stem Cancer Cell Metastasis Via CCL5 Induced Epithelial-Mesenchymal Transition","volume":"6","author":"Long","year":"2015","journal-title":"Oncotarget"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"12293","DOI":"10.1007\/s13277-014-2540-6","article-title":"The Essential Roles of CCR7 in Epithelial-to-Mesenchymal Transition Induced by Hypoxia in Epithelial Ovarian Carcinomas","volume":"35","author":"Cheng","year":"2014","journal-title":"Tumor Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/bjc.2011.34","article-title":"Downregulation of Cell Surface CA125\/MUC16 Induces Epithelial-to-Mesenchymal Transition and Restores EGFR Signalling in NIH: OVCAR3 Ovarian Carcinoma Cells","volume":"104","author":"Comamala","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ygyno.2011.02.020","article-title":"MUC16 (CA125) Regulates Epithelial Ovarian Cancer Cell Growth, Tumorigenesis and Metastasis","volume":"121","author":"Pinard","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Asem, M.S., Buechler, S., Wates, R.B., Miller, D.L., and Stack, M.S. (2016). Wnt5a Signaling in Cancer. Cancers, 8.","DOI":"10.3390\/cancers8090079"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3892\/or.2014.3229","article-title":"Wnt5a Promotes Vasculogenic Mimicry and Epithelial-Mesenchymal Transition Via Protein Kinase C\u03b1 in Epithelial Ovarian Cancer","volume":"32","author":"Qi","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12943-016-0502-x","article-title":"Regulation of Epithelial-Mesenchymal Transition through Epigenetic and Post-Translational Modifications","volume":"15","author":"Maziveyi","year":"2016","journal-title":"Mol. Cancer"},{"key":"ref_129","first-page":"5195","article-title":"E-Cadherin Expression is Silenced by DNA Hypermethylation in Human Breast and Prostate Carcinomas","volume":"55","author":"Graff","year":"1995","journal-title":"Cancer Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0002-9440(10)61758-0","article-title":"Methylation of the E-Cadherin Gene in Bladder Neoplasia and in Normal Urothelial Epithelium from Elderly Individuals","volume":"159","author":"Bornman","year":"2001","journal-title":"Am. J. Pathol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/jnci\/92.7.569","article-title":"E-Cadherin Gene Promoter Hypermethylation in Primary Human Gastric Carcinomas","volume":"92","author":"Tamura","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/cam4.347","article-title":"\u03b4EF1 Associates with DNMT1 and Maintains DNA Methylation of the E-cadherin Promoter in Breast Cancer Cells","volume":"4","author":"Fukagawa","year":"2015","journal-title":"Cancer Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.bbrc.2008.12.093","article-title":"MMSET is overexpressed in Cancers: Link with Tumor Aggressiveness","volume":"379","author":"Kassambara","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1172\/JCI57349","article-title":"G9a Interacts with Snail and is Critical for Snail-Mediated E-Cadherin Repression in Human Breast Cancer","volume":"122","author":"Dong","year":"2012","journal-title":"J. Clin. Invest."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/onc.2012.169","article-title":"Interaction with Suv39H1 is Critical for Snail-Mediated E-Cadherin Repression in Breast Cancer","volume":"32","author":"Dong","year":"2013","journal-title":"Oncogene"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1083\/jcb.200706150","article-title":"The Histone Methyltransferase SET8 is Required for S-Phase Progression","volume":"179","author":"Jorgensen","year":"2007","journal-title":"J. Cell Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1128\/MCB.24.1.306-319.2004","article-title":"Snail Mediates E-Cadherin Repression by the Recruitment of the Sin3A\/Histone Deacetylase 1 (HDAC1)\/HDAC2 Complex","volume":"24","author":"Peinado","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1136\/gutjnl-2011-300060","article-title":"Recruitment of Histone Deacetylases HDAC1 and HDAC2 by the Transcriptional Repressor ZEB1 Downregulates E-Cadherin Expression in Pancreatic Cancer","volume":"61","author":"Aghdassi","year":"2012","journal-title":"Gut"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/cr.2010.118","article-title":"The TWIST\/Mi2\/NuRD Protein Complex and its Essential Role in Cancer Metastasis","volume":"21","author":"Fu","year":"2011","journal-title":"Cell Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"25431","DOI":"10.1074\/jbc.M113.527267","article-title":"Inhibition of Epithelial to Mesenchymal Transition by E-Cadherin Up-Regulation Via Repression of Slug Transcription and Inhibition of E-Cadherin Degradation: Dual Role of Scaffold\/Matrix Attachment Region-Binding Protein 1 (SMAR1) in Breast Cancer Cells","volume":"289","author":"Adhikary","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Longacre, M., Snyder, N.A., Housman, G., Leary, M., Lapinska, K., Heerboth, S., Willbanks, A., and Sarkar, S. (2016). A Comparative Analysis of Genetic and Epigenetic Events of Breast and Ovarian Cancer Related to Tumorigenesis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17050759"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.4161\/15592294.2014.971608","article-title":"TGF-B Induces Global Changes in DNA Methylation during the Epithelial-to-Mesenchymal Transition in Ovarian Cancer Cells","volume":"9","author":"Cardenas","year":"2014","journal-title":"Epigenetics"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/ijc.25083","article-title":"Epigenetic Silencing of SFRP5 is Related to Malignant Phenotype and Chemoresistance of Ovarian Cancer through Wnt Signaling Pathway","volume":"127","author":"Su","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3892\/ijo.2015.3228","article-title":"Epigenetic Regulation of IQGAP2 Promotes Ovarian Cancer Progression Via Activating Wnt\/B-Catenin Signaling","volume":"48","author":"Deng","year":"2016","journal-title":"Int. J. Oncol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.gore.2017.03.007","article-title":"Epigenetic Therapy for the Treatment of Epithelial Ovarian Cancer: A Clinical Review","volume":"20","author":"Smith","year":"2017","journal-title":"Gynecol. Oncol. Rep."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.canlet.2011.12.036","article-title":"Epigenetic Biomarkers in Epithelial Ovarian Cancer","volume":"342","author":"Gloss","year":"2014","journal-title":"Cancer Lett."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1158\/0008-5472.CAN-14-1022","article-title":"Epigenetic Targeting of Ovarian Cancer Stem Cells","volume":"74","author":"Wang","year":"2014","journal-title":"Cancer Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/ncb1173","article-title":"Dual Regulation of Snail by GSK-3\u03b2-Mediated Phosphorylation in Control of Epithelial\u2013mesenchymal Transition","volume":"6","author":"Zhou","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"7810","DOI":"10.1158\/0008-5472.CAN-09-4481","article-title":"Protein Kinase D1 Suppresses Epithelial-to-Mesenchymal Transition through Phosphorylation of Snail","volume":"70","author":"Du","year":"2010","journal-title":"Cancer Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ccr.2014.07.022","article-title":"PKD1 Phosphorylation-Dependent Degradation of SNAIL by SCF-FBXO11 Regulates Epithelial-Mesenchymal Transition and Metastasis","volume":"26","author":"Zheng","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1038\/emboj.2010.254","article-title":"Snail1 is Stabilized by O-GlcNAc Modification in Hyperglycaemic Condition","volume":"29","author":"Park","year":"2010","journal-title":"EMBO J."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.canlet.2013.07.004","article-title":"FOXM1 Promotes the Epithelial to Mesenchymal Transition by Stimulating the Transcription of Slug in Human Breast Cancer","volume":"340","author":"Yang","year":"2013","journal-title":"Cancer Lett."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1002\/jcb.23150","article-title":"Over-expression of FoxM1 Leads to Epithelial\u2013mesenchymal Transition and Cancer Stem Cell Phenotype in Pancreatic Cancer Cells","volume":"112","author":"Bao","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"35477","DOI":"10.1074\/jbc.M504477200","article-title":"Pc2-Mediated Sumoylation of Smad-Interacting Protein 1 Attenuates Transcriptional Repression of E-Cadherin","volume":"280","author":"Long","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13008-016-0013-6","article-title":"New Insights into Posttranslational Modifications of Hippo Pathway in Carcinogenesis and Therapeutics","volume":"11","author":"He","year":"2016","journal-title":"Cell Div."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"8517","DOI":"10.1158\/0008-5472.CAN-10-1242","article-title":"Hippo Pathway Effector Yap is an Ovarian Cancer Oncogene","volume":"70","author":"Hall","year":"2010","journal-title":"Cancer Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10555-012-9368-6","article-title":"MicroRNA Control of Epithelial\u2013mesenchymal Transition and Metastasis","volume":"31","author":"Zhang","year":"2012","journal-title":"Cancer Metastasis Rev."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Abba, M.L., Patil, N., Leupold, J.H., and Allgayer, H. (2016). MicroRNA Regulation of Epithelial to Mesenchymal Transition. J. Clin. Med., 5.","DOI":"10.3390\/jcm5010008"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ncb1722","article-title":"The miR-200 Family and miR-205 Regulate Epithelial to Mesenchymal Transition by Targeting ZEB1 and SIP1","volume":"10","author":"Gregory","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1101\/gad.1640608","article-title":"The miR-200 Family Determines the Epithelial Phenotype of Cancer Cells by Targeting the E-Cadherin Repressors ZEB1 and ZEB2","volume":"22","author":"Park","year":"2008","journal-title":"Genes Dev."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/ijc.25461","article-title":"Coordinated Epigenetic Repression of the miR-200 Family and miR-205 in Invasive Bladder Cancer","volume":"128","author":"Wiklund","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/pros.23241","article-title":"MicroRNA-132\/212 Upregulation Inhibits TGF-\u03b2-Mediated Epithelial\u2013Mesenchymal Transition of Prostate Cancer Cells by Targeting SOX4","volume":"76","author":"Fu","year":"2016","journal-title":"Prostate"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/iub.1381","article-title":"miR-212\/132 Downregulates SMAD2 Expression to Suppress the G1\/S Phase Transition of the Cell Cycle and the Epithelial to Mesenchymal Transition in Cervical Cancer Cells","volume":"67","author":"Zhao","year":"2015","journal-title":"IUBMB Life"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"6515","DOI":"10.3748\/wjg.v20.i21.6515","article-title":"miR-132 Inhibits Colorectal Cancer Invasion and Metastasis Via Directly Targeting ZEB2","volume":"20","author":"Zheng","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"You, J., Li, Y., Fang, N., Liu, B., Zu, L., Chang, R., Li, X., and Zhou, Q. (2014). MiR-132 Suppresses the Migration and Invasion of Lung Cancer Cells Via Targeting the EMT Regulator ZEB2. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0091827"},{"key":"ref_166","first-page":"3793","article-title":"MicroRNA-132 Inhibits Migration, Invasion and Epithelial-Mesenchymal Transition by Regulating TGFbeta1\/Smad2 in Human Non-Small Cell Lung Cancer","volume":"20","author":"Zhang","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"39001","DOI":"10.1038\/srep39001","article-title":"MiR-150 Promotes Cellular Metastasis in Non-Small Cell Lung Cancer by Targeting FOXO4","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/cas.12030","article-title":"MiR-150 is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma Via Targeting the EMT Inducer ZEB1","volume":"104","author":"Yokobori","year":"2013","journal-title":"Cancer Sci."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ncb2024","article-title":"miR-9, a MYC\/MYCN-Activated microRNA, Regulates E-Cadherin and Cancer Metastasis","volume":"12","author":"Ma","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"8953","DOI":"10.1007\/s13277-014-2158-8","article-title":"MiR-145 Regulates Cancer Stem-Like Properties and Epithelial-to-Mesenchymal Transition in Lung Adenocarcinoma-Initiating Cells","volume":"35","author":"Hu","year":"2014","journal-title":"Tumor Biol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.lungcan.2016.04.017","article-title":"MiR-145 and miR-203 Represses TGF-B-Induced Epithelial-Mesenchymal Transition and Invasion by Inhibiting SMAD3 in Non-Small Cell Lung Cancer Cells","volume":"97","author":"Hu","year":"2016","journal-title":"Lung Cancer"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.cancergen.2011.07.004","article-title":"miR-27 Promotes Human Gastric Cancer Cell Metastasis by Inducing Epithelial-to-Mesenchymal Transition","volume":"204","author":"Zhang","year":"2011","journal-title":"Cancer Genet."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/1476-4598-13-193","article-title":"miR-27a Regulates Cisplatin Resistance and Metastasis by Targeting RKIP in Human Lung Adenocarcinoma Cells","volume":"13","author":"Li","year":"2014","journal-title":"Mol. Cancer"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.bbadis.2016.08.014","article-title":"MiR-29a Promotes Cell Proliferation and EMT in Breast Cancer by Targeting Ten Eleven Translocation 1","volume":"1862","author":"Pei","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/embor.2009.9","article-title":"miR-29a Suppresses Tristetraprolin, which is a Regulator of Epithelial Polarity and Metastasis","volume":"10","author":"Gebeshuber","year":"2009","journal-title":"EMBO Rep."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3892\/or.2014.3036","article-title":"Diverse Roles of miR-29 in Cancer (Review)","volume":"31","author":"Jiang","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.3892\/ol.2016.4814","article-title":"MicroRNA-103 Promotes Tumor Growth and Metastasis in Colorectal Cancer by Directly Targeting LATS2","volume":"12","author":"Zheng","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1158\/0008-5472.CAN-12-0667","article-title":"miR-103\/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4","volume":"72","author":"Chen","year":"2012","journal-title":"Cancer Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/gm272","article-title":"MicroRNAs miR-221 and miR-222: A New Level of Regulation in Aggressive Breast Cancer","volume":"3","author":"Shah","year":"2011","journal-title":"Genome Med."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Hwang, M.S., Yu, N., Stinson, S.Y., Yue, P., Newman, R.J., Allan, B.B., and Dornan, D. (2013). miR-221\/222 Targets Adiponectin Receptor 1 to Promote the Epithelial-to-Mesenchymal Transition in Breast Cancer. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0066502"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"pt5","DOI":"10.1126\/scisignal.2001538","article-title":"miR-221\/222 Targeting of Trichorhinophalangeal 1 (TRPS1) Promotes Epithelial-to-Mesenchymal Transition in Breast Cancer","volume":"4","author":"Stinson","year":"2011","journal-title":"Sci. Signal."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1038\/onc.2010.181","article-title":"miR-661 Expression in SNAI1-Induced Epithelial to Mesenchymal Transition Contributes to Breast Cancer Cell Invasion by Targeting Nectin-1 and StarD10 Messengers","volume":"29","author":"Vetter","year":"2010","journal-title":"Oncogene"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13045-015-0229-y","article-title":"MicroRNA-26a Suppresses Epithelial-Mesenchymal Transition in Human Hepatocellular Carcinoma by Repressing Enhancer of Zeste Homolog 2","volume":"9","author":"Ma","year":"2016","journal-title":"J. Hematol. Oncol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00109-016-1381-8","article-title":"miR-26a Suppresses EMT by Disrupting the Lin28B\/Let-7d Axis: Potential Cross-Talks among miRNAs in IPF","volume":"94","author":"Liang","year":"2016","journal-title":"J. Mol. Med."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s12094-016-1582-1","article-title":"miR-26a-5p Suppresses Tumor Metastasis by Regulating EMT and is Associated with Prognosis in HCC","volume":"19","author":"Chang","year":"2016","journal-title":"Clin. Transl. Oncol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"24383","DOI":"10.18632\/oncotarget.8328","article-title":"Twist1-Related miR-26b-5p Suppresses Epithelial-Mesenchymal Transition, Migration and Invasion by Targeting SMAD1 in Hepatocellular Carcinoma","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Zhang, L., Wang, Y., Li, W., Tsonis, P.A., Li, Z., Xie, L., and Huang, Y. (2017). MicroRNA-30a Regulation of Epithelial-Mesenchymal Transition in Diabetic Cataracts through Targeting SNAI1. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-01320-3"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"24032","DOI":"10.3390\/ijms161024032","article-title":"MiR-30a Inhibits the Epithelial\u2014Mesenchymal Transition of Podocytes through Downregulation of NFATc3","volume":"16","author":"Peng","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.ajpath.2013.05.019","article-title":"miR-30a Negatively Regulates TGF-\u03b21\u2013Induced Epithelial-Mesenchymal Transition and Peritoneal Fibrosis by Targeting Snai1","volume":"183","author":"Zhou","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1159\/000447823","article-title":"MiR-30a-5p Suppresses Tumor Metastasis of Human Colorectal Cancer by Targeting ITGB3","volume":"39","author":"Wei","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1016\/j.febslet.2012.09.016","article-title":"miR-134 Inhibits Epithelial to Mesenchymal Transition by Targeting FOXM1 in Non-Small Cell Lung Cancer Cells","volume":"586","author":"Li","year":"2012","journal-title":"FEBS Lett."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1476-4598-10-99","article-title":"MicroRNA-194 Inhibits Epithelial to Mesenchymal Transition of Endometrial Cancer Cells by Targeting Oncogene BMI-1","volume":"10","author":"Dong","year":"2011","journal-title":"Mol. Cancer"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1002\/hep.23915","article-title":"miR-194 is a Marker of Hepatic Epithelial Cells and Suppresses Metastasis of Liver Cancer Cells in Mice","volume":"52","author":"Meng","year":"2010","journal-title":"Hepatology"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1093\/carcin\/bgt184","article-title":"miR-192, miR-194 and miR-215: A Convergent microRNA Network Suppressing Tumor Progression in Renal Cell Carcinoma","volume":"34","author":"Khella","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Zhang, L., Wang, X., and Chen, P. (2013). MiR-204 Down Regulates SIRT1 and Reverts SIRT1-Induced Epithelial-Mesenchymal Transition, Anoikis Resistance and Invasion in Gastric Cancer Cells. BMC Cancer, 13.","DOI":"10.1186\/1471-2407-13-290"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1159\/000354531","article-title":"miR-204 Inhibits Epithelial to Mesenchymal Transition by Targeting Slug in Intrahepatic Cholangiocarcinoma Cells","volume":"32","author":"Qiu","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_197","first-page":"12775","article-title":"miR-204 Inhibits Invasion and Epithelial-Mesenchymal Transition by Targeting FOXM1 in Esophageal Cancer","volume":"8","author":"Sun","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"8327","DOI":"10.1007\/s13277-015-4627-0","article-title":"miR-204 Regulates the EMT by Targeting Snai1 to Suppress the Invasion and Migration of Gastric Cancer","volume":"37","author":"Liu","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ygyno.2009.08.009","article-title":"Regulation of miR-200 Family microRNAs and ZEB Transcription Factors in Ovarian Cancer: Evidence Supporting a Mesothelial-to-Epithelial Transition","volume":"116","author":"Bendoraite","year":"2010","journal-title":"Gynecol. Oncol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nm1230","article-title":"Lineage Infidelity of Epithelial Ovarian Cancers is Controlled by HOX Genes that Specify Regional Identity in the Reproductive Tract","volume":"11","author":"Cheng","year":"2005","journal-title":"Nat. Med."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s11684-017-0518-7","article-title":"Overexpressed miR-9 Promotes Tumor Metastasis Via Targeting E-Cadherin in Serous Ovarian Cancer","volume":"11","author":"Zhou","year":"2017","journal-title":"Front. Med."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1097\/IGC.0000000000000546","article-title":"miR-30d Blocked Transforming Growth Factor Beta1-Induced Epithelial-Mesenchymal Transition by Targeting Snail in Ovarian Cancer Cells","volume":"25","author":"Ye","year":"2015","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.biocel.2017.01.020","article-title":"MicroRNA-424 Inhibits Cell Migration, Invasion, and Epithelial Mesenchymal Transition by Downregulating Doublecortin-Like Kinase 1 in Ovarian Clear Cell Carcinoma","volume":"85","author":"Wu","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3892\/ijo.2015.3241","article-title":"miR-382 Inhibits Migration and Invasion by Targeting ROR1 through Regulating EMT in Ovarian Cancer","volume":"48","author":"Tan","year":"2016","journal-title":"Int. J. Oncol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/path.4443","article-title":"MiR-506 Inhibits Multiple Targets in the Epithelial-to-mesenchymal Transition Network and is Associated with Good Prognosis in Epithelial Ovarian Cancer","volume":"235","author":"Sun","year":"2015","journal-title":"J. Pathol."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Zhou, X., Hu, Y., Dai, L., Wang, Y., Zhou, J., Wang, W., Di, W., and Qiu, L. (2014). MicroRNA-7 Inhibits Tumor Metastasis and Reverses Epithelial-Mesenchymal Transition through AKT\/ERK1\/2 Inactivation by Targeting EGFR in Epithelial Ovarian Cancer. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096718"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.biocel.2009.12.017","article-title":"Role of microRNAs in Ovarian Cancer Pathogenesis and Potential Clinical Implications","volume":"42","author":"Mezzanzanica","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"16923","DOI":"10.18632\/oncotarget.7850","article-title":"Diagnostic and Prognostic Relevance of Circulating Exosomal miR-373, miR-200a, miR-200b and miR-200c in Patients with Epithelial Ovarian Cancer","volume":"7","author":"Meng","year":"2016","journal-title":"Oncotarget"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/IGC.0b013e31828c166d","article-title":"Detection of microRNA as Novel Biomarkers of Epithelial Ovarian Cancer from the Serum of Ovarian Cancer Patients","volume":"23","author":"Chung","year":"2013","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.7150\/ijbs.13453","article-title":"Blockage of Epithelial to Mesenchymal Transition and Upregulation of Let 7b are Critically Involved in Ursolic Acid Induced Apoptosis in Malignant Mesothelioma Cell","volume":"12","author":"Sohn","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ijc.28371","article-title":"Meta-analysis of Transcriptome Reveals Let-7b as an Unfavorable Prognostic Biomarker and Predicts Molecular and Clinical Subclasses in High-grade Serous Ovarian Carcinoma","volume":"134","author":"Tang","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.3892\/or.2015.3937","article-title":"Urinary microRNA-30a-5p is a Potential Biomarker for Ovarian Serous Adenocarcinoma","volume":"33","author":"Zhou","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Vang, S., Wu, H., Fischer, A., Miller, D.H., MacLaughlan, S., Douglass, E., Steinhoff, M., Collins, C., Smith, P.J., and Brard, L. (2013). Identification of Ovarian Cancer Metastatic miRNAs. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058226"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1038\/ncomms3977","article-title":"microRNA-181a has a Critical Role in Ovarian Cancer Progression through the Regulation of the Epithelial\u2013mesenchymal Transition","volume":"5","author":"Parikh","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"249393","DOI":"10.1155\/2014\/249393","article-title":"The Role of microRNAs in Ovarian Cancer","volume":"2014","author":"Kinose","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"R157","DOI":"10.1530\/ERC-16-0525","article-title":"MicroRNA Applications for Prostate, Ovarian and Breast Cancer in the Era of Precision Medicine","volume":"24","author":"Smith","year":"2017","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature12303","article-title":"Maternal Imprinting at the H19-Igf2 Locus Maintains Adult Haematopoietic Stem Cell Quiescence","volume":"500","author":"Venkatraman","year":"2013","journal-title":"Nature"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"19534","DOI":"10.18632\/oncotarget.14663","article-title":"Long Non-Coding RNA ZFAS1 Interacts with miR-150\u20135p to Regulate Sp1 Expression and Ovarian Cancer Cell Malignancy","volume":"8","author":"Xia","year":"2017","journal-title":"Oncotarget"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/0008-5472.CAN-10-2483","article-title":"Long Intergenic Noncoding RNAs: New Links in Cancer Progression","volume":"71","author":"Tsai","year":"2011","journal-title":"Cancer Res."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ccr.2014.03.010","article-title":"A Long Noncoding RNA Activated by TGF-B Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma","volume":"25","author":"Yuan","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"32433","DOI":"10.18632\/oncotarget.8653","article-title":"Comprehensive Analysis of lncRNA Expression Profiles Reveals a Novel lncRNA Signature to Discriminate Nonequivalent Outcomes in Patients with Ovarian Cancer","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ygyno.2014.03.556","article-title":"Overexpression of Long Non-Coding RNA HOTAIR Predicts Poor Patient Prognosis and Promotes Tumor Metastasis in Epithelial Ovarian Cancer","volume":"134","author":"Qiu","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"6857","DOI":"10.1074\/jbc.M114.610915","article-title":"Long Non-Coding RNAs (LncRNA) Regulated by Transforming Growth Factor (TGF) Beta: LncRNA-Hit-Mediated TGFbeta-Induced Epithelial to Mesenchymal Transition in Mammary Epithelia","volume":"290","author":"Richards","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1699-0463.1953.tb04805.x","article-title":"Pathogenesis of Ascites in Peritoneal Carcinomatosis1","volume":"33","year":"1953","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"ref_225","first-page":"1663","article-title":"The Role of Lymphatic Obstruction in the Formation of Ascites in a Murine Ovarian Carcinoma","volume":"32","author":"Feldman","year":"1972","journal-title":"Cancer Res."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0022-4804(87)90109-0","article-title":"Mechanisms of Malignant Ascites Production","volume":"42","author":"Garrison","year":"1987","journal-title":"J. Surg. Res."},{"key":"ref_227","first-page":"348","article-title":"Angiogenesis in Epithelian Ovarian Cancer","volume":"55","author":"Bamberger","year":"2002","journal-title":"J. Clin. Pathol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-0774.2005.tb00052.x","article-title":"Tumor Angiogenesis and Molecular Target Therapy in Ovarian Carcinomas","volume":"18","author":"Ueda","year":"2005","journal-title":"Hum. Cell"},{"key":"ref_229","first-page":"2631","article-title":"Pathogenesis of Malignant Ascites Formation: Initiating Events that Lead to Fluid Accumulation","volume":"53","author":"Nagy","year":"1993","journal-title":"Cancer Res."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/S0002-9440(10)64791-8","article-title":"Role of Endothelin-1 in Neovascularization of Ovarian Carcinoma","volume":"157","author":"Salani","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Chen, Y., Gou, X., Ke, X., Cui, H., and Chen, Z. (2012). Human Tumor Cells Induce Angiogenesis through Positive Feedback between CD147 and Insulin-Like Growth Factor-I. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040965"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.6823562","article-title":"Tumor Cells Secrete a Vascular Permeability Factor that Promotes Accumulation of Ascites Fluid","volume":"219","author":"Senger","year":"1983","journal-title":"Science"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1096\/fasebj.13.1.9","article-title":"Vascular Endothelial Growth Factor (VEGF) and its Receptors","volume":"13","author":"Neufeld","year":"1999","journal-title":"FASEB J."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0015-0282(00)00670-1","article-title":"Role of Vascular Endothelial Growth Factor in Ovarian Physiology and Pathology","volume":"74","author":"Geva","year":"2000","journal-title":"Fertil. Steril."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.clinbiochem.2004.01.014","article-title":"Vascular Endothelial Growth Factor and Interleukin-8 are Associated with Poor Prognosis in Epithelial Ovarian Cancer Patients","volume":"37","author":"Kassim","year":"2004","journal-title":"Clin. Biochem."},{"key":"ref_236","first-page":"177","article-title":"Secretion of Vascular Endothelial Growth Factor in Ovarian Cancer","volume":"20","author":"Santin","year":"1999","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/00000658-198606000-00009","article-title":"Malignant Ascites. Clinical and Experimental Observations","volume":"203","author":"Garrison","year":"1986","journal-title":"Ann. Surg."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0748-7983(96)80009-6","article-title":"Malignant Ascites: A 2-Year Review from a Teaching Hospital","volume":"22","author":"Parsons","year":"1996","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"E1974","DOI":"10.1073\/pnas.1216989110","article-title":"Flow Induces Epithelial-Mesenchymal Transition, Cellular Heterogeneity and Biomarker Modulation in 3D Ovarian Cancer Nodules","volume":"110","author":"Rizvi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"32876","DOI":"10.18632\/oncotarget.8765","article-title":"Fluid Shear Stress Induces Epithelial-Mesenchymal Transition (EMT) in Hep-2 Cells","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3892\/ijo.2017.3865","article-title":"Fluid Shear Stress Induces Cancer Stem Cell-Like Phenotype in MCF7 Breast Cancer Cell Line without Inducing Epithelial to Mesenchymal Transition","volume":"50","author":"Triantafillu","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10047-015-0864-7","article-title":"Fluid Dwell Impact Induces Peritoneal Fibrosis in the Peritoneal Cavity Reconstructed in Vitro","volume":"19","author":"Aoki","year":"2016","journal-title":"J. Artif. Organs"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"27468","DOI":"10.18632\/oncotarget.8322","article-title":"Transcriptome-Wide Analysis of Compression-Induced microRNA Expression Alteration in Breast Cancer for Mining Therapeutic Targets","volume":"7","author":"Kim","year":"2016","journal-title":"Oncotarget"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1039\/c5ib00282f","article-title":"Interstitial Fluid Pressure Regulates Collective Invasion in Engineered Human Breast Tumors via Snail, Vimentin, and E-Cadherin","volume":"8","author":"Tien","year":"2016","journal-title":"Integr. Biol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3109\/03008207.2014.959118","article-title":"Mechanical Compression Upregulates MMP9 through SMAD3 but Not SMAD2 Modulation in Hypertrophic Scar Fibroblasts. Connect","volume":"55","author":"Huang","year":"2014","journal-title":"Tissue Res."},{"key":"ref_246","unstructured":"Burkhalter, R.J. (2012). Microenvironmental Regulation of Ovarian Cancer Dissemination via Activation of the Wnt Signaling Pathway, University of Missouri-Columbia."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ygyno.2013.03.019","article-title":"Notch3 Induces Epithelial\u2013mesenchymal Transition and Attenuates Carboplatin-Induced Apoptosis in Ovarian Cancer Cells","volume":"130","author":"Gupta","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s13402-016-0308-2","article-title":"HPIP Promotes Epithelial-Mesenchymal Transition and Cisplatin Resistance in Ovarian Cancer Cells through PI3K\/AKT Pathway Activation","volume":"40","author":"Bugide","year":"2017","journal-title":"Cell. Oncol."},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Qin, S., Li, Y., Cao, X., Du, J., and Huang, X. (2017). NANOG Regulates Epithelial-Mesenchymal Transition and Chemoresistance in Ovarian Cancer. Biosci. Rep., 37.","DOI":"10.1042\/BSR20160247"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"9671","DOI":"10.1007\/s13277-016-4848-x","article-title":"NANOG Regulates Epithelial-Mesenchymal Transition and Chemoresistance through Activation of the STAT3 Pathway in Epithelial Ovarian Cancer","volume":"37","author":"Liu","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"37652","DOI":"10.1038\/srep37652","article-title":"TWIST1 Drives Cisplatin Resistance and Cell Survival in an Ovarian Cancer Model, Via Upregulation of GAS6, L1CAM, and Akt Signalling","volume":"6","author":"Roberts","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/onc.2015.84","article-title":"miR-186 Regulation of Twist1 and Ovarian Cancer Sensitivity to Cisplatin","volume":"35","author":"Zhu","year":"2016","journal-title":"Oncogene"},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Lim, S., Becker, A., Zimmer, A., Lu, J., Buettner, R., and Kirfel, J. (2013). SNAI1-Mediated Epithelial-Mesenchymal Transition Confers Chemoresistance and Cellular Plasticity by Regulating Genes Involved in Cell Death and Stem Cell Maintenance. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0066558"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.18632\/oncotarget.2957","article-title":"FOXM1 Confers to Epithelial-Mesenchymal Transition, Stemness and Chemoresistance in Epithelial Ovarian Carcinoma Cells","volume":"6","author":"Chiu","year":"2015","journal-title":"Oncotarget"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1038\/onc.2011.8","article-title":"The Hippo Pathway Transcriptional Co-Activator, YAP, is an Ovarian Cancer Oncogene","volume":"30","author":"Zhang","year":"2011","journal-title":"Oncogene"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4161\/cbt.7.2.5297","article-title":"miR-210 Links Hypoxia with Cell Cycle Regulation and is Deleted in Human Epithelial Ovarian Cancer","volume":"7","author":"Giannakakis","year":"2008","journal-title":"Cancer Boil. Ther."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1091\/mbc.e11-06-0537","article-title":"Matrix Rigidity Regulates a Switch between TGF-Beta1-Induced Apoptosis and Epithelial-Mesenchymal Transition","volume":"23","author":"Leight","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/ncb3157","article-title":"Matrix Stiffness Drives Epithelial-Mesenchymal Transition and Tumour Metastasis through a TWIST1-G3BP2 Mechanotransduction Pathway","volume":"17","author":"Wei","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.18632\/oncotarget.1875","article-title":"Epigenetic Plasticity: A Central Regulator of Epithelial-to-Mesenchymal Transition in Cancer","volume":"5","author":"Bedi","year":"2014","journal-title":"Oncotarget"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.tig.2012.05.005","article-title":"Epigenetic Reprogramming and Post-Transcriptional Regulation during the Epithelial\u2013mesenchymal Transition","volume":"28","author":"Wu","year":"2012","journal-title":"Trends Genet."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"18144","DOI":"10.1073\/pnas.1318192110","article-title":"MicroRNA-Based Regulation of Epithelial-Hybrid-Mesenchymal Fate Determination","volume":"110","author":"Lu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.bpj.2013.07.011","article-title":"Coupled Reversible and Irreversible Bistable Switches Underlying TGF\u03b2-Induced Epithelial to Mesenchymal Transition","volume":"105","author":"Tian","year":"2013","journal-title":"Biophys. J."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"5963","DOI":"10.1158\/0008-5472.CAN-14-0225","article-title":"Network Modeling of TGFbeta Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation","volume":"74","author":"Steinway","year":"2014","journal-title":"Cancer Res."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"15436","DOI":"10.18632\/oncotarget.3623","article-title":"OVOL Guides the Epithelial-Hybrid-Mesenchymal Transition","volume":"6","author":"Jia","year":"2015","journal-title":"Oncotarget"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/15384101.2017.1295181","article-title":"Suppression of the Grainyhead Transcription Factor 2 Gene (GRHL2) Inhibits the Proliferation, Migration, Invasion and Mediates Cell Cycle Arrest of Ovarian Cancer Cells","volume":"16","author":"Faddaoui","year":"2017","journal-title":"Cell Cycle"},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Boareto, M., Jolly, M.K., Goldman, A., Pietila, M., Mani, S.A., Sengupta, S., Ben-Jacob, E., Levine, H., and Onuchic, J.N. (2016). Notch-Jagged Signalling can Give Rise to Clusters of Cells Exhibiting a Hybrid Epithelial\/Mesenchymal Phenotype. J. R. Soc. Interface, 13.","DOI":"10.1098\/rsif.2015.1106"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"17949","DOI":"10.1039\/C6CP03174A","article-title":"Quantifying the Landscape and Kinetic Paths for Epithelial\u2013Mesenchymal Transition from a Core Circuit","volume":"18","author":"Li","year":"2016","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"20140774","DOI":"10.1098\/rsif.2014.0774","article-title":"Quantifying the Underlying Landscape and Paths of Cancer","volume":"11","author":"Li","year":"2014","journal-title":"J. R. Soc. Interface"},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"Cohen, D.P., Martignetti, L., Robine, S., Barillot, E., Zinovyev, A., and Calzone, L. (2015). Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration. PLoS Comput. Biol., 11.","DOI":"10.1371\/journal.pcbi.1004571"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"13235","DOI":"10.1073\/pnas.1414714111","article-title":"Surprisal Analysis Characterizes the Free Energy Time Course of Cancer Cells Undergoing Epithelial-to-Mesenchymal Transition","volume":"111","author":"Zadran","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1093\/nar\/gkw126","article-title":"Synergistic Action of Master Transcription Factors Controls Epithelial-to-Mesenchymal Transition","volume":"44","author":"Chang","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.15252\/emmm.201404208","article-title":"Epithelial-Mesenchymal Transition Spectrum Quantification and its Efficacy in Deciphering Survival and Drug Responses of Cancer Patients","volume":"6","author":"Tan","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1529\/biophysj.107.114678","article-title":"Modeling the Influence of the E-Cadherin-B-Catenin Pathway in Cancer Cell Invasion: A Multiscale Approach","volume":"95","author":"Drasdo","year":"2008","journal-title":"Biophys. J."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biosystems.2009.12.004","article-title":"Computational Modeling of Epithelial\u2013mesenchymal Transformations","volume":"100","author":"Neagu","year":"2010","journal-title":"BioSystems"},{"key":"ref_275","doi-asserted-by":"crossref","unstructured":"Turner, C., and Kohandel, M. (2012). Quantitative Approaches to Cancer Stem Cells and Epithelial\u2013Mesenchymal Transition. Sem. Cancer Biol., 374\u2013378.","DOI":"10.1016\/j.semcancer.2012.04.005"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/9\/8\/104\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:41:54Z","timestamp":1760208114000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/9\/8\/104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,9]]},"references-count":275,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8]]}},"alternative-id":["cancers9080104"],"URL":"https:\/\/doi.org\/10.3390\/cancers9080104","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,9]]}}}