{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:11:15Z","timestamp":1784887875690,"version":"3.55.0"},"reference-count":80,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL143000"],"award-info":[{"award-number":["R01HL143000"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR061385\/AR070752\/DK106394\/AG056919\/HL138570"],"award-info":[{"award-number":["AR061385\/AR070752\/DK106394\/AG056919\/HL138570"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["PR170989"],"award-info":[{"award-number":["PR170989"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-18-1-0787"],"award-info":[{"award-number":["W81XWH-18-1-0787"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771377\/31571273\/31371256"],"award-info":[{"award-number":["31771377\/31571273\/31371256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education Central Universities Research Fund","award":["GK20130100\/201701005"],"award-info":[{"award-number":["GK20130100\/201701005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Under natural conditions, injured cells can be repaired rapidly through inherent biological processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy, and other degenerative conditions, the natural repair process is impaired. Repair of injury to the cell membrane is an important aspect of physiology. Inadequate membrane repair function is implicated in the pathophysiology of many human disorders. Recent studies show that Mitsugumin 53 (MG53), a TRIM family protein, plays a key role in repairing cell membrane damage and facilitating tissue regeneration. Clarifying the role of MG53 and its molecular mechanism are important for the application of MG53 in regenerative medicine. In this review, we analyze current research dissecting MG53\u2032s function in cell membrane repair and tissue regeneration, and highlight the development of recombinant human MG53 protein as a potential therapeutic agent to repair multiple-organ injuries.<\/jats:p>","DOI":"10.3390\/cells10010122","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T11:36:11Z","timestamp":1610364971000},"page":"122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine"],"prefix":"10.3390","volume":"10","author":[{"given":"Zhongguang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"},{"name":"Laboratory of Cell Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi\u2019an 710062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi\u2019an 710062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Yue","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi\u2019an 710062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan A.","family":"Whitson","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Haggard","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehong","family":"Xu","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi\u2019an 710062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjie","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"m718","DOI":"10.1136\/bmj.m718","article-title":"Advances in Regenerative Medicine for Otolaryngology\/Head and Neck Surgery","volume":"369","author":"McPhail","year":"2020","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceca.2007.10.006","article-title":"Immuno-proteomic approach to excitation\u2014Contraction coupling in skeletal and cardiac muscle: Molecular insights revealed by the mitsugumins","volume":"43","author":"Weisleder","year":"2008","journal-title":"Cell Calcium"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ncb1812","article-title":"MG53 nucleates assembly of cell membrane repair machinery","volume":"11","author":"Cai","year":"2009","journal-title":"Nat. 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