{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:36:30Z","timestamp":1787027790821,"version":"build-2736575974"},"reference-count":133,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T00:00:00Z","timestamp":1622937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007475","name":"Canadian Dermatology Foundation","doi-asserted-by":"publisher","award":["0035718"],"award-info":[{"award-number":["0035718"]}],"id":[{"id":"10.13039\/100007475","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Mycosis fungoides (MF) is the most prevalent type of skin lymphoma. In its early stages, it has a favorable prognosis. However, in its late stages, it is associated with an increased risk of mortality. This systematic review aimed to identify the transcriptomic changes involved in MF pathogenesis and progression. A literature search was conducted using the database PubMed, followed by the extraction of 2245 genes which were further filtered to 150 recurrent genes that appeared in two or more publications. Categorization of these genes identified activated pathways involved in pathways such as cell cycle and proliferation, chromosomal instability, and DNA repair. We identified 15 genes implicated in MF progression, which were involved in cell proliferation, immune checkpoints, resistance to apoptosis, and immune response. In highlighting the discrepancies in the way MF transcriptomic data is obtained, further research can focus on not only unifying their approach but also focus on the 150 pertinent genes identified in this review.<\/jats:p>","DOI":"10.3390\/cells10061409","type":"journal-article","created":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T23:59:55Z","timestamp":1623023995000},"page":"1409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Patterns of Gene Expression in Cutaneous T-Cell Lymphoma: Systematic Review of Transcriptomic Studies in Mycosis Fungoides"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7754-3615","authenticated-orcid":false,"given":"Melika","family":"Motamedi","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7534-6079","authenticated-orcid":false,"given":"Maggie Z. X.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7370-2378","authenticated-orcid":false,"given":"Aishwarya","family":"Iyer","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2310-8300","authenticated-orcid":false,"given":"Robert","family":"Gniadecki","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada"},{"name":"8-112 Clinical Sciences Building, University of Alberta, Edmonton, AB T6G 2G3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1182\/blood-2018-11-881268","article-title":"The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas","volume":"133","author":"Willemze","year":"2019","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1158\/1078-0432.CCR-12-0604","article-title":"Long-term Outcomes of 1263 Patients with Mycosis Fungoides and S\u00e9zary Syndrome from 1982 to 2009","volume":"18","author":"Talpur","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1200\/JCO.2015.61.7142","article-title":"Cutaneous Lymphoma International Consortium Study of Outcome in Advanced Stages of Mycosis Fungoides and S\u00e9zary Syndrome: Effect of Specific Prognostic Markers on Survival and Development of a Prognostic Model","volume":"33","author":"Scarisbrick","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1200\/JCO.2009.27.7665","article-title":"Survival Outcomes and Prognostic Factors in Mycosis fungoides\/S\u00e9zary Syndrome: Validation of the Revised In-ternational Society for Cutaneous Lymphomas\/European Organisation for Research and Treatment of Cancer Staging Proposal","volume":"28","author":"Agar","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ng.2764","article-title":"The Cancer Genome Atlas Pan-Cancer analysis project","volume":"45","author":"Weinstein","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"eaan2507","DOI":"10.1126\/science.aan2507","article-title":"A pathology atlas of the human cancer transcriptome","volume":"357","author":"Zhang","year":"2017","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1182\/bloodadvances.2020001441","article-title":"Branched evolution and genomic intratumor heterogeneity in the pathogenesis of cutaneous T-cell lymphoma","volume":"4","author":"Iyer","year":"2020","journal-title":"Blood Adv."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1016\/j.jid.2018.06.176","article-title":"An Integrated Data Resource for Genomic Analysis of Cutaneous T-Cell Lymphoma","volume":"138","author":"Chang","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/ng.3356","article-title":"Ge-nomic Landscape of Cutaneous T Cell Lymphoma","volume":"47","author":"Choi","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/ng.3442","article-title":"The mutational landscape of cutaneous T cell lymphoma and S\u00e9zary syndrome","volume":"47","author":"Almeida","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/ng.3370","article-title":"Genomic analysis of mycosis fungoides and S\u00e9zary syndrome identifies recurrent alterations in TNFR","volume":"47","author":"Ungewickell","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1182\/blood-2009-11-251926","article-title":"S\u00e9zary syndrome and mycosis fungoides arise from distinct T-cell subsets: A biologic rationale for their distinct clinical behaviors","volume":"116","author":"Campbell","year":"2010","journal-title":"Blood"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1182\/blood-2008-04-153031","article-title":"Oncogenomic analysis of mycosis fungoides reveals major differences with S\u00e9zary syndrome","volume":"113","author":"Dijkman","year":"2009","journal-title":"Blood"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/jid.2012.13","article-title":"Molecular Markers of Early-Stage Mycosis Fungoides","volume":"132","author":"Zhang","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1158\/2326-6066.CIR-17-0270","article-title":"Primary T Cells from Cutaneous T-cell Lymphoma Skin Explants Display an Exhausted Immune Checkpoint Profile","volume":"6","author":"Querfeld","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"ref_16","first-page":"e1467856","article-title":"Gene expression profiling and immune cell-type deconvolution highlight robust disease progression and survival markers in multiple cohorts of CTCL patients","volume":"7","author":"Xie","year":"2018","journal-title":"Oncoimmunology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e1306618","DOI":"10.1080\/2162402X.2017.1306618","article-title":"Gene expression analysis in Cutaneous T-Cell Lymphomas (CTCL) highlights disease heterogeneity and potential diagnostic and prognostic indicators","volume":"6","author":"Litvinov","year":"2017","journal-title":"Oncoimmunology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1158\/1078-0432.CCR-14-0307","article-title":"Ectopic Expression of Cancer\u2013Testis Antigens in Cutaneous T-cell Lymphoma Patients","volume":"20","author":"Litvinov","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1158\/1078-0432.CCR-14-3322","article-title":"The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-Cell Lympho-ma (CTCL)","volume":"21","author":"Litvinov","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1158\/1078-0432.CCR-19-0148","article-title":"Single-Cell Lymphocyte Heter-ogeneity in Advanced Cutaneous T-Cell Lymphoma Skin Tumors","volume":"25","author":"Gaydosik","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1182\/blood.2019004725","article-title":"Genome-wide transcriptome analysis of the STAT6-regulated genes in advanced-stage cutaneous T-cell lymphoma","volume":"136","author":"Gaydosik","year":"2020","journal-title":"Blood"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1158\/1078-0432.CCR-06-0532","article-title":"Th1 Response and Cytotoxicity Genes Are down-Regulated in Cutaneous T-Cell Lymphoma","volume":"12","author":"Hahtola","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/gcc.22679","article-title":"Genomic Analysis Reveals Recurrent Deletion of JAK-STAT Signaling Inhibitors HNRNPK and SOCS1 in Mycosis Fungoides","volume":"57","author":"Cats","year":"2018","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1038\/jid.2012.117","article-title":"A Meta-Analysis of Gene Expression Data Identifies a Molecular Signature Characteristic for Tu-mor-Stage Mycosis Fungoides","volume":"132","author":"Borg","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/bjd.12578","article-title":"Lessons learned from gene expression profiling of cutaneous T-cell lymphoma","volume":"169","author":"Dulmage","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1182\/blood-2006-12-061507","article-title":"Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome","volume":"110","author":"Shin","year":"2007","journal-title":"Blood"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1158\/1078-0432.CCR-09-2879","article-title":"Transcriptional Profiles Predict Disease Outcome in Patients with Cu-taneous T-Cell Lymphoma","volume":"16","author":"Litvinov","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"ref_28","first-page":"220","article-title":"Review of the Treatment of Mycosis Fungoides and S\u00e9Zary Syndrome: A Stage-Based Approach","volume":"7","author":"Alhothali","year":"2013","journal-title":"Int. J. Health Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1182\/blood-2002-11-3574","article-title":"Mycosis Fun-goides Shows Concurrent Deregulation of Multiple Genes Involved in the TNF Signaling Pathway: An Expression Profile Study","volume":"102","author":"Tracey","year":"2003","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3349\/ymj.2011.52.3.445","article-title":"Overexpressions of Cyclin B1, cdc2, p16 and p53 in Human Breast Cancer: The Clinicopathologic Correlations and Prognostic Implications","volume":"52","author":"Chae","year":"2011","journal-title":"Yonsei Med. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s004280050319","article-title":"Determination of the Prognostic Significance of Cyclin B1 Overexpres-sion in Patients with Esophageal Squamous Cell Carcinoma","volume":"434","author":"Murakami","year":"1999","journal-title":"Virchows Arch."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0002-9440(10)64722-0","article-title":"Expression of Cdc2 and Cyclin B1 in Helicobacter pylori-Associated Gastric MALT and MALT Lymphoma: Relationship to Cell Death, Proliferation, and Transformation","volume":"156","author":"Banerjee","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_33","first-page":"4000","article-title":"Overexpression of cyclin B1 in early-stage non-small cell lung cancer and its clinical implication","volume":"60","author":"Soria","year":"2000","journal-title":"Cancer Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Androic, I., Kr\u00e4mer, A., Yan, R., R\u00f6del, F., G\u00e4tje, R., Kaufmann, M., Strebhardt, K., and Yuan, J. (2008). Targeting Cyclin B1 Inhibits Pro-liferation and Sensitizes Breast Cancer Cells to Taxol. BMC Cancer, 8.","DOI":"10.1186\/1471-2407-8-391"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3109\/10428194.2014.929673","article-title":"Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage","volume":"56","author":"Savorani","year":"2014","journal-title":"Leuk. Lymphoma"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jdermsci.2016.09.010","article-title":"Small-molecule inhibitors of Ataxia Telangiectasia and Rad3 related kinase (ATR) sensitize lymphoma cells to UVA radiation","volume":"84","author":"Biskup","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.4081\/dr.2010.e8","article-title":"Growth Dynamics and Cyclin Expression in Cutaneous T-Cell Lym-phoma Cell Lines","volume":"2","author":"Biskup","year":"2010","journal-title":"Dermatol. Rep."},{"key":"ref_38","first-page":"538","article-title":"Cyclin B2 and p53 Control Proper Timing of Centrosome Separation","volume":"16","author":"Nam","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"11639","DOI":"10.1074\/jbc.M312895200","article-title":"Cyclin L2, a Novel RNA Polymerase II-Associated Cyclin, Is Involved in Pre-mRNA Splicing and Induces Apoptosis of Human Hepatocellular Carcinoma Cells","volume":"279","author":"Yang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Dastsooz, H., Cereda, M., Donna, D., and Oliviero, S. (2019). A Comprehensive Bioinformatics Analysis of UBE2C in Cancers. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092228"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kovalchuk, I., and Kovalchuk, O. (2016). Chapter 27-Cancer and Genomic Instability. Genome Stability, Academic Press.","DOI":"10.1016\/B978-0-12-803309-8.00001-X"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.cell.2018.08.027","article-title":"The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment","volume":"174","author":"Bakhoum","year":"2018","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10555-013-9428-6","article-title":"Chromosomal instability and transcriptome dynamics in cancer","volume":"32","author":"Stevens","year":"2013","journal-title":"Cancer Metastasis Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1182\/blood.V89.9.3371","article-title":"Recur-ring Structural Chromosome Abnormalities in Peripheral Blood Lymphocytes of Patients with Mycosis fungoides\/S\u00e9zary Syndrome","volume":"89","author":"Thangavelu","year":"1997","journal-title":"Blood"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/1523-1747.ep12285617","article-title":"Chromosomal Abnormalities in Cutaneous T-Cell Lymphoma and in Its Premalignant Conditions as Detected by G-Banding and Interphase Cytogenetic Methods","volume":"108","author":"Karenko","year":"1997","journal-title":"J. Investig. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/gcc.20469","article-title":"Common chromosomal abnormalities in mycosis fungoides transformation","volume":"46","author":"Prochazkova","year":"2007","journal-title":"Genes Chromosom. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"R285","DOI":"10.1016\/j.cub.2010.01.034","article-title":"Mechanisms of Chromosomal Instability","volume":"20","author":"Thompson","year":"2010","journal-title":"Curr. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semcancer.2004.09.004","article-title":"Mechanisms leading to chromosomal instability","volume":"15","author":"Gollin","year":"2005","journal-title":"Semin. Cancer Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nrc1526","article-title":"Aurora-A\u2014A Guardian of Poles","volume":"5","author":"Marumoto","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Lentini, L., Amato, A., Schillaci, T., and Di Leonardo, A. (2007). Simultaneous Aurora-A\/STK15 Overexpression and Centrosome Ampli-fication Induce Chromosomal Instability in Tumour Cells with a MIN Phenotype. BMC Cancer, 7.","DOI":"10.1186\/1471-2407-7-212"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4161\/cbt.6.4.3817","article-title":"High Copy Amplification of the Aurora-A Gene Is Associ-ated with Chromosomal Instability Phenotype in Human Colorectal Cancers","volume":"6","author":"Nishida","year":"2007","journal-title":"Cancer Biol. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/10428194.2019.1672052","article-title":"Phase 1 Study of the Aurora Kinase A Inhibitor Alisertib (MLN8237) Combined with the Histone Deacetylase Inhibitor Vo-rinostat in Lymphoid Malignancies","volume":"61","author":"Siddiqi","year":"2020","journal-title":"Leuk. Lymphoma"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1083\/jcb.200208092","article-title":"The Small Molecule Hesperadin Reveals a Role for Aurora B in Correcting Kinetochore\u2013microtubule Attachment and in Main-taining the Spindle Assembly Checkpoint","volume":"161","author":"Hauf","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1083\/jcb.200208091","article-title":"Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores","volume":"161","author":"Ditchfield","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1083\/jcb.200403084","article-title":"Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2","volume":"166","author":"Gruneberg","year":"2004","journal-title":"J. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/ncb1167","article-title":"The anaphase promoting complex\/cyclosome is recruited to centromeres by the spindle assembly checkpoint","volume":"6","author":"Acquaviva","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"R966","DOI":"10.1016\/j.cub.2012.10.006","article-title":"The Spindle Assembly Checkpoint","volume":"22","author":"Pablo","year":"2012","journal-title":"Curr. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.celrep.2017.05.021","article-title":"Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit","volume":"19","author":"Marks","year":"2017","journal-title":"Cell Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"26718","DOI":"10.18632\/oncotarget.14957","article-title":"TRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma","volume":"8","author":"Tao","year":"2017","journal-title":"Oncotarget"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"12019","DOI":"10.1073\/pnas.1412901111","article-title":"Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31comet","volume":"111","author":"Eytan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/jcb.10688","article-title":"Rho Exchange Factor ECT2 Is Induced by Growth Factors and Regulates Cytokinesis through the N-Terminal Cell Cycle Regulator-Related Do-mains","volume":"90","author":"Saito","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.dsi.2012.08.004","article-title":"Pathophysiology of Chemokines and Chemokine Receptors in Dermatological Science: A Focus on Psoriasis and Cutaneous T-Cell Lymphoma","volume":"30","author":"Lee","year":"2012","journal-title":"Dermatol. Sin."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00281-016-0594-9","article-title":"Malignant Inflammation in Cutaneous T-Cell Lymphoma-a Hostile Takeover","volume":"39","author":"Krejsgaard","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3389\/fcell.2020.00851","article-title":"Cel-lular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma","volume":"8","author":"Stolearenco","year":"2020","journal-title":"Front Cell Dev. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.ajpath.2011.05.040","article-title":"Up-Regulation of the Chemokine CCL18 by Macrophages Is a Potential Immunomodulatory Pathway in Cutaneous T-Cell Lymphoma","volume":"179","author":"Zimmermann","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1111\/j.1468-3083.2012.04495.x","article-title":"Increased CCL18 Ex-pression in Patients with Cutaneous T-Cell Lymphoma: Association with Disease Severity and Prognosis","volume":"27","author":"Miyagaki","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1046\/j.1523-1747.2003.12555.x","article-title":"Chemokine Receptor Expression on Neoplastic and Reactive T Cells in the Skin at Different Stages of Mycosis Fungoides","volume":"121","author":"Kallinich","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jdermsci.2013.12.003","article-title":"CCR7 Expression Correlates with Subcutaneous In-volvement in Mycosis Fungoides Skin Lesions and Promotes Migration of Mycosis Fungoides Cells (MyLa) through mTOR Activation","volume":"74","author":"Hu","year":"2014","journal-title":"J. Dermatol. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1155\/2000\/74372","article-title":"Proteolytic Activity of Human Lym-phoid Tumor Cells. Correlation with Tumor Progression","volume":"7","author":"Vacca","year":"2000","journal-title":"Dev. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0959-8049(97)00186-X","article-title":"Pro-gression of Mycosis Fungoides Is Associated with Changes in Angiogenesis and Expression of the Matrix Metalloproteinases 2 and 9","volume":"33","author":"Vacca","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1158\/1078-0432.CCR-12-3488","article-title":"TH2 Cytokines from Malignant Cells Suppress TH1 Responses and Enforce a Global TH2 Bias in Leukemic Cutaneous T-Cell Lymphoma","volume":"19","author":"Guenova","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1080\/10428194.2018.1516037","article-title":"IL-10 Is Overexpressed in Human Cutane-ous T-Cell Lymphoma and Is Required for Maximal Tumor Growth in a Mouse Model","volume":"60","author":"Wu","year":"2019","journal-title":"Leuk. Lymphoma"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1034\/j.1600-0625.2000.009004248.x","article-title":"IL-15 and IL-16 Overexpression in Cutaneous T-Cell Lymphomas: Stage-Dependent Increase in Mycosis Fungoides Progression","volume":"9","author":"Asadullah","year":"2000","journal-title":"Exp. Dermatol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1158\/2326-6066.CIR-13-0199-T","article-title":"IL32 Is Progressively Expressed in Mycosis Fungoides Independent of Helper T-cell 2 and Helper T-cell 9 Polarization","volume":"2","author":"Ohmatsu","year":"2014","journal-title":"Cancer Immunol. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.4161\/cc.28256","article-title":"IL-15 and IL-17F are differentially regulated and expressed in mycosis fungoides (MF)","volume":"13","author":"Litvinov","year":"2014","journal-title":"Cell Cycle"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/jid.2013.488","article-title":"The Role of IL-32 in Cutaneous T-Cell Lymphoma","volume":"134","author":"Suga","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/sj.leu.2403610","article-title":"Constitutive SOCS-3 Expression Protects T-Cell Lymphoma against Growth Inhibition by IFNalpha","volume":"19","author":"Brender","year":"2005","journal-title":"Leukemia"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1046\/j.1365-2567.1997.00134.x","article-title":"Antigen-Presenting Cell-Derived Signals Determine Expression Levels of CD70 on Primed T Cells","volume":"90","author":"Lens","year":"1997","journal-title":"Immunology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2015.07.007","article-title":"CD70: An emerging target in cancer immunotherapy","volume":"155","author":"Jacobs","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1182\/blood-2018-99-118204","article-title":"Argx-110 for Treatment of CD70-Positive Advanced Cutaneous T-Cell Lymphoma in a Phase 1\/2 Clinical Trial","volume":"132","author":"Bagot","year":"2018","journal-title":"Blood"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1126\/science.1063486","article-title":"Coupling of the TCR to Integrin Activation by SLAP-130\/Fyb","volume":"293","author":"Peterson","year":"2001","journal-title":"Science"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.1128\/MCB.00283-09","article-title":"The Adapter Protein SLP-76 Mediates \u201cOutside-in\u201d Integrin Signaling and Function in T Cells","volume":"29","author":"Baker","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"6291","DOI":"10.1038\/sj.onc.1204772","article-title":"The role of the adapter molecule SLP-76 in platelet function","volume":"20","author":"Judd","year":"2001","journal-title":"Oncogene"},{"key":"ref_84","first-page":"111","article-title":"Insights into the Molecular and Cellular Underpinnings of Cutaneous T Cell Lymphoma","volume":"93","author":"Yumeen","year":"2020","journal-title":"Yale J. Biol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1182\/blood.V97.5.1388","article-title":"CD4+ cutaneous T-cell lymphoma cells express the p140\u2013killer cell immunoglobulin-like receptor","volume":"97","author":"Bagot","year":"2001","journal-title":"Blood"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1182\/blood-2007-02-071993","article-title":"Killer Cell Ig-like Receptors CD158a and CD158b Display a Coactivatory Function, Involving the c-Jun NH2-Terminal Protein Kinase Signaling Pathway, When Expressed on Malignant CD4+ T Cells from a Patient with Sezary Syndrome","volume":"109","author":"Huet","year":"2007","journal-title":"Blood"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-065X.2008.00660.x","article-title":"Negative signaling by inhibitory receptors: The NK cell paradigm","volume":"224","author":"Long","year":"2008","journal-title":"Immunol. Rev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.coi.2011.12.001","article-title":"The many roles of TOX in the immune system","volume":"24","author":"Aliahmad","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.18632\/oncotarget.2031","article-title":"Thymocyte Selection-Associated High Mobility Group Box Gene (TOX) Is Aberrantly over-Expressed in Mycosis Fungoides and Corre-lates with Poor Prognosis","volume":"5","author":"Huang","year":"2014","journal-title":"Oncotarget"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Yu, X., Luo, Y., Liu, J., Liu, Y., and Sun, Q. (2015). TOX Acts an Oncological Role in Mycosis Fungoides. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117479"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/01.EWX.0000525982.47129.30","article-title":"TOX as a diagnostic and prognostic marker for mycosis fungoides","volume":"15","author":"Neinaa","year":"2018","journal-title":"J. Egypt. Womens Dermatol. Soc."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12943-015-0405-2","article-title":"Erratum: Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation","volume":"14","author":"Toricelli","year":"2015","journal-title":"Mol. Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.leukres.2009.08.035","article-title":"High levels of serum TIMP-1 correlate with advanced disease and predict for poor survival in patients with multiple myeloma treated with novel agents","volume":"34","author":"Terpos","year":"2010","journal-title":"Leuk. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"290854","DOI":"10.1155\/2012\/290854","article-title":"Prognostic Signifi-cance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer","volume":"2012","author":"Dechaphunkul","year":"2012","journal-title":"Int. J. Breast Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00018-013-1457-3","article-title":"Cytokine functions of TIMP-1","volume":"71","author":"Ries","year":"2014","journal-title":"Cell Mol. Life Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-5793(92)80015-9","article-title":"Growth-Promoting Activity of Tissue Inhibitor of Metal-loproteinases-1 (TIMP-1) for a Wide Range of Cells A Possible New Growth Factor in Serum","volume":"298","author":"Hayakawa","year":"1992","journal-title":"FEBS Lett."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.0902-4441.2004.00168.x","article-title":"Clinicopathological correlations of TIMP-1 and TIMP-2 in Hodgkin\u2019s lymphoma","volume":"72","author":"Pennanen","year":"2003","journal-title":"Eur. J. Haematol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1172\/JCI24826","article-title":"Immunopathogenesis and Therapy of Cutaneous T Cell Lymphoma","volume":"115","author":"Kim","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1182\/bloodadvances.2018025114","article-title":"Progression of mycosis fungoides occurs through divergence of tumor immunophenotype by differential expression of HLA-DR","volume":"3","author":"Murray","year":"2019","journal-title":"Blood Adv."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1365-2567.2010.03255.x","article-title":"T-cell exhaustion: Characteristics, causes and conversion","volume":"129","author":"Yi","year":"2010","journal-title":"Immunology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-065X.2009.00767.x","article-title":"PD-1 Signaling in Primary T Cells","volume":"229","author":"Riley","year":"2009","journal-title":"Immunol. Rev."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/DAD.0b013e31821c35cb","article-title":"Expression Patterns of the Immunosuppressive Proteins PD-1\/CD279 and PD-L1\/CD274 at Different Stages of Cutaneous T-Cell Lympho-ma\/mycosis Fungoides","volume":"34","author":"Kantekure","year":"2012","journal-title":"Am. J. Dermatopathol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1200\/JCO.2015.65.9789","article-title":"Nivolumab in Patients with Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study","volume":"34","author":"Lesokhin","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1200\/JCO.19.01056","article-title":"Pembrolizumab in Relapsed and Refractory Mycosis Fungoides and S\u00e9zary Syndrome: A Multicenter Phase II Study","volume":"38","author":"Khodadoust","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41577-019-0224-6","article-title":"TIM3 Comes of Age as an Inhibitory Receptor","volume":"20","author":"Wolf","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"186ra66","DOI":"10.1126\/scitranslmed.3005723","article-title":"Ectopic Activation of Germline and Placental Genes Identifies Aggressive Metastasis-Prone Lung Cancers","volume":"5","author":"Rousseaux","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Gantchev, J., Mart\u00ednez Villarreal, A., Xie, P., Lefran\u00e7ois, P., Gunn, S., Netchiporouk, E., Sasseville, D., and Litvinov, I.V. (2019). The Ectopic Expression of Meiosis Regulatory Genes in Cutaneous T-Cell Lymphomas (CTCL). Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00429"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/ncb1258","article-title":"Sensitized RNAi Screen of Human Kinases and Phosphatases Identifies New Regulators of Apoptosis and Chemoresistance","volume":"7","author":"MacKeigan","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"ref_110","first-page":"236","article-title":"A Hematopoietic Protein Tyrosine Phosphatase (HePTP) Gene That Is Amplified and Overexpressed in Myeloid Malignancies Maps to Chromosome 1q32.1","volume":"8","author":"Zanke","year":"1994","journal-title":"Leukemia"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1046\/j.1523-1747.2002.19610.x","article-title":"Increased CCR4 Expression in Cutaneous T Cell Lymphoma","volume":"119","author":"Ferenczi","year":"2002","journal-title":"J. Invest. Dermatol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2340\/00015555-3207","article-title":"Expression of CCR3 and CCR4 Suggests a Poor Prognosis in Mycosis Fungoides and S\u00e9zary Syndrome","volume":"99","author":"Shono","year":"2019","journal-title":"Acta Derm. Venereol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S1470-2045(18)30449-2","article-title":"CCR4-Targeted Therapy in Cutaneous T-Cell Lymphoma","volume":"19","author":"Gniadecki","year":"2018","journal-title":"Lancet Oncol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S1470-2045(18)30379-6","article-title":"Mogamulizumab versus Vorinostat in Previously Treated Cutaneous T-Cell Lymphoma (MAVORIC): An International, Open-Label, Randomised, Controlled Phase 3 Trial","volume":"19","author":"Kim","year":"2018","journal-title":"Lancet Oncol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/bjd.18098","article-title":"Advanced-Stage Mycosis Fungoides: Role of the Signal Transducer and Activator of Transcription 3, Nuclear Factor-\u03baB and Nuclear Factor of Activated T Cells Pathways","volume":"182","author":"Cereceda","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_116","first-page":"7207","article-title":"MicroRNA Expression in Early Mycosis Fungoides Is Distinctly Different from Atopic Dermatitis and Advanced Cutaneous T-Cell Lymphoma","volume":"34","author":"Ralfkiaer","year":"2014","journal-title":"Anticancer Res."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Zerdes, I., Wallerius, M., Sifakis, E.G., Wallmann, T., Betts, S., Bartish, M., Tsesmetzis, N., Tobin, N.P., Coucoravas, C., and Bergh, J. (2019). STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer. Cancers, 11.","DOI":"10.3390\/cancers11101479"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Mojic, M., Takeda, K., and Hayakawa, Y. (2017). The Dark Side of IFN-\u03b3: Its Role in Promoting Cancer Immunoevasion. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010089"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40364-020-00228-x","article-title":"Roles of IFN-\u03b3 in Tumor Progression and Regression: A Review","volume":"8","author":"Jorgovanovic","year":"2020","journal-title":"Biomark Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.immuni.2019.01.006","article-title":"Clonal Deletion of Tumor-Specific T Cells by Interferon-\u03b3 Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade","volume":"50","author":"Pai","year":"2019","journal-title":"Immunity"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nature09666","article-title":"Interferon-\u03b3 Links Ultraviolet Radiation to Melanomagenesis in Mice","volume":"469","author":"Zaidi","year":"2011","journal-title":"Nature"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1399-0039.2008.01218.x","article-title":"Biology and Clinical Relevance of Granulysin","volume":"73","author":"Krensky","year":"2009","journal-title":"Tissue Antigens"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1056\/NEJMoa051424","article-title":"Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer","volume":"353","author":"Berger","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1440-1746.2006.04796.x","article-title":"Serum Granulysin Level as a Novel Prognostic Marker in Patients with Gastric Carcinoma","volume":"22","author":"Saigusa","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s002620100228","article-title":"Differential Expression of Granulysin and Perforin by NK Cells in Cancer Patients and Correlation of Impaired Granulysin Expression with Progression of Cancer","volume":"50","author":"Kishi","year":"2002","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1182\/blood-2010-03-273953","article-title":"Granulysin Activates Antigen-Presenting Cells through TLR4 and Acts as an Immune Alarmin","volume":"116","author":"Tewary","year":"2010","journal-title":"Blood"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1182\/blood-2009-05-220111","article-title":"Monocytes Promote Tumor Cell Survival in T-Cell Lymphoproliferative Disorders and Are Impaired in Their Ability to Differentiate into Mature Dendritic Cells","volume":"114","author":"Wilcox","year":"2009","journal-title":"Blood"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1182\/blood.V99.8.2929","article-title":"The Growth of Cutaneous T-Cell Lymphoma Is Stimulated by Immature Dendritic Cells","volume":"99","author":"Berger","year":"2002","journal-title":"Blood"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2001.tb03705.x","article-title":"Cutaneous T Cell Lymphoma: The Helping Hand of Dendritic Cells","volume":"941","author":"Edelson","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/s41590-020-0767-5","article-title":"NKG7 Makes a Better Killer","volume":"21","author":"Malarkannan","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"10","DOI":"10.21037\/cco.2019.01.02","article-title":"Systemic Therapy of Cutaneous T-Cell Lymphoma (CTCL)","volume":"8","author":"Alpdogan","year":"2019","journal-title":"Chin. Clin. Oncol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1177\/1203475419867610","article-title":"Immunotherapy for Cutaneous T-Cell Lymphoma: Current Landscape and Future Developments","volume":"23","author":"Sivanand","year":"2019","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S1470-2045(19)30320-1","article-title":"IPH4102, a First-in-Class Anti-KIR3DL2 Monoclonal Antibody, in Patients with Relapsed or Refractory Cutaneous T-Cell Lymphoma: An International, First-in-Human, Open-Label, Phase 1 Trial","volume":"20","author":"Bagot","year":"2019","journal-title":"Lancet Oncol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/6\/1409\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:11:26Z","timestamp":1760163086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/6\/1409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,6]]},"references-count":133,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["cells10061409"],"URL":"https:\/\/doi.org\/10.3390\/cells10061409","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,6]]}}}