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Myocardial infarction (MI) was induced by ligating the left anterior descending coronary artery in 45 Wistar rats, and patches with or without cells were attached to the hearts. After one week, the animals underwent echocardiography to assess for ejection fraction and left ventricular end-diastolic and end-systolic volumes. Following patch formation, the cocultured cells retained viability of &gt;90% over 14 days in culture. The patch was applied to the myocardial surface of the infarcted area after staying 14 days in culture. Interestingly, the BC membrane without cellular treatment showed higher preservation of cardiac dimensions; however, we did not observe improvement in the left ventricular ejection fraction of this group compared to coculture-treated membranes. Our results demonstrated an important role for BC in supporting cells known to produce cardioprotective soluble factors and may thus provide effective future therapeutic outcomes for patients suffering from ischemic heart disease.<\/jats:p>","DOI":"10.3390\/cells10020424","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T21:35:42Z","timestamp":1613597742000},"page":"424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Beneficial Roles of Cellulose Patch-Mediated Cell Therapy in Myocardial Infarction: A Preclinical Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-5809","authenticated-orcid":false,"given":"Rossana","family":"Simeoni","sequence":"first","affiliation":[{"name":"Experimental Laboratory of Institute of Biological and Health Sciences of Pontifical Catholic University of Paran\u00e1 (PUCPR), Street Imaculada Concei\u00e7\u00e3o, 1155, 80215-901 Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-0693","authenticated-orcid":false,"given":"Bassam","family":"Mogharbel","sequence":"additional","affiliation":[{"name":"Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pel\u00e9 Pequeno Pr\u00edncipe Research Institute &amp; Pequeno Pr\u00edncipe Faculties, Ave., Silva Jardim, 1632, 80240-020 Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1970-6399","authenticated-orcid":false,"given":"Julio","family":"Francisco","sequence":"additional","affiliation":[{"name":"Experimental Laboratory of Institute of Biological and Health Sciences of Pontifical Catholic University of Paran\u00e1 (PUCPR), Street Imaculada Concei\u00e7\u00e3o, 1155, 80215-901 Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Miyague","sequence":"additional","affiliation":[{"name":"Experimental Laboratory of Institute of Biological and Health Sciences of Pontifical Catholic University of Paran\u00e1 (PUCPR), Street Imaculada Concei\u00e7\u00e3o, 1155, 80215-901 Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5236-4928","authenticated-orcid":false,"given":"Ana","family":"Irioda","sequence":"additional","affiliation":[{"name":"Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pel\u00e9 Pequeno Pr\u00edncipe Research Institute &amp; Pequeno Pr\u00edncipe Faculties, Ave., Silva Jardim, 1632, 80240-020 Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8483-5352","authenticated-orcid":false,"given":"Carolina","family":"Souza","sequence":"additional","affiliation":[{"name":"Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pel\u00e9 Pequeno Pr\u00edncipe Research Institute &amp; Pequeno Pr\u00edncipe Faculties, Ave., Silva Jardim, 1632, 80240-020 Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3734-9893","authenticated-orcid":false,"given":"Daiany","family":"Souza","sequence":"additional","affiliation":[{"name":"Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pel\u00e9 Pequeno Pr\u00edncipe Research Institute &amp; Pequeno Pr\u00edncipe Faculties, Ave., Silva Jardim, 1632, 80240-020 Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-137X","authenticated-orcid":false,"given":"Priscila","family":"Stricker","sequence":"additional","affiliation":[{"name":"Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pel\u00e9 Pequeno Pr\u00edncipe Research Institute &amp; Pequeno Pr\u00edncipe Faculties, Ave., Silva Jardim, 1632, 80240-020 Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7933-5417","authenticated-orcid":false,"given":"N\u00e1dia","family":"da Rosa","sequence":"additional","affiliation":[{"name":"Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pel\u00e9 Pequeno Pr\u00edncipe Research Institute &amp; Pequeno Pr\u00edncipe Faculties, Ave., Silva Jardim, 1632, 80240-020 Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-4185","authenticated-orcid":false,"given":"Clayton","family":"Souza","sequence":"additional","affiliation":[{"name":"Biopol, Chemistry Department, Federal University of Paran\u00e1, Avenue Cel. 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