{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:16:20Z","timestamp":1792030580172,"version":"4.4.0"},"reference-count":154,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Helicobacter pylori (H. pylori) is most known to cause a wide spectrum of gastrointestinal impairments; however, an increasing number of studies indicates that H. pylori infection might be involved in numerous extragastric diseases such as neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, hepatobiliary, or even allergic diseases. In this review, we focused on the nervous system and aimed to summarize the findings regarding H. pylori infection and its involvement in the induction\/progression of neurological disorders. Neurological impairments induced by H. pylori infection are primarily due to impairments in the gut\u2013brain axis (GBA) and to an altered gut microbiota facilitated by H. pylori colonization. Currently, regarding a potential relationship between Helicobacter infection and neurological disorders, most of the studies are mainly focused on H. pylori.<\/jats:p>","DOI":"10.3390\/cells10092191","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:19:26Z","timestamp":1629937166000},"page":"2191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Helicobacter pylori Infection and Extragastric Diseases\u2014A Focus on the Central Nervous System"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-8987","authenticated-orcid":false,"given":"Jacek","family":"Baj","sequence":"first","affiliation":[{"name":"Chair and Department of Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-7627","authenticated-orcid":false,"given":"Alicja","family":"Forma","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Medical University of Lublin, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0509-868X","authenticated-orcid":false,"given":"Wojciech","family":"Flieger","sequence":"additional","affiliation":[{"name":"Chair and Department of Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9462-8779","authenticated-orcid":false,"given":"Izabela","family":"Morawska","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9598-373X","authenticated-orcid":false,"given":"Adam","family":"Michalski","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7637-6387","authenticated-orcid":false,"given":"Grzegorz","family":"Buszewicz","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Medical University of Lublin, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Sitarz","sequence":"additional","affiliation":[{"name":"Chair and I Department of Psychiatry, Psychotherapy, and Early Intervention, Medical University of Lublin, 20-439 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5359-1471","authenticated-orcid":false,"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[{"name":"Clinica Medica \u201cA. Murri\u201d, Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Garruti","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Department of Emergency and Organ Transplantations, University of Bari \u201cAldo Moro\u201d Medical School, Piazza G. 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Pharmacol. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","article-title":"Helicobacter pyloriInfection and the Risk of Gastric Carcinoma","volume":"325","author":"Parsonnet","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1056\/NEJMra020542","article-title":"Helicobacter pylori Infection","volume":"347","author":"Suerbaum","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1128\/CMR.00054-05","article-title":"Pathogenesis of Helicobacter pylori infection","volume":"19","author":"Kusters","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1128\/CMR.10.4.720","article-title":"Helicobacter\u00a0pylori","volume":"10","author":"Dunn","year":"1997","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_7","first-page":"72","article-title":"Helicobacter pylori, trans-mission routes and recurrence of infection: State of the art","volume":"89","author":"Kayali","year":"2018","journal-title":"Acta Biomed."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/oxfordjournals.epirev.a018040","article-title":"Helicobacter pylori: Epidemiology and routes of transmission","volume":"22","author":"Brown","year":"2000","journal-title":"Epidemiol. Rev."},{"key":"ref_9","first-page":"3889","article-title":"Helicobacter pylori in animals affecting the human habitat through the food chain","volume":"19","author":"Dimola","year":"1999","journal-title":"Anticancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jare.2013.07.007","article-title":"Contaminated water as a source of Helicobacter pylori infection: A review","volume":"6","author":"Aziz","year":"2015","journal-title":"J. Adv. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pyloriInfection and the Development of Gastric Cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1056\/NEJMcp1710945","article-title":"Helicobacter pylori Infection","volume":"380","author":"Crowe","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Machlowska, J., Kapusta, P., Baj, J., Morsink, F.H.M., Wo\u0142kow, P., Maciejewski, R., Offerhaus, G.J.A., and Sitarz, R. (2020). High-Throughput Se-quencing of Gastric Cancer Patients: Unravelling Genetic Predispositions Towards an Early-Onset Subtype. Cancers, 12.","DOI":"10.3390\/cancers12071981"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.3748\/wjg.v20.i18.5212","article-title":"Brain-gut axis in the pathogenesis of Helicobacter pylori infection","volume":"20","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_15","first-page":"506","article-title":"The gut-brain axis: Interactions between Helicobacter pylori and enteric and central nervous systems","volume":"28","author":"Kountouras","year":"2015","journal-title":"Ann. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-2982.2010.01664.x","article-title":"The microbiome-gut-brain axis: From bowel to behavior","volume":"23","author":"Cryan","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.3748\/wjg.v21.i37.10609","article-title":"Brain-gut-microbiota axis in Parkinson\u2019s disease","volume":"21","author":"Mulak","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/hel.12256","article-title":"Extragastric Diseases and Helicobacter pylori","volume":"20","author":"Franceschi","year":"2015","journal-title":"Helicobacter"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jalz.2008.12.001","article-title":"Alzheimer\u2019s disease and infection: Do infectious agents contribute to progression of Alzheimer\u2019s disease?","volume":"5","author":"Honjo","year":"2009","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1212\/01.wnl.0000203644.68059.5f","article-title":"Relationship between Helicobacter pylori infection and Alzheimer disease","volume":"66","author":"Kountouras","year":"2006","journal-title":"Neurology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jneuroim.2007.06.007","article-title":"Helicobacter pylori and multiple sclerosis","volume":"188","author":"Gavalas","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/cen3.12401","article-title":"Helicobacter pylori and gut microbiota in multiple sclerosis versus Alzheimer\u2019s disease: 10 pitfalls of microbiome studies","volume":"8","author":"Park","year":"2017","journal-title":"Clin. Exp. Neuroimmunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e13218","DOI":"10.1111\/eci.13218","article-title":"Association between Helicobacter pylori infection and Guillain-Barr\u00e9 Syndrome: A meta-analysis","volume":"50","author":"Dardiotis","year":"2020","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jns.2011.03.015","article-title":"Helicobacter pylori infection may trigger Guillain-Barr\u00e9 syndrome, Fisher syndrome and Bickerstaff brainstem encephalitis","volume":"305","author":"Kountouras","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"ref_25","unstructured":"(1994). Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994. IARC Monogr. Eval. Carcinog. Risks Hum., 61, 1\u2013241."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e12403","DOI":"10.1111\/hel.12403","article-title":"Epidemiology of Helicobacter pylori infection","volume":"22","author":"Burucoa","year":"2017","journal-title":"Helicobacter"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Baj, J., Korona-G\u0142owniak, I., Forma, A., Maani, A., Sitarz, E., Rahnama-Hezavah, M., Radzikowska, E., and Portincasa, P. (2020). Mechanisms of the Epithelial\u2013Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer. Cells, 9.","DOI":"10.3390\/cells9041055"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Baj, J., Brzozowska, K., Forma, A., Maani, A., Sitarz, E., and Portincasa, P. (2020). Immunological Aspects of the Tumor Microenvironment and Epithelial-Mesenchymal Transition in Gastric Carcinogenesis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072544"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Kozak, J., Forma, A., Czeczelewski, M., Kozyra, P., Sitarz, E., Radzikowska-B\u00fcchner, E., Sitarz, M., and Baj, J. (2021). Inhibition or Reversal of the Epithelial-Mesenchymal Transition in Gastric Cancer: Pharmacological Approaches. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010277"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Baj, J., Forma, A., Sitarz, M., Portincasa, P., Garruti, G., Krasowska, D., and Maciejewski, R. (2020). Helicobacter pylori Virulence Factors-Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment. Cells, 10.","DOI":"10.3390\/cells10010027"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"104675","DOI":"10.1016\/j.micpath.2020.104675","article-title":"Human gut microbiota and its association with pathogenesis and treatments of neurodegenerative diseases","volume":"150","author":"Chen","year":"2021","journal-title":"Microb. Pathog."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrmicro2876","article-title":"The interplay between the intestinal microbiota and the brain","volume":"10","author":"Collins","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s41575-018-0051-4","article-title":"Neuroimmunophysiology of the gut: Advances and emerging concepts focusing on the epithelium","volume":"15","author":"Sharkey","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fnins.2013.00134","article-title":"Molecular anatomy of the gut-brain axis revealed with transgenic technologies: Implications in metabolic research","volume":"7","author":"Udit","year":"2013","journal-title":"Front. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hattori, N., and Yamashiro, Y. (2021). The Gut-Brain Axis. Ann. Nutr. Metab., 1\u20133.","DOI":"10.1159\/000512226"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00018-012-1028-z","article-title":"Voices from within: Gut microbes and the CNS","volume":"70","author":"Forsythe","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1172\/JCI76304","article-title":"Gut\/brain axis and the microbiota","volume":"125","author":"Mayer","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.bpg.2004.06.004","article-title":"Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome","volume":"18","author":"Delvaux","year":"2004","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ncpgasthep0259","article-title":"Mechanisms of disease: The role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases","volume":"2","author":"Fasano","year":"2005","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/cphy.c150037","article-title":"Overview of the Anatomy, Physiology, and Pharmacology of the Autonomic Nervous System","volume":"Volume 6","author":"Wehrwein","year":"2016","journal-title":"Comprehensive Physiology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1053\/j.gastro.2012.10.003","article-title":"Brain-gut interactions in inflammatory bowel disease","volume":"144","author":"Bonaz","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fphys.2011.00094","article-title":"Brain-gut-microbe communication in health and disease","volume":"2","author":"Grenham","year":"2011","journal-title":"Front. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1053\/j.gastro.2005.11.033","article-title":"Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome: Plasma Cytokines as a Potential Biomarker?","volume":"130","author":"Dinan","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/mp.2012.77","article-title":"The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner","volume":"18","author":"Clarke","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2174\/1570159X14666160223120742","article-title":"Gut-Brain Axis in Gastric Mucosal Damage and Protection","volume":"14","author":"Sgambato","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/embor.2012.96","article-title":"Innate immune signalling at the intestinal epithelium in homeostasis and disease","volume":"13","author":"Pott","year":"2012","journal-title":"EMBO Repo."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.coph.2013.09.008","article-title":"Gut microbiota, enteroendocrine functions and metabolism","volume":"13","author":"Cani","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1096\/fj.14-259598","article-title":"Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells","volume":"29","author":"Reigstad","year":"2014","journal-title":"FASEB J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41564-018-0307-3","article-title":"GABA-modulating bacteria of the human gut microbiota","volume":"4","author":"Strandwitz","year":"2018","journal-title":"Nat. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nrgastro.2009.35","article-title":"Principles and clinical implications of the brain-gut-enteric microbiota axis","volume":"6","author":"Rhee","year":"2009","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"eaat5236","DOI":"10.1126\/science.aat5236","article-title":"A gut-brain neural circuit for nutrient sensory transduction","volume":"361","author":"Kaelberer","year":"2018","journal-title":"Science"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1743-3150.2004.00471.x","article-title":"Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract","volume":"16","author":"Berthoud","year":"2004","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bbi.2005.03.015","article-title":"The cholinergic anti-inflammatory pathway","volume":"19","author":"Pavlov","year":"2005","journal-title":"Brain Behav. Immunity"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00006842-195307000-00006","article-title":"Development of new symptoms following medical and surgical treatment for duodenal ulcer","volume":"15","author":"Browning","year":"1953","journal-title":"Psychosom. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1136\/bmj.1.5239.1560","article-title":"Some psychiatric consequences of gastrectomy","volume":"1","author":"Whitlock","year":"1961","journal-title":"Br. Med. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neubiorev.2015.06.019","article-title":"The antidepressant mechanism of action of vagus nerve stimulation: Evidence from preclinical studies","volume":"56","author":"Grimonprez","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.neubiorev.2021.02.044","article-title":"Mining microbes for mental health: Determining the role of microbial metabolic pathways in human brain health and disease","volume":"125","author":"Spichak","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Anderson, G., Rodriguez, M., and Reiter, R.J. (2019). Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20215500"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"104938","DOI":"10.1016\/j.neuint.2020.104938","article-title":"The trimebutine effect on Helicobacter pylori-related gastrointestinal tract and brain disorders: A hypothesis","volume":"144","author":"Boziki","year":"2021","journal-title":"Neurochem. Int."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00441-014-1811-2","article-title":"Novel insights into the development and maintenance of the blood-brain barrier","volume":"355","author":"Engelhardt","year":"2014","journal-title":"Cell Tissue Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1136\/jcp.2005.031146","article-title":"Mucosa-associated lymphoid tissue (MALT) lymphoma: A practical guide for pathologists","volume":"60","author":"Bacon","year":"2007","journal-title":"J Clin Pathol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/j.1365-2036.2006.03078.x","article-title":"Review article: Modulation of the brain-gut axis as a therapeutic approach in gastrointestinal disease","volume":"24","author":"Mayer","year":"2006","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_64","first-page":"3085181","article-title":"Dangerous Liaison: Helicobacter pylori, Ganglionitis, and Myenteric Gastric Neurons: A Histopathological Study","volume":"2019","author":"Sticlaru","year":"2019","journal-title":"Anal. Cell. Pathol. (Amst.)"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.3748\/wjg.v24.i29.3204","article-title":"Helicobacter pylori and extragastric diseases: A review","volume":"24","author":"Gravina","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_66","first-page":"203","article-title":"The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems","volume":"28","author":"Carabotti","year":"2015","journal-title":"Ann. Gastroenterol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-4939-0897-4_5","article-title":"Vagal pathways for microbiome-brain-gut axis communication","volume":"817","author":"Forsythe","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"696","DOI":"10.2174\/156652411797536660","article-title":"Gastrointestinal immune system and brain dialogue implicated in neuroinflammatory and neurodegenerative diseases","volume":"11","author":"Deretzi","year":"2011","journal-title":"Curr. Mol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.mehy.2009.04.021","article-title":"From the \u201clittle brain\u201d gastrointestinal infection to the \u201cbig brain\u201d neuroinflammation: A proposed fast axonal transport pathway involved in multiple sclerosis","volume":"73","author":"Deretzi","year":"2009","journal-title":"Med. Hypotheses"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e12451","DOI":"10.1111\/hel.12454","article-title":"Review: Impact of Helicobacter pylori on Alzheimer\u2019s disease: What do we know so far?","volume":"23","author":"Doulberis","year":"2018","journal-title":"Helicobacter"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1128\/IAI.71.4.2266-2271.2003","article-title":"Expression of Helicobacter pylori vacuolating toxin in Escherichia coli","volume":"71","author":"McClain","year":"2003","journal-title":"Infect Immun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"584165","DOI":"10.3389\/fimmu.2020.584165","article-title":"Helicobacter and the Potential Role in Neurological Disorders: There Is More Than Helicobacter pylori","volume":"11","author":"Bauwens","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s00259-002-0854-x","article-title":"Gastric emptying in patients with vitamin B(12) deficiency","volume":"29","author":"Acar","year":"2002","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12929-018-0469-6","article-title":"H. pylori infection and extra-gastroduodenal diseases","volume":"25","author":"Tsay","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jns.2005.03.009","article-title":"Vitamin B12, demyelination, remyelination and repair in multiple sclerosis","volume":"233","author":"Miller","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"470","DOI":"10.4103\/1673-5374.291381","article-title":"Role of vitamin B12 deficiency in ischemic stroke risk and outcome","volume":"16","author":"Yahn","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0306-9877(96)90223-6","article-title":"Gastric Helicobacter pylori infection as a cause of idiopathic Parkinson disease and non-arteric anterior optic ischemic neuropathy","volume":"47","author":"Altschuler","year":"1996","journal-title":"Med. Hypotheses"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-0404.1999.tb00654.x","article-title":"Parkinsonism: Siblings share Helicobacter pylori seropositivity and facets of syndrome","volume":"99","author":"Charlett","year":"1999","journal-title":"Acta Neurol. Scand."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1523-5378.2005.00330.x","article-title":"Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. Part 2: Response of facets of clinical idiopathic parkinsonism to Helicobacter pylori eradication. A randomized, double-blind, placebo-controlled efficacy study","volume":"10","author":"Bjarnason","year":"2005","journal-title":"Helicobacter"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e12398","DOI":"10.1111\/hel.12398","article-title":"Meta-analysis: Association of Helicobacter pylori infection with Parkinson\u2019s diseases","volume":"22","author":"Shen","year":"2017","journal-title":"Helicobacter"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.parkreldis.2017.11.331","article-title":"Helicobacter pylori infection is associated with an increased risk of Parkinson\u2019s disease: A population-based retrospective cohort study","volume":"47","author":"Huang","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Gravina, A.G., Priadko, K., Ciamarra, P., Granata, L., Facchiano, A., Miranda, A., Dallio, M., Federico, A., and Romano, M. (2020). Extra-Gastric Manifestations of Helicobacter pylori Infection. J. Clin. Med., 9.","DOI":"10.3390\/jcm9123887"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/S1353-8020(11)70008-6","article-title":"Misfolded \u03b1-synuclein and Toll-like receptors: Therapeutic targets for Parkinson\u2019s disease","volume":"18","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3988\/jcn.2017.13.2.181","article-title":"Association of Helicobacter pylori with Parkinson\u2019s Disease","volume":"13","author":"Mridula","year":"2017","journal-title":"J. Clin. Neurol. (Seoul, Korea)"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/mds.25522","article-title":"The role of small intestinal bacterial overgrowth in Parkinson\u2019s disease","volume":"28","author":"Fasano","year":"2013","journal-title":"Mov. Disord."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.jocn.2013.11.018","article-title":"Association between Helicobacter pylori infection and dementia","volume":"21","author":"Huang","year":"2014","journal-title":"J. Clin. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/jgs.12065","article-title":"Does Helicobacter pylori infection increase incidence of dementia? The Personnes Ag\u00e9es QUID Study","volume":"61","author":"Letenneur","year":"2013","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/PSY.0b013e31829108c3","article-title":"Helicobacter pylori seropositivity and cognitive performance among US adults: Evidence from a large national survey","volume":"75","author":"Beydoun","year":"2013","journal-title":"Psychosom. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1080\/00207450902782083","article-title":"Increased cerebrospinal fluid Helicobacter pylori antibody in Alzheimer\u2019s disease","volume":"119","author":"Kountouras","year":"2009","journal-title":"Int. J. Neurosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/WNN.0b013e3181df3034","article-title":"Five-year survival after Helicobacter pylori eradication in Alzheimer disease patients","volume":"23","author":"Kountouras","year":"2010","journal-title":"Cogn. Behav. Neurol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s00415-009-5011-z","article-title":"Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer\u2019s disease","volume":"256","author":"Kountouras","year":"2009","journal-title":"J. Neurol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/hel.12340","article-title":"Helicobacter pylori and extragastric diseases","volume":"21","author":"Goni","year":"2016","journal-title":"Helicobacter"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"175729","DOI":"10.1155\/2013\/175729","article-title":"Eradication of Helicobacter pylori Is Associated with the Progression of Dementia: A PopulationBased Study","volume":"2013","author":"Chang","year":"2013","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1007\/s00415-011-5957-5","article-title":"The relationship between Helicobacter pylori infection and Alzheimer\u2019s disease in Japan","volume":"258","author":"Shiota","year":"2011","journal-title":"J. Neurol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.dadm.2017.01.005","article-title":"Pathophysiologic relationship between Alzheimer\u2019s disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis","volume":"7","author":"Santos","year":"2017","journal-title":"Alzheimers Dement. (Amst.)"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jneuroim.2018.06.017","article-title":"Helicobacter pylori infection and demyelinating disease of the central nervous system","volume":"329","author":"Kira","year":"2019","journal-title":"J. Neuroimmunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S1474-4422(08)70042-5","article-title":"Environmental factors and multiple sclerosis","volume":"7","author":"Ebers","year":"2008","journal-title":"Lancet Neurol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e517","DOI":"10.1212\/NXI.0000000000000517","article-title":"Disease-modifying therapies alter gut microbial composition in MS","volume":"6","author":"Sand","year":"2018","journal-title":"Neurol.-Neuroimmunol. Neuroinflammation"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.3389\/fmicb.2018.02966","article-title":"Bacteria\u2013host interactions in multiple sclerosis","volume":"9","author":"Cossu","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jneuroim.2006.12.010","article-title":"Helicobacter pylori infection is a potential protective factor against conventional multiple sclerosis in the Japanese population","volume":"184","author":"Li","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fmicb.2015.00052","article-title":"Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis","volume":"6","author":"Cook","year":"2015","journal-title":"Front. Microbiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3748\/wjg.v20.i3.613","article-title":"Helicobacter pylori and autoimmune disease: Cause or bystander","volume":"20","author":"Smyk","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1515\/cclm-2012-0477","article-title":"Helicobacter pylori serology in autoimmune diseases \u2013 fact or fiction?","volume":"51","author":"Ram","year":"2013","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_104","unstructured":"(2021, April 23). Relationship between Helicobacter pylori Infection and Multiple Sclerosis\u2014ScienceOpen n.d. Available online: https:\/\/www.scienceopen.com\/document?vid=4c548e26-5a70-4735-8991-80c42e3ea4ff."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000345838","article-title":"Helicobacter pyloriInfection in Neuromyelitis Optica and Multiple Sclerosis","volume":"20","author":"Long","year":"2013","journal-title":"Neuroimmunomodulation"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/ane.12453","article-title":"Impact ofHelicobacter pylorion multiple sclerosis-related clinically isolated syndrome","volume":"133","author":"Deretzi","year":"2015","journal-title":"Acta Neurol. Scand."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s41983-018-0043-x","article-title":"Relevance of Helicobacter pylori infection in Egyptian multiple sclerosis patients","volume":"54","author":"Gerges","year":"2018","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Fourie, K.R., and Wilson, H.L. (2020). Understanding groel and dnak stress response proteins as antigens for bacterial diseases. Vaccines, 8.","DOI":"10.3390\/vaccines8040773"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jneuroim.2015.11.005","article-title":"Guillain Barr\u00e9 syndrome (GBS): New insights in the molecular mimicry between C. jejuni and human peripheral nerve (HPN) proteins","volume":"289","author":"Regazzoni","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Elfaitouri, A., Herrmann, B., B\u00f6lin-Wiener, A., Wang, Y., Gottfries, C.-G., Zachrisson, O., Pipkorn, R., R\u00f6nnblom, L., and Blomberg, J. (2013). Epitopes of Microbial and Human Heat Shock Protein 60 and Their Recognition in Myalgic Encephalomyelitis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081155"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Chiricosta, L., Gugliandolo, A., Bramanti, P., and Mazzon, E. (2020). Could the heat shock proteins 70 family members exacerbate the immune response in multiple sclerosis? An in silico study. Genes, 11.","DOI":"10.3390\/genes11060615"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2016.03.037","article-title":"Meta-analysis of association between Helicobacter pylori infection and multiple sclerosis","volume":"620","author":"Yao","year":"2016","journal-title":"Neurosci. Lett."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1136\/jnnp-2014-309495","article-title":"Helicobacter pyloriinfection as a protective factor against multiple sclerosis risk in females","volume":"86","author":"Pedrini","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4081\/ni.2013.e10","article-title":"Relation of Helicobacter pylori infection and multiple sclerosis in Iranian patients","volume":"5","author":"Mohebi","year":"2013","journal-title":"Neurol. Int."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5339\/qmj.2020.45","article-title":"Correlation of dietary intake and Helicobacter pylori infection with multiple sclerosis, a case-control study in Rafsanjan, Iran, 2017\u20132018","volume":"2020","author":"Kiani","year":"2021","journal-title":"Qatar Med. J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"577069","DOI":"10.1016\/j.jneuroim.2019.577069","article-title":"The protective effect of Helicobacter pylori infection on the susceptibility of multiple sclerosis","volume":"337","author":"Ranjbar","year":"2019","journal-title":"J. Neuroimmunol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Robinson, K., Stephens, J., Constantinescu, C.S., and Gran, B. (2016). Helicobacter pylori, experimental autoimmune encephalomyelitis, and multiple sclerosis. Neuro-Immuno-Gastroenterology, Springer International Publishing.","DOI":"10.1007\/978-3-319-28609-9_6"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fcimb.2012.00010","article-title":"The immunomodulatory properties of Helicobacter pylori confer protection against allergic and chronic inflammatory disorders","volume":"2","author":"Arnold","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1136\/gutjnl-2013-306253","article-title":"CCL20\/CCR6-mediated migration of regulatory T cells to theHelicobacter pylori-infected human gastric mucosa","volume":"63","author":"Cook","year":"2014","journal-title":"Gut"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/bies.201000063","article-title":"An immune paradox: How can the same chemokine axis regulate both immune tolerance and activation?","volume":"32","author":"Comerford","year":"2010","journal-title":"BioEssays"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jneuroim.2009.05.011","article-title":"Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis","volume":"213","author":"Elhofy","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.4049\/jimmunol.0713169","article-title":"Inhibition of CCR6 Function Reduces the Severity of Experimental Autoimmune Encephalomyelitis via Effects on the Priming Phase of the Immune Response","volume":"182","author":"Liston","year":"2009","journal-title":"J. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(16)00339-1","article-title":"Guillain-Barr\u00e9 syndrome","volume":"388","author":"Willison","year":"2016","journal-title":"Lancet"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41582-019-0250-9","article-title":"Diagnosis and management of Guillain\u2013Barr\u00e9 syndrome in ten steps","volume":"15","author":"Leonhard","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0140-6736(16)00562-6","article-title":"Guillain-Barr\u00e9 Syndrome outbreak associated with Zika virus infection in French Polynesia: A case-control study","volume":"387","author":"Blake","year":"2016","journal-title":"Lancet"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1212\/WNL.0000000000000111","article-title":"Guillain-Barr\u00e9 syndrome associated with preceding hepatitis E virus infection","volume":"82","author":"Pas","year":"2014","journal-title":"Neurology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1212\/WNL.51.4.1110","article-title":"The spectrum of antecedent infections in Guillain-Barr\u00e9 syndrome","volume":"51","author":"Jacobs","year":"1998","journal-title":"Neurology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ncl.2013.01.005","article-title":"Guillain-Barr\u00e9 syndrome and variants","volume":"31","author":"Dimachkie","year":"2013","journal-title":"Neurol. Clin."},{"key":"ref_129","unstructured":"Rocha Cabrero, F., and Morrison, E.H. (2021, April 23). Miller Fisher Syndrome, StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507717\/."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1177\/08830738060210061401","article-title":"Bickerstaff brainstem encephalitis associated with Mycoplasma pneumoniae infection","volume":"21","author":"Steer","year":"2006","journal-title":"J. Child Neurol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/brain\/118.3.597","article-title":"Guillain-Barr\u00e9 syndrome in northern China. Relationship to Campylobacter jejuni infection and anti-glycolipid antibodies","volume":"118","author":"Ho","year":"1995","journal-title":"Brain"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/ana.410390512","article-title":"Immune attack on the Schwann cell surface in acute inflammatory demyelinating polyneuropathy","volume":"39","author":"Sheikh","year":"1996","journal-title":"Ann. Neurol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1468-1331.2004.00977.x","article-title":"Association between Helicobacter pylori infection and acute inflammatory demyelinating polyradiculoneuropathy","volume":"12","author":"Kountouras","year":"2005","journal-title":"Eur. J. Neurol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/jaut.2000.0490","article-title":"Molecular mimicry in Campylobacter jejuni and Helicobacter pylori lipopolysaccharides: Contribution of gastrointestinal infections to autoimmunity","volume":"16","author":"Moran","year":"2001","journal-title":"J. Autoimmun."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1136\/jnnp.73.1.76","article-title":"An antibody to VacA of Helicobacter pylori in cerebrospinal fluid from patients with Guillain-Barre syndrome","volume":"73","author":"Chiba","year":"2002","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"400","DOI":"10.4291\/wjgp.v5.i4.400","article-title":"Helicobacter pylori and neurological diseases: Married by the laws of inflammation","volume":"5","year":"2014","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1136\/bmj.1.5032.1384","article-title":"Brain-stem Encephalitis","volume":"1","author":"Bickerstaff","year":"1957","journal-title":"BMJ"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/ana.410310619","article-title":"Serum IgG antibody to ganglioside GQ1b is a possible marker of Miller Fisher syndrome","volume":"31","author":"Chiba","year":"1992","journal-title":"Ann. Neurol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-510X(93)90250-3","article-title":"An immunologic abnormality common to Bickerstaff\u2019s brain stem encephalitis and Fisher\u2019s syndrome","volume":"118","author":"Yuki","year":"1993","journal-title":"J. Neurol. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1136\/jnnp.70.1.50","article-title":"Anti-GQ1b IgG antibody syndrome: Clinical and immunological range","volume":"70","author":"Odaka","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jneuroim.2006.04.005","article-title":"Spectrum of neurological diseases associated with antibodies to minor gangliosides GM1b and GalNAc-GD1a","volume":"177","author":"Tatsumoto","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s00415-008-0775-0","article-title":"Bickerstaff\u2019s brainstem encephalitis and Fisher syndrome form a continuous spectrum","volume":"255","author":"Ito","year":"2008","journal-title":"J. Neurol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S1474-4422(08)70247-3","article-title":"Guillain-Barr\u00e9 syndrome","volume":"7","author":"Kountouras","year":"2008","journal-title":"Lancet Neurol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","article-title":"The spectrum of neuromyelitis optica","volume":"6","author":"Wingerchuk","year":"2007","journal-title":"Lancet Neurol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1212\/WNL.53.5.1107","article-title":"The clinical course of neuromyelitis optica (Devic\u2019s syndrome)","volume":"53","author":"Wingerchuk","year":"1999","journal-title":"Neurology"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jaut.2009.09.013","article-title":"The clinical spectrum and immunobiology of parainfectious neuromyelitis optica (Devic) syndromes","volume":"34","author":"Sellner","year":"2010","journal-title":"J. Autoimmun."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrneurol.2010.72","article-title":"AQP4 antibodies in neuromyelitis optica: Diagnostic and pathogenetic relevance","volume":"6","author":"Jarius","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1177\/1352458509348961","article-title":"Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica","volume":"15","author":"Li","year":"2009","journal-title":"Mult. Scler. J."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pathophys.2010.04.008","article-title":"Neuromyelitis optica and opticospinal multiple sclerosis: Mechanisms and pathogenesis","volume":"18","author":"Kira","year":"2011","journal-title":"Pathophysiology"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1007\/s00415-012-6558-7","article-title":"Helicobacter pylori infection contributes to high risk of ischemic stroke: Evidence from a meta-analysis","volume":"259","author":"Wang","year":"2012","journal-title":"J. Neurol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1136\/gutjnl-2012-303018","article-title":"Association between Helicobacter pylori and mortality in the NHANES III study","volume":"62","author":"Chen","year":"2013","journal-title":"Gut"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/hel.12159","article-title":"Helicobacter pylori and extragastric diseases","volume":"19","author":"Franceschi","year":"2014","journal-title":"Helicobacter"},{"key":"ref_153","first-page":"161","article-title":"Is Helicobacter pylori infection a risk factor for migraine? A case-control study","volume":"104","author":"Tunca","year":"2004","journal-title":"Acta Neurol. Belg."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"844","DOI":"10.5114\/aoms.2011.25560","article-title":"Evaluation of Helicobacter pylori infection in patients with common migraine headache","volume":"7","author":"Hosseinzadeh","year":"2011","journal-title":"Arch. Med. 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