{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:18:34Z","timestamp":1775027914344,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1C1C1008999"],"award-info":[{"award-number":["2019R1C1C1008999"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Cancer Center, Korea","award":["NCC- 1910050"],"award-info":[{"award-number":["NCC- 1910050"]}]},{"name":"National Cancer Center, Korea","award":["NCC- 2110480"],"award-info":[{"award-number":["NCC- 2110480"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Adoptive cell therapy (ACT) using tumor-reactive T cells is a promising form of immunotherapy to specifically target cancer. However, the survival and functional maintenance of adoptively transferred T cells remains a challenge, ultimately limiting their efficacy. Here, we evaluated the use of recombinant IL7-Fc in ACT. In a lymphopenic murine melanoma model, IL7-Fc treatment led to the enhanced inhibition of tumor growth with an increased number of adoptively transferred CD8+ T cells in tumor tissue and tumor-draining lymph nodes. Additionally, IL7-Fc further enhanced anti-tumor responses that were induced by recombinant human IL2 in the same mouse model. In contrast, in an immunocompetent murine melanoma model, IL7-Fc dampened the anti-tumor immunity. Further, IL7-Fc decreased the proliferation of adoptively transferred and immune-activated tumor-reactive CD8+ T cells in immunocompetent mice by inducing the massive expansion of endogenous T cells, thereby limiting the space for adoptively transferred T cells. Our data suggest that IL7-Fc is principally beneficial for enhancing the efficacy of tumor-reactive T-cells in lymphopenic conditions for the ACT.<\/jats:p>","DOI":"10.3390\/cells10082018","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T21:49:41Z","timestamp":1628459381000},"page":"2018","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["IL7-Fc Enhances the Efficacy of Adoptive T Cell Therapy under Lymphopenic Conditions in a Murine Melanoma Model"],"prefix":"10.3390","volume":"10","author":[{"given":"Eun M.","family":"Yu","sequence":"first","affiliation":[{"name":"Biomedicine Production Branch, Program for Immunotherapy Research, National Cancer Center, Goyang 10408, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunjung","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Tumor Immunology, National Cancer Center, Goyang 10408, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Tumor Immunology, National Cancer Center, Goyang 10408, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon-Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Tumor Immunology, National Cancer Center, Goyang 10408, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chungyong","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Tumor Immunology, National Cancer Center, Goyang 10408, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongeun","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Tumor Immunology, National Cancer Center, Goyang 10408, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don G.","family":"Lee","sequence":"additional","affiliation":[{"name":"Biomedicine Production Branch, Program for Immunotherapy Research, National Cancer Center, Goyang 10408, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Biomedicine Production Branch, Program for Immunotherapy Research, National Cancer Center, Goyang 10408, Korea"},{"name":"Eutilex, Co., Ltd., Geumcheon-gu, Seoul 08594, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byoung S.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Eutilex, Co., Ltd., Geumcheon-gu, Seoul 08594, Korea"},{"name":"Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beom K.","family":"Choi","sequence":"additional","affiliation":[{"name":"Biomedicine Production Branch, Program for Immunotherapy Research, National Cancer Center, Goyang 10408, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/imr.12132","article-title":"Exploiting the curative potential of adoptive T-cell therapy for cancer","volume":"257","author":"Hinrichs","year":"2014","journal-title":"Immunol. 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