{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:26:52Z","timestamp":1790767612820,"version":"4.1.0"},"reference-count":142,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["206566\/Z\/17\/Z"],"award-info":[{"award-number":["206566\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome Trust-University of Edinburgh Institutional Strategic Support Fund","award":["1S2-101\/02"],"award-info":[{"award-number":["1S2-101\/02"]}]},{"name":"Pathological Society Award","award":["1147, TSGS 2016 10 04"],"award-info":[{"award-number":["1147, TSGS 2016 10 04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Respiratory diseases are frequently characterised by epithelial injury, airway inflammation, defective tissue repair, and airway remodelling. This may occur in a subacute or chronic context, such as asthma and chronic obstructive pulmonary disease, or occur acutely as in pathogen challenge and acute respiratory distress syndrome (ARDS). Despite the frequent challenge of lung homeostasis, not all pulmonary insults lead to disease. Traditionally thought of as a quiescent organ, emerging evidence highlights that the lung has significant capacity to respond to injury by repairing and replacing damaged cells. This occurs with the appropriate and timely resolution of inflammation and concurrent initiation of tissue repair programmes. Airway epithelial cells are key effectors in lung homeostasis and host defence; continual exposure to pathogens, toxins, and particulate matter challenge homeostasis, requiring robust defence and repair mechanisms. As such, the epithelium is critically involved in the return to homeostasis, orchestrating the resolution of inflammation and initiating tissue repair. This review examines the pivotal role of pulmonary airway epithelial cells in initiating and moderating tissue repair and restitution. We discuss emerging evidence of the interactions between airway epithelial cells and candidate stem or progenitor cells to initiate tissue repair as well as with cells of the innate and adaptive immune systems in driving successful tissue regeneration. Understanding the mechanisms of intercellular communication is rapidly increasing, and a major focus of this review includes the various mediators involved, including growth factors, extracellular vesicles, soluble lipid mediators, cytokines, and chemokines. Understanding these areas will ultimately identify potential cells, mediators, and interactions for therapeutic targeting.<\/jats:p>","DOI":"10.3390\/cells10020339","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T14:04:13Z","timestamp":1612706653000},"page":"339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Epithelial Cells and Inflammation in Pulmonary Wound Repair"],"prefix":"10.3390","volume":"10","author":[{"given":"Amanda","family":"Croasdell Lucchini","sequence":"first","affiliation":[{"name":"University of Edinburgh Centre for Inflammation Research, Queen\u2019s Medical Research Institute, Edinburgh Bioquarter, Edinburgh EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi N.","family":"Gachanja","sequence":"additional","affiliation":[{"name":"University of Edinburgh Centre for Inflammation Research, Queen\u2019s Medical Research Institute, Edinburgh Bioquarter, Edinburgh EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano G.","family":"Rossi","sequence":"additional","affiliation":[{"name":"University of Edinburgh Centre for Inflammation Research, Queen\u2019s Medical Research Institute, Edinburgh Bioquarter, Edinburgh EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Dorward","sequence":"additional","affiliation":[{"name":"University of Edinburgh Centre for Inflammation Research, Queen\u2019s Medical Research Institute, Edinburgh Bioquarter, Edinburgh EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7523-0295","authenticated-orcid":false,"given":"Christopher D.","family":"Lucas","sequence":"additional","affiliation":[{"name":"University of Edinburgh Centre for Inflammation Research, Queen\u2019s Medical Research Institute, Edinburgh Bioquarter, Edinburgh EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries","volume":"315","author":"Bellani","year":"2016","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nm.3642","article-title":"Lung regeneration: Mechanisms, applications and emerging stem cell populations","volume":"20","author":"Kotton","year":"2014","journal-title":"Nat. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"170048","DOI":"10.1183\/16000617.0048-2017","article-title":"Shared epithelial pathways to lung repair and disease","volume":"26","author":"Spella","year":"2017","journal-title":"Eur. Respir. Rev."},{"key":"ref_4","unstructured":"Kia\u2019I, N., and Bajaj, T. (2020). Histology, Respiratory Epithelium, StatPearls Publishing LLC."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/labinvest.3700081","article-title":"Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: Development of an alveolo-capillary barrier in vitro","volume":"84","author":"Hermanns","year":"2004","journal-title":"Lab. Investig."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-08831-9","article-title":"An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics","volume":"10","author":"Angelidis","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1165\/rcmb.2018-0416TR","article-title":"The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease","volume":"61","author":"Schiller","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_8","first-page":"619","article-title":"A molecular cell atlas of the human lung from single-cell RNA sequencing","volume":"587","author":"Travaglini","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1164\/arrd.1969.100.3.372","article-title":"Identification of Cells Labeled with Tritiated Thymidine in the Pulmonary Alveolar Walls of the Mouse1,2,3","volume":"100","author":"Evans","year":"1969","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium","volume":"106","author":"Rock","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"L296","DOI":"10.1152\/ajplung.1994.266.3.L296","article-title":"Growth and differentiation of tracheal epithelial progenitor cells","volume":"266","author":"Liu","year":"1994","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.stem.2009.04.002","article-title":"The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium","volume":"4","author":"Rawlins","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1165\/ajrcmb.24.6.4498","article-title":"Clara Cell Secretory Protein\u2013Expressing Cells of the Airway Neuroepithelial Body Microenvironment Include a Label-Retaining Subset and Are Critical for Epithelial Renewal after Progenitor Cell Depletion","volume":"24","author":"Hong","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature12777","article-title":"Dedifferentiation of com-mitted epithelial cells into stem cells in vivo","volume":"503","author":"Tata","year":"2013","journal-title":"Nature"},{"key":"ref_15","first-page":"35","article-title":"The type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen","volume":"30","author":"Adamson","year":"1974","journal-title":"Lab. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1172\/JCI68782","article-title":"Type 2 alveolar cells are stem cells in adult lung","volume":"123","author":"Barkauskas","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_17","first-page":"621","article-title":"Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury","volume":"517","author":"Vaughan","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_18","first-page":"616","article-title":"p63+Krt5+ distal airway stem cells are essential for lung regeneration","volume":"517","author":"Zuo","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1172\/JCI57673","article-title":"Integrin \u03b16\u03b24 identifies an adult distal lung epithelial population with regenerative potential in mice","volume":"121","author":"Chapman","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.stem.2019.12.014","article-title":"Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration","volume":"26","author":"Kathiriya","year":"2020","journal-title":"Cell Stem Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2013.12.039","article-title":"Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis","volume":"156","author":"Lee","year":"2014","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ccm.2012.06.006","article-title":"Resolution of Inflammation in Asthma","volume":"33","author":"Levy","year":"2012","journal-title":"Clin. Chest Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/mi.2013.106","article-title":"Transmigrated neutrophils in the intestinal lumen engage ICAM-1 to regulate the epithelial barrier and neutrophil recruitment","volume":"7","author":"Sumagin","year":"2014","journal-title":"Mucosal Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9415","DOI":"10.1073\/pnas.1300290110","article-title":"Macrophages are required for adult salamander limb re-generation","volume":"110","author":"Godwin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1242\/dev.098459","article-title":"Macrophages modulate adult zebrafish tail fin regeneration","volume":"141","author":"Petrie","year":"2014","journal-title":"Development"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0002-9440(10)64534-8","article-title":"Delayed Wound Healing in the Absence of Intercellular Adhesion Molecule-1 or L-Selectin Expression","volume":"157","author":"Nagaoka","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in Tissue Repair, Regeneration, and Fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1016\/j.ajpath.2015.06.001","article-title":"Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration","volume":"185","author":"Das","year":"2015","journal-title":"Am. J. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1165\/ajrcmb.20.6.f151","article-title":"Matrix metalloproteinases. Matrix degradation and more","volume":"20","author":"Shapiro","year":"1999","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1083\/jcb.146.2.517","article-title":"Airway epithelial cell migration dynamics. MMP-9 role in cell-extracellular matrix remodeling","volume":"146","author":"Legrand","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri3600","article-title":"Alveolar macrophages: Plasticity in a tissue-specific context","volume":"14","author":"Hussell","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8686","DOI":"10.1073\/pnas.0500419102","article-title":"The primary mechanism of the IL-10-regulated antiinflammatory response is to se-lectively inhibit transcription","volume":"102","author":"Murray","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2016.08.006","article-title":"Tissue-specific contribution of macrophages to wound healing","volume":"61","author":"Minutti","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3389\/fphys.2018.00419","article-title":"The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-Wound Healing Phenotypes","volume":"9","author":"Krzyszczyk","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.4049\/jimmunol.0903356","article-title":"Differential Roles of Macrophages in Diverse Phases of Skin Repair","volume":"184","author":"Lucas","year":"2010","journal-title":"J. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1165\/rcmb.2016-0361OC","article-title":"Three Unique Interstitial Macrophages in the Murine Lung at Steady State","volume":"57","author":"Gibbings","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.3389\/fimmu.2018.01645","article-title":"The Role of Efferocytosis in Autoimmune Diseases","volume":"9","author":"Abdolmaleki","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1126\/science.aai8132","article-title":"Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells","volume":"356","author":"Bosurgi","year":"2017","journal-title":"Science"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/ACI.0000000000000133","article-title":"Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation","volume":"15","author":"Divekar","year":"2015","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1073\/pnas.1315854111","article-title":"IL-25 and type 2 in-nate lymphoid cells induce pulmonary fibrosis","volume":"111","author":"Hams","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1165\/rcmb.2013-0093OC","article-title":"Interleukin-33 poten-tiates bleomycin-induced lung injury","volume":"49","author":"Luzina","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4049\/jimmunol.1201576","article-title":"IL-33 induces a hyporesponsive phe-notype in human and mouse mast cells","volume":"190","author":"Jung","year":"2013","journal-title":"J. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/cei.12409","article-title":"The route to pathologies in chronic inflammatory diseases characterized by T helper type 2 immune cells","volume":"178","author":"Jovanovic","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"G627","DOI":"10.1152\/ajpgi.00224.2005","article-title":"Epithelial Cells and Their Neighbors. III. Interactions between intraepithelial lymphocytes and neighboring epithelial cells","volume":"289","author":"Havran","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/imm.13060","article-title":"Regulatory T-cells promote pulmonary repair by modulating T helper cell immune responses in lipopolysaccharide-induced acute respiratory distress syndrome","volume":"157","author":"Tan","year":"2019","journal-title":"Immunology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ajpath.2012.04.010","article-title":"NK Cells Modulate the Inflammatory Response to Corneal Epithelial Abrasion and Thereby Support Wound Healing","volume":"181","author":"Liu","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/imr.12183","article-title":"Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense","volume":"260","author":"McAleer","year":"2014","journal-title":"Immunol. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Wirsd\u00f6rfer, F., and Jendrossek, V. (2016). The Role of Lymphocytes in Radiotherapy-Induced Adverse Late Effects in the Lung. Front. Immunol., 7.","DOI":"10.3389\/fimmu.2016.00591"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.coi.2012.03.012","article-title":"Innate lymphoid cells: Critical regulators of allergic in-flammation and tissue repair in the lung","volume":"24","author":"Monticelli","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s13167-017-0081-y","article-title":"Impaired wound healing: Facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine","volume":"8","author":"Avishai","year":"2017","journal-title":"EPMA J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0022034509359125","article-title":"Factors Affecting Wound Healing","volume":"89","author":"Guo","year":"2010","journal-title":"J. Dent. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Dorward, D.A., Russell, C.D., Um, I.H., Elshani, M., Armstrong, S.D., Penrice-Randal, R., Millar, T., Lerpiniere, C.E.B., Tagliavini, G., and Hartley, C.S. (2020). Tissue-specific tolerance in fatal Covid-19. medRxiv.","DOI":"10.1101\/2020.07.02.20145003"},{"key":"ref_54","unstructured":"Group, R.C., Horby, P., Lim, W.S., Emberson, J.R., Mafham, M., Bell, J.L., Linsell, L., Staplin, N., Brightling, C., and Ustianowski, A. (2020). Dexamethasone in Hospitalized Patients with Covid-19\u2014Preliminary Report. N. Engl. J. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fcimb.2019.00182","article-title":"Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues","volume":"9","author":"Ruffin","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.burns.2008.11.010","article-title":"Pseudomonas pyocyanin inhibits wound repair by inducing prema-ture cellular senescence: Role for p38 mitogen-activated protein kinase","volume":"35","author":"Muller","year":"2009","journal-title":"Burns"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.bbamcr.2016.02.004","article-title":"Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering \u03b2-catenin degradation","volume":"1863","author":"Cott","year":"2016","journal-title":"Biochim. Biophys. Acta BBA Bioenerg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pupt.2019.01.003","article-title":"Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fi-brosis","volume":"55","author":"Tzilas","year":"2019","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s12931-019-1232-6","article-title":"Vitamin D deficiency exacerbates bleo-mycin-induced pulmonary fibrosis partially through aggravating TGF-\u03b2\/Smad2\/3-mediated epitheli-al-mesenchymal transition","volume":"20","author":"Li","year":"2019","journal-title":"Respir. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e1513","DOI":"10.1542\/peds.2010-3054","article-title":"Cord Blood Vitamin D Deficiency Is Associated With Respiratory Syncytial Virus Bronchiolitis","volume":"127","author":"Belderbos","year":"2011","journal-title":"Pediatrics"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-2613.1996.d01-213.x","article-title":"Induction of EGF receptor and erbB-2 during endotoxin-induced alveolar type II cell proliferation in the rat lung","volume":"77","author":"Tesfaigzi","year":"1996","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_62","first-page":"443","article-title":"Distribution of epidermal growth factor receptor and lig-ands during bronchiolar epithelial repair from naphthalene-induced Clara cell injury in the mouse","volume":"151","author":"Isaac","year":"1997","journal-title":"Am. J. Pathol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1183\/09031936.00125809","article-title":"Epidermal growth factor receptor signalling contrib-utes to house dust mite-induced epithelial barrier dysfunction","volume":"36","author":"Heijink","year":"2010","journal-title":"Eur. Respir. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1165\/ajrcmb.18.1.2740","article-title":"Stimulation of Migration and Wound Repair of Guinea-Pig Airway Epithelial Cells in Response to Epidermal Growth Factor","volume":"18","author":"Kim","year":"1998","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"L725","DOI":"10.1152\/ajplung.00131.2006","article-title":"Ultrafine carbon particles induce apoptosis and proliferation in rat lung epithelial cells via specific signaling pathways both using EGF-R","volume":"291","author":"Sydlik","year":"2006","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"L800","DOI":"10.1152\/ajplung.00201.2014","article-title":"Epidermal growth factor receptor activity is nec-essary for mouse basal cell proliferation","volume":"307","author":"Brechbuhl","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1096\/fasebj.14.10.1362","article-title":"Involvement of the epidermal growth factor receptor in epithelial repair in asthma","volume":"14","author":"Puddicombe","year":"2000","journal-title":"FASEB J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1096\/fj.11-197061","article-title":"Histamine may induce airway remodeling through release of epidermal growth factor receptor ligands from bronchial epi-thelial cells","volume":"26","author":"Hirota","year":"2012","journal-title":"FASEB J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"L485","DOI":"10.1152\/ajplung.00233.2005","article-title":"The beta-agonist isoproterenol attenuates EGF-stimulated wound closure in human airway epithelial cells","volume":"290","author":"Schnackenberg","year":"2006","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"L870","DOI":"10.1152\/ajplung.00362.2006","article-title":"Involvement of KATP and KvLQT1 K+ channels in EGF-stimulated alveolar epithelial cell repair processes","volume":"293","author":"Trinh","year":"2007","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"76437","DOI":"10.18632\/oncotarget.13261","article-title":"Stimulus-dependent dissociation between XB130 and Tks5 scaffold proteins promotes airway epithelial cell migration","volume":"7","author":"Moodley","year":"2016","journal-title":"Oncotarget"},{"key":"ref_72","first-page":"529","article-title":"In vivo localization of the insulin-like growth factors I and II (IGF I and IGF II) gene expression during human lung development","volume":"39","author":"Lallemand","year":"1995","journal-title":"Int. J. Dev. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1164\/ajrccm.158.5.9804025","article-title":"Morphometric Analysis of Insulin-like Growth Factor-I Localization in Lung Tissues of Patients with Idiopathic Pulmonary Fibrosis","volume":"158","author":"Uh","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1165\/rcmb.2012-0079OC","article-title":"Acute Inflammation Induces Insulin-like Growth Factor-1 to Mediate Bcl-2 and Muc5ac Expression in Airway Epithelial Cells","volume":"47","author":"Chand","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/jcb.20653","article-title":"Expression profile of IGF system during lung injury and recovery in rats exposed to hyperoxia: A possible role of IGF-1 in alveolar epithelial cell proliferation and differentiation","volume":"97","author":"Narasaraju","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.3389\/fimmu.2020.01585","article-title":"Alveolar Epithelial Cells Promote IGF-1 Production by Alveolar Macrophages Through TGF-\u03b2 to Suppress Endogenous Inflammatory Signals","volume":"11","author":"Mu","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"L222","DOI":"10.1152\/ajplung.00014.2013","article-title":"Insulin-like growth factor-I stimulates differentiation of ATII cells to ATI-like cells through activation of Wnt5a","volume":"305","author":"Ghosh","year":"2013","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/mt.2015.66","article-title":"Monocyte\/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine Polarization","volume":"23","author":"Tonkin","year":"2015","journal-title":"Mol. Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"L768","DOI":"10.1152\/ajplung.00353.2009","article-title":"VEGF in the lung: A role for novel isoforms","volume":"298","author":"Varet","year":"2010","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1097\/01.CCM.0000281451.73202.F6","article-title":"Vascular endothelial growth factor promotes physical wound repair and is anti-apoptotic in primary distal lung epithelial and A549 cells","volume":"35","author":"Roberts","year":"2007","journal-title":"Crit. Care Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"L585","DOI":"10.1152\/ajplung.00048.2002","article-title":"Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury","volume":"283","author":"Karmpaliotis","year":"2002","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1083\/jcb.92.1.79","article-title":"Action of cytochalasin D on cytoskeletal networks","volume":"92","author":"Schliwa","year":"1982","journal-title":"J. Cell Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1152\/japplphysiol.00221.2004","article-title":"Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice","volume":"97","author":"Tang","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1203\/00006450-199512000-00005","article-title":"Immunolocalization of Transforming Growth Factor-\u03b1, Epidermal Growth Factor (EGF), and EGF-Receptor in Normal and Injured Developing Human Lung","volume":"38","author":"Strandjord","year":"1995","journal-title":"Pediatr. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"L728","DOI":"10.1152\/ajplung.1994.267.6.L728","article-title":"Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model","volume":"267","author":"Kheradmand","year":"1994","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"L115","DOI":"10.1152\/ajplung.2002.282.1.L115","article-title":"TGF-beta isoform release and activation during in vitro bronchial epithelial wound repair","volume":"282","author":"Howat","year":"2002","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"L525","DOI":"10.1152\/ajplung.00163.2007","article-title":"TGF-beta-induced EMT: Mechanisms and implications for fibrotic lung disease","volume":"293","author":"Willis","year":"2007","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1378\/chest.125.2.754","article-title":"The role of transforming growth factor beta in lung development and disease","volume":"125","author":"Bartram","year":"2004","journal-title":"Chest"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"L438","DOI":"10.1152\/ajplung.1993.264.5.L438","article-title":"Transcellular eicosanoid synthesis in cocultures of alveolar epithelial cells and macrophages","volume":"264","author":"Feyssa","year":"1993","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1365-2222.2007.02733.x","article-title":"Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4and C4","volume":"37","author":"Jame","year":"2007","journal-title":"Clin. Exp. Allergy"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"L342","DOI":"10.1152\/ajplung.00168.2002","article-title":"Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1\/CCR2 and mediated by PGE2","volume":"284","author":"Moore","year":"2003","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1073\/pnas.1602023113","article-title":"PGE2 induced in and released by dying cells functions as an inhibitory DAMP","volume":"113","author":"Hangai","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.4049\/jimmunol.1002414","article-title":"Bronchial Epithelial Cell-Derived Prostaglandin E2 Dampens the Reactivity of Dendritic Cells","volume":"186","author":"Schmidt","year":"2011","journal-title":"J. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1124\/dmd.112.046466","article-title":"Cytochrome P450 2S1 Depletion Enhances Cell Proliferation and Migration in Bronchial Epithelial Cells, in Part, through Modulation of Prostaglandin E2 Synthesis","volume":"40","author":"Madanayake","year":"2012","journal-title":"Drug Metab. Dispos."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"L421","DOI":"10.1152\/ajplung.2001.280.3.L421","article-title":"Prostaglandin E2regulates wound closure in airway epithelium","volume":"280","author":"Savla","year":"2001","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.biopha.2007.02.016","article-title":"Synthesis and anti-inflammatory effect of lipoxins in human airway epithelial cells","volume":"61","author":"Bonnans","year":"2007","journal-title":"Biomed. Pharm."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.4049\/jimmunol.1400313","article-title":"Resolvin D1 Attenuates Polyinosinic-Polycytidylic Acid\u2013Induced Inflammatory Signaling in Human Airway Epithelial Cells via TAK1","volume":"193","author":"Hsiao","year":"2014","journal-title":"J. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"875","DOI":"10.4049\/jimmunol.1500244","article-title":"Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4","volume":"195","author":"Fang","year":"2015","journal-title":"J. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"00079","DOI":"10.1183\/23120541.00079-2015","article-title":"Lipoxin A4promotes lung epithelial repair whilst inhibiting fibroblast proliferation","volume":"2","author":"Zheng","year":"2016","journal-title":"ERJ Open Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.2353\/ajpath.2006.051056","article-title":"Lipoxin A4 Regulates Bronchial Epithelial Cell Responses to Acid Injury","volume":"168","author":"Bonnans","year":"2006","journal-title":"Am. J. Pathol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1165\/rcmb.2012-0424OC","article-title":"Activation of P2RY11 and ATP Release by Lipoxin A4 Restores the Airway Surface Liquid Layer and Epithelial Repair in Cystic Fibrosis","volume":"51","author":"Higgins","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.ajpath.2016.03.011","article-title":"Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia","volume":"186","author":"Colby","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"L101","DOI":"10.1152\/ajplung.00018.2008","article-title":"LXA4 stimulates ZO-1 expression and transepithelial electrical resistance in human airway epithelial (16HBE14o-) cells","volume":"296","author":"Grumbach","year":"2009","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.freeradbiomed.2016.01.026","article-title":"Lipoxin A4 attenuates LPS-induced mouse acute lung injury via Nrf2-mediated E-cadherin expression in airway epithelial cells","volume":"93","author":"Cheng","year":"2016","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s10753-016-0433-0","article-title":"Maresin 1 Maintains the Permeability of Lung Epithelial Cells In Vitro and In Vivo","volume":"39","author":"Chen","year":"2016","journal-title":"Inflammation"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1165\/rcmb.2013-0468OC","article-title":"Attenuation of Lipopolysaccharide-Induced Lung Vascular Stiffening by Lipoxin Reduces Lung Inflammation","volume":"52","author":"Meng","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1016\/j.biocel.2013.09.018","article-title":"Resolvin D1 inhibits TGF-\u03b21-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor\/formyl peptide receptor 2 and GPR32","volume":"45","author":"Lee","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/SHK.0000000000000446","article-title":"Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo","volume":"44","author":"Wang","year":"2015","journal-title":"Shock"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.4049\/jimmunol.177.5.3344","article-title":"Functional Analysis of the Chemokine Receptor CCR3 on Airway Epithelial Cells","volume":"177","author":"Beck","year":"2006","journal-title":"J. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.ajpath.2012.12.007","article-title":"IL-22 Is Essential for Lung Epithelial Repair following Influenza Infection","volume":"182","author":"Pociask","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/mi.2012.49","article-title":"IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection","volume":"6","author":"Kumar","year":"2013","journal-title":"Mucosal Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-15-587","article-title":"Micro-RNAs in regenerating lungs: An integrative systems biology analysis of murine influenza pneumonia","volume":"15","author":"Tan","year":"2014","journal-title":"BMC Genom."},{"key":"ref_114","first-page":"1120","article-title":"Engulfment of Apoptotic Cells by Macrophages: A Role of MicroRNA-21 in the Resolution of Wound Inflammation","volume":"192","author":"Das","year":"2014","journal-title":"J. Immunol. Baltim. 1950"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ydbio.2007.08.007","article-title":"Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells","volume":"310","author":"Lu","year":"2007","journal-title":"Dev. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1242\/dev.061762","article-title":"Regulation of lung endoderm progenitor cell behavior by miR302\/367","volume":"138","author":"Tian","year":"2011","journal-title":"Development"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"L364","DOI":"10.1152\/ajplung.00354.2011","article-title":"Microparticles and acute lung injury","volume":"303","author":"McVey","year":"2012","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Schneider, D.J., Speth, J.M., and Peters-Golden, M. (2016). Signed, Sealed, Delivered: Microenvironmental Modulation of Extracellular Vesicle-Dependent Immunoregulation in the Lung. Front. Cell Dev. Biol., 4.","DOI":"10.3389\/fcell.2016.00094"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/cdd.2017.47","article-title":"Killers creating new life: Caspases drive apoptosis-induced proliferation in tissue repair and disease","volume":"24","author":"Fogarty","year":"2017","journal-title":"Cell Death Differ."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cub.2015.12.064","article-title":"Extracellular Reactive Oxygen Species Drive Apoptosis-Induced Proliferation via Drosophila Macrophages","volume":"26","author":"Fogarty","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1189\/jlb.3A1116-483R","article-title":"Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221\/222","volume":"101","author":"Zhu","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s12015-016-9713-1","article-title":"Exosome and Microvesicle-Enriched Fractions Isolated from Mesenchymal Stem Cells by Gradient Separation Showed Different Molecular Signatures and Functions on Renal Tubular Epithelial Cells","volume":"13","author":"Collino","year":"2017","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"srep40548","DOI":"10.1038\/srep40548","article-title":"Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization","volume":"7","author":"Han","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1089\/scd.2012.0266","article-title":"Transfer of Growth Factor Receptor mRNA Via Exosomes Unravels the Regenerative Effect of Mesenchymal Stem Cells","volume":"22","author":"Tomasoni","year":"2013","journal-title":"Stem Cells Dev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1681\/ASN.2012101031","article-title":"TGF-\u03b21\u2013Containing Exosomes from Injured Epithelial Cells Activate Fibroblasts to Initiate Tissue Regenerative Responses and Fibrosis","volume":"24","author":"Borges","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e2016","DOI":"10.1038\/cddis.2015.282","article-title":"Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway","volume":"6","author":"Moon","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"35250","DOI":"10.1038\/srep35250","article-title":"Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.molimm.2013.01.017","article-title":"Lymphocyte-derived microparticles induce bronchial epithelial cells\u2019 pro-inflammatory cytokine production and apoptosis","volume":"55","author":"Qiu","year":"2013","journal-title":"Mol. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1242\/jcs.03389","article-title":"Wound-induced ATP release and EGF receptor activation in epithelial cells","volume":"120","author":"Yin","year":"2007","journal-title":"J. Cell Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2310\/6650.2007.00019","article-title":"Adenosine Promotion of Cellular Migration in Bronchial Epithelial Cells Is Mediated by the Activation of Cyclic Adenosine Monophosphate-Dependent Protein Kinase A","volume":"55","author":"Spurzem","year":"2007","journal-title":"J. Investig. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"S275","DOI":"10.1067\/mai.2002.129412","article-title":"Effects of \u03b2-agonists on airway epithelial cells","volume":"110","author":"Salathe","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_132","first-page":"57","article-title":"Overexpression of transforming growth factor-alpha and epidermal growth factor-receptor in idiopathic pulmonary fibrosis","volume":"16","author":"Baughman","year":"1999","journal-title":"Sarcoidosis Vasc. Diffus. Lung Dis. Off. J. WASOG"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/654354","article-title":"Increased Expression of Epidermal Growth Factor Receptor (EGF-R) in Patients with Different Forms of Lung Fibrosis","volume":"2013","author":"Tzouvelekis","year":"2013","journal-title":"Biomed Res. Int."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1096\/fj.201901719RR","article-title":"IPF pathogenesis is dependent upon TGF\u03b2 induction of IGF-1","volume":"34","author":"Hernandez","year":"2020","journal-title":"FASEB J."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Barratt, S.L., Flower, V.A., Pauling, J.D., and Millar, A.B. (2018). VEGF (Vascular Endothelial Growth Factor) and Fibrotic Lung Disease. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051269"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12931-017-0711-x","article-title":"Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)","volume":"19","author":"Barratt","year":"2018","journal-title":"Respir. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"L741","DOI":"10.1152\/ajplung.00208.2003","article-title":"Conditional expression of transforming growth factor-\u03b1 in adult mouse lung causes pulmonary fibrosis","volume":"286","author":"Hardie","year":"2004","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jaci.2019.11.032","article-title":"Inhibiting eicosanoid degradation exerts antifibrotic effects in a pulmonary fibrosis mouse model and human tissue","volume":"145","author":"Theiler","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Castelino, F.V. (2012). Lipids and eicosanoids in fibrosis: Emerging targets for therapy. Curr. Opin. Rheumatol., 24.","DOI":"10.1097\/BOR.0b013e328356d9f6"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0002-9440(10)61235-7","article-title":"Role of Eotaxin-1 (CCL11) and CC Chemokine Receptor 3 (CCR3) in Bleomycin-Induced Lung Injury and Fibrosis","volume":"167","author":"Huaux","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1513\/AnnalsATS.201503-110AW","article-title":"MUC5B and Idiopathic Pulmonary Fibrosis","volume":"12","author":"Yang","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1056\/NEJMoa1013660","article-title":"A common MUC5B promoter polymorphism and pulmonary fibrosis","volume":"364","author":"Seibold","year":"2011","journal-title":"N. Engl. J. Med."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/2\/339\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:20:14Z","timestamp":1760160014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/2\/339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,5]]},"references-count":142,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["cells10020339"],"URL":"https:\/\/doi.org\/10.3390\/cells10020339","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,5]]}}}