{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T18:34:55Z","timestamp":1775586895350,"version":"3.50.1"},"reference-count":22,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AmsterdamUMC","award":["Flexibel OiO"],"award-info":[{"award-number":["Flexibel OiO"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>In 2020, three articles were published on a protein that can activate the immune system by binding to macrophage-inducible C-type lectin receptor (Mincle). In the articles, the protein was referred to as \u2018SAP130, a subunit of the histone deacetylase complex.\u2019 However, the Mincle ligand the authors aimed to investigate is splicing factor 3b subunit 3 (SF3B3). This splicing factor is unrelated to SAP130 (Sin3A associated protein 130, a subunit of the histone deacetylase-dependent Sin3A corepressor complex). The conclusions in the three articles were formulated for SF3B3, while the researchers used qPCR primers and antibodies against SAP130. We retraced the origins of the ambiguity about the two proteins and found that Online Mendelian Inheritance in Man (OMIM) added a Nature publication on SF3B3 as a reference for Sin3A associated protein 130 in 2016. Subsequently, companies such as Abcam referred to OMIM and the Nature article in their products for both SF3B3 and SAP130. In turn, the mistake by OMIM followed in the persistent and confusing use of \u2018SAP130\u2032 (spliceosome-associated protein 130) as an alternative symbol for SF3B3. With this report, we aim to eliminate the persistent confusion and separate the literature regarding the two proteins.<\/jats:p>","DOI":"10.3390\/cells10030590","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T04:01:25Z","timestamp":1615176085000},"page":"590","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ambiguity about Splicing Factor 3b Subunit 3 (SF3B3) and Sin3A Associated Protein 130 (SAP130)"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1529-2774","authenticated-orcid":false,"given":"Paula I.","family":"Metselaar","sequence":"first","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, AGEM, Amsterdam UMC, University of Amsterdam, 1105BK Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine","family":"Hos","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, AGEM, Amsterdam UMC, University of Amsterdam, 1105BK Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Welting","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, AGEM, Amsterdam UMC, University of Amsterdam, 1105BK Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos A.","family":"Bosch","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Amsterdam, 1018WS Amsterdam, The Netherlands"},{"name":"Department of Medical Psychology, Amsterdam UMC, University of Amsterdam, 1001NK Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9819-383X","authenticated-orcid":false,"given":"Aletta D.","family":"Kraneveld","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-1547","authenticated-orcid":false,"given":"Wouter J.","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, AGEM, Amsterdam UMC, University of Amsterdam, 1105BK Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4261-8450","authenticated-orcid":false,"given":"Anje A.","family":"Te Velde","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, AGEM, Amsterdam UMC, University of Amsterdam, 1105BK Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/nyas.14240","article-title":"Preliminary exploration of the potential of spliceosome-associated protein 130 for predicting disease severity in Crohn\u2032s disease","volume":"1462","author":"Gong","year":"2020","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/ecco-jcc\/jjaa088","article-title":"Mincle\/Syk signaling promotes intestinal mucosal inflammation through induction of macrophage pyroptosis in Crohn\u2019s disease","volume":"14","author":"Gong","year":"2020","journal-title":"J. Crohns. Colitis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"986","DOI":"10.21037\/atm-20-4404","article-title":"Spliceosome-associated protein 130: A novel biomarker for idiopathic pulmonary fibrosis","volume":"8","author":"Liu","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_4","unstructured":"(2021, January 20). Online Mendelian Inheritance in Man, OMIM\u00ae. Johns Hopkins University, Baltimore, MD. MIM Number: 609697. Available online: https:\/\/omim.org\/entry\/609697."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature17403","article-title":"The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression","volume":"532","author":"Seifert","year":"2016","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1800166","DOI":"10.1002\/bies.201800166","article-title":"Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation","volume":"41","author":"Das","year":"2019","journal-title":"BioEssays"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1093\/emboj\/20.12.3187","article-title":"UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation","volume":"20","author":"Brand","year":"2001","journal-title":"EMBO J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6782","DOI":"10.1128\/MCB.21.20.6782-6795.2001","article-title":"Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo","volume":"21","author":"Martinez","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Menon, S., Tsuge, T., Dohmae, N., Takio, K., and Wei, N. (2008). Association of SAP130\/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. BMC Biochem., 9.","DOI":"10.1186\/1471-2091-9-1"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/ni.1651","article-title":"Mincle is an ITAM-coupled activating receptor that senses damaged cells","volume":"9","author":"Yamasaki","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1128\/MCB.23.10.3456-3467.2003","article-title":"Identification and characterization of three new components of the mSin3A corepressor complex","volume":"23","author":"Fleischer","year":"2003","journal-title":"Mol. Cell. 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Open"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1089\/neu.2014.3436","article-title":"Mincle signaling in the innate immune response after traumatic brain injury","volume":"32","author":"Brand","year":"2015","journal-title":"J. Neurotrauma"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1161\/STROKEAHA.115.010088","article-title":"Macrophage-Inducible C-Type Lectin\/Spleen Tyrosine Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats","volume":"46","author":"He","year":"2015","journal-title":"Stroke"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.4049\/jimmunol.1600598","article-title":"Mincle Signaling Promotes Con A Hepatitis","volume":"197","author":"Greco","year":"2016","journal-title":"J. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1002\/hep.28811","article-title":"IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease","volume":"64","author":"Zhou","year":"2016","journal-title":"Hepatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bbi.2016.11.004","article-title":"Human albumin attenuates excessive innate immunity via inhibition of microglial Mincle\/Syk signaling in subarachnoid hemorrhage","volume":"60","author":"Xie","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ajpath.2017.12.010","article-title":"Spliceosome-Associated Protein 130 Exacerbates Alcohol-Induced Liver Injury by Inducing NLRP3 Inflammasome-Mediated IL-1beta in Mice","volume":"188","author":"Kim","year":"2018","journal-title":"Am. J. 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Investig."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/3\/590\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:34:37Z","timestamp":1760160877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/3\/590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["cells10030590"],"URL":"https:\/\/doi.org\/10.3390\/cells10030590","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,8]]}}}