{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:00:53Z","timestamp":1768471253761,"version":"3.49.0"},"reference-count":68,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH 3UTGM13-175-02S1"],"award-info":[{"award-number":["NIH 3UTGM13-175-02S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"QOL Medical, LLC","award":["Unrestricted Research Grant"],"award-info":[{"award-number":["Unrestricted Research Grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Nonsteroidal anti-inflammatory drugs cause gastric ulcers and gastritis. No drug that treats GI injury directly stimulates mucosal healing. ZINC40099027 (ZN27) activates focal adhesion kinase (FAK) and heals acute indomethacin-induced small bowel injury. We investigated the efficacy of ZN27 in rat and human gastric epithelial cells and ongoing aspirin-associated gastric injury. ZN27 (10 nM) stimulated FAK activation and wound closure in rat and human gastric cell lines. C57BL\/6J mice were treated with 300 mg\/kg\/day aspirin for five days to induce ongoing gastric injury. One day after the initial injury, mice received 900 \u00b5g\/kg\/6 h ZN27, 10 mg\/kg\/day omeprazole, or 900 \u00b5g\/kg\/6 h ZN27 plus 10 mg\/kg\/day omeprazole. Like omeprazole, ZN27 reduced gastric injury vs. vehicle controls. ZN27-treated mice displayed better gastric architecture, with thicker mucosa and less hyperemia, inflammation, and submucosal edema, and lost less weight than vehicle controls. Gastric pH, serum creatinine, serum alanine aminotransferase (ALT), and renal and hepatic histology were unaffected by ZN27. Blinded scoring of pFAK-Y-397 immunoreactivity at the edge of ZN27-treated lesions demonstrated increased FAK activation, compared to vehicle-treated lesions, confirming target activation in vivo. These results suggest that ZN27 ameliorates ongoing aspirin-associated gastric mucosal injury by a pathway involving FAK activation. ZN27-derivatives may be useful to promote gastric mucosal repair.<\/jats:p>","DOI":"10.3390\/cells10040908","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T12:11:00Z","timestamp":1618488660000},"page":"908","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["ZINC40099027 Promotes Gastric Mucosal Repair in Ongoing Aspirin-Associated Gastric Injury by Activating Focal Adhesion Kinase"],"prefix":"10.3390","volume":"10","author":[{"given":"Sema","family":"Oncel","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of North Dakota School of Medicine &amp; Health Sciences, Grand Forks, ND 58203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of North Dakota School of Medicine &amp; Health Sciences, Grand Forks, ND 58203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinggang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of North Dakota School of Medicine &amp; Health Sciences, Grand Forks, ND 58203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9696-2789","authenticated-orcid":false,"given":"Marc D.","family":"Basson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of North Dakota School of Medicine &amp; Health Sciences, Grand Forks, ND 58203, USA"},{"name":"Department of Surgery, University of North Dakota School of Medicine &amp; Health Sciences, Grand Forks, ND 58203, USA"},{"name":"Department of Pathology, University of North Dakota School of Medicine &amp; Health Sciences, Grand Forks, ND 58203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2147\/JPR.S156938","article-title":"Coprescribing Proton-Pump Inhibitors with Nonsteroidal Anti-Inflammatory Drugs: Risks versus Benefits","volume":"11","author":"Gwee","year":"2018","journal-title":"J. Pain Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00535-009-0102-2","article-title":"Present Status and Strategy of NSAIDs-Induced Small Bowel Injury","volume":"44","author":"Higuchi","year":"2009","journal-title":"J. Gastroenterol."},{"key":"ref_3","first-page":"1749","article-title":"Prevalence and Incidence of NSAID-Induced Gastrointestinal Ulcers and Bleeding","volume":"65","author":"Yamagata","year":"2007","journal-title":"Nippon rinsho. Jpn. J. Clin. Med."},{"key":"ref_4","first-page":"1","article-title":"Quantifying the Impact of NSAID-Associated Adverse Events","volume":"19","author":"Fine","year":"2013","journal-title":"Am. J. Manag. Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1152\/physrev.00004.2008","article-title":"Prostaglandins, NSAIDs, and Gastric Mucosal Protection: Why Doesn\u2019t the Stomach Digest Itself?","volume":"88","author":"Wallace","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1476-5381.2011.01509.x","article-title":"NSAID Gastropathy and Enteropathy: Distinct Pathogenesis Likely Necessitates Distinct Prevention Strategies","volume":"165","author":"Wallace","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1152\/ajpgi.00387.2009","article-title":"Effect of Indomethacin on Bile Acid-Phospholipid Interactions: Implication for Small Intestinal Injury Induced by Nonsteroidal Anti-Inflammatory Drugs","volume":"298","author":"Zhou","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_8","first-page":"789","article-title":"Hierarchies of Healing in Gut Mucosal Injury","volume":"68","author":"Basson","year":"2017","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.biopha.2018.10.118","article-title":"Spirulina Ameliorates Aspirin-Induced Gastric Ulcer in Albino Mice by Alleviating Oxidative Stress and Inflammation","volume":"109","author":"Mahmoud","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3164\/jcbn.13-84","article-title":"The Impact of Non-Steroidal Anti-Inflammatory Drugs on the Small Intestinal Epithelium","volume":"54","author":"Handa","year":"2014","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.mayocp.2014.07.015","article-title":"Nonsteroidal Anti-Inflammatory Drugs, Proton Pump Inhibitors, and Gastrointestinal Injury: Contrasting Interactions in the Stomach and Small Intestine","volume":"89","author":"Marlicz","year":"2014","journal-title":"Mayo Clin. Proc."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Owen, K.A., Abshire, M.Y., Tilghman, R.W., Casanova, J.E., and Bouton, A.H. (2011). FAK Regulates Intestinal Epithelial Cell Survival and Proliferation during Mucosal Wound Healing. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023123"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1111\/febs.14195","article-title":"Focal Adhesions: A Personal Perspective on a Half Century of Progress","volume":"284","author":"Burridge","year":"2017","journal-title":"FEBS J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1091\/mbc.7.8.1209","article-title":"Inhibition of Focal Adhesion Kinase (FAK) Signaling in Focal Adhesions Decreases Cell Motility and Proliferation","volume":"7","author":"Gilmore","year":"1996","journal-title":"Mol. Biol. Cell"},{"key":"ref_15","first-page":"952","article-title":"Human Caco-2 Motility Redistributes FAK and Paxillin and Activates P38 MAPK in a Matrix-Dependent Manner","volume":"278","author":"Yu","year":"2000","journal-title":"Am. J. Physiol."},{"key":"ref_16","first-page":"119","article-title":"Restitution at the Cellular Level: Regulation of the Migrating Phenotype","volume":"69","author":"Basson","year":"1996","journal-title":"Yale J. Biol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"E1380","DOI":"10.1073\/pnas.1218446110","article-title":"Enterocyte Loss of Polarity and Gut Wound Healing Rely upon the F-Actin-Severing Function of Villin","volume":"110","author":"Ubelmann","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1073\/pnas.1312076111","article-title":"Theory of Epithelial Sheet Morphology in Three Dimensions","volume":"111","author":"Hannezo","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/1097-0029(20001015)51:2<191::AID-JEMT10>3.0.CO;2-1","article-title":"Matrix-Specific FAK and MAPK Reorganization during Caco-2 Cell Motility","volume":"51","author":"Yu","year":"2000","journal-title":"Microsc. Res. Tech."},{"key":"ref_20","first-page":"1","article-title":"Identification of Potential Small-Molecule Protein-Protein Inhibitors of Cancer Metastasis by 3D Epitope-Based Computational Screening","volume":"69","author":"Raschka","year":"2018","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_21","unstructured":"More, S.K., Wang, Q., Vomhof-DeKrey, E.E., Porter, J.E., and Basson, M.D. (2021). ZINC40099027 Activates Human Focal Adhesion Kinase by Accelerating the Enzymatic Activity of the FAK Kinase Domain. Pharmacol. Res. Perspect."},{"key":"ref_22","first-page":"1","article-title":"Small Molecule FAK Activator Promotes Human Intestinal Epithelial Monolayer Wound Closure and Mouse Ulcer Healing","volume":"9","author":"Wang","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_23","first-page":"5251","article-title":"ZINC4085554 Inhibits Cancer Cell Adhesion by Interfering with the Interaction of Akt1 and FAK","volume":"17","author":"More","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1172\/JCI115828","article-title":"Human Enterocyte (Caco-2) Migration Is Modulated in Vitro by Extracellular Matrix Composition and Epidermal Growth Factor","volume":"90","author":"Basson","year":"1992","journal-title":"J. Clin. Invest."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/10915810600961531","article-title":"Nonclinical Vehicle Use in Studies by Multiple Routes in Multiple Species","volume":"25","author":"Gad","year":"2006","journal-title":"Int. J. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/1056-8719(95)00027-F","article-title":"A New Technique for Continuous Measurement and Recording of Gastric Potential Difference in the Rat: Evaluation of NSAID-Induced Gastric Mucosal Damage","volume":"34","author":"Scarpignato","year":"1995","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s13765-012-2004-x","article-title":"Effect of Decursinol on the Aspirin-Induced Gastric Ulcer in Mice","volume":"55","author":"Choi","year":"2012","journal-title":"J. Korean Soc. Appl. Biol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF00351774","article-title":"Distention Ulcer as a Model for Testing of Drugs for Ulcerogenic Side Effects","volume":"41","author":"Szelenyi","year":"1978","journal-title":"Arch. Toxicol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Brenneman, K.E., Willingham, C., Kilbourne, J.A., Curtiss, R., and Roland, K.L. (2014). A Low Gastric PH Mouse Model to Evaluate Live Attenuated Bacterial Vaccines. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0087411"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1211\/jpp.60.1.0008","article-title":"Measurements of Rat and Mouse Gastrointestinal PH, Fluid and Lymphoid Tissue, and Implications for in-Vivo Experiments","volume":"60","author":"McConnell","year":"2008","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1002\/jps.23212","article-title":"Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Acetylsalicylic Acid","volume":"101","author":"Dressman","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"ref_32","first-page":"57","article-title":"A Reproducible Scoring System for Quantification of Histologic Lesions of Inflammatory Disease in Mouse Gastric Epithelium","volume":"57","author":"Eaton","year":"2007","journal-title":"Comp. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/0016-5085(86)90865-6","article-title":"Does Sucralfate Affect the Normal Gastric Mucosa? Histologic, Ultrastructural, and Functional Assessment in the Rat","volume":"90","author":"Tarnawski","year":"1986","journal-title":"Gastroenterology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.cell.2016.11.052","article-title":"In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming","volume":"167","author":"Ocampo","year":"2016","journal-title":"Cell"},{"key":"ref_35","first-page":"11","article-title":"Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats","volume":"54","author":"Wang","year":"2011","journal-title":"Yonago Acta Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1053\/bega.2001.0229","article-title":"Pathogenesis of NSAID-Induced Gastroduodenal Mucosal Injury","volume":"15","author":"Wallace","year":"2001","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12325-019-01144-9","article-title":"Ibuprofen Safety at the Golden Anniversary: Are All NSAIDs the Same? A Narrative Review","volume":"37","author":"Varrassi","year":"2020","journal-title":"Adv. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Vonkeman, H.E., and van de Laar, M.A.F.J. (2010). Nonsteroidal Anti-Inflammatory Drugs: Adverse Effects and Their Prevention. Semin. Arthr. Rheum., 34.","DOI":"10.1016\/j.semarthrit.2008.08.001"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1574-695X.1999.tb01277.x","article-title":"Chronic Gastrointestinal Inflammation","volume":"24","author":"Bamford","year":"1999","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_40","first-page":"1","article-title":"The Management of Acute and Chronic Pancreatitis","volume":"6","author":"Banks","year":"2010","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_41","first-page":"3899","article-title":"Functional Analysis of Focal Adhesion Kinase (FAK) Reduction by Small Inhibitory RNAs","volume":"24","author":"Han","year":"2004","journal-title":"Anticancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ncb1094","article-title":"FAK-Src Signalling through Paxillin, ERK and MLCK Regulates Adhesion Disassembly","volume":"6","author":"Webb","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1152\/ajpgi.00292.2005","article-title":"Focal Adhesion Kinase Protein Levels in Gut Epithelial Motility","volume":"291","author":"Basson","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00441-009-0776-z","article-title":"Role of ERK\/MTOR Signaling in TGF\u03b2-Modulated Focal Adhesion Kinase MRNA Stability and Protein Synthesis in Cultured Rat IEC-6 Intestinal Epithelial Cells","volume":"336","author":"Suer","year":"2009","journal-title":"Cell Tissue Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bbagrm.2008.11.002","article-title":"TGF-\u03921 Modulates Focal Adhesion Kinase Expression in Rat Intestinal Epithelial IEC-6 Cells via Stimulatory and Inhibitory Smad Binding Elements","volume":"1789","author":"Walsh","year":"2009","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2353\/ajpath.2008.070729","article-title":"Transforming Growth Factor-\u03b2 Stimulates Intestinal Epithelial Focal Adhesion Kinase Synthesis via Smad- and P38-Dependent Mechanisms","volume":"173","author":"Walsh","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e2304","DOI":"10.1038\/cddis.2016.218","article-title":"Proton Pump Inhibitors Protect Mice from Acute Systemic Inflammation and Induce Long-Term Cross-Tolerance","volume":"7","author":"Balza","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.expneurol.2009.02.002","article-title":"Proton Pump Inhibitors Exert Anti-Inflammatory Effects and Decrease Human Microglial and Monocytic THP-1 Cell Neurotoxicity","volume":"217","author":"Hashioka","year":"2009","journal-title":"Exp. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellsig.2017.06.012","article-title":"Focal Adhesion Kinase Signaling Regulates Anti-Inflammatory Function of Bone Marrow Mesenchymal Stromal Cells Induced by Biomechanical Force","volume":"38","author":"Lee","year":"2017","journal-title":"Cell. Signal."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-019-1265-1","article-title":"The Roles of Nuclear Focal Adhesion Kinase (FAK) on Cancer: A Focused Review","volume":"38","author":"Zhou","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cyto.2018.08.009","article-title":"Interleukin 33 Regulates Gene Expression in Intestinal Epithelial Cells Independently of Its Nuclear Localization","volume":"111","author":"He","year":"2018","journal-title":"Cytokine"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nri.2016.95","article-title":"Interleukin-33 in Health and Disease","volume":"16","author":"Liew","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4049\/jimmunol.1401414","article-title":"Focal Adhesion Kinase\u2013Mediated Activation of Glycogen Synthase Kinase 3\u03b2 Regulates IL-33 Receptor Internalization and IL-33 Signaling","volume":"194","author":"Zhao","year":"2015","journal-title":"J. Immunol."},{"key":"ref_54","first-page":"1","article-title":"Chemotactic Antiviral Cytokines Promote Infectious Apical Entry of Human Adenovirus into Polarized Epithelial Cells","volume":"2","author":"Boucke","year":"2011","journal-title":"Nat. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neo.2016.03.003","article-title":"PIAS1-FAK Interaction Promotes the Survival and Progression of Non-Small Cell Lung Cancer","volume":"18","author":"Constanzo","year":"2016","journal-title":"Neoplasia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s13402-016-0304-6","article-title":"Targeting CXCR4 and FAK Reverses Doxorubicin Resistance and Suppresses Invasion in Non-Small Cell Lung Carcinoma","volume":"40","author":"Dragoj","year":"2017","journal-title":"Cell. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cellsig.2017.12.008","article-title":"HBP Induces the Expression of Monocyte Chemoattractant Protein-1 via the FAK\/PI3K\/AKT and P38 MAPK\/NF-\u039aB Pathways in Vascular Endothelial Cells","volume":"43","author":"Chang","year":"2018","journal-title":"Cell. Signal."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mvr.2011.06.015","article-title":"Neutrophil Transmigration, Focal Adhesion Kinase and Endothelial Barrier Function","volume":"83","author":"Yuan","year":"2012","journal-title":"Microvasc. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"18427","DOI":"10.1074\/jbc.M113.540294","article-title":"Interactions of the Protein-Tyrosine Phosphatase-\u03b1 with the Focal Adhesion Targeting Domain of Focal Adhesion Kinase Are Involved in Interleukin-1 Signaling in Fibroblasts","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"7393","DOI":"10.4049\/jimmunol.174.11.7393","article-title":"Cross Talk between MyD88 and Focal Adhesion Kinase Pathways","volume":"174","author":"Zeisel","year":"2005","journal-title":"J. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.4049\/jimmunol.1301587","article-title":"Focal Adhesion Kinase Negatively Regulates Lck Function Downstream of the T Cell Antigen Receptor","volume":"191","author":"Chapman","year":"2013","journal-title":"J. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12026-014-8527-y","article-title":"Functions of the FAK Family Kinases in T Cells: Beyond Actin Cytoskeletal Rearrangement","volume":"59","author":"Chapman","year":"2014","journal-title":"Immunol. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"C1358","DOI":"10.1152\/ajpcell.00553.2003","article-title":"Extracellular Pressure Stimulates Macrophage Phagocytosis by Inhibiting a Pathway Involving FAK and ERK","volume":"286","author":"Shiratsuchi","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Owen, K.A., Meyer, C.B., Bouton, A.H., and Casanova, J.E. (2014). Activation of Focal Adhesion Kinase by Salmonella Suppresses Autophagy via an Akt\/MTOR Signaling Pathway and Promotes Bacterial Survival in Macrophages. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004159"},{"key":"ref_65","first-page":"31","article-title":"Gastrointestinal Injury Associated with NSAID Use: A Case Study and Review of Risk Factors and Preventative Strategies","volume":"7","author":"Goldstein","year":"2014","journal-title":"Drug. Healthc. Patient Saf."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1053\/j.gastro.2011.06.075","article-title":"Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis","volume":"141","author":"Wallace","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Blackler, R., Syer, S., Bolla, M., Ongini, E., and Wallace, J.L. (2012). Gastrointestinal-Sparing Effects of Novel Nsaids in Rats with Compromised Mucosal Defence. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035196"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s00535-018-1483-x","article-title":"A Case\u2013Control Study of the Risk of Upper Gastrointestinal Mucosal Injuries in Patients Prescribed Concurrent NSAIDs and Antithrombotic Drugs Based on Data from the Japanese National Claims Database of 13 Million Accumulated Patients","volume":"53","author":"Sugisaki","year":"2018","journal-title":"J. Gastroenterol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/4\/908\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:48:11Z","timestamp":1760161691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/4\/908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":68,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["cells10040908"],"URL":"https:\/\/doi.org\/10.3390\/cells10040908","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,15]]}}}