{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:39:15Z","timestamp":1790534355960,"version":"4.1.0"},"reference-count":131,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:00:00Z","timestamp":1608768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Radiation cystitis is a potential complication following the therapeutic irradiation of pelvic cancers. Its clinical management remains unclear, and few preclinical data are available on its underlying pathophysiology. The therapeutic strategy is difficult to establish because few prospective and randomized trials are available. In this review, we report on the clinical presentation and pathophysiology of radiation cystitis. Then we discuss potential therapeutic approaches, with a focus on the immunopathological processes underlying the onset of radiation cystitis, including the fibrotic process. Potential therapeutic avenues for therapeutic modulation will be highlighted, with a focus on the interaction between mesenchymal stromal cells and macrophages for the prevention and treatment of radiation cystitis.<\/jats:p>","DOI":"10.3390\/cells10010021","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T09:02:44Z","timestamp":1608800564000},"page":"21","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7774-349X","authenticated-orcid":false,"given":"Carole","family":"Helissey","sequence":"first","affiliation":[{"name":"Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, 91220 Br\u00e9tigny-sur-Orge, France"},{"name":"Clinical Unit Research, HIA B\u00e9gin, 94160 Saint-Mand\u00e9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Cavallero","sequence":"additional","affiliation":[{"name":"Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Brossard","sequence":"additional","affiliation":[{"name":"Radiobiology of Medical Exposure Laboratory (LRMed), Institute for Radiological Protection and Nuclear Safety (IRSN), 92260 Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Dusaud","sequence":"additional","affiliation":[{"name":"Department of Urology, HIA B\u00e9gin, 94160 Saint-Mand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-3695","authenticated-orcid":false,"given":"Cyrus","family":"Chargari","sequence":"additional","affiliation":[{"name":"Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, 91220 Br\u00e9tigny-sur-Orge, France"},{"name":"Gustave Roussy Comprehensive Cancer Center, Department of Radiation Oncology, 94805 Villejuif, France"},{"name":"French Military Health Academy, Ecole du Val-de-Gr\u00e2ce (EVDG), 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,24]]},"reference":[{"key":"ref_1","first-page":"151","article-title":"Medical prevention and treatment of radiation-induced urological and nephrological complications","volume":"23","author":"He","year":"2019","journal-title":"Cancer Radiother. 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