{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:47:00Z","timestamp":1792813620873,"version":"4.5.0"},"reference-count":160,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agence Nationale Recherche","award":["ANR-18-IDEX-0001"],"award-info":[{"award-number":["ANR-18-IDEX-0001"]}]},{"name":"ANSES","award":["2019\/1\/230"],"award-info":[{"award-number":["2019\/1\/230"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The GH\/IGF axis is a major regulator of bone formation and resorption and is essential to the achievement of normal skeleton growth and homeostasis. Beyond its key role in bone physiology, the GH\/IGF axis has also major pleiotropic endocrine and autocrine\/paracrine effects on mineralized tissues throughout life. This article aims to review the literature on GH, IGFs, IGF binding proteins, and their respective receptors in dental tissues, both epithelium (enamel) and mesenchyme (dentin, pulp, and tooth-supporting periodontium). The present review re-examines and refines the expression of the elements of the GH\/IGF axis in oral tissues and their in vivo and in vitro mechanisms of action in different mineralizing cell types of the dento-alveolar complex including ameloblasts, odontoblasts, pulp cells, cementoblasts, periodontal ligament cells, and jaw osteoblasts focusing on cell-specific activities. Together, these data emphasize the determinant role of the GH\/IGF axis in physiological and pathological development, morphometry, and aging of the teeth, the periodontium, and oral bones in humans, rodents, and other vertebrates. These advancements in oral biology have elicited an enormous interest among investigators to translate the fundamental discoveries on the GH\/IGF axis into innovative strategies for targeted oral tissue therapies with local treatments, associated or not with materials, for orthodontics and the repair and regeneration of the dento-alveolar complex and oral bones.<\/jats:p>","DOI":"10.3390\/cells10051181","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T10:59:12Z","timestamp":1620817152000},"page":"1181","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Role of GH\/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9700-5526","authenticated-orcid":false,"given":"Kouassi Armel","family":"Koffi","sequence":"first","affiliation":[{"name":"Centre de Recherche des Cordeliers, Lab. of Molecular Oral Pathophysiology, Universit\u00e9 de Paris, Sorbonne Universit\u00e9, INSERM, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Doublier","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Lab. of Molecular Oral Pathophysiology, Universit\u00e9 de Paris, Sorbonne Universit\u00e9, INSERM, 75006 Paris, France"},{"name":"Department of Oral Biology, Dental Faculty, Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Ricort","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Lab. of Molecular Oral Pathophysiology, Universit\u00e9 de Paris, Sorbonne Universit\u00e9, INSERM, 75006 Paris, France"},{"name":"Ecole Normale Sup\u00e9rieure Paris-Saclay, Universit\u00e9 Paris-Saclay, 91290 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-3490","authenticated-orcid":false,"given":"Sylvie","family":"Babajko","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Lab. of Molecular Oral Pathophysiology, Universit\u00e9 de Paris, Sorbonne Universit\u00e9, INSERM, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Nassif","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Lab. of Molecular Oral Pathophysiology, Universit\u00e9 de Paris, Sorbonne Universit\u00e9, INSERM, 75006 Paris, France"},{"name":"Service d\u2019Orthop\u00e9die Dento-Faciale, Sites Hospitaliers Piti\u00e9 Salp\u00eatri\u00e8re et Rothschild, Centre de R\u00e9f\u00e9rence Maladies Rares Orales et Dentaires (O-Rares), AP-HP, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7898-022X","authenticated-orcid":false,"given":"Juliane","family":"Isaac","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Lab. of Molecular Oral Pathophysiology, Universit\u00e9 de Paris, Sorbonne Universit\u00e9, INSERM, 75006 Paris, France"},{"name":"Department of Oral Biology, Dental Faculty, Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"ref_1","first-page":"263","article-title":"Growth Hormone and Insulin-like Growth Factor-I in Odontogenesis","volume":"39","author":"Young","year":"1995","journal-title":"Int. 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