{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:19:38Z","timestamp":1790691578080,"version":"4.1.0"},"reference-count":121,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Proper functioning of the body depends on hormonal homeostasis. White adipose tissue is now known as an endocrine organ due to the secretion of multiple molecules called adipokines. These proteins exert direct effects on whole body functions, including lipid metabolism, angiogenesis, inflammation, and reproduction, whereas changes in their level are linked with pathological events, such as infertility, diabetes, and increased food intake. Vaspin-visceral adipose tissue-derived serine protease inhibitor, or SERPINA12 according to serpin nomenclature, is an adipokine discovered in 2005 that is connected to the development of insulin resistance, obesity, and inflammation. A significantly higher amount of vaspin was observed in obese patients. The objective of this review was to summarize the latest findings about vaspin expression and action in endocrine tissues, such as the hypothalamus, pituitary gland, adipose tissue, thyroid, ovary, placenta, and testis, as well as discuss the link between vaspin and pathologies connected with hormonal imbalance.<\/jats:p>","DOI":"10.3390\/cells10071710","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T11:36:44Z","timestamp":1625571404000},"page":"1710","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells"],"prefix":"10.3390","volume":"10","author":[{"given":"Patrycja","family":"Kurowska","sequence":"first","affiliation":[{"name":"Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, 31-387 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Mlyczy\u0144ska","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, 31-387 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Dawid","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, 31-387 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Jurek","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, 31-387 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-5671","authenticated-orcid":false,"given":"Dominika","family":"Klimczyk","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, 31-387 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-7705","authenticated-orcid":false,"given":"Joelle","family":"Dupont","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Physiologie de la Reproduction et des Comportements, UMR85, INRAE, 37380 Nouzilly, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9572-7151","authenticated-orcid":false,"given":"Agnieszka","family":"Rak","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, 31-387 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1080\/10937404.2011.578556","article-title":"Early Developmental Actions of Endocrine Disruptors on the Hypothalamus, Hippocampus, and Cerebral Cortex","volume":"14","author":"Parent","year":"2011","journal-title":"J. Toxicol. Environ. Heal. Part B"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2010.05936.x","article-title":"Neuroendocrinology: A short historical review","volume":"1220","author":"Guillemin","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1210\/en.2010-0583","article-title":"Minireview: Early-Life Programming by Inflammation of the Neuroendocrine System","volume":"151","author":"Kentner","year":"2010","journal-title":"Endocrinology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2362.2011.02575.x","article-title":"In the mind or in the brain? Scientific evidence for central sensitisation in chronic fatigue syndrome","volume":"42","author":"Nijs","year":"2011","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tem.2011.01.004","article-title":"Visualizing hormone actions in the brain","volume":"22","author":"Brabant","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1210\/er.2009-0007","article-title":"Molecular Aspects of Thyroid Hormone Actions","volume":"31","author":"Cheng","year":"2010","journal-title":"Endocr. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.nut.2009.09.020","article-title":"Obesity: Genes, brain, gut, and environment","volume":"26","author":"Das","year":"2010","journal-title":"Nutrition"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1210\/en.2003-1607","article-title":"Prostaglandin Biosynthesis, Transport, and Signaling in Corpus Luteum: A Basis for Autoregulation of Luteal Function","volume":"145","author":"Arosh","year":"2004","journal-title":"Endocrinology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/prca.201100052","article-title":"Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders","volume":"6","author":"Lehr","year":"2012","journal-title":"Proteom. Clin. Appl."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1515\/hmbci-2015-0034","article-title":"Adipokines in human reproduction","volume":"24","author":"Dupont","year":"2015","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10610","DOI":"10.1073\/pnas.0504703102","article-title":"Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity","volume":"102","author":"Hida","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s00125-011-2137-1","article-title":"Central vaspin administration acutely reduces food intake and has sustained blood glucose-lowering effects","volume":"54","author":"Kovacs","year":"2011","journal-title":"Diabetologia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.2337\/db08-0127","article-title":"Metformin Decreases the Adipokine Vaspin in Overweight Women with Polycystic Ovary Syndrome Concomitant With Improvement in Insulin Sensitivity and a Decrease in Insulin Resistance","volume":"57","author":"Tan","year":"2008","journal-title":"Diabetes"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s00018-013-1258-8","article-title":"Vaspin inhibits kallikrein 7 by serpin mechanism","volume":"70","author":"Heiker","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1515\/hsz-2018-0108","article-title":"Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin","volume":"399","author":"Ulbricht","year":"2018","journal-title":"Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1074\/jbc.M116.748020","article-title":"Basic Residues of \u03b2-Sheet A Contribute to Heparin Binding and Activation of Vaspin (Serpin A12)","volume":"292","author":"Ulbricht","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/psc.2621","article-title":"Vaspin (serpinA12) in obesity, insulin resistance, and inflammation","volume":"20","author":"Heiker","year":"2014","journal-title":"J. Pept. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1042\/BJ20150643","article-title":"A unique serpin P1\u2032 glutamate and a conserved \u03b2-sheet C arginine are key residues for activity, protease recognition and stability of serpinA12 (vaspin)","volume":"470","author":"Ulbricht","year":"2015","journal-title":"Biochem. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.bbapap.2017.06.020","article-title":"Glycosylation of human vaspin (SERPINA12) and its impact on serpin activity, heparin binding and thermal stability","volume":"1865","author":"Oertwig","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) Proteins Proteom."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/5584_2018_241","article-title":"Molecular Mechanisms of Vaspin Action-From Adipose Tissue to Skin and Bone, from Blood Vessels to the Brain","volume":"1111","author":"Weiner","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/21623945.2021.1910154","article-title":"Cleavage of the vaspin N-terminus releases cell-penetrating peptides that affect early stages of adipogenesis and inhibit lipolysis in mature adipocytes","volume":"10","author":"Tindall","year":"2021","journal-title":"Adipocyte"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s00109-013-1062-9","article-title":"Analysis of a rare functional truncating mutation rs61757459 in vaspin (SERPINA12) on circulating vaspin levels","volume":"91","author":"Breitfeld","year":"2013","journal-title":"J. Mol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"E1202","DOI":"10.1210\/jc.2011-3297","article-title":"Serum Vaspin Concentrations Are Closely Related to Insulin Resistance, and rs77060950 atSERPINA12Genetically Defines Distinct Group with Higher Serum Levels in Japanese Population","volume":"97","author":"Teshigawara","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.bbrc.2005.11.039","article-title":"Vaspin gene expression in human adipose tissue: Association with obesity and type 2 diabetes","volume":"339","author":"Berndt","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1600-0625.2012.01460.x","article-title":"Vaspin-a link of obesity and psoriasis?","volume":"21","author":"Saalbach","year":"2012","journal-title":"Exp. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ijo.2010.196","article-title":"Vaspin is related to gender, puberty and deteriorating insulin sensitivity in children","volume":"35","author":"Neef","year":"2011","journal-title":"Int. J. Obes."},{"key":"ref_27","first-page":"979","article-title":"Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status","volume":"24","author":"Caminos","year":"2009","journal-title":"Histol. Histopathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1530\/REP-19-0034","article-title":"Vaspin in the pig ovarian follicles: Expression and regulation by different hormones","volume":"158","author":"Kurowska","year":"2019","journal-title":"Reproduction"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.molmet.2017.03.004","article-title":"Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation","volume":"6","author":"Weiner","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.diabres.2014.07.026","article-title":"Higher vaspin levels in subjects with obesity and type 2 diabetes mellitus: A meta-analysis","volume":"106","author":"Feng","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_31","first-page":"1065","article-title":"Role of circulating adipocytokines vaspin, apelin, and visfatin in the loss of appetite in underweight children: A pilot trial","volume":"28","author":"Ustabas","year":"2015","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1684\/ecn.2011.0295","article-title":"Short-term effect of weight loss through restrictive bariatric surgery on serum levels of vaspin in morbidly obese subjects","volume":"22","author":"Golpaie","year":"2011","journal-title":"Eur. Cytokine Netw."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11010-012-1494-5","article-title":"Vaspin gene in rat adipose tissue: Relation to obesity-induced insulin resistance","volume":"373","author":"Shaker","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1517\/13543784.17.3.327","article-title":"Vaspin: A novel serpin with insulin-sensitizing effects","volume":"17","author":"Wada","year":"2008","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1113\/jphysiol.2009.172510","article-title":"Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue","volume":"587","author":"Caminos","year":"2009","journal-title":"J. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1530\/EJE-09-0737","article-title":"Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans","volume":"162","author":"Arafat","year":"2010","journal-title":"Eur. J. Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1210\/jc.2009-1088","article-title":"Circadian Rhythm of Serum Vaspin in Healthy Male Volunteers: Relation to Meals","volume":"95","author":"Jeong","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.2337\/db12-0232","article-title":"Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78\/MTJ-1 Complex","volume":"61","author":"Nakatsuka","year":"2012","journal-title":"Diabetes"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"19620","DOI":"10.1074\/jbc.M001333200","article-title":"Interaction of Murine BiP\/GRP78 with the DnaJ Homologue MTJ","volume":"275","author":"Chevalier","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2148-8-19","article-title":"hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions","volume":"8","author":"Brocchieri","year":"2008","journal-title":"BMC Evol. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gene.2017.03.005","article-title":"HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum","volume":"618","author":"Wang","year":"2017","journal-title":"Gene"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.lfs.2019.04.022","article-title":"GRP78: A cell\u2019s response to stress","volume":"226","author":"Ibrahim","year":"2019","journal-title":"Life Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1089\/ars.2009.2568","article-title":"GRP78: A Multifunctional Receptor on the Cell Surface","volume":"11","author":"Selim","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1177\/1933719114553445","article-title":"Endoplasmic Reticulum Stress-Mediated Apoptotic Pathway Is Involved in Corpus Luteum Regression in Rats","volume":"22","author":"Yang","year":"2015","journal-title":"Reprod. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/humrep\/dev066","article-title":"Maternal age and ovarian stimulation independently affect oocyte mtDNA copy number and cumulus cell gene expression in bovine clones","volume":"30","author":"Cree","year":"2015","journal-title":"Hum. Reprod."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Thon, M., Hosoi, T., Yoshii, M., and Ozawa, K. (2014). Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells. Sci. Rep.","DOI":"10.1038\/srep07096"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0968-0004(01)01908-9","article-title":"The glucose-regulated proteins: Stress induction and clinical applications","volume":"26","author":"Lee","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-3-319-51409-3_7","article-title":"Roles of Grp78 in Female Mammalian Reproduction","volume":"222","author":"Zhang","year":"2017","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"ref_49","first-page":"1557","article-title":"Humoral immune responses to cathepsin D and glucose-regulated protein 78 in ovarian cancer patients","volume":"3","author":"Chinni","year":"1997","journal-title":"Clin. Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.bcp.2007.10.008","article-title":"Therapeutic angiogenesis of mouse hind limb ischemia by novel peptide activating GRP78 receptor on endothelial cells","volume":"75","author":"Hardy","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nm1259","article-title":"Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis","volume":"11","author":"Scheuner","year":"2005","journal-title":"Nat. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1038\/srep16067","article-title":"Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer","volume":"5","author":"Niu","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s12192-020-01134-9","article-title":"Interaction of HSPA5 (Grp78, BIP) with negatively charged phospholipid membranes via oligomerization involving the N-terminal end domain","volume":"25","author":"Cauvi","year":"2020","journal-title":"Cell Stress Chaperones"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Tindall, C.A., Dommel, S., Riedl, V., Ulbricht, D., Hanke, S., Str\u00e4ter, N., and Heiker, J.T. (2020). Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin). Molecules, 25.","DOI":"10.3390\/molecules25081992"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e0189722","DOI":"10.1371\/journal.pone.0189722","article-title":"Effects of vaspin on pancreatic \u03b2 cell secretion via PI3K\/Akt and NF-\u03baB signaling pathways","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS ONE"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2840-13-41","article-title":"Vaspin inhibits cytokine-induced nuclear factor-kappa B activation and adhesion molecule expression via AMP-activated protein kinase activation in vascular endothelial cells","volume":"13","author":"Jung","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e52346","DOI":"10.1371\/journal.pone.0052346","article-title":"Vaspin Increases Nitric Oxide Bioavailability through the Reduction of Asymmetric Dimethylarginine in Vascular Endothelial Cells","volume":"7","author":"Jung","year":"2012","journal-title":"PLoS ONE"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1530\/JOE-20-0332","article-title":"The role of vaspin in porcine corpus luteum","volume":"247","author":"Kurowska","year":"2020","journal-title":"J. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kurowska, P., Mlyczy\u0144ska, E., Dawid, M., Opydo-Chanek, M., Dupont, J., and Rak, A. (2019). In Vitro Effects of Vaspin on Porcine Granulosa Cell Proliferation, Cell Cycle Progression, and Apoptosis by Activation of GRP78 Receptor and Several Kinase Signaling Pathways Including MAP3\/1, AKT, and STAT3. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20225816"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00726-012-1425-5","article-title":"Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway","volume":"44","author":"Zhu","year":"2013","journal-title":"Amino Acids"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/ijo.2016.24","article-title":"Central administration of vaspin inhibits glucose production and augments hepatic insulin signaling in high-fat-diet-fed rat","volume":"40","author":"Luo","year":"2016","journal-title":"Int. J. Obes."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.peptides.2011.08.003","article-title":"Effects of vaspin, chemerin and omentin-1 on feeding behavior and hypothalamic peptide gene expression in the rat","volume":"32","author":"Brunetti","year":"2011","journal-title":"Peptides"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Breitfeld, J., Tonjes, A., Gast, M.-T., Schleinitz, R., Bl\u00fcher, M., Stumvoll, M., Kovacs, P., and B\u00f6ttcher, Y. (2013). Role of Vaspin in Human Eating Behaviour. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0054140"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2337\/db15-1547","article-title":"Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity","volume":"66","author":"Contreras","year":"2016","journal-title":"Diabetes"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Li\u00f1ares-Pose, L., Rial-Pensado, E., Est\u00e9vez-Salguero, \u00c1., Milbank, E., Gonz\u00e1lez-Garc\u00eda, I., Rodr\u00edguez, C., Seoane-Collazo, P., Martinez-S\u00e1nchez, N., Nogueiras, R., and Prieto, D. (2018). Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake. Genes, 9.","DOI":"10.3390\/genes9070357"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1507\/endocrj.K10E-330","article-title":"The effect of weight loss and treatment with metformin on serum vaspin levels in women with polycystic ovary syndrome","volume":"58","author":"Koiou","year":"2011","journal-title":"Endocr. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1530\/JOE-18-0528","article-title":"Vaspin promotes insulin sensitivity in elderly muscle and is upregulated in obesity","volume":"241","author":"Nicholson","year":"2019","journal-title":"J. Endocrinol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1507\/endocrj.K11E-073","article-title":"Relationship between vaspin gene expression and abdominal fat distribution of Korean women","volume":"58","author":"Lee","year":"2011","journal-title":"Endocr. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"113584","DOI":"10.1016\/j.ygcen.2020.113584","article-title":"Adipokines expression profiles in both plasma and peri renal adipose tissue in Large White and Meishan sows: A possible involvement in the fattening and the onset of puberty","volume":"299","author":"Barbe","year":"2020","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.mce.2017.07.022","article-title":"Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NF\u03baB pathway","volume":"460","author":"Zieger","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1177\/1535370214565081","article-title":"Vaspin promotes 3T3-L1 preadipocyte differentiation","volume":"240","author":"Liu","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12902-019-0452-6","article-title":"The role of the adipocytokines vaspin and visfatin in vascular endothelial function and insulin resistance in obese children","volume":"19","author":"Yin","year":"2019","journal-title":"BMC Endocr. Disord."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"13542","DOI":"10.1038\/s41598-018-31923-3","article-title":"Effects of Vaspin on Insulin Resistance in Rats and Underlying Mechanisms","volume":"8","author":"Liu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bbrc.2011.08.083","article-title":"Vaspin protects vascular endothelial cells against free fatty acid-induced apoptosis through a phosphatidylinositol 3-kinase\/Akt pathway","volume":"413","author":"Jung","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1530\/EJE-11-0180","article-title":"Serum vaspin levels in hypothyroid patients","volume":"165","author":"Usman","year":"2011","journal-title":"Eur. J. Endocrinol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"713","DOI":"10.21123\/bsj.2017.14.4.0713","article-title":"Determination of the Level of some Adipokines in Hypo-and Hyperthyroids Patients in Baghdad City","volume":"14","year":"2017","journal-title":"Baghdad Sci. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s11695-009-9882-y","article-title":"Serum Vaspin Concentrations in Relation to Insulin Sensitivity Following RYGB-Induced Weight Loss","volume":"20","author":"Handisurya","year":"2010","journal-title":"Obes. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Kurowska, P., Mlyczy\u0144ska, E., Estienne, A., Barbe, A., Rajska, I., Sob\u00f3l, K., Poniedzia\u0142ek-Kempny, K., Dupont, J., and Rak, A. (2020). Expression and Impact of Vaspin on In Vitro Oocyte Maturation through MAP3\/1 and PRKAA1 Signalling Pathways. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249342"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1530\/JOE-20-0550","article-title":"Vaspin, a novel adipokine in woman granulosa cells physiology and PCOS pathogenesis?","volume":"249","author":"Bongrani","year":"2021","journal-title":"J. Endocrinol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/biolre\/ioaa027","article-title":"Role of vaspin in porcine ovary: Effect on signaling pathways and steroid synthesis via GRP78 receptor and protein kinase A\u2020","volume":"102","author":"Kurowska","year":"2020","journal-title":"Biol. Reprod."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kurowska, P., Mlyczy\u0144ska, E., Dupont, J., and Rak, A. (2020). Novel Insights on the Corpus Luteum Function: Role of Vaspin on Porcine Luteal Cell Angiogenesis, Proliferation and Apoptosis by Activation of GRP78 Receptor and MAP3\/1 Kinase Pathways. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186823"},{"key":"ref_82","first-page":"183","article-title":"In Vitro Maturation (IVM) of Porcine Oocytes","volume":"825","author":"Yuan","year":"2011","journal-title":"Adv. Struct. Saf. Stud."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1590\/1414-431x20143432","article-title":"Plasma levels and placental expression of vaspin in pregnant women with diabetes mellitus","volume":"48","author":"Huo","year":"2015","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Trojnar, M., Patro-Ma\u0142ysza, J., Kimber-Trojnar, \u017b., Czuba, M., Mosiewicz, J., and Leszczy\u0144ska-Gorzelak, B. (2019). Vaspin in Serum and Urine of Post-Partum Women with Excessive Gestational Weight Gain. Medicina, 55.","DOI":"10.3390\/medicina55030076"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Brzoskwinia, M., Pardyak, L., Rak, A., Kaminska, A., Hejmej, A., Marek, S., Kotula-Balak, M., and Bilinska, B. (2020). Flutamide Alters the Expression of Chemerin, Apelin, and Vaspin and Their Respective Receptors in the Testes of Adult Rats. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124439"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pathophys.2019.02.001","article-title":"Experimental obesity and diabetes reduce male fertility: Potential involvement of hypothalamic Kiss-1, pituitary nitric oxide, serum vaspin and visfatin","volume":"26","author":"Allah","year":"2019","journal-title":"Pathophysiology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.peptides.2012.03.005","article-title":"Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat","volume":"35","author":"Ivars","year":"2012","journal-title":"Peptides"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/00365513.2015.1085080","article-title":"Serum vaspin and adiponectin levels in patients with prolactinoma","volume":"76","author":"Ginis","year":"2015","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3906\/sag-1502-138","article-title":"The association of vaspin rs2236242 and leptin rs7799039 polymorphism with metabolic syndrome in Egyptian women","volume":"46","author":"Alnory","year":"2016","journal-title":"Turk. J. Med. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1089\/met.2017.0133","article-title":"The Association Between Serum Vaspin and Omentin-1 Levels in Obese Children with Metabolic Syndrome","volume":"16","author":"Buyukinan","year":"2018","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4093\/dmj.2014.38.2.143","article-title":"Association of Vaspin with Metabolic Syndrome: The Pivotal Role of Insulin Resistance","volume":"38","author":"Esteghamati","year":"2014","journal-title":"Diabetes Metab. J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1365-2265.2011.04095.x","article-title":"Plasma vaspin concentrations are elevated in metabolic syndrome in men and are correlated with coronary atherosclerosis in women","volume":"75","author":"Choi","year":"2011","journal-title":"Clin. Endocrinol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/met.2013.0054","article-title":"Association Between Serum Vaspin Level and Metabolic Syndrome in Healthy Korean Subjects","volume":"11","author":"Kim","year":"2013","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"ref_94","first-page":"139","article-title":"Fenofibrate increases serum vaspin by upregulating its expression in adipose tissue","volume":"31","author":"Chen","year":"2014","journal-title":"Endocrine"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2478\/bjmg-2019-0013","article-title":"Associations between vaspin rs2236242 gene polymorphism, walking time and the risk of metabolic syndrome","volume":"22","author":"Suliga","year":"2019","journal-title":"Balk. J. Med. Genet."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.dld.2018.04.023","article-title":"Abdominal obesity and insulin resistance after an episode of acute pancreatitis","volume":"50","author":"Singh","year":"2018","journal-title":"Dig. Liver Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/iep.12220","article-title":"Experimental type 2 diabetes induction reduces serum vaspin, but not serum omentin, in Wistar rats","volume":"98","author":"Buffo","year":"2017","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"11356","DOI":"10.4238\/2015.September.25.2","article-title":"Changes and clinical significance of serum vaspin levels in patients with type 2 diabetes","volume":"14","author":"Yang","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.diabres.2015.12.001","article-title":"Association between vaspin level and coronary artery disease in patients with type 2 diabetes","volume":"113","author":"Hao","year":"2016","journal-title":"Diabetes Res. Clin. Pr."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Tomimatsu, T., Mimura, K., Matsuzaki, S., Endo, M., Kumasawa, K., and Kimura, T. (2019). Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20174246"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"16097","DOI":"10.1002\/jcp.28267","article-title":"Association of vaspin rs2236242 gene variants with type 2 diabetes and obesity in a Chinese population: A prospective, single-center study","volume":"234","author":"Li","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Jian, W., Peng, W., Xiao, S., Li, H., Jin, J., Qin, L., Dong, Y., and Su, Q. (2014). Role of Serum Vaspin in Progression of Type 2 Diabetes: A 2-Year Cohort Study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094763"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2337\/db07-1045","article-title":"Serum Vaspin Concentrations in Human Obesity and Type 2 Diabetes","volume":"57","author":"Youn","year":"2007","journal-title":"Diabetes"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/phar.1301","article-title":"Variation in Inflammatory Markers and Glycemic Parameters After 12 Months of Exenatide Plus Metformin Treatment Compared with Metformin Alone: A Randomized Placebo-Controlled Trial","volume":"33","author":"Franzetti","year":"2013","journal-title":"Pharmacotherapy"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.2147\/DDDT.S131670","article-title":"Effects of metformin extended release compared to immediate release formula on glycemic control and glycemic variability in patients with type 2 diabetes","volume":"11","author":"Derosa","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.7314\/APJCP.2015.16.15.6507","article-title":"Medullary Thyroid Carcinoma-Circulating Status of Vaspin and Retinol Binding Protein-4 in Iranian Patients","volume":"16","author":"Jabbari","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0002-9378(15)30642-6","article-title":"Amenorrhea associated with bilateral polycystic ovaries","volume":"29","author":"Stein","year":"1935","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1684\/ecn.2011.0279","article-title":"Evaluation of new adipocytokines and insulin resistance in adolescents with polycystic ovary syndrome","volume":"22","author":"Cekmez","year":"2011","journal-title":"Eur. Cytokine Netw."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3109\/09513590.2010.501874","article-title":"Serum vaspin and C-reactive protein levels in women with polycystic ovaries and polycystic ovary syndrome","volume":"27","author":"Cakal","year":"2010","journal-title":"Gynecol. Endocrinol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3109\/09513590.2011.650747","article-title":"Relationship among plasma adipokines, insulin and androgens level as well as biochemical glycemic and lipidemic markers with incidence of PCOS in women with normal BMI","volume":"28","author":"Akbarzadeh","year":"2012","journal-title":"Gynecol. Endocrinol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1177\/0300060516645421","article-title":"Assessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome","volume":"44","author":"Guvenc","year":"2016","journal-title":"J. Int. Med. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejogrb.2017.08.006","article-title":"Can serum vaspin levels predict clomiphene resistance in infertile women with PCOS?","volume":"217","author":"Dogan","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Akta\u015f, H.\u015e., Uzun, Y.E., Kutlu, O., Pen\u00e7e, H.H., \u00d6z\u00e7elik, F., \u00c7il, E.\u00d6., Irak, L., Altun, \u00d6., \u00d6zcan, M., and \u00d6zsoy, N. (2019). The effects of high intensity-interval training on vaspin, adiponectin and leptin levels in women with polycystic ovary syndrome. Arch. Physiol. Biochem., 1\u20136.","DOI":"10.1080\/13813455.2019.1662450"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Mierzy\u0144ski, R., Poniedzia\u0142ek-Czajkowska, E., D\u0142uski, D., Patro-Ma\u0142ysza, J., Kimber-Trojnar, \u017b., Majsterek, M., and Leszczy\u0144ska-Gorzelak, B. (2019). Nesfatin-1 and Vaspin as Potential Novel Biomarkers for the Prediction and Early Diagnosis of Gestational Diabetes Mellitus. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20010159"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejogrb.2014.09.008","article-title":"Serum vaspin levels and vaspin mRNA expression in subcutaneous adipose tissue in women with gestational diabetes mellitus","volume":"182","author":"Mm","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/cen.13403","article-title":"Comparison of serum vaspin levels and vaspin expression in adipose tissue and smooth muscle tissue in pregnant women with and without gestational diabetes","volume":"87","author":"Tang","year":"2017","journal-title":"Clin. Endocrinol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.metabol.2009.11.001","article-title":"Preliminary report: Circulating levels of the adipokine vaspin in gestational diabetes mellitus and preeclampsia","volume":"59","author":"Stepan","year":"2010","journal-title":"Metabolism"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cyto.2012.09.006","article-title":"Serum vaspin levels in women with and without gestational diabetes mellitus during pregnancy and postpartum","volume":"61","author":"Gkiomisi","year":"2013","journal-title":"Cytokine"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/09513590.2019.1597346","article-title":"The role of adipokines in the pathogenesis of gestational diabetes mellitus","volume":"35","author":"Palla","year":"2019","journal-title":"Gynecol. Endocrinol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1053\/j.semperi.2007.11.003","article-title":"The IUGR Newborn","volume":"32","author":"Rosenberg","year":"2008","journal-title":"Semin. Perinatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1515\/jpem-2012-0111","article-title":"Umbilical cord and fifth-day serum vaspin concentrations in small-, appropriate-, and large-for-gestational age neonates","volume":"26","author":"Akcay","year":"2013","journal-title":"J. Pediatr. Endocrinol. Metab."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/7\/1710\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:26:49Z","timestamp":1760164009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/7\/1710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,6]]},"references-count":121,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["cells10071710"],"URL":"https:\/\/doi.org\/10.3390\/cells10071710","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,6]]}}}