{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:25:20Z","timestamp":1792401920201,"version":"4.4.0"},"reference-count":72,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Many studies evaluated the functional role of adult hippocampal neurogenesis (AHN) and its key role in cognitive functions and mood regulation. The effects of promoting AHN on the recovery of stress-induced symptoms have been well studied, but its involvement in stress resilience remains elusive. We used a mouse model enabling us to foster AHN before the exposure to unpredictable chronic mild stress (UCMS) to evaluate the potential protective effects of AHN on stress, assessing the depressive-like phenotype and executive functions. For this purpose, an inducible transgenic mouse model was used to delete the pro-apoptotic gene Bax from neural progenitors four weeks before UCMS, whereby increasing the survival of adult-generated neurons. Our results showed that UCMS elicited a depressive-like phenotype, highlighted by a deteriorated coat state, a higher immobility duration in the tail suspension test (TST), and a delayed reversal learning in a water maze procedure. Promoting AHN before UCMS was sufficient to prevent the development of stressed-induced behavioral changes in the TST and the water maze, reflecting an effect of AHN on stress resilience. Taken together, our data suggest that increasing AHN promotes stress resilience on some depressive-like symptoms but also in cognitive symptoms, which are often observed in MD.<\/jats:p>","DOI":"10.3390\/cells10050972","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T12:47:07Z","timestamp":1619009227000},"page":"972","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression"],"prefix":"10.3390","volume":"10","author":[{"given":"Barbara","family":"Planchez","sequence":"first","affiliation":[{"name":"UMR 1253, iBrain, Universit\u00e9 de Tours, Inserm, CEDEX 1, 37032 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4847-9578","authenticated-orcid":false,"given":"Natalia","family":"Lagunas","sequence":"additional","affiliation":[{"name":"UMR 1253, iBrain, Universit\u00e9 de Tours, Inserm, CEDEX 1, 37032 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Le Guisquet","sequence":"additional","affiliation":[{"name":"UMR 1253, iBrain, Universit\u00e9 de Tours, Inserm, CEDEX 1, 37032 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Legrand","sequence":"additional","affiliation":[{"name":"UMR 1253, iBrain, Universit\u00e9 de Tours, Inserm, CEDEX 1, 37032 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0333-4634","authenticated-orcid":false,"given":"Alexandre","family":"Surget","sequence":"additional","affiliation":[{"name":"UMR 1253, iBrain, Universit\u00e9 de Tours, Inserm, CEDEX 1, 37032 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Hen","sequence":"additional","affiliation":[{"name":"Departments of Neuroscience, Psychiatry &amp; Pharmacology, Columbia University, New York, NY 10027, USA"},{"name":"Division of Integrative Neuroscience, Department of Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA"},{"name":"Kavli Institute for Brain Sciences, Columbia University, New York, NY 10027, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Belzung","sequence":"additional","affiliation":[{"name":"UMR 1253, iBrain, Universit\u00e9 de Tours, Inserm, CEDEX 1, 37032 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1176\/appi.ajp.163.1.28","article-title":"Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: Implications for clinical practice","volume":"163","author":"Trivedi","year":"2006","journal-title":"Am. 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