{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:03:35Z","timestamp":1791435815094,"version":"4.3.3"},"reference-count":264,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01 EY026547"],"award-info":[{"award-number":["R01 EY026547"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"name":"P30","award":["EY025580"],"award-info":[{"award-number":["EY025580"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The extracellular matrix (ECM) plays a crucial role in all parts of the eye, from maintaining clarity and hydration of the cornea and vitreous to regulating angiogenesis, intraocular pressure maintenance, and vascular signaling. This review focuses on the interactions of the ECM for homeostasis of normal physiologic functions of the cornea, vitreous, retina, retinal pigment epithelium, Bruch\u2019s membrane, and choroid as well as trabecular meshwork, optic nerve, conjunctiva and tenon\u2019s layer as it relates to glaucoma. A variety of pathways and key factors related to ECM in the eye are discussed, including but not limited to those related to transforming growth factor-\u03b2, vascular endothelial growth factor, basic-fibroblastic growth factor, connective tissue growth factor, matrix metalloproteinases (including MMP-2 and MMP-9, and MMP-14), collagen IV, fibronectin, elastin, canonical signaling, integrins, and endothelial morphogenesis consistent of cellular activation-tubulogenesis and cellular differentiation-stabilization. Alterations contributing to disease states such as wound healing, diabetes-related complications, Fuchs endothelial corneal dystrophy, angiogenesis, fibrosis, age-related macular degeneration, retinal detachment, and posteriorly inserted vitreous base are also reviewed.<\/jats:p>","DOI":"10.3390\/cells10030687","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T22:00:37Z","timestamp":1616364037000},"page":"687","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Cell\u2013Matrix Interactions in the Eye: From Cornea to Choroid"],"prefix":"10.3390","volume":"10","author":[{"given":"Andrew E.","family":"Pouw","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa Hospitals &amp; Clinics, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Greiner","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa Hospitals &amp; Clinics, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razek G.","family":"Coussa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa Hospitals &amp; Clinics, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa Hospitals &amp; Clinics, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-727X","authenticated-orcid":false,"given":"Ian C.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa Hospitals &amp; Clinics, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Skeie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa Hospitals &amp; Clinics, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0377-0479","authenticated-orcid":false,"given":"John H.","family":"Fingert","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa Hospitals &amp; Clinics, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-0891","authenticated-orcid":false,"given":"Robert F.","family":"Mullins","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa Hospitals &amp; Clinics, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3778-9362","authenticated-orcid":false,"given":"Elliott H.","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa Hospitals &amp; Clinics, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.exer.2014.07.001","article-title":"Extracellular matrix remodeling during retinal development","volume":"133","author":"Reinhard","year":"2015","journal-title":"Exp. 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