{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:45:25Z","timestamp":1793043925086,"version":"4.5.0"},"reference-count":94,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Endometriosis (EMS) is a common gynecological disease characterized by the presence of endometrial tissue outside the uterus. Approximately 10% of women around the world suffer from this disease. Recent studies suggest that endometriosis has potential to transform into endometriosis-associated ovarian cancer (EAOC). Endometriosis is connected with chronic inflammation and changes in the phenotype, activity, and function of immune cells. The underlying mechanisms include quantitative and functional disturbances of neutrophils, monocytes\/macrophages (MO\/MA), natural killer cells (NK), and T cells. A few reports have shown that immunosuppressive cells such as regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) may promote the progression of endometriosis. MDSCs are a heterogeneous population of immature myeloid cells (dendritic cells, granulocytes, and MO\/MA precursors), which play an important role in the development of immunological diseases such as chronic inflammation and cancer. The presence of MDSCs in pathological conditions correlates with immunosuppression, angiogenesis, or release of growth factors and cytokines, which promote progression of these diseases. In this paper, we review the impact of MDSCs on different populations of immune cells, focusing on their immunosuppressive role in the immune system, which may be related with the pathogenesis and\/or progression of endometriosis and its transformation into ovarian cancer.<\/jats:p>","DOI":"10.3390\/cells10030677","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T11:41:06Z","timestamp":1616067666000},"page":"677","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Role of Myeloid-Derived Suppressor Cells (MDSCs) in the Development and\/or Progression of Endometriosis-State of the Art"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1022-3323","authenticated-orcid":false,"given":"Dorota","family":"Suszczyk","sequence":"first","affiliation":[{"name":"Independent Laboratory of Cancer Diagnostics and Immunology, Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9599-6773","authenticated-orcid":false,"given":"Wiktoria","family":"Skiba","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Cancer Diagnostics and Immunology, Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-804X","authenticated-orcid":false,"given":"Joanna","family":"Jakubowicz-Gil","sequence":"additional","affiliation":[{"name":"Department of Functional Anatomy and Cytobiology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2300-3266","authenticated-orcid":false,"given":"Jan","family":"Kotarski","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology and Gynaecology, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3396-1679","authenticated-orcid":false,"given":"Iwona","family":"Wertel","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Cancer Diagnostics and Immunology, Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00404-018-4968-1","article-title":"Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: A meta-analysis","volume":"299","author":"Liu","year":"2019","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3802\/jgo.2018.29.e28","article-title":"Risk factors in progression from endometriosis to ovarian cancer: A cohort study based on medical insurance data","volume":"29","author":"Chiang","year":"2018","journal-title":"J. Gynecol. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.freeradbiomed.2018.12.015","article-title":"Endometriosis and cancer","volume":"133","author":"Kajiyama","year":"2019","journal-title":"Free Radic Biol. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.gmit.2017.08.003","article-title":"Clinical implication for endometriosis associated with ovarian cancer","volume":"6","author":"Torng","year":"2017","journal-title":"Gynecol. Minim. Invasive Ther."},{"key":"ref_5","first-page":"1","article-title":"Endometriosis and risk of ovarian cancer: What do we know?","volume":"301","author":"Ghezzi","year":"2019","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/jog.13559","article-title":"Involvement of immune cells in the pathogenesis of endometriosis","volume":"44","author":"Izumi","year":"2018","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.intimp.2017.03.026","article-title":"Expansion of monocytic myeloid-derived suppressor cells in endometriosis patients: A pilot study","volume":"47","author":"Chen","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1177\/1933719118808923","article-title":"Alteration of myeloid-derived suppressor cells, chronic inflammatory cytokines, and exosomal miRNA contribute to the peritoneal immune disorder of patients with endometriosis","volume":"26","author":"Chen","year":"2019","journal-title":"Reprod. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/eji.201747417","article-title":"MDSCs drive the process of endometriosis by enhancing angiogenesis and are a new potential therapeutic target","volume":"48","author":"Zhang","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e13067","DOI":"10.1111\/aji.13067","article-title":"CD33+ CD14+ CD11b+ HLA-DR\u2212 monocytic myeloid-derived suppressor cells recruited and activated by CCR9\/CCL25 are crucial for the pathogenic progression of endometriosis","volume":"81","author":"Sun","year":"2019","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"76843","DOI":"10.18632\/oncotarget.20164","article-title":"Ascites-derived IL-6 and IL-10 synergistically expand CD14+ HLA-DR-\/low myeloid-derived suppressor cells in ovarian cancer patients","volume":"8","author":"Wu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"200111","DOI":"10.1098\/rsob.200111","article-title":"Mechanisms of immune suppression by myeloid-derived suppressor cells: The role of interleukin-10 as a key immunoregulatory cytokine","volume":"10","author":"Yaseen","year":"2020","journal-title":"Open Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/2326-6066.CIR-16-0297","article-title":"Myeloid-derived suppressor cells","volume":"5","author":"Gabrilovich","year":"2017","journal-title":"Cancer Immunol. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3389\/fimmu.2019.01099","article-title":"Myeloid-derived suppressor cells: Not only in tumor immunity","volume":"10","author":"Pawelec","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived-suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.4161\/onci.21566","article-title":"Instruction of myeloid cells by the tumor microenvironment: Open questions on the dynamics and plasticity of different tumor-associated myeloid cell populations","volume":"1","author":"Schouppe","year":"2012","journal-title":"Oncoimmunology"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhou, J., Nefedova, Y., Lei, A., and Gabrilowich, D. (2018). Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells. Semin. Immunol., 19\u201328.","DOI":"10.1016\/j.smim.2017.12.004"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.21037\/atm-20-4499","article-title":"Current and future immunotherapy approaches in ovarian cancer","volume":"8","author":"Demircan","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"114554","DOI":"10.18632\/oncotarget.23020","article-title":"CXCR2+ MDSCs promote breast cancer progression by inducing EMT and activated T cell exhaustion","volume":"8","author":"Zhu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Law, A.M., Valdes-Mora, F., and Gallego-Ortega, D. (2020). Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer. Cells, 9.","DOI":"10.3390\/cells9030561"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jitc-2020-001223","article-title":"Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation","volume":"8","author":"Cassetta","year":"2020","journal-title":"J. Immunother. Cancer."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1080\/10408363.2018.1477729","article-title":"Blood-based analyses of cancer: Circulating myeloid-derived suppressor cells\u2013is a new era coming?","volume":"55","author":"Okla","year":"2018","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41590-017-0022-x","article-title":"Myeloid-derived suppressor cells coming of age","volume":"19","author":"Veglia","year":"2018","journal-title":"Nat. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Cha, Y.J., and Koo, J.S. (2020). Role of Tumor-Associated Myeloid Cells in Breast Cancer. Cells, 9.","DOI":"10.3390\/cells9081785"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.semcancer.2012.01.011","article-title":"Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression","volume":"22","author":"Sinha","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4049\/jimmunol.176.1.284","article-title":"Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression","volume":"176","author":"Bun","year":"2006","journal-title":"J. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1158\/0008-5472.CAN-09-4672","article-title":"Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes","volume":"70","author":"Movahedi","year":"2010","journal-title":"Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1189\/jlb.3A0414-210R","article-title":"Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors","volume":"96","author":"Beury","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1189\/jlb.0708446","article-title":"Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4","volume":"85","author":"Bunt","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1158\/0008-5472.CAN-13-2347","article-title":"HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells","volume":"74","author":"Parker","year":"2014","journal-title":"Cancer Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"977","DOI":"10.4049\/jimmunol.179.2.977","article-title":"Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response","volume":"179","author":"Sinha","year":"2007","journal-title":"J. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1158\/0008-5472.CAN-05-1299","article-title":"Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host","volume":"66","author":"Huang","year":"2006","journal-title":"Cancer Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"104254","DOI":"10.1016\/j.cellimm.2020.104254","article-title":"IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy","volume":"359","author":"Weber","year":"2021","journal-title":"Cell Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ccell.2019.02.009","article-title":"Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets","volume":"35","author":"Cassetta","year":"2019","journal-title":"Cancer Cell."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Vankerckhoven, A., Wouters, R., Mathivet, T., Ceusters, J., Baert, T., Van Hoylandt, A., Gerhardt, H., Vergote, I., and Coosemans, A. (2020). Opposite Macrophage Polarization in Different Subsets of Ovarian Cancer: Observation from a Pilot Study. Cells, 9.","DOI":"10.3390\/cells9020305"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1757-2215-7-19","article-title":"A high M1\/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients","volume":"7","author":"Zhang","year":"2014","journal-title":"J. Ovarian Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/09513590.2019.1683821","article-title":"Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease","volume":"36","author":"Salmeri","year":"2020","journal-title":"Gynecol. Endocrinol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/6285813","article-title":"Serum and Ectopic Endometrium from Women with Endometriosis Modulate Macrophage M1\/M2 Polarization via the Smad2\/Smad3 Pathway","volume":"2018","author":"Nie","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2353\/ajpath.2009.081011","article-title":"Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease","volume":"175","author":"Bacci","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1084\/jem.20100587","article-title":"HIF-1\u03b1 regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment","volume":"207","author":"Corzo","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3389\/fimmu.2019.00771","article-title":"Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression","volume":"10","author":"Bruno","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.imbio.2019.07.002","article-title":"TGF-\u03b2 regulated leukemia cell susceptibility against NK targeting through the down-regulation of the CD48 expression","volume":"224","author":"Huang","year":"2019","journal-title":"Immunobiology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00262-018-2200-6","article-title":"Interactions among myeloid regulatory cells in cancer","volume":"68","author":"Umansky","year":"2019","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fimmu.2018.00398","article-title":"Targeting myeloid-derived suppressor cells to bypass tumor-induced immunosuppression","volume":"9","author":"Fleming","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.3390\/ijms19051468","article-title":"Immunomodulatory function of myeloid-derived suppressor cells during B cell-mediated immune response","volume":"19","author":"Lim","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s00018-019-03048-x","article-title":"Immunosenescence: The potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency","volume":"76","author":"Salminen","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"106352","DOI":"10.1016\/j.intimp.2020.106352","article-title":"Reduction of myeloid derived suppressor cells by inhibiting Notch pathway prevents the progression of endometriosis in mice model","volume":"82","author":"Jiang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Gupta, P., Chen, C., Chaluvally-Raghavan, P., and Pradeep, S. (2019). B cells as an immune-regulatory signature in ovarian cancer. Cancers, 11.","DOI":"10.3390\/cancers11070894"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/JCMA.0000000000000283","article-title":"Immunology and ovarian cancers","volume":"83","author":"Lee","year":"2020","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.imlet.2017.07.003","article-title":"Myeloid-derived suppressor cells modulate B-cell responses","volume":"188","author":"Lelis","year":"2017","journal-title":"Immunol. Lett."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.4049\/jimmunol.1500957","article-title":"Inhibition of B lymphopoiesis by adipocytes and IL-1\u2013producing myeloid-derived suppressor cells","volume":"195","author":"Kennedy","year":"2015","journal-title":"J. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jri.2017.09.001","article-title":"The role of the B lymphocytes in endometriosis: A systematic review","volume":"123","author":"Riccio","year":"2017","journal-title":"J. Reprod. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/09513590.2019.1655727","article-title":"High prevalence of autoimmune diseases in women with endometriosis: A case-control study","volume":"36","author":"Porpora","year":"2020","journal-title":"Gynecol Endocrinol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/humupd\/dmz014","article-title":"The association between endometriosis and autoimmune diseases: A systematic review and meta-analysis","volume":"25","author":"Shigesi","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.3389\/fimmu.2020.599117","article-title":"Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target","volume":"11","author":"Agostinis","year":"2021","journal-title":"Front. Immunol"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jri.2016.01.003","article-title":"Increased IL-25 levels in the peritoneal fluid of patients with endometriosis","volume":"114","author":"Bungum","year":"2016","journal-title":"J. Reprod. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/09513590.2017.1409717","article-title":"Expression of inflammatory cytokines in serum and peritoneal fluid from patients with different stages of endometriosis","volume":"34","author":"Fan","year":"2018","journal-title":"Gynecol. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejogrb.2017.08.019","article-title":"Extra pelvic endometriosis: Retrospective analysis on 200 cases in two different countries","volume":"217","author":"Matalliotakis","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jmig.2019.10.004","article-title":"Extrapelvic endometriosis: A systematic review","volume":"27","author":"Andres","year":"2020","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jmig.2012.03.005","article-title":"A case report of nasal endometriosis in a patient affected by Behcet\u2019s disease","volume":"19","author":"Mignemi","year":"2012","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00001703-199810000-00003","article-title":"Endometriosis: Abnormal endometrium and dysfunctional immune response","volume":"10","author":"Braun","year":"1998","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.biocel.2010.03.008","article-title":"Endometriosis: New concepts in the pathogenesis","volume":"42","author":"Signorile","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.gyobfe.2007.07.021","article-title":"Pathogen\u00e8se de l\u2019endom\u00e9triose","volume":"35","author":"Nisolle","year":"2007","journal-title":"Gynecol. Obstet. Fertil."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1749-6632.2011.05969.x","article-title":"Stem cells in endometrium and their role in the pathogenesis of endometriosis","volume":"1221","author":"Figueira","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/rmb2.12340","article-title":"Extra-pelvic endometriosis: A review","volume":"19","author":"Hirata","year":"2020","journal-title":"Reprod. Med. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-1596-8-194","article-title":"Extrapelvic endometriosis: A rare entity or an under diagnosed condition?","volume":"8","author":"Machairiotis","year":"2013","journal-title":"Diagn Pathol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1093\/humrep\/17.10.2715","article-title":"High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: A survey analysis","volume":"17","author":"Sinaii","year":"2002","journal-title":"Hum. Reprod."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5411\/wji.v4.i1.26","article-title":"Role of myeloid-derived suppressor cells in autoimmune disease","volume":"4","author":"Crook","year":"2014","journal-title":"World J. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.rbmo.2019.05.014","article-title":"CCR5\/CCR5 ligands induced myeloid-derived suppressor cells are related to the progression of endometriosis","volume":"39","author":"Guo","year":"2019","journal-title":"Reprod. Biomed. Online"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10456-017-9580-7","article-title":"Notch signaling controls sprouting angiogenesis of endometriotic lesions","volume":"21","author":"Gerstner","year":"2018","journal-title":"Angiogenesis"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1158\/0008-5472.CAN-17-0348","article-title":"CCR5+ myeloid-derived suppressor cells are enriched and activated in melanoma lesions","volume":"78","author":"Blattner","year":"2018","journal-title":"Cancer Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/humrep\/dei462","article-title":"Endometriosis and the risk of cancer with special emphasis on ovarian cancer","volume":"21","author":"Melin","year":"2006","journal-title":"Hum. Reprod."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ygyno.2016.07.095","article-title":"Endometriosis and risks for ovarian, endometrial and breast cancers: A nationwide cohort study","volume":"143","author":"Mogensen","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3332\/ecancer.2018.803","article-title":"Endometriosis and endometriosis-associated cancers: New insights into the molecular mechanisms of ovarian cancer development","volume":"12","author":"Dawson","year":"2018","journal-title":"Ecancermedicalscience"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Robinson, K.A., Menias, C.O., Chen, L., Schiappacasse, G., Shaaban, A.M., Caserta, M.P., Elsayes, K.M., VanBuren, W.M., and Bolan, C.W. (2020). Understanding malignant transformation of endometriosis: Imaging features with pathologic correlation. Abdom. Radiol., 1\u201314.","DOI":"10.1007\/s00261-019-01914-7"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ajog.2015.03.044","article-title":"New insights in the pathophysiology of ovarian cancer and implications for screening and prevention","volume":"213","author":"Nezhat","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2013.00009","article-title":"Endometriosis, a disease of the macrophage","volume":"4","author":"Capobianco","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_79","first-page":"1707","article-title":"Allelotyping of Endometriosis with Adjacent Ovarian Carcinoma Reveals Evidence of a Common Lineage","volume":"58","author":"Jiang","year":"1998","journal-title":"Cancer Res."},{"key":"ref_80","first-page":"11","article-title":"Endometriosis and ovarian cancer: An integrative review (endometriosis and ovarian cancer)","volume":"18","author":"Brilhante","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0140-6736(18)32552-2","article-title":"Epithelial ovarian cancer","volume":"393","author":"Lheureux","year":"2019","journal-title":"Lancet"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ygyno.2012.05.007","article-title":"Unraveling the two entities of endometrioid ovarian cancer: A single center clinical experience","volume":"126","author":"Mangili","year":"2012","journal-title":"Gynecol. Oncol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ygyno.2020.02.011","article-title":"An integrated molecular profile of endometrioid ovarian cancer","volume":"157","author":"Pierson","year":"2020","journal-title":"Gynecol. Oncol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.21037\/atm-20-3022a","article-title":"Endometriosis-associated ovarian carcinomas: Insights into pathogenesis, diagnostics, and therapeutic targets\u2014A narrative review","volume":"8","author":"Samartzis","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/2162402X.2016.1277308","article-title":"Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1\/PD-L1 expression","volume":"6","author":"Howitt","year":"2017","journal-title":"Oncoimmunology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ygyno.2016.11.045","article-title":"Identification of novel mutations in Japanese ovarian clear cell carcinoma patients using optimized targeted NGS for clinical diagnosis","volume":"144","author":"Maru","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Boussios, S., Mikropoulos, C., Samartzis, E., Karihtala, P., Moschetta, M., Sheriff, M., and Pavlidis, N. (2020). Wise management of ovarian cancer: On the cutting edge. J. Pers. Med., 10.","DOI":"10.3390\/jpm10020041"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1055\/a-0717-5411","article-title":"Low-grade serous ovarian carcinoma","volume":"78","author":"Ricciardi","year":"2018","journal-title":"Geburtshilfe Frauenheilkd."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00428-016-2040-8","article-title":"Ovarian borderline tumors in the 2014 WHO classification: Evolving concepts and diagnostic criteria","volume":"470","author":"Hauptmann","year":"2017","journal-title":"Virchows Arch."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.anndiagpath.2017.01.002","article-title":"Seromucinous ovarian tumor A comparison with the rest of ovarian epithelial tumors","volume":"27","author":"Karpathiou","year":"2017","journal-title":"Ann. Diagn. Pathol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2147\/IJWH.S258478","article-title":"Ultraconservative, Fertility Sparing Treatment of Bilateral Borderline Ovarian Tumors: A Case Report of a 26-Year-Old, 0-Gravida with an Endometrioid Borderline Ovarian Tumor of the Right Ovary and a Sero-Mucinous Borderline Ovarian Tumor of the Left Ovary and a Review of the Literature","volume":"12","author":"Verta","year":"2020","journal-title":"Int. J. Womens Health"},{"key":"ref_92","first-page":"190","article-title":"Endometriosis-associated ovarian neoplasia","volume":"50","author":"Stewart","year":"2018","journal-title":"Pathology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccr.2005.02.013","article-title":"Smoldering and polarized inflammation in the initiation and promotion of malignant disease","volume":"7","author":"Balkwill","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.3389\/fimmu.2019.01608","article-title":"A Call for Epidemiological Research on Myeloid-Derived Suppressor Cells in Ovarian Cancer: A Review of the Existing Immunological Evidence and Suggestions for Moving Forward","volume":"10","author":"Stenzel","year":"2019","journal-title":"Front. Immunol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/3\/677\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:37:46Z","timestamp":1760161066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/3\/677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,18]]},"references-count":94,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["cells10030677"],"URL":"https:\/\/doi.org\/10.3390\/cells10030677","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,18]]}}}