{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:19:17Z","timestamp":1793776757866,"version":"4.6.1"},"reference-count":165,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_159824"],"award-info":[{"award-number":["31003A_159824"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Swiss Cancer League","award":["KFS 4400-02-2018"],"award-info":[{"award-number":["KFS 4400-02-2018"]}]},{"name":"The Swiss Heart Foundation","award":["FF18115"],"award-info":[{"award-number":["FF18115"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>MAGI1 is a cytoplasmic scaffolding protein initially identified as a component of cell-to-cell contacts stabilizing cadherin-mediated cell\u2013cell adhesion in epithelial and endothelial cells. Clinical-pathological and experimental evidence indicates that MAGI1 expression is decreased in some inflammatory diseases, and also in several cancers, including hepatocellular carcinoma, colorectal, cervical, breast, brain, and gastric cancers and appears to act as a tumor suppressor, modulating the activity of oncogenic pathways such as the PI3K\/AKT and the Wnt\/\u03b2-catenin pathways. Genomic mutations and other mechanisms such as mechanical stress or inflammation have been described to regulate MAGI1 expression. Intriguingly, in breast and colorectal cancers, MAGI1 expression is induced by non-steroidal anti-inflammatory drugs (NSAIDs), suggesting a role in mediating the tumor suppressive activity of NSAIDs. More recently, MAGI1 was found to localize at mature focal adhesion and to regulate integrin-mediated adhesion and signaling in endothelial cells. Here, we review MAGI1\u2032s role as scaffolding protein, recent developments in the understanding of MAGI1 function as tumor suppressor gene, its role in endothelial cells and its implication in cancer and vascular biology. We also discuss outstanding questions about its regulation and potential translational implications in oncology.<\/jats:p>","DOI":"10.3390\/cells10061494","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T10:30:25Z","timestamp":1623666625000},"page":"1494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["MAGI1, a Scaffold Protein with Tumor Suppressive and Vascular Functions"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2487-7029","authenticated-orcid":false,"given":"Janine","family":"W\u00f6rthm\u00fcller","sequence":"first","affiliation":[{"name":"Laboratory of Experimental and Translational Oncology, Pathology, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, CH-1700 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9137-7695","authenticated-orcid":false,"given":"Curzio","family":"R\u00fcegg","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental and Translational Oncology, Pathology, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, CH-1700 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1006\/bbrc.1998.8603","article-title":"Cloning and characterization of BAI-associated protein 1: A PDZ domain-containing protein that interacts with BAI1","volume":"247","author":"Shiratsuchi","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7810","DOI":"10.1038\/sj.onc.1203153","article-title":"Localization of membrane-associated guanylate kinase (MAGI)-1\/BAI-associated protein (BAP) 1 at tight junctions of epithelial cells","volume":"18","author":"Ide","year":"1999","journal-title":"Oncogene"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"31589","DOI":"10.1074\/jbc.272.50.31589","article-title":"MAGI-1, a Membrane-associated Guanylate Kinase with a Unique Arrangement of Protein-Protein Interaction Domains","volume":"272","author":"Dobrosotskaya","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_4","first-page":"3251-6","article-title":"Regulation and involvement in cancer and pathological conditions of MAGI1, a tight junction protein","volume":"34","author":"Feng","year":"2014","journal-title":"Anticancer. Res."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"De Mendoza, A., Suga, H., and Ruiz-Trillo, I. (2010). Evolution of the MAGUK protein gene family in premetazoan lineages. BMC Evol. Biol., 10.","DOI":"10.1186\/1471-2148-10-93"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"129-10","DOI":"10.1186\/1471-2148-7-129","article-title":"Molecular evolution of the MAGUK family in metazoan genomes","volume":"7","author":"Velthuis","year":"2007","journal-title":"BMC Evol. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0968-0004(96)30044-3","article-title":"PDZ domains bind carboxy-terminal sequences of target proteins","volume":"21","author":"Saras","year":"1996","journal-title":"Trends Biochem. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/pro.5560060225","article-title":"Evidence for PDZ domains in bacteria, yeast, and plants","volume":"6","author":"Ponting","year":"1997","journal-title":"Protein Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11515-012-1244-9","article-title":"Structure and function of the guanylate kinase-like domain of the MAGUK family scaffold proteins","volume":"7","author":"Zhu","year":"2012","journal-title":"Front. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1006\/scdb.2000.0178","article-title":"MAGUK proteins: Structure and role in the tight junction","volume":"11","author":"Betanzos","year":"2000","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1074\/jbc.M210165200","article-title":"Functional Analysis of the Nucleotide Binding Domain of Membrane-associated Guanylate Kinases","volume":"278","author":"Olsen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0092-8674(00)81043-0","article-title":"Clustering Membrane Proteins: It\u2019s All Coming Together with the PSD-95\/SAP90 Protein Family","volume":"84","author":"Gomperts","year":"1996","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/S0960-9822(96)00737-3","article-title":"Protein\u2013protein interactions: PDZ domain networks","volume":"6","author":"Fanning","year":"1996","journal-title":"Curr. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"21105","DOI":"10.1074\/jbc.273.33.21105","article-title":"A Novel Multiple PDZ Domain-containing Molecule Interacting withN-Methyl-d-aspartateReceptors and Neuronal Cell Adhesion Proteins","volume":"273","author":"Hirao","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"21477","DOI":"10.1074\/jbc.M909741199","article-title":"Interaction of the Tumor Suppressor PTEN\/MMAC with a PDZ Domain of MAGI3, a Novel Membrane-associated Guanylate Kinase","volume":"275","author":"Wu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1242\/jcs.00302","article-title":"Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins","volume":"116","author":"Adamsky","year":"2003","journal-title":"J. Cell Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/excr.2002.5475","article-title":"MAGI-1: A Widely Expressed, Alternatively Spliced Tight Junction Protein","volume":"275","author":"Laura","year":"2002","journal-title":"Exp. Cell Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"C1213","DOI":"10.1152\/ajpcell.00558.2003","article-title":"The tight junction: A multifunctional complex","volume":"286","author":"Schneeberger","year":"2004","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.bbamem.2007.09.032","article-title":"The cytoplasmic plaque of tight junctions: A scaffolding and signalling center","volume":"1778","author":"Guillemot","year":"2008","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1128\/MCB.23.12.4267-4282.2003","article-title":"JAM4, a Junctional Cell Adhesion Molecule Interacting with a Tight Junction Protein, MAGI-1","volume":"23","author":"Hirabayashi","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.yexcr.2004.07.010","article-title":"Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts","volume":"300","author":"Wegmann","year":"2004","journal-title":"Exp. Cell Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1006\/bbrc.2001.4880","article-title":"Identification of mNET1 as a Candidate Ligand for the First PDZ Domain of MAGI-1","volume":"283","author":"Dobrosotskaya","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1046\/j.1365-2443.2000.00385.x","article-title":"Membrane-associated guanylate kinase with inverted orientation (MAGI)-1\/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP\/GTP exchange protein at tight junctions","volume":"5","author":"Mino","year":"2000","journal-title":"Genes Cells"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1006\/bbrc.2000.2471","article-title":"MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures","volume":"270","author":"Dobrosotskaya","year":"2000","journal-title":"Biochem. Biophys Res. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1096\/fj.04-1942fje","article-title":"Implication of the MAGI-1b\/PTEN signalosome in stabilization of adherens junctions and suppression of invasiveness","volume":"19","author":"Kotelevets","year":"2004","journal-title":"FASEB J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/1097-4652(200012)185:3<358::AID-JCP6>3.0.CO;2-#","article-title":"Localization of BAI-associated protein1\/membrane-associated guanylate kinase-1 at adherens junctions in normal rat kidney cells: Polarized targeting mediated by the carboxyl-terminal PDZ domains","volume":"185","author":"Nishimura","year":"2000","journal-title":"J. Cell Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1096\/fj.08-106344","article-title":"TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness","volume":"23","author":"Chastre","year":"2008","journal-title":"FASEB J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.molcel.2013.01.037","article-title":"MEK1 Is Required for PTEN Membrane Recruitment, AKT Regulation, and the Maintenance of Peripheral Tolerance","volume":"50","author":"Zmajkovicova","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1038\/sj.onc.1203906","article-title":"Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins","volume":"19","author":"Glaunsinger","year":"2000","journal-title":"Oncogene"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/cas.12087","article-title":"Human T-cell leukemia virus type 1 Tax protein interacts with and mislocalizes the PDZ domain protein MAGI-1","volume":"104","author":"Makokha","year":"2013","journal-title":"Cancer Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"30183","DOI":"10.1074\/jbc.M203072200","article-title":"Interaction of Two Actin-binding Proteins, Synaptopodin and \u03b1-Actinin-4, with the Tight Junction Protein MAGI-1","volume":"277","author":"Patrie","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1681\/ASN.V124667","article-title":"The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes","volume":"12","author":"Patrie","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbamcr.2005.05.011","article-title":"Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1","volume":"1745","author":"Patrie","year":"2005","journal-title":"Biochim. Biophys. Acta Bioenergy"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/labinvest.3700347","article-title":"MAGI-1 is a component of the glomerular slit diaphragm that is tightly associated with nephrin","volume":"85","author":"Hirabayashi","year":"2005","journal-title":"Lab. Investig."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/mcne.1998.0677","article-title":"Atrophin-1, the DRPLA Gene Product, Interacts with Two Families of WW Domain-Containing Proteins","volume":"11","author":"Wood","year":"1998","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"46962","DOI":"10.1074\/jbc.M405874200","article-title":"PSD-95 and Lin-7b Interact with Acid-sensing Ion Channel-3 and Have Opposite Effects on H+-gated Current","volume":"279","author":"Benson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1038\/sj.onc.1207817","article-title":"MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap","volume":"23","author":"Yao","year":"2004","journal-title":"Oncogene"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1074\/jbc.275.8.5485","article-title":"Identification and Characterization of a PDZ Protein That Interacts with Activin Type II Receptors","volume":"275","author":"Shoji","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1073\/pnas.97.8.4233","article-title":"Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2","volume":"97","author":"Wu","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s40139-016-0108-4","article-title":"Involvement of Tight Junction Plaque Proteins in Cancer","volume":"4","author":"Miranda","year":"2016","journal-title":"Curr. Pathobiol. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/jb\/mvv009","article-title":"MAGI2\/S-SCAM outside brain","volume":"157","author":"Nagashima","year":"2015","journal-title":"J. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1038\/ncomms4743","article-title":"AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion","volume":"5","author":"Hultin","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1091\/mbc.e05-07-0647","article-title":"MAGI-1 Is Required for Rap1 Activation upon Cell-Cell Contact and for Enhancement of Vascular Endothelial Cadherin-mediated Cell Adhesion","volume":"17","author":"Sakurai","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-2443.2010.01387.x","article-title":"Interaction of endothelial cell-selective adhesion molecule and MAGI-1 promotes mature cell-cell adhesion via activation of RhoA","volume":"15","author":"Kimura","year":"2010","journal-title":"Genes Cells"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1093\/emboj\/17.14.4075","article-title":"Activation of RhoA and SAPK\/JNK signalling pathways by the RhoA-specific exchange factor mNET1","volume":"17","author":"Alberts","year":"1998","journal-title":"EMBO J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0092-8674(92)90163-7","article-title":"The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors","volume":"70","author":"Ridley","year":"1992","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1083\/jcb.200105109","article-title":"The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness","volume":"155","author":"Kotelevets","year":"2001","journal-title":"J. Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.pathol.4.110807.092311","article-title":"PTEN and the PI3-Kinase Pathway in Cancer","volume":"4","author":"Chalhoub","year":"2009","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_49","first-page":"381","article-title":"MAGI1 inhibits cancer cell migration and invasion of hepatocellular carcinoma via regulating PTEN","volume":"36","author":"Zhang","year":"2011","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/08941939.2011.606875","article-title":"Downregulation of MAGI1 Associates with Poor Prognosis of Hepatocellular Carcinoma","volume":"25","author":"Zhang","year":"2011","journal-title":"J. Investig. Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12185-017-2359-1","article-title":"MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia","volume":"107","author":"Kozakai","year":"2017","journal-title":"Int. J. Hematol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2007.07.027","article-title":"MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells","volume":"467","author":"Hu","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"20693","DOI":"10.1074\/jbc.274.29.20693","article-title":"PTEN Interactions with Focal Adhesion Kinase and Suppression of the Extracellular Matrix-dependent Phosphatidylinositol 3-Kinase\/Akt Cell Survival Pathway","volume":"274","author":"Tamura","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_54","first-page":"502","article-title":"MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression","volume":"28","author":"Ma","year":"2015","journal-title":"Biomed. Environ. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1158\/1535-7163.MCT-13-0448","article-title":"MiR-134\/487b\/655 cluster regulates TGF-beta-induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung adenocarcinoma cells","volume":"13","author":"Kitamura","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ccr.2011.02.020","article-title":"Disruptive Events in the Life of Prostate Cancer","volume":"19","author":"Brenner","year":"2011","journal-title":"Cancer Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"9639","DOI":"10.2147\/OTT.S215400","article-title":"Silencing Of MAGI1 Promotes The Proliferation And Inhibits Apoptosis Of Glioma Cells Via The Wnt\/beta-Catenin And PTEN\/AKT Signaling Pathways","volume":"12","author":"Lu","year":"2019","journal-title":"Onco. Targets Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"11281","DOI":"10.2147\/OTT.S230236","article-title":"MAGI1 Inhibits the Proliferation, Migration and Invasion of Glioma Cells","volume":"ume 12","author":"Li","year":"2019","journal-title":"OncoTargets Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"35851","DOI":"10.18632\/oncotarget.5323","article-title":"MAGI3 negatively regulates Wnt\/beta-catenin signaling and suppresses malignant phenotypes of glioma cells","volume":"6","author":"Qian","year":"2015","journal-title":"Oncotarget"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/onc.2011.218","article-title":"Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells","volume":"31","author":"Zaric","year":"2011","journal-title":"Oncogene"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Alday-Parejo, B., Richard, F., W\u00f6rthm\u00fcller, J., Rau, T., Galv\u00e1n, J.A., Desmedt, C., Santamaria-Martinez, A., and R\u00fcegg, C. (2020). MAGI1, a New Potential Tumor Suppressor Gene in Estrogen Receptor Positive Breast Cancer. Cancers, 12.","DOI":"10.3390\/cancers12010223"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-85056-1","article-title":"MAGI1 inhibits the AMOTL2\/p38 stress pathway and prevents luminal breast tumorigenesis","volume":"11","author":"Kantar","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.21147\/j.issn.1000-9604.2017.01.04","article-title":"MAGI1 inhibits migration and invasion via blocking MAPK\/ERK signaling pathway in gastric cancer","volume":"29","author":"Jia","year":"2017","journal-title":"Chin. J. Cancer Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1242\/jcs.02560","article-title":"Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells","volume":"118","author":"Latorre","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/aps.2011.20","article-title":"Epithelial cell polarity and tumorigenesis: New perspectives for cancer detection and treatment","volume":"32","author":"Coradini","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1128\/JVI.01756-10","article-title":"A Systematic Analysis of Human Papillomavirus (HPV) E6 PDZ Substrates Identifies MAGI-1 as a Major Target of HPV Type 16 (HPV-16) and HPV-18 Whose Loss Accompanies Disruption of Tight Junctions","volume":"85","author":"Kranjec","year":"2010","journal-title":"J. Virol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1128\/JVI.03247-13","article-title":"Restoration of MAGI-1 Expression in Human Papillomavirus-Positive Tumor Cells Induces Cell Growth Arrest and Apoptosis","volume":"88","author":"Kranjec","year":"2014","journal-title":"J. Virol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tcb.2008.10.001","article-title":"Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player","volume":"19","author":"Vestweber","year":"2009","journal-title":"Trends Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0092-8674(00)81279-9","article-title":"Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis","volume":"84","author":"Gumbiner","year":"1996","journal-title":"Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1113\/jphysiol.2005.096537","article-title":"Endothelial focal adhesions and barrier function","volume":"569","author":"Wu","year":"2005","journal-title":"J. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.7150\/ijbs.7502","article-title":"The Vascular Endothelium and Human Diseases","volume":"9","author":"Rajendran","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0002-9440(10)63794-7","article-title":"Brain Angiogenesis Inhibitor 1 Is Differentially Expressed in Normal Brain and Glioblastoma Independently of p53 Expression","volume":"162","author":"Kaur","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_73","first-page":"967","article-title":"Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer","volume":"13","author":"Fukushima","year":"1998","journal-title":"Int. J. Oncol."},{"key":"ref_74","first-page":"181","article-title":"Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1)","volume":"5","author":"Hatanaka","year":"2000","journal-title":"Int. J. Mol. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ydbio.2011.05.673","article-title":"PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation","volume":"356","author":"Li","year":"2011","journal-title":"Dev. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1080\/19336918.2021.1911472","article-title":"MAGI1 localizes to mature focal adhesion and modulates endothelial cell adhesion, migration and angiogenesis","volume":"15","author":"Ghimire","year":"2021","journal-title":"Cell Adhes. Migr."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Ghimire, K., Zaric, J., Alday-Parejo, B., Seebach, J., Bousquenaud, M., Stalin, J., Bieler, G., Schnittler, H.-J., and R\u00fcegg, C. (2019). MAGI1 Mediates eNOS Activation and NO Production in Endothelial Cells in Response to Fluid Shear Stress. Cells, 8.","DOI":"10.3390\/cells8050388"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3389\/fphys.2020.00861","article-title":"Fluid Shear Stress Sensing by the Endothelial Layer","volume":"11","author":"Roux","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev.pharmtox.37.1.339","article-title":"Structure-function aspects in the nitric oxide synthases","volume":"37","author":"Stuehr","year":"1997","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.pharmthera.2013.07.004","article-title":"Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets?","volume":"140","author":"Rochette","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Abe, J.-I., Ko, K.A., Kotla, S., Wang, Y., Paez-Mayorga, J., Shin, I.J., Imanishi, M., Vu, H.T., Tao, Y., and Leiva-Juarez, M.M. (2019). MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI Insight, 4.","DOI":"10.1172\/jci.insight.125570"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"rs15","DOI":"10.1126\/scisignal.2004712","article-title":"Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions","volume":"6","author":"Couzens","year":"2013","journal-title":"Sci. Signal."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"542485","DOI":"10.3389\/fcvm.2020.542485","article-title":"p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway","volume":"7","author":"Abe","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1159\/000348828","article-title":"Endothelial junction regulation: A prerequisite for leukocytes crossing the vessel wall","volume":"5","author":"Daniel","year":"2013","journal-title":"J. Innate. Immun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1242\/jcs.017897","article-title":"The role of adherens junctions and VE-cadherin in the control of vascular permeability","volume":"121","author":"Dejana","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ni.2824","article-title":"Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin","volume":"15","author":"Wessel","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1242\/jcs.111.13.1853","article-title":"Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells","volume":"111","author":"Esser","year":"1998","journal-title":"J. Cell Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1161\/ATVBAHA.107.147694","article-title":"JAM Family and Related Proteins in Leukocyte Migration (Vestweber Series)","volume":"27","author":"Bradfield","year":"2007","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1084\/jem.20060565","article-title":"ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability","volume":"203","author":"Wegmann","year":"2006","journal-title":"J. Exp. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nri3908","article-title":"How leukocytes cross the vascular endothelium","volume":"15","author":"Vestweber","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S1471-4906(03)00117-0","article-title":"Leukocyte\u2013endothelial-cell interactions in leukocyte transmigration and the inflammatory response","volume":"24","author":"Muller","year":"2003","journal-title":"Trends Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1447-073x.2004.00066.x","article-title":"Process formation of the renal glomerular podocyte: Is there common molecular machinery for processes of podocytes and neurons?","volume":"79","author":"Kobayashi","year":"2004","journal-title":"Anat. Sci. Int."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1515\/bmc-2014-0020","article-title":"Podocytes: Recent biomolecular developments","volume":"5","author":"Armelloni","year":"2014","journal-title":"Biomol. Concepts"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1083\/jcb.111.3.1255","article-title":"The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium","volume":"111","author":"Schnabel","year":"1990","journal-title":"J. Cell Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"25677","DOI":"10.1074\/jbc.M110.133959","article-title":"Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis","volume":"285","author":"Kaufman","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1523\/JNEUROSCI.6319-09.2010","article-title":"Synaptic Localization and Function of Sidekick Recognition Molecules Require MAGI Scaffolding Proteins","volume":"30","author":"Yamagata","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"12241","DOI":"10.1074\/jbc.M707738200","article-title":"MAGI-1a Functions as a Scaffolding Protein for the Distal Renal Tubular Basolateral K+ Channels","volume":"283","author":"Tanemoto","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"C55","DOI":"10.1152\/ajpcell.00073.2009","article-title":"MAGI-1 interacts with Slo1 channel proteins and suppresses Slo1 expression on the cell surface","volume":"297","author":"Ridgway","year":"2009","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"24406","DOI":"10.1074\/jbc.M116.745026","article-title":"MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes","volume":"291","author":"Ni","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"14876","DOI":"10.1073\/pnas.1417297111","article-title":"MAGI-2 scaffold protein is critical for kidney barrier function","volume":"111","author":"Balbas","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1016\/j.ajpath.2014.06.019","article-title":"MAGI-2 Is Critical for the Formation and Maintenance of the Glomerular Filtration Barrier in Mouse Kidney","volume":"184","author":"Ihara","year":"2014","journal-title":"Am. J. Pathol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.kint.2020.09.027","article-title":"MAGI-2 orchestrates the localization of backbone proteins in the slit diaphragm of podocytes","volume":"99","author":"Yamada","year":"2021","journal-title":"Kidney Int."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1681\/ASN.2016121356","article-title":"Glomerulosclerosis Induced by Deficiency of Membrane-Associated Guanylate Kinase Inverted 2 in Kidney Podocytes","volume":"28","author":"Shirata","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ki.2015.140","article-title":"Alternatively spliced isoforms of WT1 control podocyte-specific gene expression","volume":"88","author":"Lefebvre","year":"2015","journal-title":"Kidney Int."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1681\/ASN.2016040387","article-title":"MAGI2 Mutations Cause Congenital Nephrotic Syndrome","volume":"28","author":"Bierzynska","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-04193-w","article-title":"Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment","volume":"9","author":"Ashraf","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"F1336","DOI":"10.1152\/ajprenal.00292.2018","article-title":"MAGI-2 and scaffold proteins in glomerulopathy","volume":"315","author":"Empitu","year":"2018","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1471-4159.2006.04170.x","article-title":"Synaptic scaffolding molecule (S-SCAM) membrane-associated guanylate kinase with inverted organization (MAGI)-2 is associated with cell adhesion molecules at inhibitory synapses in rat hippocampal neurons","volume":"100","author":"Sumita","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1128\/MCB.01901-06","article-title":"Synaptic Scaffolding Molecule \u03b1 Is a Scaffold To Mediate N-Methyl-d-Aspartate Receptor-Dependent RhoA Activation in Dendrites","volume":"27","author":"Iida","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1471-4159.2011.07250.x","article-title":"Regulation of glutamate transporter GLT-1 by MAGI-1","volume":"117","author":"Zou","year":"2011","journal-title":"J. Neurochem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"5","DOI":"10.5334\/1750-2187-11-5","article-title":"MAGI Proteins Regulate the Trafficking and Signaling of Corticotropin-Releasing Factor Receptor 1 via a Compensatory Mechanism","volume":"11","author":"Hammad","year":"2016","journal-title":"J. Mol. Signal."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.biopsych.2012.01.020","article-title":"MAGI1 Copy Number Variation in Bipolar Affective Disorder and Schizophrenia","volume":"71","author":"Karlsson","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jad.2013.10.027","article-title":"Investigating the genetic variation underlying episodicity in major depressive disorder: Suggestive evidence for a bipolar contribution","volume":"155","author":"Ferentinos","year":"2014","journal-title":"J. Affect. Disord."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1001\/jamapsychiatry.2015.0554","article-title":"Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder","volume":"72","author":"Berg","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature09744","article-title":"The genomic complexity of primary human prostate cancer","volume":"470","author":"Berger","year":"2011","journal-title":"Nature"},{"key":"ref_116","first-page":"191","article-title":"A comprehensive catalogue of somatic mutations from a human cancer genome","volume":"463","author":"Pleasance","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_117","first-page":"502","article-title":"Melanoma genome sequencing reveals frequent PREX2 mutations","volume":"485","author":"Berger","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Cabrita, R., Mitra, S., Sanna, A., Ekedahl, H., L\u00f6vgren, K., Olsson, H., Ingvar, C., Isaksson, K., Lauss, M., and Carneiro, A. (2020). The Role of PTEN Loss in Immune Escape, Melanoma Prognosis and Therapy Response. Cancers, 12.","DOI":"10.3390\/cancers12030742"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/onc.2010.463","article-title":"MicroRNA-101-mediated Akt activation and estrogen-independent growth","volume":"30","author":"Sachdeva","year":"2010","journal-title":"Oncogene"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1016\/j.jmb.2013.03.007","article-title":"The Role of miRNAs in Regulating Gene Expression Networks","volume":"425","author":"Gurtan","year":"2013","journal-title":"J. Mol. Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/ncb2769","article-title":"Control of metastatic progression by microRNA regulatory networks","volume":"15","author":"Pencheva","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1007\/s11033-014-3491-0","article-title":"Expression profile of MAGI2 gene as a novel biomarker in combination with major deregulated genes in prostate cancer","volume":"41","author":"Mahdian","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/ijc.28658","article-title":"Methylomics analysis identifies epigenetically silenced genes and implies an activation of beta-catenin signaling in cervical cancer","volume":"135","author":"Chen","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_124","first-page":"405","article-title":"Sequence analysis of mutations and translocations across breast cancer subtypes","volume":"486","author":"Banerji","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s10495-019-01562-8","article-title":"MAGI1 mediates tumor metastasis through c-Myb\/miR-520h\/MAGI1 signaling pathway in renal cell carcinoma","volume":"24","author":"Wang","year":"2019","journal-title":"Apoptosis"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-79195-0","article-title":"Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer","volume":"10","author":"Sakuta","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Ravi, N., Yang, M., Mylona, N., Wennerberg, J., and Paulsson, K. (2020). Global RNA Expression and DNA Methylation Patterns in Primary Anaplastic Thyroid Cancer. Cancers, 12.","DOI":"10.3390\/cancers12030680"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-3-319-43624-1_7","article-title":"The Role of DNA Methylation in Cancer","volume":"945","author":"Lakshminarasimhan","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/leu.2008.130","article-title":"Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia","volume":"22","author":"Kuang","year":"2008","journal-title":"Leuk."},{"key":"ref_130","first-page":"5063","article-title":"Next generation DNA sequencing of atypical choroid plexus papilloma of brain: Identification of novel mutations in a female patient by Ion Proton","volume":"18","author":"Taher","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/ijc.31948","article-title":"Preliminary exploration of potential molecular therapeutic targets in recurrent and metastatic parathyroid carcinomas","volume":"144","author":"Cui","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.pathol.2019.01.010","article-title":"Several genotypes, one phenotype: PIK3CA\/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network","volume":"51","author":"Pfarr","year":"2019","journal-title":"Pathology"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1017\/S1461145710000714","article-title":"Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses","volume":"13","author":"Cruceanu","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10495-006-0579-6","article-title":"Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis","volume":"12","author":"Gregorc","year":"2007","journal-title":"Apoptosis"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1515\/BC.2007.141","article-title":"Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis","volume":"388","author":"Ivanova","year":"2007","journal-title":"Biol. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00281-012-0342-8","article-title":"Multifaceted roles of PGE2 in inflammation and cancer","volume":"35","author":"Nakanishi","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/2048731","article-title":"Cyclooxygenase-2: A Role in Cancer Stem Cell Survival and Repopulation of Cancer Cells during Therapy","volume":"2016","author":"Pang","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35094017","article-title":"Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2","volume":"1","author":"Gupta","year":"2001","journal-title":"Nat. Rev. Cancer"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1158\/1940-6207.CAPR-11-0166","article-title":"Coxibs and Other Nonsteroidal Anti-Inflammatory Drugs in Animal Models of Cancer Chemoprevention","volume":"4","author":"Fischer","year":"2011","journal-title":"Cancer Prev. Res."},{"key":"ref_140","first-page":"4375","article-title":"Cyclooxygenase-2 expression in human gliomas: Prognostic significance and molecular correlations","volume":"61","author":"Shono","year":"2001","journal-title":"Cancer Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11060-011-0662-x","article-title":"The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NF-kappaB pathway","volume":"106","author":"Sareddy","year":"2012","journal-title":"J. Neurooncol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of Cancer: The Next Generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1210\/me.2011-1302","article-title":"Minireview: Inflammation: An Instigator of More Aggressive Estrogen Receptor (ER) Positive Breast Cancers","volume":"26","author":"Baumgarten","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13058-015-0542-y","article-title":"Mechanisms of endocrine resistance in breast cancer: An overview of the proposed roles of noncoding RNA","volume":"17","author":"Hayes","year":"2015","journal-title":"Breast Cancer Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000452315","article-title":"The Role of NSAIDs in Breast Cancer Prevention and Relapse: Current Evidence and Future Perspectives","volume":"11","author":"Moris","year":"2016","journal-title":"Breast Care"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrclinonc.2017.194","article-title":"Perioperative events influence cancer recurrence risk after surgery","volume":"15","author":"Hiller","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"i82","DOI":"10.1093\/bja\/aet464","article-title":"Intraoperative use of ketorolac or diclofenac is associated with improved disease-free survival and overall survival in conservative breast cancer surgery","volume":"113","author":"Forget","year":"2014","journal-title":"Br. J. Anaesth."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/jnci\/djy042","article-title":"Potential Benefit of Intra-operative Administration of Ketorolac on Breast Cancer Recurrence According to the Patient\u2019s Body Mass Index","volume":"110","author":"Desmedt","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Forget, P., Bouche, G., Duhoux, F.P., Coulie, P.G., Decloedt, J., Dekleermaker, A., Guillaume, J.-E., Ledent, M., Machiels, J.-P., and Mustin, V. (2019). Intraoperative ketorolac in high-risk breast cancer patients. A prospective, randomized, placebo-controlled clinical trial. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0225748"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13058-018-1065-0","article-title":"No association between low-dose aspirin use and breast cancer outcomes overall: A Swedish population-based study","volume":"20","author":"Frisk","year":"2018","journal-title":"Breast Cancer Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/gut.2004.047100","article-title":"Prostaglandins and cancer","volume":"55","author":"Wang","year":"2006","journal-title":"Gut"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev.med.57.121304.131253","article-title":"NSAIDs and Cancer Prevention: Targets Downstream of COX-2","volume":"58","author":"Cha","year":"2007","journal-title":"Annu. Rev. Med."},{"key":"ref_154","first-page":"G365","article-title":"Pilot study of small bowel mucosal gene expression in patients with irritable bowel syndrome with diarrhea","volume":"311","author":"Camilleri","year":"2016","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1136\/annrheumdis-2014-207190","article-title":"A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk","volume":"74","author":"Julia","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1053\/j.gastro.2014.12.030","article-title":"Identification of Risk Loci for Crohn\u2019s Disease Phenotypes Using a Genome-Wide Association Study","volume":"148","author":"Alonso","year":"2015","journal-title":"Gastroenterol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/MPG.0000000000000338","article-title":"Alteration of Tight Junction Gene Expression in Celiac Disease","volume":"58","author":"Irastorza","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_158","first-page":"105","article-title":"Genetic Variation and Gene Expression Levels of Tight Junction Genes Indicates Relationships Between PTEN as well as MAGI1 and Microscopic Colitis","volume":"63","author":"Mellander","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"ref_159","first-page":"1","article-title":"Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease","volume":"17","author":"Almer","year":"2017","journal-title":"BMC Gastroenterol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/ibd.20611","article-title":"MAGI2 genetic variation and inflammatory bowel disease","volume":"15","author":"McGovern","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/gut.2007.133132","article-title":"Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitisAn unusual case of ascites","volume":"57","author":"Wapenaar","year":"2008","journal-title":"Gut"},{"key":"ref_162","unstructured":"(2021, April 29). Available online: https:\/\/www.proteinatlas.org\/ENSG00000151276-MAGI1\/pathology."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"616","DOI":"10.4103\/aja.aja_142_19","article-title":"MAGI-2 downregulation: A potential predictor of tumor progression and early recurrence in Han Chinese patients with prostate cancer","volume":"22","author":"Sun","year":"2020","journal-title":"Asian J. Androl."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Bazzichetto, C., Conciatori, F., Pallocca, M., Falcone, I., Fanciulli, M., Cognetti, F., Milella, M., and Ciuffreda, L. (2019). PTEN as a Prognostic\/Predictive Biomarker in Cancer: An Unfulfilled Promise?. Cancers, 11.","DOI":"10.3390\/cancers11040435"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.peptides.2013.07.020","article-title":"Endothelial permeability in vitro and in vivo: Protective actions of ANP and omapatrilat in experimental atherosclerosis","volume":"48","author":"Ichiki","year":"2013","journal-title":"Peptides"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/6\/1494\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:14:06Z","timestamp":1760163246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/6\/1494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,14]]},"references-count":165,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["cells10061494"],"URL":"https:\/\/doi.org\/10.3390\/cells10061494","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,14]]}}}