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The influenza A virus genome consists of eight single-stranded RNA segments sequestered within a protein capsid and a lipid bilayer envelope. During host cell entry, cellular cues contribute to viral conformational changes that promote critical events such as fusion with late endosomes, capsid uncoating and viral genome release into the cytosol. In this focused review, we concisely describe the virus infection cycle and highlight the recent findings of host cell pathways and cytosolic proteins that assist influenza uncoating during host cell entry.<\/jats:p>","DOI":"10.3390\/cells10071722","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T04:32:49Z","timestamp":1625718769000},"page":"1722","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["How Influenza Virus Uses Host Cell Pathways during Uncoating"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2976-5325","authenticated-orcid":false,"given":"Etori Aguiar","family":"Moreira","sequence":"first","affiliation":[{"name":"Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8233-9133","authenticated-orcid":false,"given":"Yohei","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3927-1452","authenticated-orcid":false,"given":"Patrick","family":"Matthias","sequence":"additional","affiliation":[{"name":"Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland"},{"name":"Faculty of Sciences, University of Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/ilar\/ilx026","article-title":"Are RNA Viruses Candidate Agents for the Next Global Pandemic? 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