{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:55:55Z","timestamp":1789131355451,"version":"build-2803163510"},"reference-count":154,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY017006 (DMP), EY026009 (DMP); P30 EY016665 (Core grant to Department of Ophthalmology & Visual Sciences"],"award-info":[{"award-number":["EY017006 (DMP), EY026009 (DMP); P30 EY016665 (Core grant to Department of Ophthalmology & Visual Sciences"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Studies from our laboratory have suggested that activation of \u03b1v\u03b23 integrin-mediated signaling could contribute to the fibrotic-like changes observed in primary open angle glaucoma (POAG) and glucocorticoid-induced glaucoma. To determine how \u03b1v\u03b23 integrin signaling could be involved in this process, RNA-Seq analysis was used to analyze the transcriptomes of immortalized trabecular meshwork (TM) cell lines overexpressing either a control vector or a wild type (WT) or a constitutively active (CA) \u03b1v\u03b23 integrin. Compared to control cells, hierarchical clustering, PANTHER pathway and protein-protein interaction (PPI) analysis of cells overexpressing WT-\u03b1v\u03b23 integrin or CA-\u03b1v\u03b23 integrin resulted in a significant differential expression of genes encoding for transcription factors, adhesion and cytoskeleton proteins, extracellular matrix (ECM) proteins, cytokines and GTPases. Cells overexpressing a CA-\u03b1v\u03b23 integrin also demonstrated an enrichment for genes encoding proteins found in TGF\u03b22, Wnt and cadherin signaling pathways all of which have been implicated in POAG pathogenesis. These changes were not observed in cells overexpressing WT-\u03b1v\u03b23 integrin. Our results suggest that activation of \u03b1v\u03b23 integrin signaling in TM cells could have significant impacts on TM function and POAG pathogenesis.<\/jats:p>","DOI":"10.3390\/cells10081923","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T10:47:46Z","timestamp":1627555666000},"page":"1923","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Overexpression and Activation of \u03b1v\u03b23 Integrin Differentially Affects TGF\u03b22 Signaling in Human Trabecular Meshwork Cells"],"prefix":"10.3390","volume":"10","author":[{"given":"Mark S.","family":"Filla","sequence":"first","affiliation":[{"name":"Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy K.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Faralli","sequence":"additional","affiliation":[{"name":"Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Peters","sequence":"additional","affiliation":[{"name":"Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI 53705, USA"},{"name":"Ophthalmology & Visual Sciences, University of Wisconsin, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJMra0804630","article-title":"Primary Open-Angle Glaucoma","volume":"360","author":"Kwon","year":"2009","journal-title":"N. 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