{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:30:30Z","timestamp":1790523030536,"version":"4.1.0"},"reference-count":166,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Pulmonary hypertension (PH) is a severe and multifactorial disease characterized by a progressive elevation of pulmonary arterial resistance and pressure due to remodeling, inflammation, oxidative stress, and vasoreactive alterations of pulmonary arteries (PAs). Currently, the etiology of these pathological features is not clearly understood and, therefore, no curative treatment is available. Since the 1990s, hydrogen sulfide (H2S) has been described as the third gasotransmitter with plethoric regulatory functions in cardiovascular tissues, especially in pulmonary circulation. Alteration in H2S biogenesis has been associated with the hallmarks of PH. H2S is also involved in pulmonary vascular cell homeostasis via the regulation of hypoxia response and mitochondrial bioenergetics, which are critical phenomena affected during the development of PH. In addition, H2S modulates ATP-sensitive K+ channel (KATP) activity, and is associated with PA relaxation. In vitro or in vivo H2S supplementation exerts antioxidative and anti-inflammatory properties, and reduces PA remodeling. Altogether, current findings suggest that H2S promotes protective effects against PH, and could be a relevant target for a new therapeutic strategy, using attractive H2S-releasing molecules. Thus, the present review discusses the involvement and dysregulation of H2S metabolism in pulmonary circulation pathophysiology.<\/jats:p>","DOI":"10.3390\/cells10061477","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T10:30:25Z","timestamp":1623666625000},"page":"1477","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Hydrogen Sulfide Metabolism and Pulmonary Hypertension"],"prefix":"10.3390","volume":"10","author":[{"given":"Lukas","family":"Roubenne","sequence":"first","affiliation":[{"name":"INSERM, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, Avenue du Haut-L\u00e9v\u00eaque, F-33604 Pessac, France"},{"name":"Centre de Recherche Cardio-Thoracique de Bordeaux, Univ Bordeaux, U1045, 146 Rue L\u00e9o Saignat, F-33000 Bordeaux, France"},{"name":"OP2 Drugs, Avenue du Haut L\u00e9v\u00eaque, F-33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5412-5712","authenticated-orcid":false,"given":"Roger","family":"Marthan","sequence":"additional","affiliation":[{"name":"INSERM, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, Avenue du Haut-L\u00e9v\u00eaque, F-33604 Pessac, France"},{"name":"Centre de Recherche Cardio-Thoracique de Bordeaux, Univ Bordeaux, U1045, 146 Rue L\u00e9o Saignat, F-33000 Bordeaux, France"},{"name":"CHU de Bordeaux, Avenue du Haut L\u00e9v\u00eaque, F-33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Le Grand","sequence":"additional","affiliation":[{"name":"OP2 Drugs, Avenue du Haut L\u00e9v\u00eaque, F-33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-5694","authenticated-orcid":false,"given":"Christelle","family":"Guibert","sequence":"additional","affiliation":[{"name":"INSERM, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, Avenue du Haut-L\u00e9v\u00eaque, F-33604 Pessac, France"},{"name":"Centre de Recherche Cardio-Thoracique de Bordeaux, Univ Bordeaux, U1045, 146 Rue L\u00e9o Saignat, F-33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S2213-2600(19)30111-0","article-title":"An insider view on the World Symposium on Pulmonary Hypertension","volume":"7","author":"Humbert","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"ref_2","first-page":"67","article-title":"2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)","volume":"37","author":"Humbert","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1801900","DOI":"10.1183\/13993003.01900-2018","article-title":"Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: An update","volume":"53","author":"Noordegraaf","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1801887","DOI":"10.1183\/13993003.01887-2018","article-title":"Pathology and pathobiology of pulmonary hypertension: State of the art and research perspectives","volume":"53","author":"Humbert","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"De La Roque, E.D., Smeralda, G., Quignard, J.-F., Freund-Michel, V., Courtois, A., Marthan, R., Muller, B., Guibert, C., and Dubois, M. (2017). Altered vasoreactivity in neonatal rats with pulmonary hypertension associated with bronchopulmonary dysplasia: Implication of both eNOS phosphorylation and calcium signaling. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173044"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1700745","DOI":"10.1183\/13993003.00745-2017","article-title":"Pulmonary vascular endothelium: The orchestra conductor in respiratory diseases","volume":"51","author":"Huertas","year":"2018","journal-title":"Eur. Respir. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"L893","DOI":"10.1152\/ajplung.00430.2017","article-title":"Reactive oxygen species induced Ca2+ influx via TRPV4 and microvascular endothelial dysfunction in the SU5416\/hypoxia model of pulmonary arterial hypertension","volume":"314","author":"Suresh","year":"2018","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00424-006-0178-y","article-title":"Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteries","volume":"454","author":"Rodat","year":"2006","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.7150\/ijbs.20316","article-title":"Activation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: An Insight from a Plant Polyphenol","volume":"13","author":"Chen","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1172\/JCI96462","article-title":"Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension","volume":"128","author":"Tamura","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1701024","DOI":"10.1183\/13993003.01024-2017","article-title":"Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension","volume":"51","author":"Pak","year":"2018","journal-title":"Eur. Respir. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/978-3-319-63245-2_17","article-title":"Cross Talk Between Mitochondrial Reactive Oxygen Species and Sarcoplasmic Reticulum Calcium in Pulmonary Arterial Smooth Muscle Cells","volume":"967","author":"Song","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"942","DOI":"10.7150\/ijms.16810","article-title":"Resveratrol alleviate hypoxic pulmonary hypertension via anti-inflammation and anti-oxidant pathways in rats","volume":"13","author":"Xu","year":"2016","journal-title":"Int. J. Med. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s13181-019-00710-5","article-title":"Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development","volume":"15","author":"Ng","year":"2019","journal-title":"J. Med. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_16","first-page":"1","article-title":"Endogenous CSE\/Hydrogen Sulfide System Regulates the Effects of Glucocorticoids and Insulin on Muscle Protein Synthesis","volume":"2019","author":"Wang","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1113\/EP086775","article-title":"Endogenous peripheral hydrogen sulfide is propyretic: Its permissive role in brown adipose tissue thermogenesis in rats","volume":"103","author":"Soriano","year":"2018","journal-title":"Exp. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"H71","DOI":"10.1152\/ajpheart.00574.2014","article-title":"MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery","volume":"310","author":"Kuo","year":"2016","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"22457","DOI":"10.1074\/jbc.M109.010868","article-title":"Relative Contributions of Cystathionine \u03b2-Synthase and \u03b3-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions","volume":"284","author":"Singh","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/ars.2010.3781","article-title":"The Quantitative Significance of the Transsulfuration Enzymes for H2S Production in Murine Tissues","volume":"15","author":"Kabil","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1089\/ars.2013.5309","article-title":"Production and Physiological Effects of Hydrogen Sulfide","volume":"20","author":"Kimura","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/jb\/mvp111","article-title":"Vascular Endothelium Expresses 3-Mercaptopyruvate Sulfurtransferase and Produces Hydrogen Sulfide","volume":"146","author":"Shibuya","year":"2009","journal-title":"J. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/BJ20110841","article-title":"Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide","volume":"439","author":"Mikami","year":"2011","journal-title":"Biochem. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","article-title":"The Possible Role of Hydrogen Sulfide as an Endogenous Smooth Muscle Relaxant in Synergy with Nitric Oxide","volume":"237","author":"Hosoki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a Novel, Water-Soluble Hydrogen Sulfide\u2013Releasing Molecule (GYY4137)","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine -Lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.3389\/fphar.2019.01568","article-title":"Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide","volume":"10","author":"Sun","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.2337\/db16-0020","article-title":"Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation","volume":"65","author":"Xie","year":"2016","journal-title":"Diabetes"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"782","DOI":"10.3389\/fphys.2017.00782","article-title":"Hydrogen Sulfide Attenuates Atherosclerosis in a Partially Ligated Carotid Artery Mouse model via Regulating Angiotensin Converting Enzyme 2 Expression","volume":"8","author":"Lin","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"113833","DOI":"10.1016\/j.bcp.2020.113833","article-title":"Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase","volume":"176","author":"Peleli","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/bs.mie.2014.11.042","article-title":"Oxidation of H2S in Mammalian Cells and Mitochondria","volume":"554","author":"Lenoir","year":"2015","journal-title":"Methods Enzymol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"882","DOI":"10.3389\/fimmu.2018.00882","article-title":"The Increased Endogenous Sulfur Dioxide Acts as a Compensatory Mechanism for the Downregulated Endogenous Hydrogen Sulfide Pathway in the Endothelial Cell Inflammation","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0006-291X(03)00256-0","article-title":"The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats","volume":"302","author":"Chunyu","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/FJC.0000000000000714","article-title":"A Novel Mechanism of Sildenafil Improving the Excessive Proliferation and H2S Production in Pulmonary Arterial Smooth Muscle Cells","volume":"74","author":"Yao","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1042\/CS20190514","article-title":"Endogenous hydrogen sulfide sulfhydrates IKK\u03b2 at cysteine 179 to control pulmonary artery endothelial cell inflammation","volume":"133","author":"Zhang","year":"2019","journal-title":"Clin. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1242\/jeb.02480","article-title":"Hydrogen sulfide as an oxygen sensor\/transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation","volume":"209","author":"Olson","year":"2006","journal-title":"J. Exp. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"R51","DOI":"10.1152\/ajpregu.00576.2009","article-title":"Hypoxic pulmonary vasodilation: A paradigm shift with a hydrogen sulfide mechanism","volume":"298","author":"Olson","year":"2010","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1080\/00071668.2012.728284","article-title":"Sodium hydrosulfide prevents hypoxia-induced pulmonary arterial hypertension in broilers","volume":"53","author":"Yang","year":"2012","journal-title":"Br. Poult. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cyto.2008.11.009","article-title":"Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma","volume":"45","author":"Chen","year":"2009","journal-title":"Cytokine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/aps.2011.9","article-title":"The vasorelaxing effect of hydrogen sulfide on isolated rat aortic rings versus pulmonary artery rings","volume":"32","author":"Sun","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1113\/jphysiol.2014.277046","article-title":"Hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries is not inhibited by antagonists of H2S-synthesizing pathways","volume":"593","author":"Shaifta","year":"2015","journal-title":"J. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbrc.2013.03.014","article-title":"Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow","volume":"433","author":"Luo","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1152\/japplphysiol.01049.2011","article-title":"Precursors and inhibitors of hydrogen sulfide synthesis affect acute hypoxic pulmonary vasoconstriction in the intact lung","volume":"112","author":"Madden","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e13368","DOI":"10.1111\/apha.13368","article-title":"Extended hypoxia-mediated H2S production provides for long-term oxygen sensing","volume":"228","author":"Olson","year":"2020","journal-title":"Acta Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/00029330-200803010-00010","article-title":"Effects of nitric oxide and hydrogen sulfide on the relaxation of pulmonary arteries in rats","volume":"121","author":"Wang","year":"2008","journal-title":"Chin. Med. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00380-008-1059-4","article-title":"Sodium hydrosulfide alleviates pulmonary artery collagen remodeling in rats with high pulmonary blood flow","volume":"23","author":"Li","year":"2008","journal-title":"Heart Vessel."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.lfs.2007.07.021","article-title":"The regulatory effect of endogenous hydrogen sulfide on pulmonary vascular structure and gasotransmitters in rats with high pulmonary blood flow","volume":"81","author":"Li","year":"2007","journal-title":"Life Sci."},{"key":"ref_50","first-page":"2091","article-title":"Protective effect of hydrogen sulfide on monocrotaline-induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition","volume":"44","author":"Zhang","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"20190304","DOI":"10.1042\/BSR20190304","article-title":"H2S attenuates endoplasmic reticulum stress in hypoxia-induced pulmonary artery hypertension","volume":"39","author":"Wu","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Vadivel, A., Alphonse, R.S., Ionescu, L., Machado, D.S., O\u2019Reilly, M., Eaton, F., Haromy, A., Michelakis, E.D., and Th\u00e9baud, B. (2014). Exogenous Hydrogen Sulfide (H2S) Protects Alveolar Growth in Experimental O2-Induced Neonatal Lung Injury. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0090965"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1745-7254.2008.00796.x","article-title":"Hydrogen sulfide regulates lung tissue-oxidized glutathione and total antioxidant capacity in hypoxic pulmonary hypertensive rats","volume":"29","author":"Wei","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bcp.2017.11.014","article-title":"A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications","volume":"149","author":"Powell","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/bs.mie.2014.11.014","article-title":"GYY4137, a Novel Water-Soluble, H2S-Releasing Molecule","volume":"554","author":"Rose","year":"2015","journal-title":"Methods Enzymol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jconrel.2020.11.060","article-title":"Microfluidic fabrication of inhalable large porous microspheres loaded with H2S-releasing aspirin derivative for pulmonary arterial hypertension therapy","volume":"329","author":"Zhang","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"L283","DOI":"10.1152\/ajplung.1998.275.2.L283","article-title":"Garlic prevents hypoxic pulmonary hypertension in rats","volume":"275","author":"Fallon","year":"1998","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen sulfide mediates the vasoactivity of garlic","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-019-0431-5","article-title":"Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6","volume":"2","author":"Yang","year":"2019","journal-title":"Commun. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"R592","DOI":"10.1152\/ajpregu.00421.2012","article-title":"Thiosulfate: A readily accessible source of hydrogen sulfide in oxygen sensing","volume":"305","author":"Olson","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bcp.2017.12.010","article-title":"H2S and polysulfide metabolism: Conventional and unconventional pathways","volume":"149","author":"Olson","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.niox.2013.07.001","article-title":"Chemical foundations of hydrogen sulfide biology","volume":"35","author":"Li","year":"2013","journal-title":"Nitric Oxide"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"R1479","DOI":"10.1152\/ajpregu.90566.2008","article-title":"Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values","volume":"295","author":"Furne","year":"2008","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1089\/ars.2011.4310","article-title":"High Turnover Rates for Hydrogen Sulfide Allow for Rapid Regulation of Its Tissue Concentrations","volume":"17","author":"Vitvitsky","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"12077","DOI":"10.1074\/jbc.RA119.009442","article-title":"Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells","volume":"294","author":"Libiad","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"13098","DOI":"10.1096\/fj.201901304R","article-title":"Hydrogen sulfide signaling in mitochondria and disease","volume":"33","author":"Murphy","year":"2019","journal-title":"FASEB J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10863-008-9166-6","article-title":"The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: Chemical mechanism and physiological significance","volume":"40","author":"Cooper","year":"2008","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1096\/fj.15-278648","article-title":"Cystathionine \u03b2-synthase regulates endothelial function via protein S -sulfhydration","volume":"30","author":"Saha","year":"2016","journal-title":"FASEB J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"12679","DOI":"10.1073\/pnas.1308487110","article-title":"Oxygen-sensitive mitochondrial accumulation of cystathionine -synthase mediated by Lon protease","volume":"110","author":"Teng","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1073\/pnas.1115634109","article-title":"Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production","volume":"109","author":"Fu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1089\/ars.2013.5339","article-title":"Enzymology of H2S Biogenesis, Decay and Signaling","volume":"20","author":"Kabil","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1074\/jbc.M115.685578","article-title":"Transcriptional Regulation of Cystathionine-\u03b3-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling","volume":"291","author":"Mistry","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"7603","DOI":"10.1074\/jbc.M111.304576","article-title":"Integrated Stress Response Modulates Cellular Redox State via Induction of Cystathionine \u03b3-Lyase","volume":"287","author":"Dickhout","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.yexcr.2016.08.004","article-title":"Inhibition of hydrogen sulfide on the proliferation of vascular smooth muscle cells involved in the modulation of calcium sensing receptor in high homocysteine","volume":"347","author":"Wang","year":"2016","journal-title":"Exp. Cell Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.yexcr.2017.06.013","article-title":"Calcium sensing receptor initiating cystathionine-gamma-lyase\/hydrogen sulfide pathway to inhibit platelet activation in hyperhomocysteinemia rat","volume":"358","author":"Wang","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molcel.2011.10.021","article-title":"Hydrogen Sulfide-Linked Sulfhydration of NF-\u03baB Mediates Its Antiapoptotic Actions","volume":"45","author":"Sen","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ncomms2371","article-title":"A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells","volume":"4","author":"Shibuya","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/bph.14464","article-title":"Homeostatic impact of sulfite and hydrogen sulfide on cysteine catabolism","volume":"176","author":"Kohl","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1113\/expphysiol.2011.057455","article-title":"Hydrogen sulfide: Its production and functions","volume":"96","author":"Kimura","year":"2011","journal-title":"Exp. Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1096\/fj.12-216507","article-title":"Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics","volume":"27","author":"Coletta","year":"2013","journal-title":"FASEB J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.bbrc.2015.07.115","article-title":"Laminar shear flow increases hydrogen sulfide and activates a nitric oxide producing signaling cascade in endothelial cells","volume":"464","author":"Huang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/bph.14100","article-title":"Multiple role of 3-mercaptopyruvate sulfurtransferase: Antioxidative function, H2S and polysulfide production and possible SOxproduction","volume":"175","author":"Nagahara","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"101772","DOI":"10.1016\/j.redox.2020.101772","article-title":"Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics","volume":"38","author":"Paul","year":"2021","journal-title":"Redox Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1089\/ars.2012.5010","article-title":"The Cysteine Dioxgenase Knockout Mouse: Altered Cysteine Metabolism in Nonhepatic Tissues Leads to Excess H2S\/HS\u2212Production and Evidence of Pancreatic and Lung Toxicity","volume":"19","author":"Roman","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/ars.2014.5930","article-title":"Hydrogen Sulfide as an Oxygen Sensor","volume":"22","author":"Olson","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1365-2125.2010.03636.x","article-title":"Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide","volume":"69","author":"Toombs","year":"2010","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1165\/rcmb.2017-0114TR","article-title":"Hydrogen Sulfide: A Novel Player in Airway Development, Pathophysiology of Respiratory Diseases, and Antiviral Defenses","volume":"57","author":"Bazhanov","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.alit.2020.10.003","article-title":"Hydrogen sulfide as a novel biomarker of asthma and chronic obstructive pulmonary disease","volume":"70","author":"Suzuki","year":"2021","journal-title":"Allergol. Int."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10545-009-9006-9","article-title":"Dealing with methionine\/homocysteine sulfur: Cysteine metabolism to taurine and inorganic sulfur","volume":"34","author":"Stipanuk","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"L710","DOI":"10.1152\/ajplung.00134.2015","article-title":"The H2S-generating enzymes cystathionine \u03b2-synthase and cystathionine \u03b3-lyase play a role in vascular development during normal lung alveolarization","volume":"309","author":"Madurga","year":"2015","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1113\/expphysiol.2011.057448","article-title":"Hydrogen sulfide and asthma","volume":"96","author":"Wang","year":"2011","journal-title":"Exp. Physiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.bbrc.2006.04.162","article-title":"Impact of l-arginine on hydrogen sulfide\/cystathionine-\u03b3-lyase pathway in rats with high blood flow-induced pulmonary hypertension","volume":"345","author":"Yanfei","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1253\/circj.69.1418","article-title":"Down-Regulation of Endogenous Hydrogen Sulfide Pathway in Pulmonary Hypertension and Pulmonary Vascular Structural Remodeling Induced by High Pulmonary Blood Flow in Rats","volume":"69","author":"Xiaohui","year":"2005","journal-title":"Circ. J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1089\/ars.2010.3821","article-title":"Hydrogen Sulfide Ameliorates Tobacco Smoke-Induced Oxidative Stress and Emphysema in Mice","volume":"15","author":"Han","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/bph.12171","article-title":"Selectivity of commonly used pharmacological inhibitors for cystathionine \u03b2 synthase (CBS) and cystathionine \u03b3 lyase (CSE)","volume":"169","author":"Asimakopoulou","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/j.1745-7254.2008.00845.x","article-title":"Endogenously generated sulfur dioxide and its vasorelaxant effect in rats1","volume":"29","author":"Du","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbrc.2011.10.012","article-title":"Endogenous generation of sulfur dioxide in rat tissues","volume":"415","author":"Luo","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"19503","DOI":"10.1038\/srep19503","article-title":"Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-\u03b2\/Smad pathway in vascular smooth muscle cells","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"21112","DOI":"10.1038\/srep21112","article-title":"Mechanical stretching stimulates collagen synthesis via down-regulating SO2\/AAT1 pathway","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e003910","DOI":"10.1161\/JAHA.116.003910","article-title":"Sulfur Dioxide Protects Against Collagen Accumulation in Pulmonary Artery in Association with Downregulation of the Transforming Growth Factor \u03b21\/Smad Pathway in Pulmonary Hypertensive Rats","volume":"5","author":"Yu","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"L389","DOI":"10.1152\/ajplung.00432.2012","article-title":"Thioredoxin-1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation","volume":"305","author":"Chen","year":"2013","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"L599","DOI":"10.1152\/ajplung.00258.2016","article-title":"Hypoxia inhibits expression and function of mitochondrial thioredoxin 2 to promote pulmonary hypertension","volume":"312","author":"Adesina","year":"2017","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.niox.2020.12.002","article-title":"The H2S-generating enzyme 3-mercaptopyruvate sulfurtransferase regulates pulmonary vascular smooth muscle cell migration and proliferation but does not impact normal or aberrant lung development","volume":"107","author":"Lignelli","year":"2021","journal-title":"Nitric Oxide"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3389\/fphar.2017.00657","article-title":"3-Mercaptopyruvate Sulfurtransferase, Not Cystathionine \u03b2-Synthase Nor Cystathionine \u03b3-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells","volume":"8","author":"Tao","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1113\/JP275852","article-title":"Sensors and signals: The role of reactive oxygen species in hypoxic pulmonary vasoconstriction","volume":"597","author":"Smith","year":"2018","journal-title":"J. Physiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"L223","DOI":"10.1152\/ajplung.1994.266.3.L223","article-title":"Hypoxic vasoconstriction in rat pulmonary and mesenteric arteries","volume":"266","author":"Leach","year":"1994","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1183\/13993003.00945-2015","article-title":"Oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction","volume":"47","author":"Sommer","year":"2015","journal-title":"Eur. Respir. J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"L670","DOI":"10.1152\/ajplung.00283.2016","article-title":"Role of reactive oxygen species and sulfide-quinone oxoreductase in hydrogen sulfide-induced contraction of rat pulmonary arteries","volume":"314","author":"Snetkov","year":"2018","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1161\/HYPERTENSIONAHA.117.10562","article-title":"Cystathionine \u03b3-Lyase\u2013Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure","volume":"71","author":"Filipovic","year":"2018","journal-title":"Hypertension"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1113\/jphysiol.2013.253682","article-title":"Hypoxic pulmonary vasoconstriction in the absence of pretone: Essential role for intracellular Ca2+ release","volume":"591","author":"Connolly","year":"2013","journal-title":"J. Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mvr.2013.09.002","article-title":"Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension?","volume":"90","author":"Ariyaratnam","year":"2013","journal-title":"Microvasc. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"110240","DOI":"10.1016\/j.biopha.2020.110240","article-title":"Antihypertensive effects of allicin on spontaneously hypertensive rats via vasorelaxation and hydrogen sulfide mechanisms","volume":"128","author":"Cui","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1152\/jappl.2000.89.1.353","article-title":"Analysis of responses of garlic derivatives in the pulmonary vascular bed of the rat","volume":"89","author":"Kaye","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1046\/j.1440-1681.2002.03596.x","article-title":"Garlic and its Active Metabolite Allicin Produce Endothelium- and Nitric Oxide-Dependent Relaxation In Rat Pulmonary Arteries","volume":"29","author":"Ku","year":"2002","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1046\/j.1440-1681.2000.03333.x","article-title":"Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats","volume":"27","author":"Ku","year":"2000","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels","volume":"109","author":"Mustafa","year":"2011","journal-title":"Circ. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.lfs.2008.08.006","article-title":"Hydrogen sulfide decreases adenosine triphosphate levels in aortic rings and leads to vasorelaxation via metabolic inhibition","volume":"83","author":"Kiss","year":"2008","journal-title":"Life Sci."},{"key":"ref_118","first-page":"1","article-title":"Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology","volume":"2018","author":"Vicente","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.niox.2017.10.010","article-title":"The mechanism of action and role of hydrogen sulfide in the control of vascular tone","volume":"81","author":"Dybvig","year":"2018","journal-title":"Nitric Oxide"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"31888","DOI":"10.18632\/oncotarget.16649","article-title":"Sulfhydration-associated phosphodiesterase 5A dimerization mediates vasorelaxant effect of hydrogen sulfide","volume":"8","author":"Sun","year":"2017","journal-title":"Oncotarget"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"C537","DOI":"10.1152\/ajpcell.00329.2016","article-title":"Vascular biology of hydrogen sulfide","volume":"312","author":"Kanagy","year":"2017","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_122","first-page":"1","article-title":"Imbalance of Homocysteine and H2S: Significance, Mechanisms, and Therapeutic Promise in Vascular Injury","volume":"2019","author":"Yang","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.atherosclerosis.2012.08.036","article-title":"Relationship between hydrogen sulfide levels and HDL-cholesterol, adiponectin, and potassium levels in the blood of healthy subjects","volume":"225","author":"Jain","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e000387","DOI":"10.1161\/JAHA.113.000387","article-title":"Plasma Free H2S Levels are Elevated in Patients with Cardiovascular Disease","volume":"2","author":"Peter","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.redox.2018.01.007","article-title":"Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease","volume":"15","author":"Rajpal","year":"2018","journal-title":"Redox Biol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3760\/cma.j.issn.0366-6999.20132694","article-title":"Potential biomarkers predicting risk of pulmonary hypertension in congenital heart disease: The role of homocysteine and hydrogen sulfide","volume":"127","author":"Sun","year":"2014","journal-title":"Chin. Med. J."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00246-012-0321-9","article-title":"Elevated Homocysteine and Asymmetric Dimethyl Arginine Levels in Pulmonary Hypertension Associated with Congenital Heart Disease","volume":"33","author":"Sanli","year":"2012","journal-title":"Pediatr. Cardiol."},{"key":"ref_128","first-page":"1915","article-title":"The prognostic implications of perioperative endogenous hydrogen sulfide and nitric oxide levels in children with congenital heart disease complicated by pulmonary arterial hypertension","volume":"180","author":"Tan","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"D109","DOI":"10.1016\/j.jacc.2013.10.036","article-title":"Pulmonary Hypertension in Chronic Lung Diseases","volume":"62","author":"Seeger","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1378\/chest.128.5.3205","article-title":"Endogenous Hydrogen Sulfide in Patients With COPD","volume":"128","author":"Chen","year":"2005","journal-title":"Chest"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"14971","DOI":"10.1038\/srep14971","article-title":"Metabolic changes of H2S in smokers and patients of COPD which might involve in inflammation, oxidative stress and steroid sensitivity","volume":"5","author":"Sun","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4187\/respcare.03519","article-title":"Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD","volume":"60","author":"Zhang","year":"2014","journal-title":"Respir. Care"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1053\/j.semperi.2018.09.001","article-title":"Recent advances in the pathogenesis of BPD","volume":"42","author":"Morty","year":"2018","journal-title":"Semin. Perinatol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.pedneo.2018.11.007","article-title":"Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia","volume":"60","author":"Kurata","year":"2019","journal-title":"Pediatr. Neonatol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Donda, K., Zambrano, R., Moon, Y., Percival, J., Vaidya, R., Dapaah-Siakwan, F., Luo, S., Duncan, M.R., Bao, Y., and Wang, L. (2018). Riociguat prevents hyperoxia-induced lung injury and pulmonary hypertension in neonatal rats without effects on long bone growth. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0199927"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/MOP.0000000000000095","article-title":"Disrupted lung development and bronchopulmonary dysplasia: Opportunities for Lung Repair and Regeneration","volume":"26","author":"Baker","year":"2014","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/ajcn\/61.5.1067","article-title":"L-cysteine and glutathione metabolism are impaired in premature infants due to cystathionase deficiency","volume":"61","author":"Vento","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1203\/00006450-198201001-00013","article-title":"The Development of Cystathionase Activity During the First Year of Life","volume":"16","author":"Zlotkin","year":"1982","journal-title":"Pediatr. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.phrs.2017.08.003","article-title":"Animal models of pulmonary arterial hypertension: A systematic review and meta-analysis of data from 6126 animals","volume":"125","author":"Sztuka","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"H1484","DOI":"10.1152\/ajpheart.1988.255.6.H1484","article-title":"Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension","volume":"255","author":"Rosenberg","year":"1988","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/labinvest.2016.129","article-title":"H2S inhibits pulmonary arterial endothelial cell inflammation in rats with monocrotaline-induced pulmonary hypertension","volume":"97","author":"Feng","year":"2017","journal-title":"Lab. Investig."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbrc.2004.02.176","article-title":"Impact of hydrogen sulfide on carbon monoxide\/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension","volume":"317","author":"Qingyou","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.lfs.2005.07.009","article-title":"Effects of hydrogen sulfide on hypoxic pulmonary vascular structural remodeling","volume":"78","author":"Hongfang","year":"2006","journal-title":"Life Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3389\/fphys.2018.00606","article-title":"Plasmatic Concentrations of ADMA and Homocystein in Llama (Lama glama) and Regulation of Arginase Type II: An Animal Resistent to the Development of Pulmonary Hypertension Induced by Hypoxia","volume":"9","author":"Moraga","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_145","first-page":"3032","article-title":"Hydrogen sulfide induces apoptosis of pulmonary artery smooth muscle cell in rats with pulmonary hypertension induced by high pulmonary blood flow","volume":"122","author":"Li","year":"2009","journal-title":"Chin. Med. J."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1161\/ATVBAHA.118.311402","article-title":"Cystathionine \u03b3-Lyase Modulates Flow-Dependent Vascular Remodeling","volume":"38","author":"Yuan","year":"2018","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1089\/ham.2015.0086","article-title":"Chronic Normobaric Hypoxia Induces Pulmonary Hypertension in Rats: Role of NF-\u03baB","volume":"17","author":"Fan","year":"2016","journal-title":"High Alt. Med. Biol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.biopha.2018.10.109","article-title":"AOS ameliorates monocrotaline-induced pulmonary hypertension by restraining the activation of P-selectin\/p38MAPK\/NF-\u03baB pathway in rats","volume":"109","author":"Hu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.freeradbiomed.2010.02.014","article-title":"Modulation of thiol homeostasis induced by H2S-releasing aspirin","volume":"48","author":"Giustarini","year":"2010","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.biopha.2018.05.131","article-title":"Protective effect of exogenous hydrogen sulfide on pulmonary artery endothelial cells by suppressing endoplasmic reticulum stress in a rat model of chronic obstructive pulmonary disease","volume":"105","author":"Ding","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_151","first-page":"1481","article-title":"A crucial role of endoplasmic reticulum stress in cellular responses during pulmonary arterial hypertension","volume":"12","author":"Pan","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"9372","DOI":"10.1096\/fj.202000173R","article-title":"Cystathionine beta synthase regulates mitochondrial dynamics and function in endothelial cells","volume":"34","author":"Rao","year":"2020","journal-title":"FASEB J."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"L684","DOI":"10.1152\/ajplung.00361.2013","article-title":"Systemic hydrogen sulfide administration partially restores normal alveolarization in an experimental animal model of bronchopulmonary dysplasia","volume":"306","author":"Madurga","year":"2014","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_154","unstructured":"Terjung, R. (2017). Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure. Comprehensive Physiology, John Wiley & Sons."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/1755-5922.12128","article-title":"A Novel Hydrogen Sulfide Prodrug, SG 1002, Promotes Hydrogen Sulfide and Nitric Oxide Bioavailability in Heart Failure Patients","volume":"33","author":"Polhemus","year":"2015","journal-title":"Cardiovasc. Ther."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/CIRCULATIONAHA.112.000855","article-title":"H2S Protects Against Pressure Overload\u2013Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase","volume":"127","author":"Kondo","year":"2013","journal-title":"Circulation"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"10061","DOI":"10.2147\/IJN.S216667","article-title":"A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-\u03b21\/Smad Pathway","volume":"14","author":"Tran","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1172\/JCI120847","article-title":"Mitochondrial metabolism in pulmonary hypertension: Beyond mountains there are mountains","volume":"128","author":"Culley","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/bph.13861","article-title":"Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3-dependent manner","volume":"175","author":"Meng","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/4296985","article-title":"Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner","volume":"2018","author":"Zhang","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1096\/fj.201701095R","article-title":"Cystathionine \u03b2-synthase regulates mitochondrial morphogenesis in ovarian cancer","volume":"32","author":"Chakraborty","year":"2018","journal-title":"FASEB J."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Quatredeniers, M., Mendes-Ferreira, P., Santos-Ribeiro, D., Nakhleh, M., Ghigna, M.-R., Cohen-Kaminsky, S., and Perros, F. (2021). Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms. Cells, 10.","DOI":"10.3390\/cells10020477"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"389S","DOI":"10.3945\/jn.114.202192","article-title":"Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review","volume":"146","author":"Ried","year":"2016","journal-title":"J. Nutr."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: A Major Update to the DrugBank Database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/bjp.2008.326","article-title":"H2 S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: Role of protein kinases A and G","volume":"155","author":"Muzaffar","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2174\/1872211311666170911160914","article-title":"A Review of Patents on Therapeutic Potential and Delivery of Hydroge n Sulfide","volume":"11","author":"Verma","year":"2017","journal-title":"Recent Pat. Drug Deliv. Formul."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/6\/1477\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:13:41Z","timestamp":1760163221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/6\/1477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,12]]},"references-count":166,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["cells10061477"],"URL":"https:\/\/doi.org\/10.3390\/cells10061477","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,12]]}}}