{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:04:59Z","timestamp":1793156699036,"version":"4.5.0"},"reference-count":91,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft (DFG)","award":["RO 4109\/2-1 to E.H.R. and HU 2701\/3-1 \/ KFO 2722 to E.H.R."],"award-info":[{"award-number":["RO 4109\/2-1 to E.H.R. and HU 2701\/3-1 \/ KFO 2722 to E.H.R."]}]},{"name":"Koeln Fortune Program\/ Faculty of Medicine, University of Cologne","award":["7\/2019 to P.K."],"award-info":[{"award-number":["7\/2019 to P.K."]}]},{"name":"Cologne Clinician Scientist Program (CCSP) \/ Faculty of Medicine \/ University of Cologne","award":["FI 773\/15-1 to I.B.G"],"award-info":[{"award-number":["FI 773\/15-1 to I.B.G"]}]},{"name":"Walter and Marga Boll Foundation","award":["project number 210-03-17 to E.H.R. and I.B.G."],"award-info":[{"award-number":["project number 210-03-17 to E.H.R. and I.B.G."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Maternal obesity is associated with an increased risk of hepatic metabolic dysfunction for both mother and offspring and targeted interventions to address this growing metabolic disease burden are urgently needed. This study investigates whether maternal exercise (ME) could reverse the detrimental effects of hepatic metabolic dysfunction in obese dams and their offspring while focusing on the AMP-activated protein kinase (AMPK), representing a key regulator of hepatic metabolism. In a mouse model of maternal western-style-diet (WSD)-induced obesity, we established an exercise intervention of voluntary wheel-running before and during pregnancy and analyzed its effects on hepatic energy metabolism during developmental organ programming. ME prevented WSD-induced hepatic steatosis in obese dams by alterations of key hepatic metabolic processes, including activation of hepatic \u00df-oxidation and inhibition of lipogenesis following increased AMPK and peroxisome-proliferator-activated-receptor-\u03b3-coactivator-1\u03b1 (PGC-1\u03b1)-signaling. Offspring of exercised dams exhibited a comparable hepatic metabolic signature to their mothers with increased AMPK-PGC1\u03b1-activity and beneficial changes in hepatic lipid metabolism and were protected from WSD-induced adipose tissue accumulation and hepatic steatosis in later life. In conclusion, this study demonstrates that ME provides a promising strategy to improve the metabolic health of both obese mothers and their offspring and highlights AMPK as a potential metabolic target for therapeutic interventions.<\/jats:p>","DOI":"10.3390\/cells10051247","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T12:58:07Z","timestamp":1621429087000},"page":"1247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Maternal Exercise Mediates Hepatic Metabolic Programming via Activation of AMPK-PGC1\u03b1 Axis in the Offspring of Obese Mothers"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6218-2239","authenticated-orcid":false,"given":"Philipp","family":"Kasper","sequence":"first","affiliation":[{"name":"Clinic for Gastroenterology and Hepatology, Faculty of Medicine and University Hospital Cologne, University of Cologne, D-50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3723-5762","authenticated-orcid":false,"given":"Saida","family":"Breuer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, D-50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorben","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, D-50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Vohlen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, D-50937 Cologne, 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