{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:08:11Z","timestamp":1787242091832,"version":"build-2736575974"},"reference-count":132,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CPI19\/00149"],"award-info":[{"award-number":["CPI19\/00149"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01039"],"award-info":[{"award-number":["PI17\/01039"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016386","name":"Conselleria de Innovaci\u00f3n, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana","doi-asserted-by":"publisher","award":["PROMETEO\/2018\/137"],"award-info":[{"award-number":["PROMETEO\/2018\/137"]}],"id":[{"id":"10.13039\/501100016386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016386","name":"Conselleria de Innovaci\u00f3n, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana","doi-asserted-by":"publisher","award":["ACIF\/2017\/117"],"award-info":[{"award-number":["ACIF\/2017\/117"]}],"id":[{"id":"10.13039\/501100016386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["FPU19\/04850"],"award-info":[{"award-number":["FPU19\/04850"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["FPU18\/06327"],"award-info":[{"award-number":["FPU18\/06327"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Adult stem cells (ASCs) were long suspected to exist in the endometrium. Indeed, several types of endometrial ASCs were identified in rodents and humans through diverse isolation and characterization techniques. Putative stromal and epithelial stem cell niches were identified in murine models using label-retention techniques. In humans, functional methods (clonogenicity, long-term culture, and multi-lineage differentiation assays) and stem cell markers (CD146, SUSD2\/W5C5, LGR5, NTPDase2, SSEA-1, or N-cadherin) facilitated the identification of three main types of endogenous endometrial ASCs: stromal, epithelial progenitor, and endothelial stem cells. Further, exogenous populations of stem cells derived from bone marrow may act as key effectors of the endometrial ASC niche. These findings are promoting the development of stem cell therapies for endometrial pathologies, with an evolution towards paracrine approaches. At the same time, promising therapeutic alternatives based on bioengineering have been proposed.<\/jats:p>","DOI":"10.3390\/cells10030595","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T12:12:18Z","timestamp":1615205538000},"page":"595","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Stem Cells and the Endometrium: From the Discovery of Adult Stem Cells to Pre-Clinical Models"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-9108","authenticated-orcid":false,"given":"Luc\u00eda","family":"de Miguel-G\u00f3mez","sequence":"first","affiliation":[{"name":"IVI Foundation, Health Research Institute La Fe, 46026 Valencia, Spain"},{"name":"Department of Pediatrics, Obstetrics, and Gynaecology, School of Medicine, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"L\u00f3pez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"IVI Foundation, Health Research Institute La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5202-8967","authenticated-orcid":false,"given":"Emilio","family":"Franc\u00e9s-Herrero","sequence":"additional","affiliation":[{"name":"IVI Foundation, Health Research Institute La Fe, 46026 Valencia, Spain"},{"name":"Department of Pediatrics, Obstetrics, and Gynaecology, School of Medicine, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1266-8513","authenticated-orcid":false,"given":"Adolfo","family":"Rodr\u00edguez-Eguren","sequence":"additional","affiliation":[{"name":"IVI Foundation, Health Research Institute La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pellicer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Obstetrics, and Gynaecology, School of Medicine, University of Valencia, 46010 Valencia, Spain"},{"name":"IVIRMA Rome Parioli, 00197 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cervell\u00f3","sequence":"additional","affiliation":[{"name":"IVI Foundation, Health Research Institute La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.18388\/abp.2015_1023","article-title":"Adult stem cells: Hopes and hypes of regenerative medicine","volume":"62","author":"Dulak","year":"2015","journal-title":"Acta Biochim. Pol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1126\/science.aad7016","article-title":"What is an adult stem cell?","volume":"350","author":"Clevers","year":"2015","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-019-1165-5","article-title":"Stem cells: Past, present, and future","volume":"10","author":"Zakrzewski","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1055\/s-0035-1559581","article-title":"Cell Therapy and Tissue Engineering from and toward the Uterus","volume":"33","author":"Santamaria","year":"2015","journal-title":"Semin. Reprod. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"165399","DOI":"10.1242\/dev.165399","article-title":"Signaling in the stem cell niche: Regulating cell fate, function and plasticity","volume":"145","author":"Koester","year":"2018","journal-title":"Development"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmbts.2018.07.009","article-title":"Adult Stem Cells for Regenerative Therapy","volume":"160","author":"Gurusamy","year":"2018","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tmrv.2018.11.003","article-title":"Peripheral Blood or Bone Marrow Stem Cells? Practical Considerations in Hematopoietic Stem Cell Transplantation","volume":"33","author":"Amouzegar","year":"2019","journal-title":"Transfus. Med. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41586-019-1154-y","article-title":"Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell","volume":"569","author":"Ayyaz","year":"2019","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.devcel.2017.10.001","article-title":"Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche","volume":"43","author":"Gonzales","year":"2017","journal-title":"Dev. Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/bs.ctdb.2017.08.003","article-title":"The Muscle Stem Cell Niche in Health and Disease","volume":"Volume 126","author":"Mashinchian","year":"2018","journal-title":"Current Topics in Developmental Biology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.stem.2016.05.022","article-title":"Stem Cell Models of Human Brain Development","volume":"18","author":"Kelava","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1055\/s-0032-1331800","article-title":"Somatic Stem Cells in the Human Endometrium","volume":"31","author":"Mas","year":"2013","journal-title":"Semin. Reprod. Med."},{"key":"ref_13","unstructured":"Sim\u00f3n, C., Horcajadas, J.A., Garc\u00eda-Velasco, J., and Pellicer, A. (2009). El Endometrio Humano: Desde la Investigaci\u00f3n a La Cl\u00ednica, Editorial M\u00e9dica Panamericana. [1st ed.]."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1210\/er.2004-0021","article-title":"Endocrine Regulation of Menstruation","volume":"27","author":"Jabbour","year":"2006","journal-title":"Endocr. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Byers, S.L., Wiles, M.V., Dunn, S.L., and Taft, R.A. (2012). Mouse estrous cycle identification tool and images. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035538"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11154-012-9221-9","article-title":"Endometrial regeneration and endometrial stem\/progenitor cells","volume":"13","author":"Gargett","year":"2012","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Teixeira, J., Rueda, B.R., and Pru, J.K. (2008). Uterine Stem cells. StemBook, Harvard Stem Cell Institute. [1st ed.]. Available online: http:\/\/www.stembook.org.","DOI":"10.3824\/stembook.1.16.1"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0010-7824(78)80015-8","article-title":"On the concept of stem cell and a model of functional-morphological structure of the endometrium","volume":"18","author":"Prianishnikov","year":"1978","journal-title":"Contraception"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/GCO.0b013e32836024e7","article-title":"Regenerating endometrium from stem\/progenitor cells: Is it abnormal in endometriosis, Asherman\u2019s syndrome and infertility?","volume":"25","author":"Deane","year":"2013","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2147\/IJWH.S165474","article-title":"Asherman\u2019s syndrome: Current perspectives on diagnosis and management","volume":"11","author":"Dreisler","year":"2019","journal-title":"Int. J. Women Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/09513590.2014.906571","article-title":"Treating patients with \u201cthin\u201d endometrium-an ongoing challenge","volume":"30","author":"Lebovitz","year":"2014","journal-title":"Gynecol. Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/rda.12309","article-title":"The Endometrium of Cycling Cows Contains Populations of Putative Mesenchymal Progenitor Cells","volume":"49","author":"Cabezas","year":"2014","journal-title":"Reprod. Domest. Anim."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1530\/REP-11-0202","article-title":"Porcine uterus contains a population of mesenchymal stem cells","volume":"143","author":"Miernik","year":"2012","journal-title":"Reproduction"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Letouzey, V., Tan, K.S., Deane, J.A., Ulrich, D., Gurung, S., Ong, Y.R., and Gargett, C.E. (2015). Isolation and Characterisation of Mesenchymal Stem\/Stromal Cells in the Ovine Endometrium. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127531"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.theriogenology.2017.09.035","article-title":"Equine mesenchymal stem cells derived from endometrial or adipose tissue share significant biological properties, but have distinctive pattern of surface markers and migration","volume":"106","author":"Cabezas","year":"2018","journal-title":"Theriogenology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1095\/biolreprod40.3.681","article-title":"The Basalis of the Primate Endometrium: A Bifunctional Germinal Compartment","volume":"40","author":"Padykula","year":"1989","journal-title":"Biol. Reprod."},{"key":"ref_27","first-page":"7","article-title":"The relationship between the spleen colony-forming cell and the haemopoietic stem cell","volume":"4","author":"Schofield","year":"1978","journal-title":"Blood Cells"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nbt.2978","article-title":"Modulating the stem cell niche for tissue regeneration","volume":"32","author":"Lane","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-1-4419-7037-4_11","article-title":"Adult stem cells and their niches","volume":"695","author":"Ferraro","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0090-8258(78)90050-1","article-title":"A functional model of the structure of the epithelium of normal, hyperplastic, and malignant human endometrium: A review","volume":"6","author":"Prianishnikov","year":"1978","journal-title":"Gynecol. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bpobgyn.2018.01.011","article-title":"Endometrial stem\/progenitor cells and their role in the pathogenesis of endometriosis","volume":"50","author":"Cousins","year":"2018","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1749-6632.1991.tb37849.x","article-title":"Regeneration in the Primate Uterus: The Role of Stem Cells","volume":"622","author":"Padykula","year":"1991","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/humupd\/dmy028","article-title":"Uterine stem cells: From basic research to advanced cell therapies","volume":"24","author":"Santamaria","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1634\/stemcells.2005-0411","article-title":"Identification of Label-Retaining Cells in Mouse Endometrium","volume":"24","author":"Chan","year":"2006","journal-title":"Stem Cells"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/humrep\/del332","article-title":"Identification, characterization and co-localization of label-retaining cell population in mouse endometrium with typical undifferentiated markers","volume":"22","author":"Horcajadas","year":"2007","journal-title":"Hum. Reprod."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1089\/scd.2014.0225","article-title":"Label-Retaining Stromal Cells in Mouse Endometrium Awaken for Expansion and Repair After Parturition","volume":"24","author":"Cao","year":"2015","journal-title":"Stem Cells Dev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1177\/1933719111414207","article-title":"Role of Label-Retaining Cells in Estrogen-Induced Endometrial Regeneration","volume":"19","author":"Chan","year":"2012","journal-title":"Reprod. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1210\/en.2009-1334","article-title":"Reepithelialization of the Uterine Surface Arises from Endometrial Glands: Evidence from a Functional Mouse Model of Breakdown and Repair","volume":"151","author":"Ye","year":"2010","journal-title":"Endocrinology"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Huang, C.-C., Orvis, G.D., Wang, Y., and Behringer, R.R. (2012). Stromal-to-epithelial transition during postpartum endometrial regeneration. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044285"},{"key":"ref_40","first-page":"184","article-title":"Identification of Label-Retaining Perivascular Cells in a Mouse Model of Endometrial Decidualization, Breakdown, and Repair","volume":"86","author":"Ye","year":"2012","journal-title":"Biol. Reprod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/molehr\/gav076","article-title":"The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase","volume":"22","author":"Deane","year":"2016","journal-title":"Mol. Hum. Reprod."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wang, Y., Sacchetti, A., Van Dijk, M.R., Van Der Zee, M., Van Der Horst, P.H., Joosten, R., Burger, C.W., Grootegoed, J.A., Blok, L.J., and Fodde, R. (2012). Identification of Quiescent, Stem-Like Cells in the Distal Female Reproductive Tract. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040691"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.4161\/cc.25917","article-title":"Long-term label retaining cells localize to distinct regions within the female reproductive epithelium","volume":"12","author":"Patterson","year":"2013","journal-title":"Cell Cycle"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Cervell\u00f3, I., Gil-Sanchis, C., Mas, A., Delgado-Rosas, F., Mart\u00ednez-Conejero, J.A., Gal\u00e1n, A., Mart\u00ednez-Romero, A., Mart\u00ednez, S., Navarro, I., and Ferro, J. (2010). Human Endometrial Side Population Cells Exhibit Genotypic, Phenotypic and Functional Features of Somatic Stem Cells. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010964"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Cervell\u00f3, I., Mas, A., Gil-Sanchis, C., Peris, L., Faus, A., Saunders, P.T.K., Critchley, H.O.D., and Sim\u00f3n, C. (2011). Reconstruction of Endometrium from Human Endometrial Side Population Cell Lines. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0021221"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Miyazaki, K., Maruyama, T., Masuda, H., Yamasaki, A., Uchida, S., Oda, H., Uchida, H., and Yoshimura, Y. (2012). Stem Cell-Like Differentiation Potentials of Endometrial Side Population Cells as Revealed by a Newly Developed In Vivo Endometrial Stem Cell Assay. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0050749"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.fertnstert.2007.08.005","article-title":"Side population cells contribute to the genesis of human endometrium","volume":"90","author":"Tsuji","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Masuda, H., Matsuzaki, Y., Hiratsu, E., Ono, M., Nagashima, T., Kajitani, T., Arase, T., Oda, H., Uchida, H., and Asada, H. (2010). Stem Cell-Like Properties of the Endometrial Side Population: Implication in Endometrial Regeneration. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010387"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1093\/humrep\/del514","article-title":"Characterization of side-population cells in human normal endometrium","volume":"22","author":"Kato","year":"2007","journal-title":"Hum. Reprod."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Cervell\u00f3, I., Gil-Sanchis, C., Mas, A., Faus, A., Sanz, J., Moscard\u00f3, F., Higueras, G., Sanz, M.A., Pellicer, A., and Sim\u00f3n, C. (2012). Bone marrow-derived cells from male donors do not contribute to the endometrial side population of the recipient. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030260"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1177\/1933719110369180","article-title":"Isolation and Characterization of Side Population Cells in the Postpartum Murine Endometrium","volume":"17","author":"Hu","year":"2010","journal-title":"Reprod. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/stem.1337","article-title":"Estrogen and progesterone together expand murine endometrial epithelial progenitor cells","volume":"31","author":"Janzen","year":"2013","journal-title":"Stem Cells"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.3727\/096368911X637362","article-title":"A Novel Marker of Human Endometrial Mesenchymal Stem-Like Cells","volume":"21","author":"Masuda","year":"2012","journal-title":"Cell Transplant."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1093\/humrep\/dem265","article-title":"Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium","volume":"22","author":"Schwab","year":"2007","journal-title":"Hum. Reprod."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1093\/humrep\/deu159","article-title":"Mesenchymal stem\/stromal cells in post-menopausal endometrium","volume":"29","author":"Ulrich","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1095\/biolreprod.111.095885","article-title":"Perivascular Human Endometrial Mesenchymal Stem Cells Express Pathways Relevant to Self-Renewal, Lineage Specification, and Functional Phenotype","volume":"86","author":"Spitzer","year":"2012","journal-title":"Biol. Reprod."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1089\/scd.2012.0584","article-title":"Prospective Isolation of Mesenchymal Stem Cells from Human Bone Marrow Using Novel Antibodies Directed Against Sushi Domain Containing 2","volume":"22","author":"Sivasubramaniyan","year":"2013","journal-title":"Stem Cells Dev."},{"key":"ref_58","first-page":"145","article-title":"Human endometrial perivascular stem cells exhibit a limited potential to regenerate endometrium after xenotransplantation","volume":"36","author":"Xinxin","year":"2020","journal-title":"Hum. Reprod."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/1933719118766251","article-title":"Human endometrial reconstitution from somatic stem cells: The importance of niche-like cells","volume":"26","author":"Ferrero","year":"2019","journal-title":"Reprod. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.fertnstert.2016.10.021","article-title":"Leucine-rich repeat-containing G-protein-coupled receptor 5-positive cells in the endometrial stem cell niche","volume":"107","author":"Faus","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1089\/scd.2009.0290","article-title":"The Mesenchymal Stem Cell Antigen MSCA-1 is Identical to Tissue Non-specific Alkaline Phosphatase","volume":"19","author":"Sobiesiak","year":"2010","journal-title":"Stem Cells Dev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.fertnstert.2010.08.035","article-title":"Characterization of endometrial mesenchymal stem-like cells obtained by endometrial biopsy during routine diagnostics","volume":"95","author":"Schulte","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1093\/humrep\/det285","article-title":"SSEA-1 isolates human endometrial basal glandular epithelial cells: Phenotypic and functional characterization and implications in the pathogenesis of endometriosis","volume":"28","author":"Valentijn","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1093\/humrep\/dex289","article-title":"N-cadherin identifies human endometrial epithelial progenitor cells by in vitro stem cell assays","volume":"32","author":"Nguyen","year":"2017","journal-title":"Hum. Reprod."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Tal, R., Shaikh, S., Pallavi, P., Tal, A., L\u00f3pez-Gir\u00e1ldez, F., Lyu, F., Fang, Y.-Y., Chinchanikar, S., Liu, Y., and Kliman, H.J. (2019). Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLoS Biol., 17.","DOI":"10.1371\/journal.pbio.3000421"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/stem.2706","article-title":"Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models","volume":"36","author":"Ong","year":"2018","journal-title":"Stem Cells"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.omtm.2017.01.001","article-title":"CXCL12 Promotes Stem Cell Recruitment and Uterine Repair after Injury in Asherman\u2019s Syndrome","volume":"4","author":"Ersoy","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nrc3023","article-title":"CD44: Can a cancer-initiating cell profit from an abundantly expressed molecule?","volume":"11","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1095\/biolreprod.103.024109","article-title":"Clonogenicity of Human Endometrial Epithelial and Stromal Cells","volume":"70","author":"Chan","year":"2004","journal-title":"Biol. Reprod."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/jama.292.1.81","article-title":"Endometrial Cells Derived From Donor Stem Cells in Bone Marrow Transplant Recipients","volume":"292","author":"Taylor","year":"2004","journal-title":"JAMA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41598-018-36698-1","article-title":"Considerations for high-yield, high-throughput cell enrichment: Fluorescence versus magnetic sorting","volume":"9","author":"Sutermaster","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"118","DOI":"10.15283\/ijsc.2014.7.2.118","article-title":"Comparison of Mesenchymal Stem Cell Markers in Multiple Human Adult Stem Cells","volume":"7","author":"Maleki","year":"2014","journal-title":"Int. J. Stem Cells"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","article-title":"A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs","volume":"3","author":"Crisan","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s13287-019-1284-z","article-title":"Human predecidual stromal cells are mesenchymal stromal\/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortion","volume":"10","author":"Requena","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"8241","DOI":"10.1158\/0008-5472.CAN-08-4808","article-title":"Cell, tumor, and stem cell biology evidence for cancer stem cells in human endometrial carcinoma","volume":"69","author":"Hubbard","year":"2009","journal-title":"Cancer Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"F29","DOI":"10.1152\/ajprenal.00538.2014","article-title":"Cutting to the chase: Taking the pulse of label-retaining cells in kidney","volume":"308","author":"Humphreys","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.stemcr.2014.02.004","article-title":"Identification of the Niche and Phenotype of the First Human Hematopoietic Stem Cells","volume":"2","author":"Ivanovs","year":"2014","journal-title":"Stem Cell Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.183.4.1797","article-title":"Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo","volume":"183","author":"Goodell","year":"1996","journal-title":"J. Exp. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"5065","DOI":"10.1210\/en.2009-0690","article-title":"In Pursuit of Leucine-Rich Repeat-Containing G Protein-Coupled Receptor-5 Regulation and Function in the Uterus","volume":"150","author":"Sun","year":"2009","journal-title":"Endocrinology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s11302-019-09656-3","article-title":"The ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in human endometrium: A novel marker of basal stroma and mesenchymal stem cells","volume":"15","author":"Trapero","year":"2019","journal-title":"Purinergic Signal."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/stem.3077","article-title":"Integrated transcriptomic, phenotypic, and functional study reveals tissue-specific immune properties of mesenchymal stromal cells","volume":"38","author":"Dulong","year":"2020","journal-title":"Stem Cells"},{"key":"ref_83","first-page":"137","article-title":"Endometrial stem\/progenitor cells: The first 10 years","volume":"22","author":"Gargett","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Tempest, N., MacLean, A., and Hapangama, D.K. (2018). Endometrial Stem Cell Markers: Current Concepts and Unresolved Questions. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103240"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/humrep\/dep036","article-title":"A re-appraisal of the morphological changes within the endometrium during menstruation: A hysteroscopic, histological and scanning electron microscopic study","volume":"24","author":"Garry","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1634\/stemcells.2006-0167","article-title":"N-Cadherin Is Expressed by Putative Stem\/Progenitor Cells and Melanocytes in the Human Limbal Epithelial Stem Cell Niche","volume":"25","author":"Hayashi","year":"2007","journal-title":"Stem Cells"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.scr.2012.11.001","article-title":"Aquaporin 1-positive stromal niche-like cells directly interact with N-cadherin-positive clusters in the basal limbal epithelium","volume":"10","author":"Higa","year":"2013","journal-title":"Stem Cell Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1128004","article-title":"Lhx2 Maintains Stem Cell Character in Hair Follicles","volume":"312","author":"Rhee","year":"2006","journal-title":"Science"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nature02041","article-title":"Identification of the haematopoietic stem cell niche and control of the niche size","volume":"425","author":"Zhang","year":"2003","journal-title":"Nature"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/sj.leu.2403796","article-title":"Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells","volume":"19","author":"Kucia","year":"2005","journal-title":"Leukemia"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/01.ogx.0000318077.57178.8b","article-title":"Endometrial Endothelial Cells are Derived from Donor Stem Cells in a Bone Marrow Transplant Recipient","volume":"63","author":"Mints","year":"2008","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/ten.tea.2020.0022","article-title":"Microphysiological Modeling of the Human Endometrium","volume":"26","author":"Campo","year":"2020","journal-title":"Tissue Eng. Part A"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/BSR20150025","article-title":"Human mesenchymal stem cells\u2014Current trends and future prospective","volume":"35","author":"Ullah","year":"2015","journal-title":"Biosci. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Giannone, G., Attademo, L., Scotto, G., Genta, S., Ghisoni, E., Tuninetti, V., Aglietta, M., Pignata, S., and Valabrega, G. (2019). Endometrial Cancer Stem Cells: Role, Characterization and Therapeutic Implications. Cancers, 11.","DOI":"10.3390\/cancers11111820"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ebiom.2018.12.044","article-title":"Targeting cancer stem cell signature gene SMOC-2 Overcomes chemoresistance and inhibits cell proliferation of endometrial carcinoma","volume":"40","author":"Lu","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1196\/annals.1434.014","article-title":"Stem Cells and the Pathogenesis of Endometriosis","volume":"1127","author":"Sasson","year":"2008","journal-title":"Ann. N Y Acad. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.fertnstert.2017.12.030","article-title":"Pathogenesis of uterine adenomyosis: Invagination or metaplasia?","volume":"109","author":"Donnez","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/molehr\/gau025","article-title":"Potential role of endometrial stem\/progenitor cells in the pathogenesis of early-onset endometriosis","volume":"20","author":"Gargett","year":"2014","journal-title":"Mol. Hum. Reprod."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.116.141325","article-title":"Endometrial Mesenchymal Stem\/Stromal Cells, Their Fibroblast Progeny in Endometriosis, and More","volume":"94","author":"Gargett","year":"2016","journal-title":"Biol. Reprod."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.fertnstert.2015.09.002","article-title":"Ultramicro-trauma in the endometrial-myometrial junctional zone and pale cell migration in adenomyosis","volume":"104","author":"Ibrahim","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1161\/CIRCRESAHA.109.208991","article-title":"Assessment and optimization of cell engraftment after transplantation into the heart","volume":"106","author":"Terrovitis","year":"2010","journal-title":"Circ. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1002\/stem.1118","article-title":"Analysis of Tissues Following Mesenchymal Stromal Cell Therapy in Humans Indicates Limited Long-Term Engraftment and No Ectopic Tissue Formation","volume":"30","author":"Batsis","year":"2012","journal-title":"Stem Cells"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/leu.2011.389","article-title":"Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: Can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?","volume":"26","author":"Ratajczak","year":"2012","journal-title":"Leukemia"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jconrel.2015.08.038","article-title":"Immunomodulatory properties of stem cells and bioactive molecules for tissue engineering","volume":"219","author":"Molina","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.fertnstert.2015.08.032","article-title":"Human CD133+ bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome","volume":"104","author":"Cabanillas","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1159\/000447857","article-title":"Application of Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Intrauterine Adhesions in Rats","volume":"39","author":"Wang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_107","first-page":"551","article-title":"Stem cell paracrine actions in tissue regeneration and potential therapeutic effect in human endometrium: A retrospective study","volume":"127","author":"Ferrero","year":"2019","journal-title":"BJOG Int. J. Obstet. Gynecol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13287-017-0535-0","article-title":"Umbilical cord-derived mesenchymal stem cells on scaffolds facilitate collagen degradation via upregulation of MMP-9 in rat uterine scars","volume":"8","author":"Xu","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-018-0777-5","article-title":"Therapeutic effect of human umbilical cord-derived mesenchymal stem cells on injured rat endometrium during its chronic phase","volume":"9","author":"Zhang","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jcyt.2017.02.003","article-title":"Human amniotic mesenchymal stromal cell transplantation improves endometrial regeneration in rodent models of intrauterine adhesions","volume":"19","author":"Gan","year":"2017","journal-title":"Cytotherapy"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1089\/scd.2019.0246","article-title":"Transplantation of Human Amnion Epithelial Cells Improves Endometrial Regeneration in Rat Model of Intrauterine Adhesions","volume":"29","author":"Ouyang","year":"2020","journal-title":"Stem Cells Dev."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s10815-014-0268-2","article-title":"Effect of stem cell application on Asherman syndrome, an experimental rat model","volume":"31","author":"Kilic","year":"2014","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_113","first-page":"813","article-title":"Effects of menstrual blood-derived stem cells on endometrial injury repair","volume":"19","author":"Hu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.actbio.2019.03.032","article-title":"Acta Biomaterialia Synergistic regenerative effects of functionalized endometrial stromal cells with hyaluronic acid hydrogel in a murine model of uterine damage","volume":"89","author":"Young","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-018-0801-9","article-title":"Human mesenchymal stem cells in spheroids improve fertility in model animals with damaged endometrium","volume":"9","author":"Domnina","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_116","unstructured":"Bast, R.C., Kufe, D.W., Pollock, R.E., Weichselbaum, R.R., Hollan, J.F., and Frei, E. (2003). Selection of Autologous or Allogeneic Transplantation. Cancer Medicine, BC Decker."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/aogs.13598","article-title":"Cellular therapies for the endometrium: An update","volume":"98","author":"Davies","year":"2019","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Bartholomew, I. (2018). Animal Models of Fetal Medicine and Obstetrics. Experimental Animal Models of Human Diseases\u2014An Effective Therapeutic Strategy, IntechOpen. [1st ed.].","DOI":"10.5772\/66030"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.fertnstert.2013.10.053","article-title":"Rat bone marrow mesenchymal stem cells improve regeneration of thin endometrium in rat","volume":"101","author":"Jing","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1177\/1933719118799201","article-title":"Bone marrow mesenchymal stem cells (BMSCs) restore functional endometrium in the rat model for severe sherman syndrome","volume":"26","author":"Gao","year":"2019","journal-title":"Reprod. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s13287-017-0718-8","article-title":"Vitamin C plus hydrogel facilitates bone marrow stromal cell-mediated endometrium regeneration in rats","volume":"8","author":"Yang","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Alawadhi, F., Du, H., Cakmak, H., and Taylor, H.S. (2014). Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman\u2019s Syndrome. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096662"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/biolre\/ioy175","article-title":"Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model","volume":"100","author":"Yi","year":"2019","journal-title":"Biol. Reprod."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/jcmm.12433","article-title":"Endometrial stem cell transplantation in MPTP-exposed primates: An alternative cell source for treatment of Parkinson\u2019s disease","volume":"19","author":"Wolff","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s12015-011-9338-3","article-title":"Human Endometrial-Derived Mesenchymal Stem Cells Suppress Inflammation in the Central Nervous System of EAE Mice","volume":"8","author":"Peron","year":"2012","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-019-1155-7","article-title":"Platelet-rich plasma improves therapeutic effects of menstrual blood-derived stromal cells in rat model of intrauterine adhesion","volume":"10","author":"Zhang","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1016\/j.biomaterials.2014.02.046","article-title":"Biomaterials transplantation of bone marrow mesenchymal stem cells on collagen scaffolds for the functional regeneration of injured rat uterus","volume":"35","author":"Ding","year":"2014","journal-title":"Biomaterials"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.1176009","article-title":"The extracellular matrix: Not just pretty fibrils","volume":"326","author":"Hynes","year":"2009","journal-title":"Science"},{"key":"ref_129","first-page":"1","article-title":"Hyaluronic acid hydrogel integrated with mesenchymal stem cell-secretome to treat endometrial injury in a rat model of Asherman \u2019s syndrome","volume":"1900411","author":"Liu","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1007\/s43032-019-00112-6","article-title":"Exosomes derived from adipose mesenchymal stem cells restore functional endometrium in a raa model of intrauterine adhesions","volume":"27","author":"Zhao","year":"2020","journal-title":"Reprod. Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/3573846","article-title":"Endometrial Mesenchymal Stem Cells Isolated from Menstrual Blood by Adherence","volume":"2016","author":"Du","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"bio038885","DOI":"10.1242\/bio.038885","article-title":"High-yield isolation of menstrual blood-derived endometrial stem cells by direct red blood cell lysis treatment","volume":"8","author":"Sun","year":"2019","journal-title":"Biol. Open"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/3\/595\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:34:56Z","timestamp":1760160896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/3\/595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":132,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["cells10030595"],"URL":"https:\/\/doi.org\/10.3390\/cells10030595","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,8]]}}}