{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:22:25Z","timestamp":1788538945016,"version":"build-2803163510"},"reference-count":171,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Lung transplantation (LTx) is the gold standard treatment for end-stage lung disease; however, waitlist mortality remains high due to a shortage of suitable donor lungs. Organ quality can be compromised by lung ischemic reperfusion injury (LIRI). LIRI causes pulmonary endothelial inflammation and may lead to primary graft dysfunction (PGD). PGD is a significant cause of morbidity and mortality post-LTx. Research into preservation strategies that decrease the risk of LIRI and PGD is needed, and ex-situ lung perfusion (ESLP) is the foremost technological advancement in this field. This review addresses three major topics in the field of LTx: first, we review the clinical manifestation of LIRI post-LTx; second, we discuss the pathophysiology of LIRI that leads to pulmonary endothelial inflammation and PGD; and third, we present the role of ESLP as a therapeutic vehicle to mitigate this physiologic insult, increase the rates of donor organ utilization, and improve patient outcomes.<\/jats:p>","DOI":"10.3390\/cells10061417","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T13:25:43Z","timestamp":1623072343000},"page":"1417","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Lung Transplantation, Pulmonary Endothelial Inflammation, and Ex-Situ Lung Perfusion: A Review"],"prefix":"10.3390","volume":"10","author":[{"given":"Keir A.","family":"Forgie","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, AB T6G 2B7, Canada"},{"name":"Mazankowski Alberta Heart Institute, Edmonton, AB T6G 2B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Fialka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6239-1444","authenticated-orcid":false,"given":"Darren H.","family":"Freed","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, AB T6G 2B7, Canada"},{"name":"Mazankowski Alberta Heart Institute, Edmonton, AB T6G 2B7, Canada"},{"name":"Alberta Transplant Institute, Edmonton, AB T6G 2E1, Canada"},{"name":"Canadian Donation and Transplantation Research Program, Edmonton, AB T6G 2E1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5827-9823","authenticated-orcid":false,"given":"Jayan","family":"Nagendran","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, AB T6G 2B7, Canada"},{"name":"Mazankowski Alberta Heart Institute, Edmonton, AB T6G 2B7, Canada"},{"name":"Alberta Transplant Institute, Edmonton, AB T6G 2E1, Canada"},{"name":"Canadian Donation and Transplantation Research Program, Edmonton, AB T6G 2E1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0022-5223(19)36439-6","article-title":"Technique of successful lung transplantation in humans","volume":"93","author":"Cooper","year":"1987","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.healun.2017.07.016","article-title":"The Registry of the International Society for Heart and Lung Transplantation: Thirty-fourth Adult Lung and Heart-Lung Transplantation Report-2017; Focus Theme: Allograft ischemic time","volume":"36","author":"Chambers","year":"2017","journal-title":"J. Heart Lung Transplant."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/ajt.14131","article-title":"OPTN\/SRTR 2015 Annual Data Report: Deceased Organ Donation","volume":"17","author":"Israni","year":"2017","journal-title":"Am. J. Transplant."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1055\/s-0033-1348464","article-title":"Donor selection and management","volume":"34","author":"Snell","year":"2013","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S1053-2498(03)00096-2","article-title":"A review of lung transplant donor acceptability criteria","volume":"22","author":"Orens","year":"2003","journal-title":"J. Heart Lung Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1183\/09031936.04.00094504","article-title":"Strategies to increase limited donor resources","volume":"23","author":"Weder","year":"2004","journal-title":"Eur. Respir. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.healun.2008.03.009","article-title":"Availability of lungs for transplantation: Exploring the real potential of the donor pool","volume":"27","author":"Snell","year":"2008","journal-title":"J. Heart Lung Transplant."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S1053-2498(00)00215-1","article-title":"Liberalization of donor criteria may expand the donor pool without adverse consequence in lung transplantation","volume":"19","author":"Bhorade","year":"2000","journal-title":"J. Heart Lung Transplant."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.jtcvs.2005.12.037","article-title":"Extended donor criteria in lung transplantation: Impact on organ allocation","volume":"131","author":"Botha","year":"2006","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1164\/rccm.200207-670SO","article-title":"Ischemia-reperfusion-induced lung injury","volume":"167","author":"Liu","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1055\/s-0033-1348474","article-title":"Primary graft dysfunction","volume":"34","author":"Suzuki","year":"2013","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.ejcts.2005.01.019","article-title":"Extended donor lungs: Eleven years experience in a consecutive series","volume":"27","author":"Lardinois","year":"2005","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0140-6736(00)04195-7","article-title":"Transplantation of lungs from a non-heart-beating donor","volume":"357","author":"Steen","year":"2001","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e652","DOI":"10.1097\/TXD.0000000000001104","article-title":"Ischemia-reperfusion injury in the transplanted lung: A literature review","volume":"7","author":"Talaie","year":"2021","journal-title":"Transplant. Direct"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.healun.2005.02.017","article-title":"Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part III: Donor-related risk factors and markers","volume":"24","author":"Bonser","year":"2005","journal-title":"J. Heart Lung Transplant."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.healun.2005.02.019","article-title":"Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part IV: Recipient-related risk factors and markers","volume":"24","author":"Barr","year":"2005","journal-title":"J. Heart Lung Transplant."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1378\/chest.124.4.1232","article-title":"Clinical risk factors for primary graft failure following lung transplantation","volume":"124","author":"Christie","year":"2003","journal-title":"Chest"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/17476348.2017.1280398","article-title":"Primary graft dysfunction: Pathophysiology to guide new preventive therapies","volume":"11","author":"Shaver","year":"2017","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.healun.2007.10.001","article-title":"The implications of pulmonary embolism in a multiorgan donor for subsequent pulmonary, renal, and cardiac transplantation","volume":"27","author":"Oto","year":"2008","journal-title":"J. Heart Lung Transplant."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ccm.2017.07.005","article-title":"Primary graft dysfunction after lung transplantation","volume":"38","author":"Porteous","year":"2017","journal-title":"Clin. Chest Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/j.1600-6143.2011.03579.x","article-title":"Liver ischemia and reperfusion injury: New insights into mechanisms of innate-adaptive immune-mediated tissue inflammation","volume":"11","author":"Zhai","year":"2011","journal-title":"Am. J. Transplant."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/CCM.0b013e31819267fb","article-title":"Molecular biology of inflammation and sepsis: A primer","volume":"37","author":"Cinel","year":"2009","journal-title":"Crit. Care Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1177\/000992288502401209","article-title":"Acute reversible pulmonary ischemia. A cause of the acute chest syndrome in sickle cell disease","volume":"24","author":"Babiker","year":"1985","journal-title":"Clin. Pediatr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1378\/chest.51.2.166","article-title":"Acquired extracardiac causes of pulmonary ischemia","volume":"51","author":"Templeton","year":"1967","journal-title":"Dis. Chest"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1540-8191.2009.00823.x","article-title":"Lung dys- function following cardiopulmonary bypass","volume":"25","author":"Apostolakis","year":"2010","journal-title":"J. Card. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/1089253212458329","article-title":"Lung ischemia reperfusion injury: A bench- to-bedside review","volume":"17","author":"Weyker","year":"2013","journal-title":"Semin. Cardiothorac. Vasc. Anesth."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000499610","article-title":"Organ preservation into the 2020s: The era of dynamic intervention","volume":"46","author":"Petrenko","year":"2019","journal-title":"Transfus. Med. Hemother."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ccm.2017.07.007","article-title":"Evaluation and management of the potential lung donor","volume":"38","author":"Courtwright","year":"2017","journal-title":"Clin. Chest Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1164\/rccm.201104-0728OC","article-title":"Obesity and primary graft dysfunction after lung transplantation: The Lung Transplant Outcomes Group Obesity Study","volume":"184","author":"Lederer","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.healun.2010.04.019","article-title":"Transfusion-related acute lung injury (TRALI) in graft by blood donor antibodies against host leukocytes","volume":"29","author":"Goodwin","year":"2010","journal-title":"J. Heart Lung Transplant."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0022-5223(98)70043-1","article-title":"Rapid reperfusion causes stress failure in ischemic rat lungs","volume":"116","author":"Pierre","year":"1998","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0003-4975(97)01002-3","article-title":"Controlled reperfusion protects lung grafts during a transient early increase in permeability","volume":"65","author":"Bhabra","year":"1998","journal-title":"Ann. Thorac. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0022-5223(98)70286-7","article-title":"Controlled reperfusion after lung ischemia: Implications for improved function after lung transplantation","volume":"115","author":"Halldorsson","year":"1998","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1152\/jappl.2000.89.4.1645","article-title":"Invited review: Mechanisms of ventilator-induced lung injury: A perspective","volume":"89","author":"Slutsky","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1067\/mtc.2002.125056","article-title":"Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model","volume":"124","author":"Imai","year":"2002","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00001503-200002000-00009","article-title":"Pulmonary transplantation","volume":"13","author":"McRae","year":"2000","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.healun.2004.11.049","article-title":"Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II: Definition. A consensus statement of the International Society for Heart and Lung Transplantation","volume":"24","author":"Christie","year":"2005","journal-title":"J. Heart Lung Transplant."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1513\/AnnalsATS.201312-419OC","article-title":"Mechanical ventilation after lung transplantation. An international survey of practices and preferences","volume":"11","author":"Beer","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.trre.2012.11.004","article-title":"Intraoperative protective ventilation strategies in lung transplantation","volume":"27","author":"Verbeek","year":"2013","journal-title":"Transplant. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0749-0704(02)00054-4","article-title":"Critical care issues in lung and heart transplantation","volume":"19","author":"Goudarzi","year":"2003","journal-title":"Crit. Care Clin."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/MOT.0000000000000232","article-title":"Primary graft dysfunction: Lessons learned about the first 72 h after lung transplantation","volume":"20","author":"Porteous","year":"2015","journal-title":"Curr. Opin. Organ. Transplant."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00540-020-02823-6","article-title":"Review 2: Primary graft dysfunction after lung transplant-pathophysiology, clinical considerations and therapeutic targets","volume":"34","author":"Jin","year":"2020","journal-title":"J. Anesth."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.healun.2010.05.013","article-title":"Construct validity of the definition of primary graft dysfunction after lung transplantation","volume":"29","author":"Christie","year":"2010","journal-title":"J. Heart Lung Transplant."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.healun.2017.07.021","article-title":"Report of the ISHLT Working Group on Primary Lung Graft Dysfunction, part I: Definition and grading-A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation","volume":"36","author":"Snell","year":"2017","journal-title":"J. Heart Lung Transplant."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/ACO.0b013e32834fdb54","article-title":"Protective ventilation for lung transplantation","volume":"25","author":"Lucangelo","year":"2012","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/MOT.0b013e3282ef7bad","article-title":"Primary graft dysfunction","volume":"12","author":"Hoffman","year":"2007","journal-title":"Curr. Opin. Organ. Transplant."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.healun.2005.03.011","article-title":"Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part VI: Treatment","volume":"24","author":"Shargall","year":"2005","journal-title":"J. Heart Lung Transplant."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1067\/mtc.2000.105639","article-title":"Selective use of extracorporeal membrane oxygenation is warranted after lung transplantation","volume":"120","author":"Meyers","year":"2000","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.athoracsur.2011.05.017","article-title":"Improved survival but marginal allograft function in patients treated with extracorporeal membrane oxygenation after lung transplantation","volume":"93","author":"Hartwig","year":"2012","journal-title":"Ann. Thorac. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.redox.2014.05.006","article-title":"Mitochondrial reactive oxygen species: A double edged sword in ischemia\/reperfusion vs. preconditioning","volume":"2","author":"Kalogeris","year":"2014","journal-title":"Redox Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1152\/ajpheart.00251.2010","article-title":"Lung ischemia-reperfusion injury: A molecular and clinical view on a complex pathophysiological process. American Journal of Physiology","volume":"299","author":"Gielis","year":"2010","journal-title":"Heart Circ. Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/1538574407304510","article-title":"Reperfusion syndrome: Cellular mechanisms of microvascular dysfunction and potential therapeutic strategies","volume":"41","author":"Girn","year":"2007","journal-title":"Vasc. Endovasc. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion\u2014From mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jss.2012.08.026","article-title":"When is injury potentially reversible in a lung ischemia-reperfusion model?","volume":"179","author":"Forgiarini","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: The evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"590987","DOI":"10.1155\/2015\/590987","article-title":"Oxidative stress and lung ischemia-reperfusion injury","volume":"2015","author":"Ferrari","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-3-319-63245-2_12","article-title":"Lung ischaemia-reperfusion injury: The role of reactive oxygen species","volume":"967","author":"Pak","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrm2256","article-title":"ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis","volume":"8","author":"Toledano","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.redox.2015.02.001","article-title":"Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species","volume":"4","author":"Mailloux","year":"2015","journal-title":"Redox Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13813450601118976","article-title":"Lung ischemia-reperfusion injury: Implications of oxidative stress and platelet-arteriolar wall interactions","volume":"113","author":"Ovechkin","year":"2007","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1165\/rcmb.2019-0082ED","article-title":"Three is better than one: An improved multiple-hit model of primary graft dysfunction","volume":"61","author":"Smirnova","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/ncomms1660","article-title":"Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice","volume":"3","author":"Weissmann","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1089\/ars.2013.5633","article-title":"NADPH oxidases in redox regulation of cell adhesion and migration","volume":"20","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1378\/chest.89.6.859","article-title":"Role of free radicals in lung injury","volume":"89","author":"Brigham","year":"1986","journal-title":"Chest"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1172\/JCI114019","article-title":"Role of reactive oxygen species in reperfusion injury of the rabbit lung","volume":"83","author":"Kennedy","year":"1989","journal-title":"J. Clin. Investig."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM198501173120305","article-title":"Oxygen-derived free radicals in postischemic tissue injury","volume":"312","author":"McCord","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1152\/ajplung.90377.2008","article-title":"Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia-reperfusion-induced lung injury","volume":"296","author":"Egemnazarov","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e787","DOI":"10.1038\/cddis.2013.313","article-title":"Characterization of oxygen radical formation mechanism at early cardiac ischemia","volume":"4","author":"Zhu","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"864946","DOI":"10.1155\/2015\/864946","article-title":"Molecular characterization of reactive oxygen species in myocardial ischemia-reperfusion injury","volume":"2015","author":"Zhou","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/abbi.1997.0367","article-title":"Hypoxia regulates xanthine dehydrogenase activity at pre- and posttranslational levels","volume":"348","author":"Terada","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/ajrccm.165.2.2011151","article-title":"Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation","volume":"165","author":"Sekine","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/01902148.2016.1158887","article-title":"Role of inflammatory cells and adenosine in lung ischemia reoxygenation injury using a model of lung donation after cardiac death","volume":"42","author":"Smail","year":"2016","journal-title":"Exp. Lung Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12967-016-0835-7","article-title":"Resolvin D1 mitigates energy metabolism disorder after ischemia-reperfusion of the rat lung","volume":"14","author":"Zhao","year":"2016","journal-title":"J. Transl. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1183\/09031936.05.00030304","article-title":"Pulmonary ischaemia-reperfusion injury: Role of apoptosis","volume":"25","author":"Ng","year":"2005","journal-title":"Eur. Respir. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.healun.2015.06.012","article-title":"Creatine supplementation attenuates pulmonary and systemic effects of lung ischemia and reperfusion injury","volume":"35","author":"Almeida","year":"2016","journal-title":"J. Heart Lung Transplant."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"L52","DOI":"10.1152\/ajplung.90406.2008","article-title":"Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema","volume":"297","author":"Zanotti","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: Sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1111\/ajt.12283","article-title":"Gene set enrichment analysis identifies key innate immune pathways in primary graft dysfunction after lung transplantation","volume":"13","author":"Cantu","year":"2013","journal-title":"Am. J. Transplant."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/MOT.0b013e3283651994","article-title":"Role of innate immunity in primary graft dysfunction after lung transplantation","volume":"18","author":"Diamond","year":"2013","journal-title":"Curr. Opin. Organ. Transplant."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1432-2277.2012.01549.x","article-title":"Innate immunity and organ transplantation: Focus on lung transplantation","volume":"26","author":"Kreisel","year":"2013","journal-title":"Transpl. Int."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.jtcvs.2015.02.045","article-title":"Differential toll-like receptor activation in lung ischemia reperfusion injury","volume":"149","author":"Phelan","year":"2015","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41423-019-0216-2","article-title":"The innate immune response to allotransplants: Mechanisms and therapeutic potentials","volume":"16","author":"Ochando","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/MOT.0000000000000304","article-title":"Mechanisms of lung ischemia-reperfusion injury","volume":"21","author":"Laubach","year":"2016","journal-title":"Curr. Opin. Organ. Transplant."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"L105","DOI":"10.1152\/ajplung.00470.2006","article-title":"Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury","volume":"293","author":"Sharma","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_87","first-page":"283","article-title":"Leukocytes in chemotactic-fragment-induced lung inflammation. Vascular emigration and alveolar surface migration","volume":"101","author":"Shaw","year":"1980","journal-title":"Am. J. Pathol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0003-4975(01)03606-2","article-title":"Ischemia-reperfusion injury after lung transplantation increases risk of late bronchiolitis obliterans syndrome","volume":"73","author":"Fiser","year":"2002","journal-title":"Ann. Thorac. Surg."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1164\/rccm.201007-1173OC","article-title":"Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury","volume":"183","author":"Sharma","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1067\/mtc.2001.113603","article-title":"Lung transplant reperfusion injury involves pulmonary macrophages and circulating leukocytes in a biphasic response","volume":"121","author":"Fiser","year":"2001","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/bjs.1800780607","article-title":"Pathophysiology of ischaemia reperfusion injury: Central role of the neutrophil","volume":"78","author":"Welbourn","year":"1991","journal-title":"Br. J. Surg."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"L1018","DOI":"10.1152\/ajplung.00086.2006","article-title":"Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury","volume":"291","author":"Zhao","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3389\/fimmu.2020.01259","article-title":"Multiple roles for chemokines in neutrophil biology","volume":"11","author":"Capucetti","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/bmb\/ldh025","article-title":"Vascular ischaemia and reperfusion injury","volume":"70","author":"Eltzschig","year":"2004","journal-title":"Br. Med. Bull."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.3389\/fimmu.2018.02171","article-title":"Update on neutrophil function in severe inflammation","volume":"9","author":"Mortaz","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1089\/ars.2016.6697","article-title":"Protein thiol redox signaling in monocytes and macrophages","volume":"25","author":"Short","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nm.2399","article-title":"The immunology of stroke: From mechanisms to translation","volume":"17","author":"Iadecola","year":"2011","journal-title":"Nat. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4049\/jimmunol.1102132","article-title":"Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice","volume":"188","author":"Elvington","year":"2012","journal-title":"J. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.4049\/jimmunol.0803980","article-title":"Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury","volume":"182","author":"Kulik","year":"2009","journal-title":"J. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1097\/SLA.0b013e3181a38f45","article-title":"Complement- mediated ischemia-reperfusion injury: Lessons learned from animal and clinical studies","volume":"249","author":"Diepenhorst","year":"2009","journal-title":"Ann. Surg."},{"key":"ref_101","first-page":"E47","article-title":"Lung as a model for evaluation of critical intracellular PO2 and PCO","volume":"241","author":"Fisher","year":"1981","journal-title":"Am. J. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1164\/ajrccm.160.2.9809023","article-title":"Influence of deflated and anaerobic conditions during cold storage on rat lungs","volume":"160","author":"Fukuse","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_103","first-page":"765","article-title":"Cellular and molecular mechanisms of endothelial ischemia\/reperfusion injury: Perspectives and implications for postischemic myocardial protection","volume":"8","author":"Yang","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1053-2498(98)00004-7","article-title":"Calcium channel blocker enhances lung preservation","volume":"18","author":"Sasaki","year":"1999","journal-title":"J. Heart Lung Transplant."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/nm1001-1123","article-title":"Heparin-binding protein (HBP\/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability","volume":"7","author":"Gautam","year":"2001","journal-title":"Nat. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000327943","article-title":"Targeting the mitochondrial permeability transition: Cardiac ischemia-reperfusion versus carcinogenesis","volume":"27","author":"Javadov","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"10346","DOI":"10.1038\/s41598-018-28724-z","article-title":"Cobra venom factor-induced complement depletion protects against lung ischemia reperfusion injury through alleviating blood-air barrier damage","volume":"8","author":"Haihua","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e13208","DOI":"10.1111\/ctr.13208","article-title":"Complement system in lung transplantation","volume":"32","author":"Ali","year":"2018","journal-title":"Clin. Transplant."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.jaci.2017.11.046","article-title":"The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target?","volume":"141","author":"Kulkarni","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-1-4614-0106-3_9","article-title":"Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis","volume":"946","author":"Bosmann","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"138358","DOI":"10.1172\/jci.insight.138358","article-title":"Local complement activation is associated with primary graft dysfunction after lung transplantation","volume":"5","author":"Kulkarni","year":"2020","journal-title":"JCI Insight"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3109\/13813455.2012.665463","article-title":"Platelet-mediated vascular dysfunction during acute lung injury","volume":"118","author":"Dixon","year":"2012","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/SHK.0000000000000044","article-title":"Neutrophils\u2014A key component of ischemia-reperfusion injury","volume":"40","author":"Schofield","year":"2013","journal-title":"Shock"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1165\/ajrcmb.23.3.4057","article-title":"Endothelin-1 changes polymorphonuclear leukocytes\u2019 deformability and CD11b expression and promotes their retention in the lung","volume":"23","author":"Sato","year":"2000","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_116","first-page":"155","article-title":"Pulmonary edema: Pathophysiology and diagnosis","volume":"15","author":"Murray","year":"2011","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_117","first-page":"21","article-title":"Pulmonary capillary pressure. A review","volume":"72","author":"Ganter","year":"2006","journal-title":"Minerva Anestesiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00007890-200101270-00003","article-title":"Protection against gas exchange abnormalities by pre-aerosolized PGE1, iloprost and nitroprus- side in lung ischemia-reperfusion","volume":"71","author":"Lockinger","year":"2001","journal-title":"Transplantation"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1164\/ajrccm.159.3.9802105","article-title":"Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation","volume":"159","author":"Ware","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1378\/chest.14-1748","article-title":"The future of lung transplantation","volume":"147","author":"Nathan","year":"2015","journal-title":"Chest"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jtcvs.2014.09.077","article-title":"Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation","volume":"149","author":"Cantu","year":"2015","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/ajt.13525","article-title":"Protein quantitative trait loci analysis identifies genetic variation in the innate immune regulator TOLLIP in post-lung transplant primary graft dysfunction risk","volume":"16","author":"Cantu","year":"2016","journal-title":"Am. J. Transplant."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/MOT.0000000000000234","article-title":"Update on ischemia-reperfusion injury in lung transplantation","volume":"20","author":"Chen","year":"2015","journal-title":"Curr. Opin. Organ Transplant."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/00000658-199909000-00009","article-title":"Lung transplantation: A decade of experience","volume":"230","author":"Meyers","year":"1999","journal-title":"Ann. Surg."},{"key":"ref_125","first-page":"161","article-title":"Bronchiolitis obliterans: Pathogenesis, prevention, and management","volume":"315","author":"Paradis","year":"1998","journal-title":"Am. J. Med. Sci."},{"key":"ref_126","first-page":"1255","article-title":"Bronchiolitis obliterans syndrome: Incidence, natural history, prognosis, and risk factors","volume":"17","author":"Heng","year":"1998","journal-title":"J. Heart Lung Transplant."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0022-5223(05)80003-0","article-title":"Obliterative bronchiolitis after lung and heart\u2013lung transplantation. An analysis of risk factors and management","volume":"110","author":"Bando","year":"1995","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/0003-4975(96)00776-X","article-title":"Stanford experience with obliterative bronchiolitis after lung and heart\u2013lung transplantation","volume":"62","author":"Reichenspurner","year":"1996","journal-title":"Ann. Thorac. Surg."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0046-8177(85)80130-1","article-title":"Pathologic pulmonary alterations in long-term human heart\u2013lung transplantation","volume":"16","author":"Yousem","year":"1985","journal-title":"Hum. Pathol."},{"key":"ref_130","first-page":"713","article-title":"A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts. International Society for Heart and Lung Transplantation","volume":"12","author":"Cooper","year":"1993","journal-title":"J. Heart Lung Transplant."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1164\/rccm.200910-1573OC","article-title":"Lung transplant airway hypoxia. A diathesis to fibrosis?","volume":"182","author":"Dhillon","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1378\/chest.109.4.870","article-title":"Delayed development of obliterative bronchiolitis syndrome with OKT3 after unilateral lung transplantation. A plea for multicenter immunosuppressive trials","volume":"109","author":"Ross","year":"1996","journal-title":"Chest"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1378\/chest.109.4.874","article-title":"Cytolytic therapy for the bronchiolitis obliterans syndrome complicating lung transplantation","volume":"109","author":"Snell","year":"1996","journal-title":"Chest"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0003-4975(10)65582-8","article-title":"Ex vivo evaluation of stored lungs","volume":"10","author":"Jirsch","year":"1970","journal-title":"Ann. Thorac. Surg."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.healun.2008.09.003","article-title":"Technique for prolonged normothermic ex vivo lung perfusion","volume":"27","author":"Cypel","year":"2008","journal-title":"J. Heart Lung Transplant."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0003-4975(03)00191-7","article-title":"Transplantation of lungs from non-heart-beating donors after functional assessment ex vivo","volume":"76","author":"Steen","year":"2003","journal-title":"Ann. Thorac. Surg."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.healun.2012.08.016","article-title":"Physiologic assessment of the ex vivo donor lung for transplantation","volume":"31","author":"Yeung","year":"2012","journal-title":"J. Heart Lung Transplant."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1586\/ers.11.93","article-title":"The clinical potential of ex vivo lung perfusion","volume":"6","author":"Cypel","year":"2012","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1056\/NEJMoa1014597","article-title":"Normothermic ex vivo lung perfusion in clinical lung transplantation","volume":"364","author":"Cypel","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/j.athoracsur.2007.01.033","article-title":"First human transplantation of a nonacceptable donor lung after reconditioning ex vivo","volume":"83","author":"Steen","year":"2007","journal-title":"Ann. Thorac. Surg."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.athoracsur.2008.09.049","article-title":"Clinical transplantation of initially rejected donor lungs after reconditioning ex vivo","volume":"87","author":"Ingemansson","year":"2009","journal-title":"Ann. Thorac. Surg."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.healun.2017.09.007","article-title":"Negative pressure ventilation decreases inflammation and lung edema during normothermic ex-vivo lung perfusion","volume":"37","author":"Aboelnazar","year":"2018","journal-title":"J. Heart Lung Transplant."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/tri.12649","article-title":"Evaluating acellular versus cellular perfusate composition during prolonged ex vivo lung perfusion after initial cold ischaemia for 24 hours","volume":"29","author":"Becker","year":"2015","journal-title":"Transpl. Int."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.healun.2015.03.023","article-title":"Comparison between cellular and acellular perfusates for ex vivo lung perfusion in a porcine model","volume":"34","author":"Roman","year":"2015","journal-title":"J. Heart Lung Transplant."},{"key":"ref_145","first-page":"643","article-title":"Ex-vivo lung perfusion","volume":"28","author":"Neyrinck","year":"2014","journal-title":"Transpl. Int."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0140-6736(12)61344-0","article-title":"Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: A pilot study of 12 patients","volume":"380","author":"Warnecke","year":"2012","journal-title":"Lancet"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/j.transproceed.2020.05.007","article-title":"A low-cost perfusate alternative for ex vivo lung perfusion","volume":"52","author":"Buchko","year":"2020","journal-title":"Transplant. Proc."},{"key":"ref_148","first-page":"31732","article-title":"Normothermic ex vivo lung perfusion: Does the indication impact organ utilization and patient out- comes after transplantation?","volume":"S0022-5223","author":"Cypel","year":"2019","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/ajt.13446","article-title":"Altered immunogenicity of donor lungs via removal of passenger leukocytes using ex vivo lung perfusion","volume":"16","author":"Stone","year":"2016","journal-title":"Am. J. Transplant."},{"key":"ref_150","first-page":"586","article-title":"Lung mechanical effects on the bronchial circulation","volume":"12","author":"Deffebach","year":"1990","journal-title":"Eur. Respir. J. Suppl."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/thx.6.4.343","article-title":"Observations on the normal anatomy of the bronchial arteries","volume":"6","author":"Cudkowicz","year":"1951","journal-title":"Thorax"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1161\/01.CIR.23.3.390","article-title":"Estimation of flow through bronchial-pulmonary vascular anastomoses with use of T-1824 dye","volume":"23","author":"Fritts","year":"1961","journal-title":"Circulation"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ppul.21135","article-title":"The bronchial circulation\u2014Worth a closer look: A review of the relationship between the bronchial vasculature and airway inflammation","volume":"45","author":"McCullagh","year":"2010","journal-title":"Pediatr. Pulmonol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/MOT.0b013e32833e1127","article-title":"Airway complications after lung transplantation can be avoided without bronchial artery revascularization","volume":"15","author":"Inci","year":"2010","journal-title":"Curr. Opin. Organ Transplant."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/0003-4975(96)00539-5","article-title":"Revascularization of the bronchial arteries in lung transplantation: An overview","volume":"62","author":"Olsen","year":"1996","journal-title":"Ann. Thorac. Surg."},{"key":"ref_156","first-page":"956","article-title":"Significance of bronchial mucosal blood flow for the monitoring of acute rejection in lung transplantation","volume":"10","author":"Takao","year":"1991","journal-title":"J. Heart Lung Transplant."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta20850","article-title":"An observational study of donor ex vivo lung perfusion in UK lung transplantation: DEVELOP-UK","volume":"20","author":"Fisher","year":"2016","journal-title":"Health Technol. Assess."},{"key":"ref_158","first-page":"577","article-title":"Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion","volume":"51","author":"Andreasson","year":"2017","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2s","DOI":"10.1183\/09031936.03.00420103","article-title":"Ventilator-induced lung injury","volume":"42","author":"Ricard","year":"2003","journal-title":"Eur. Respir. J."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.1038\/s41467-020-19581-4","article-title":"Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs","volume":"11","author":"Buchko","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1089\/hum.2016.070","article-title":"Safety and efficacy of ex vivo donor lung adenoviral IL-10 gene therapy in a large animal lung transplant survival model","volume":"28","author":"Machuca","year":"2017","journal-title":"Hum. Gene Ther."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"4ra9","DOI":"10.1126\/scitranslmed.3000266","article-title":"Functional repair of human donor lungs by IL-10 gene therapy","volume":"1","author":"Cypel","year":"2009","journal-title":"Sci. Transl. Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/mt.2012.57","article-title":"Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre- and post-lung transplantation in the pig","volume":"20","author":"Yeung","year":"2012","journal-title":"Mol. Ther."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12931-017-0704-9","article-title":"Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death","volume":"18","author":"Stone","year":"2017","journal-title":"Respir. Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1097\/TP.0000000000000830","article-title":"Ex vivo perfusion with adeno- sine A2A receptor agonist enhances rehabilitation of murine donor lungs after circulatory death","volume":"99","author":"Stone","year":"2015","journal-title":"Transplantation"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/icvts\/ivx438","article-title":"Experimental ex vivo lung perfusion with sevoflurane: Effects on damaged donor lung grafts","volume":"26","author":"Wang","year":"2018","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.athoracsur.2015.02.136","article-title":"\u03b22-Adrenoreceptor agonist inhalation during ex vivo lung perfusion attenuates lung injury","volume":"100","author":"Kondo","year":"2015","journal-title":"Ann. Thorac. Surg."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.athoracsur.2016.07.066","article-title":"Bronchodilator inhalation during ex vivo lung perfusion improves posttransplant graft function after warm ischemia","volume":"103","author":"Hijiya","year":"2017","journal-title":"Ann. Thorac. Surg."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"S1871","DOI":"10.21037\/jtd.2018.04.119","article-title":"Ex vivo lung perfusion: A potential platform for molecular diagnosis and ex vivo organ repair","volume":"10","author":"Hsin","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.21037\/jtd.2019.04.33","article-title":"Ex vivo lung perfusion prior to transplantation: An overview of current clinical practice worldwide","volume":"11","author":"Possoz","year":"2019","journal-title":"J. Thorac. Dis."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.chest.2017.02.018","article-title":"Ex vivo lung perfusion: A key tool for translational science in the lungs","volume":"151","author":"Tane","year":"2017","journal-title":"Chest"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/6\/1417\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:11:46Z","timestamp":1760163106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/6\/1417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,7]]},"references-count":171,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["cells10061417"],"URL":"https:\/\/doi.org\/10.3390\/cells10061417","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,7]]}}}