{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:22:03Z","timestamp":1793053323041,"version":"4.5.0"},"reference-count":158,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T00:00:00Z","timestamp":1619222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI140405"],"award-info":[{"award-number":["R01 AI140405"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Obesity is characterized as a complex and multifactorial excess accretion of adipose tissue (AT) accompanied with alterations in the immune response that affects virtually all age and socioeconomic groups around the globe. The abnormal accumulation of AT leads to several metabolic diseases, including nonalcoholic fatty liver disorder (NAFLD), low-grade inflammation, type 2 diabetes mellitus (T2DM), cardiovascular disorders (CVDs), and cancer. AT is an endocrine organ composed of adipocytes and immune cells, including B-Cells, T-cells and macrophages. These immune cells secrete various cytokines and chemokines and crosstalk with adipokines to maintain metabolic homeostasis and low-grade chronic inflammation. A novel form of adipokines, microRNA (miRs), is expressed in many developing peripheral tissues, including ATs, T-cells, and macrophages, and modulates the immune response. miRs are essential for insulin resistance, maintaining the tumor microenvironment, and obesity-associated inflammation (OAI). The abnormal regulation of AT, T-cells, and macrophage miRs may change the function of different organs including the pancreas, heart, liver, and skeletal muscle. Since obesity and inflammation are closely associated, the dysregulated expression of miRs in inflammatory adipocytes, T-cells, and macrophages suggest the importance of miRs in OAI. Therefore, in this review article, we have elaborated the role of miRs as epigenetic regulators affecting adipocyte differentiation, immune response, AT browning, adipogenesis, lipid metabolism, insulin resistance (IR), glucose homeostasis, obesity, and metabolic disorders. Further, we will discuss a set of altered miRs as novel biomarkers for metabolic disease progression and therapeutic targets for obesity.<\/jats:p>","DOI":"10.3390\/cells10051004","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T21:49:20Z","timestamp":1619300960000},"page":"1004","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Adipocyte, Immune Cells, and miRNA Crosstalk: A Novel Regulator of Metabolic Dysfunction and Obesity"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1902-3451","authenticated-orcid":false,"given":"Sonia","family":"Kiran","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center (UTHSC), 881 Madison Avenue, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9741-3597","authenticated-orcid":false,"given":"Vijay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center (UTHSC), 881 Madison Avenue, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7846-5674","authenticated-orcid":false,"given":"Santosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center (UTHSC), 881 Madison Avenue, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, University of South Carolina, Columbia, SC 29208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7048-4325","authenticated-orcid":false,"given":"Udai P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center (UTHSC), 881 Madison Avenue, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.metabol.2018.11.014","article-title":"Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics","volume":"92","author":"Polyzos","year":"2019","journal-title":"Metabolism"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sun, L., Cai, J., and Gonzalez, F.J. (2021). The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer. Nat. Rev. Gastroenterol. Hepatol., 1\u201313.","DOI":"10.1038\/s41575-020-00404-2"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"600824","DOI":"10.3389\/fonc.2020.600824","article-title":"Type 2 Diabetes, Obesity, and Cancer Share Some Common and Critical Pathways","volume":"10","author":"Rahman","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"626155","DOI":"10.3389\/fphar.2021.626155","article-title":"The Role of Periprostatic Adipose Tissue on Prostate Function in Vascular-Related Disorders","volume":"12","author":"Passos","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.3390\/ijms15046184","article-title":"Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease","volume":"15","author":"Jung","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"C375","DOI":"10.1152\/ajpcell.00379.2020","article-title":"Adipose tissue inflammation and metabolic dysfunction in obesity","volume":"320","author":"Kawai","year":"2021","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.3389\/fimmu.2018.02556","article-title":"Innate Lymphocytes in Adipose Tissue Homeostasis and Their Alterations in Obesity and Colorectal Cancer","volume":"9","author":"Conti","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nrendo.2017.141","article-title":"Specialized macrophages contribute to obesity","volume":"13","author":"Bradley","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fendo.2017.00293","article-title":"Obesity and Breast Cancer: Current Insights on the Role of Fatty Acids and Lipid Metabolism in Promoting Breast Cancer Growth and Progression","volume":"8","author":"Stadler","year":"2017","journal-title":"Front. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.2337\/dc08-0911","article-title":"Adult Metabolic Syndrome and Impaired Glucose Tolerance Are Associated With Different Patterns of BMI Gain During Infancy: Data from the New Delhi birth cohort","volume":"31","author":"Fall","year":"2008","journal-title":"Diabetes Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"ref_12","first-page":"242","article-title":"Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity","volume":"519","author":"Brestoff","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20121964","article-title":"Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages","volume":"210","author":"Molofsky","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1161\/CIRCRESAHA.110.218867","article-title":"Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice","volume":"107","author":"Miller","year":"2010","journal-title":"Circ. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.immuni.2016.06.016","article-title":"Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance","volume":"45","author":"Rapp","year":"2016","journal-title":"Immunity"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.cmet.2014.05.009","article-title":"IL-6 Strikes a Balance in Metabolic Inflammation","volume":"19","author":"Covarrubias","year":"2014","journal-title":"Cell Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jacc.2008.05.060","article-title":"Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Related Cardiovascular Disease","volume":"52","author":"Martin","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.febslet.2007.11.051","article-title":"TNF-\u03b1 and adipocyte biology","volume":"582","author":"Cawthorn","year":"2007","journal-title":"FEBS Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1476-5381.2011.01369.x","article-title":"Resistin: Functional roles and therapeutic considerations for cardiovascular disease","volume":"165","author":"Jamaluddin","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2012.06.018","article-title":"Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes","volume":"60","author":"Panee","year":"2012","journal-title":"Cytokine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/CIRCULATIONAHA.106.638379","article-title":"T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity","volume":"115","author":"Wu","year":"2007","journal-title":"Circulation"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1002\/eji.1830230950","article-title":"Increased cytokine production in mononuclear cells of healthy elderly people","volume":"23","author":"Fagiolo","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wei, Y., Zhu, M., and Schober, A. (2018). Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061756"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/s41366-018-0114-1","article-title":"MicroRNA-30 modulates metabolic inflammation by regulating Notch signaling in adipose tissue macrophages","volume":"42","author":"Miranda","year":"2018","journal-title":"Int. J. Obes."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4103\/0973-029X.140762","article-title":"MicroRNAs\u2014Biology and clinical applications","volume":"18","author":"Ranganathan","year":"2014","journal-title":"J. Oral Maxillofac. Pathol. JOMFP"},{"key":"ref_27","first-page":"835","article-title":"Mammalian microRNAs predominantly act to decrease target mRNA levels","volume":"466","author":"Guo","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrclinonc.2011.76","article-title":"MicroRNAs in body fluids\u2014the mix of hormones and biomarkers","volume":"8","author":"Cortez","year":"2011","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.bbamcr.2010.06.013","article-title":"MicroRNAs: Synthesis, mechanism, function, and recent clinical trials","volume":"1803","author":"Wahid","year":"2010","journal-title":"Biochim. et Biophys. Acta (BBA) Bioenerg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1038\/s41467-018-07786-7","article-title":"miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression","volume":"9","author":"Valdmanis","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Deng, Z., Chen, J.-F., and Wang, D.-Z. (2011). Transgenic overexpression of miR-133a in skeletal muscle. BMC Musculoskelet. Disord., 12.","DOI":"10.1186\/1471-2474-12-115"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Iannone, F., Montesanto, A., Cione, E., Crocco, P., Caroleo, M.C., Dato, S., Rose, G., and Passarino, G. (2020). Expression Patterns of Muscle-Specific miR-133b and miR-206 Correlate with Nutritional Status and Sarcopenia. Nutrients, 12.","DOI":"10.3390\/nu12020297"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.devcel.2009.10.013","article-title":"A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance","volume":"17","author":"Quiat","year":"2009","journal-title":"Dev. Cell"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Nachtigall, P.G., Dias, M.C., Carvalho, R.F., Martins, C., and Pinhal, D. (2015). MicroRNA-499 Expression Distinctively Correlates to Target Genes sox6 and rod1 Profiles to Resolve the Skeletal Muscle Phenotype in Nile Tilapia. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0119804"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fphys.2013.00080","article-title":"Muscle-enriched microRNA miR-486 decreases in circulation in response to exercise in young men","volume":"4","author":"Aoi","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ng1725","article-title":"The Role of MicroRNA-1 and MicroRNA-133 in Skeletal Muscle Proliferation and Differentiation","volume":"38","author":"Chen","year":"2005","journal-title":"Nat. Genet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000268088","article-title":"MicroRNAs miR-1, miR-133a, miR-133b and miR-208 Are Dysregulated in Human Myocardial Infarction","volume":"115","author":"Zidar","year":"2010","journal-title":"Cardiology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fncel.2015.00193","article-title":"An updated role of microRNA-124 in central nervous system disorders: A review","volume":"9","author":"Sun","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.04.004","article-title":"MicroRNA-mediated regulation of differentiation and trans-differentiation in stem cells","volume":"88","author":"Ong","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.gpb.2015.02.001","article-title":"Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function","volume":"13","author":"Zhang","year":"2015","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41580-020-0251-y","article-title":"RNA delivery by extracellular vesicles in mammalian cells and its applications","volume":"21","author":"Breyne","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/ijc.29417","article-title":"Extracellular vesicles as carriers of microRNA, proteins and lipids in tumor microenvironment","volume":"138","author":"Penfornis","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-60327-547-7_18","article-title":"Protein Components of the microRNA Pathway and Human Diseases","volume":"Volume 487","author":"Perron","year":"2009","journal-title":"Methods in Molecular Biology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"730","DOI":"10.4103\/1008-682X.155532","article-title":"Extracellular microRNAs from the epididymis as potential mediators of cell-to-cell communication","volume":"17","year":"2015","journal-title":"Asian J. Androl."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Chartoumpekis, D.V., Zaravinos, A., Ziros, P.G., Iskrenova, R.P., Psyrogiannis, A.I., Kyriazopoulou, V.E., and Habeos, I.G. (2012). Differential Expression of MicroRNAs in Adipose Tissue after Long-Term High-Fat Diet-Induced Obesity in Mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034872"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ortega, F.J., Moreno-Navarrete, J.M., Pardo, G., Sabater, M., Hummel, M., Ferrer, A., Rodriguez-Hermosa, J.I., Ruiz, B., Ricart, W., and Peral, B. (2010). MiRNA Expression Profile of Human Subcutaneous Adipose and during Adipocyte Differentiation. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009022"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"E846","DOI":"10.1210\/jc.2010-2701","article-title":"Differential miRNA Expression in Omental Adipose Tissue and in the Circulation of Obese Patients Identifies Novel Metabolic Biomarkers","volume":"96","author":"Heneghan","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.2337\/db11-1508","article-title":"Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity","volume":"61","author":"Arner","year":"2012","journal-title":"Diabetes"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Parra, P., Serra, F., and Palou, A. (2010). Expression of Adipose MicroRNAs Is Sensitive to Dietary Conjugated Linoleic Acid Treatment in Mice. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013005"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1210\/me.2009-0117","article-title":"MicroRNA 132 Regulates Nutritional Stress-Induced Chemokine Production through Repression of SirT","volume":"23","author":"Strum","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1210\/en.2012-1623","article-title":"MicroRNAs Regulated by Adiponectin as Novel Targets for Controlling Adipose Tissue Inflammation","volume":"153","author":"Ge","year":"2012","journal-title":"Endocrinology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"990","DOI":"10.4049\/jimmunol.1000793","article-title":"Costimulation-Dependent Expression of MicroRNA-214 Increases the Ability of T Cells To Proliferate by Targeting Pten","volume":"185","author":"Jindra","year":"2010","journal-title":"J. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1101\/gad.1522907","article-title":"Dynamic regulation of miRNA expression in ordered stages of cellular development","volume":"21","author":"Neilson","year":"2007","journal-title":"Genes Dev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.imlet.2019.05.010","article-title":"Increased levels of adipose tissue-resident Th17 cells in obesity associated with miR-326","volume":"211","year":"2019","journal-title":"Immunol. Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"20176","DOI":"10.1038\/srep20176","article-title":"miR-150 regulates obesity-associated insulin resistance by controlling B cell functions","volume":"6","author":"Ying","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Metere, A., Graves, C.E., Pietraforte, D., and Casella, G. (2020). The Effect of Sleeve Gastrectomy on Oxidative Stress in Obesity. Biomedicines, 8.","DOI":"10.3390\/biomedicines8060168"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative Stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1096\/fj.08-114553","article-title":"Regulation of the phagocyte NADPH oxidase activity: Phosphorylation of gp91 phox \/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67 phox, and p47 phox","volume":"23","author":"Raad","year":"2008","journal-title":"FASEB J."},{"key":"ref_60","first-page":"11192","article-title":"MiR-133b inhibits MPP+-induced apoptosis in Parkinson\u2019s disease model by inhibiting the ERK1\/2 signaling pathway","volume":"24","author":"Dong","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/acel.12135","article-title":"Elevated microRNA-34a in obesity reduces NAD+levels and SIRT1 activity by directly targeting NAMPT","volume":"12","author":"Choi","year":"2013","journal-title":"Aging Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1161\/CIRCULATIONAHA.109.864629","article-title":"MicroRNA 217 Modulates Endothelial Cell Senescence via Silent Information Regulator","volume":"120","author":"Menghini","year":"2009","journal-title":"Circulation"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.niox.2013.04.001","article-title":"Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol","volume":"32","author":"Xia","year":"2013","journal-title":"Nitric Oxide"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1161\/HYPERTENSIONAHA.112.197301","article-title":"Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase","volume":"60","author":"Sun","year":"2012","journal-title":"Hypertens."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s13287-017-0722-z","article-title":"MicroRNA-133 overexpression promotes the therapeutic efficacy of mesenchymal stem cells on acute myocardial infarction","volume":"8","author":"Chen","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","author":"Furukawa","year":"2004","journal-title":"J. Clin. Invest."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1182\/blood-2007-03-081133","article-title":"Interleukin-6\u2013dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer","volume":"110","author":"Pfeifer","year":"2007","journal-title":"Blood"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.molcel.2010.07.023","article-title":"STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer","volume":"39","author":"Iliopoulos","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Oh, Y.S., Bae, G.D., Park, E.-Y., and Jun, H.-S. (2019). MicroRNA-181c Inhibits Interleukin-6-mediated Beta Cell Apoptosis by Targeting TNF-\u03b1 Expression. Molecules, 24.","DOI":"10.3390\/molecules24071410"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-020-2250-5","article-title":"Exosome-transmitted miR-567 reverses trastuzumab resistance by inhibiting ATG5 in breast cancer","volume":"11","author":"Han","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1242\/jcs.104992","article-title":"A comparative perspective on lipid storage in animals","volume":"126","author":"Birsoy","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000321319","article-title":"Brown versus White Adipose Tissue: A Mini-Review","volume":"58","author":"Saely","year":"2012","journal-title":"Gerontology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fmolb.2020.00171","article-title":"miRNAs in Adipocyte-Derived Extracellular Vesicles: Multiple Roles in Development of Obesity-Associated Disease","volume":"7","author":"Zhou","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature21365","article-title":"Adipose-Derived Circulating miRNAs Regulate Gene Expression in Other Tissues","volume":"542","author":"Thomou","year":"2017","journal-title":"Nature"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"23932","DOI":"10.1073\/pnas.2011243117","article-title":"Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise","volume":"117","author":"Madsen","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/jcp.22475","article-title":"Dicer is required for the formation of white but not brown adipose tissue","volume":"226","author":"Mudhasani","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/oby.21709","article-title":"Circulating adipocyte-derived exosomal MicroRNAs associated with decreased insulin resistance after gastric bypass","volume":"25","author":"Hubal","year":"2017","journal-title":"Obesity"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"E6254","DOI":"10.1073\/pnas.1800544115","article-title":"Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue","volume":"115","author":"Serbulea","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.4049\/jimmunol.1800065","article-title":"Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype","volume":"202","author":"Ieronymaki","year":"2019","journal-title":"J. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"22617","DOI":"10.1073\/pnas.1009152108","article-title":"IL-4\/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity","volume":"107","author":"Eagle","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kern, L., Mittenb\u00fchler, M.J., Vesting, A.J., Ostermann, A.L., Wunderlich, C.M., and Wunderlich, F.T. (2018). Obesity-Induced TNF\u03b1 and IL-6 Signaling: The Missing Link between Obesity and Inflammation\u2014Driven Liver and Colorectal Cancers. Cancers, 11.","DOI":"10.3390\/cancers11010024"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1177\/0394632015593228","article-title":"TNF-a mediated inflammatory macrophage polarization contributes to the pathogenesis of steroid-induced osteonecrosis in mice","volume":"28","author":"Wu","year":"2015","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J. Clin. Invest."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cell.2017.08.035","article-title":"Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity","volume":"171","author":"Ying","year":"2017","journal-title":"Cell"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molmet.2019.08.015","article-title":"MicroRNA-10a-5p regulates macrophage polarization and promotes therapeutic adipose tissue remodeling","volume":"29","author":"Cho","year":"2019","journal-title":"Mol. Metab."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Lu, G.-D., Cheng, P., Liu, T., and Wang, Z. (2020). BMSC-Derived Exosomal miR-29a Promotes Angiogenesis and Osteogenesis. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.608521"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s00125-015-3510-2","article-title":"Identification of microRNA biomarkers in type 2 diabetes: A meta-analysis of controlled profiling studies","volume":"58","author":"Zhu","year":"2015","journal-title":"Diabetologia"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3389\/fimmu.2019.01049","article-title":"Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells","volume":"10","author":"Miranda","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41423-018-0038-7","article-title":"MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNF\u03b1","volume":"16","author":"Jaiswal","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/oby.22616","article-title":"Macrophage-Derived microRNA-155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator-Activated Receptor Gamma","volume":"27","author":"Tryggestad","year":"2019","journal-title":"Obesity"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1172\/JCI123069","article-title":"Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation","volume":"129","author":"Pan","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"7510","DOI":"10.18632\/aging.102263","article-title":"MiR-27a promotes insulin resistance and mediates glucose metabolism by targeting PPAR-\u03b3-mediated PI3K\/AKT signaling","volume":"11","author":"Chen","year":"2019","journal-title":"Aging"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Collares, R.V.A., Salgado, W., da Cunda Tirapelli, D.P., and dos Santos, J.S. (2014). The expression of LEP, LEPR, IGF1 and IL10 in obesity and the relationship with microRNAs. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0093512"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.2337\/diabetes.53.2007.S60","article-title":"Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells","volume":"53","author":"Kim","year":"2004","journal-title":"Diabetes"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"13502","DOI":"10.18632\/oncotarget.6284","article-title":"A double feedback loop mediated by microRNA-23a\/27a\/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression","volume":"7","author":"Ma","year":"2016","journal-title":"Oncotarget"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.7150\/thno.22565","article-title":"Adipocyte-Derived Exosomal MiR-27a Induces Insulin Resistance in Skeletal Muscle Through Repression of PPAR\u03b3","volume":"8","author":"Yu","year":"2018","journal-title":"Theranostics"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Cheng, C.-F., Ku, H.-C., and Lin, H. (2018). PGC-1\u03b1 as a Pivotal Factor in Lipid and Metabolic Regulation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113447"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.molmet.2017.06.020","article-title":"MicroRNAs as stress regulators in pancreatic beta cells and diabetes","volume":"6","author":"LaPierre","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.molmet.2019.11.012","article-title":"MiR-132 controls pancreatic beta cell proliferation and survival through Pten\/Akt\/Foxo3 signaling","volume":"31","author":"Mziaut","year":"2020","journal-title":"Mol. Metab."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.metabol.2017.09.006","article-title":"Change in circulating microRNA profile of obese children indicates future risk of adult diabetes","volume":"78","author":"Cui","year":"2018","journal-title":"Metabolism"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/eci.12475","article-title":"The biology of circulating microRNAs in cardiovascular disease","volume":"45","author":"Min","year":"2015","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e007442","DOI":"10.1161\/JAHA.117.007442","article-title":"Adipose-Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization","volume":"7","author":"Xie","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1042\/CS20190558","article-title":"Exosomal microRNA-122 mediates obesity-related cardiomyopathy through suppressing mitochondrial ADP-ribosylation factor-like","volume":"133","author":"Wang","year":"2019","journal-title":"Clin. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"14","DOI":"10.21037\/ncri.2018.03.05","article-title":"Inhibition of miR-29 protects against cardiac hypertrophy and fibrosis: New insight for the role of miR-29 in the heart","volume":"2","author":"McMullen","year":"2018","journal-title":"Non-Coding RNA Investig."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-26646-4","article-title":"MicroRNA-410-5p exacerbates high-fat diet-induced cardiac remodeling in mice in an endocrine fashion","volume":"8","author":"Zou","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4161\/rna.18827","article-title":"Liver-specific microRNA-122: Biogenesis and function","volume":"9","author":"Jopling","year":"2012","journal-title":"RNA Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/msb.2010.58","article-title":"microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma","volume":"6","author":"Burchard","year":"2010","journal-title":"Mol. Syst. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e302","DOI":"10.1111\/liv.12429","article-title":"Significance of serum and hepatic microRNA-122 levels in patients with non-alcoholic fatty liver disease","volume":"34","author":"Miyaaki","year":"2014","journal-title":"Liver Int."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/21623945.2020.1721970","article-title":"Transplantation of brown adipose tissue up-regulates miR-99a to ameliorate liver metabolic disorders in diabetic mice by targeting NOX4","volume":"9","author":"Li","year":"2020","journal-title":"Adipocyte"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1038\/s41388-018-0124-4","article-title":"microRNA-155 positively regulates glucose metabolism via PIK3R1-FOXO3a-cMYC axis in breast cancer","volume":"37","author":"Kim","year":"2018","journal-title":"Oncogene"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Kumar, P., Dezso, Z., MacKenzie, C., Oestreicher, J., Agoulnik, S., Byrne, M., Bernier, F., Yanagimachi, M., Aoshima, K., and Oda, Y. (2013). Circulating miRNA Biomarkers for Alzheimer\u2019s Disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069807"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s11011-019-00438-9","article-title":"Intrahippocampal miR-342-3p inhibition reduces \u03b2-amyloid plaques and ameliorates learning and memory in Alzheimer\u2019s disease","volume":"34","author":"Fu","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.3233\/JAD-170156","article-title":"Identification of Circulating miR-125b as a Potential Biomarker of Alzheimer\u2019s Disease in APP\/PS1 Transgenic Mouse","volume":"59","author":"Hong","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_114","first-page":"156","article-title":"Association of MiR-146a Expression and Type 2 Diabetes Mellitus: A Meta-Analysis","volume":"6","author":"Alipoor","year":"2017","journal-title":"Int. J. Mol. Cell. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s40618-019-01129-z","article-title":"miR-10b and miR-223-3p in serum microvesicles signal progression from prediabetes to type 2 diabetes","volume":"43","author":"Parrizas","year":"2019","journal-title":"J. Endocrinol. Investig."},{"key":"ref_116","first-page":"1529","article-title":"miR-142-3p promotes pancreatic \u03b2 cell survival through targeting FOXO1 in gestational diabetes mellitus","volume":"12","author":"Zhang","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"10567","DOI":"10.3390\/ijms150610567","article-title":"The Role of Circulating MicroRNA-126 (miR-126): A Novel Biomarker for Screening Prediabetes and Newly Diagnosed Type 2 Diabetes Mellitus","volume":"15","author":"Liu","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2013.09.105","article-title":"miR-375, a microRNA related to diabetes","volume":"533","author":"Li","year":"2014","journal-title":"Gene"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1055\/s-0033-1341516","article-title":"Dysregulated miR-155 expression in peripheral blood mononuclear cells from patients with type 2 diabetes","volume":"121","year":"2013","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3349\/ymj.2019.60.12.1187","article-title":"MicroRNA-138 Suppresses Adipogenic Differentiation in Human Adipose Tissue-Derived Mesenchymal Stem Cells by Targeting Lipoprotein Lipase","volume":"60","author":"Wang","year":"2019","journal-title":"Yonsei Med. J."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Arce, L.M., Lara-Riegos, J.C., P\u00e9rez-Mendoza, G.J., Rub\u00ed-Castellanos, R., Vega-Marc\u00edn, M., Valencia-Pacheco, G., Torres-Romero, J.C., and Gonz\u00e1lez-Herrera, L. (2020). High expression levels of circulating microRNA -122 and microRNA -222 are associated with obesity in children with Mayan ethnicity. Am. J. Hum. Biol., e23540.","DOI":"10.1002\/ajhb.23540"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"111028","DOI":"10.1016\/j.mce.2020.111028","article-title":"MiR-142-3p inhibits adipogenic differentiation and autophagy in obesity through targeting KLF9","volume":"518","author":"Wei","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_123","first-page":"1881","article-title":"Exosomes from adipose-derived stem cells promote chondrogenesis and suppress inflammation by upregulating miR-145 and miR-221","volume":"21","author":"Zhao","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1089\/nat.2020.0871","article-title":"Efficiency and Target Derepression of Anti-miR-92a: Results of a First in Human Study","volume":"30","author":"Abplanalp","year":"2020","journal-title":"Nucleic Acid Ther."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"610561","DOI":"10.3389\/fcvm.2020.610561","article-title":"MiR-223-3p in Cardiovascular Diseases: A Biomarker and Potential Therapeutic Target","volume":"7","author":"Zhang","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"106536","DOI":"10.1016\/j.prostaglandins.2021.106536","article-title":"Circulating microRNA-126 &122 in patients with coronary artery disease: Correlation with small dense LDL","volume":"153","author":"Mishra","year":"2021","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Zhelankin, A.V., Vasiliev, S.V., Stonogina, D.A., Babalyan, K.A., Sharova, E.I., Doludin, Y.V., Shchekochikhin, D.Y., Generozov, E.V., and Akselrod, A.S. (2020). Elevated Plasma Levels of Circulating Extracellular miR-320a-3p in Patients with Paroxysmal Atrial Fibrillation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103485"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-03887-3","article-title":"Downregulation of blood serum microRNA 29 family in patients with Parkinson\u2019s disease","volume":"7","author":"Bai","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neulet.2017.02.045","article-title":"MicroRNA biomarkers of Parkinson\u2019s disease in serum exosome-like microvesicles","volume":"644","author":"Cao","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3389\/fnins.2020.00930","article-title":"Knockdown of SNHG14 Alleviates MPP+-Induced Injury in the Cell Model of Parkinson\u2019s Disease by Targeting the miR-214-3p\/KLF4 Axis","volume":"14","author":"Zhou","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.canlet.2021.01.006","article-title":"Small extracellular vesicles containing miR-192\/215 mediate hypoxia-induced cancer-associated fibroblast development in head and neck squamous cell carcinoma","volume":"506","author":"Zhu","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"606045","DOI":"10.3389\/fimmu.2020.606045","article-title":"Exosomes Derived From Hypertrophic Cardiomyocytes Induce Inflammation in Macrophages via miR-155 Mediated MAPK Pathway","volume":"11","author":"Yu","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"549","DOI":"10.7150\/ijbs.54858","article-title":"Extracellular vesicles and pancreatitis: Mechanisms, status and perspectives","volume":"17","author":"Jia","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1038\/s41598-021-83365-z","article-title":"Systematic evaluation of multiple qPCR platforms, NanoString and miRNA-Seq for microRNA biomarker discovery in human biofluids","volume":"11","author":"Hong","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1038\/oby.2009.474","article-title":"miR-519d Overexpression Is Associated With Human Obesity","volume":"18","author":"Martinelli","year":"2010","journal-title":"Obesity"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nm.3862","article-title":"The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes","volume":"21","author":"Belgardt","year":"2015","journal-title":"Nat. Med."},{"key":"ref_137","unstructured":"Asl, E.R., Rasmi, Y., and Baradaran, B. (2021). MicroRNA-124-3p suppresses PD-L1 expression and inhibits tumorigenesis of colorectal cancer cells via modulating STAT3 signaling. J. Cell. Physiol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Sayed, R., Fern\u00e1ndez-Ortiz, M., Fern\u00e1ndez-Mart\u00ednez, J., Mart\u00ednez, P.A., Guerra-Librero, A., Rodr\u00edguez-Santana, C., de Haro, T., Escames, G., Acu\u00f1a-Castroviejo, D., and Rusanova, I. (2021). The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle. Antioxidants, 10.","DOI":"10.3390\/antiox10040524"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"600462","DOI":"10.3389\/fnins.2021.600462","article-title":"Dysregulation of MicroRNAs and PIWI-Interacting RNAs in a Caenorhabditis elegans Parkinson\u2019s Disease Model Overexpressing Human \u03b1-Synuclein and Influence of tdp-1","volume":"15","author":"Shen","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-21330-0","article-title":"Machine learning identifies candidates for drug repurposing in Alzheimer\u2019s disease","volume":"12","author":"Rodriguez","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Chen, D., Yang, X., Liu, M., Zhang, Z., and Xing, E. (2021). Roles of miRNA dysregulation in the pathogenesis of multiple myeloma. Cancer Gene Ther., 1\u201313.","DOI":"10.1038\/s41417-020-00291-4"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.2174\/1389450117666160201113734","article-title":"Can microRNAs be Biomarkers or Targets for Therapy of Ischemic Coronary Artery Disease in Metabolic Syndrome?","volume":"18","author":"Rocic","year":"2017","journal-title":"Curr. Drug Targets"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12948-018-0089-4","article-title":"Involvement of miR-126 in autoimmune disorders","volume":"16","author":"Casciaro","year":"2018","journal-title":"Clin. Mol. Allergy"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrrheum.2010.81","article-title":"MicroRNAs as biomarkers in rheumatic diseases","volume":"6","author":"Alevizos","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1716153","article-title":"Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis","volume":"379","author":"Adams","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-6563-2_1","article-title":"miRNA Targeting Drugs: The Next Blockbusters?","volume":"1517","author":"Schmidt","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1010428317701652","DOI":"10.1177\/1010428317701652","article-title":"MicroRNA-34 dysregulation in gastric cancer and gastric cancer stem cell","volume":"39","author":"Jafari","year":"2017","journal-title":"Tumor Biol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"241","DOI":"10.18632\/aging.103799","article-title":"In situ self-assembly of Au-antimiR-155 nanocomplexes mediates TLR3-dependent apoptosis in hepatocellular carcinoma cells","volume":"13","author":"Yin","year":"2020","journal-title":"Aging"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"15162","DOI":"10.1038\/ncomms15162","article-title":"Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice","volume":"8","author":"Lucas","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1101\/gad.1248505","article-title":"Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing","volume":"19","author":"Kanellopoulou","year":"2005","journal-title":"Genes Dev."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"22862","DOI":"10.1038\/srep22862","article-title":"miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity","volume":"6","author":"Gaudet","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"12158","DOI":"10.1073\/pnas.1808855115","article-title":"Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice","volume":"115","author":"Kalko","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.trsl.2018.09.006","article-title":"Circulating miR-143-3p inhibition protects against insulin resistance in Metabolic Syndrome via targeting of the insulin-like growth factor 2 receptor","volume":"205","author":"Xihua","year":"2019","journal-title":"Transl. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1182\/blood-2018-99-119861","article-title":"Phase 1 Trial of Cobomarsen, an Inhibitor of Mir-155, in Cutaneous T Cell Lymphoma","volume":"132","author":"Querfeld","year":"2018","journal-title":"Blood"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1128\/AAC.04220-14","article-title":"In Vitro Antiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122","volume":"59","author":"Ottosen","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/s41416-020-0802-1","article-title":"Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours","volume":"122","author":"Hong","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.2217\/epi-2016-0035","article-title":"Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer","volume":"8","author":"Reid","year":"2016","journal-title":"Epigenomics"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/14728214.2016.1257607","article-title":"Emerging drugs and therapeutics for systemic sclerosis","volume":"21","author":"Lee","year":"2016","journal-title":"Expert Opin. Emerg. 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