{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:21:35Z","timestamp":1791408095484,"version":"4.3.3"},"reference-count":36,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Colorectal cancer (CRC) is the second most frequent neoplasm in Chile and its mortality rate is rising in all ages. However, studies characterizing CRC according to the age of onset are still lacking. This study aimed to identify clinical, pathological, and molecular features of CRC in Chilean patients according to the age of diagnosis: early- (\u226450 years; EOCRC), intermediate- (51\u201369 years; IOCRC), and late-onset (\u226570 years; LOCRC). The study included 426 CRC patients from Clinica Las Condes, between 2007 and 2019. A chi-square test was applied to explore associations between age of onset and clinicopathological characteristics. Body Mass Index (BMI) differences according to age of diagnosis was evaluated through t-test. Overall (OS) and cancer-specific survival (CSS) were estimated by the Kaplan\u2013Meier method. We found significant differences between the age of onset, and gender, BMI, family history of cancer, TNM Classification of Malignant Tumors stage, OS, and CSS. EOCRC category was characterized by a family history of cancer, left-sided tumors with a more advanced stage of the disease but better survival at 10 years, and lower microsatellite instability (MSI), with predominant germline mutations. IOCRC has shown clinical similarities with the EOCRC and molecular similarities to the LOCRC, which agrees with other reports.<\/jats:p>","DOI":"10.3390\/cells10030631","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T11:56:55Z","timestamp":1615550215000},"page":"631","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical, Pathological and Molecular Characteristics of Chilean Patients with Early-, Intermediate- and Late-Onset Colorectal Cancer"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-0267","authenticated-orcid":false,"given":"Karin","family":"Alvarez","sequence":"first","affiliation":[{"name":"Oncology Center, Clinica Universidad de Los Andes, Santiago 7620157, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Cassana","sequence":"additional","affiliation":[{"name":"Joint Doctoral Degree Program in Medical Sciences, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile"},{"name":"Coloproctology Unit, Clinica Las Condes, Santiago 7591047, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"De La Fuente","sequence":"additional","affiliation":[{"name":"Academic Direction, Clinica Las Condes, Santiago 7591047, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Canales","sequence":"additional","affiliation":[{"name":"Cancer Institute, Clinica Las Condes, Santiago 7591047, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Abedrapo","sequence":"additional","affiliation":[{"name":"Coloproctology Unit, Clinica Las Condes, Santiago 7591047, Chile"},{"name":"Faculty of Medicine, Universidad de Chile, Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"L\u00f3pez-K\u00f6stner","sequence":"additional","affiliation":[{"name":"Oncology Center, Clinica Universidad de Los Andes, Santiago 7620157, Chile"},{"name":"Faculty of Medicine, Universidad de Chile, Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"ref_1","unstructured":"The Global Cancer Observatory (2021, January 28). 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