{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T15:25:16Z","timestamp":1764084316981,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007380","name":"Fondation de l'Avenir pour la Recherche M\u00e9dicale Appliqu\u00e9e","doi-asserted-by":"publisher","award":["AP-RM-17-012"],"award-info":[{"award-number":["AP-RM-17-012"]}],"id":[{"id":"10.13039\/100007380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Ischemic vascular diseases are associated with elevated tissue expression of angiomotin (AMOT), a promising molecular target for PET imaging. On that basis, we developed an AMOT-targeting radiotracer, 68Ga-sCD146 and performed the first in vivo evaluation on a myocardial infarction mice model and then, compared AMOT expression and \u03b1v\u03b23-integrin expression with 68Ga-sCD146 and 68Ga-RGD2 imaging. After myocardial infarction (MI) induced by permanent ligation of the left anterior descending coronary artery, myocardial perfusion was evaluated by Doppler ultrasound and by 18F-FDG PET imaging. 68Ga-sCD146 and 68Ga-RGD2 PET imaging were performed. In myocardial infarction model, heart-to-muscle ratio of 68Ga-sCD146 imaging showed a significantly higher radiotracer uptake in the infarcted area of MI animals than in sham (* p = 0.04). Interestingly, we also observed significant correlations between 68Ga-sCD146 imaging and delayed residual perfusion assessed by 18F-FDG (* p = 0.04), with lowest tissue fibrosis assessed by histological staining (* p = 0.04) and with functional recovery assessed by ultrasound imaging (** p = 0.01). 68Ga-sCD146 demonstrated an increase in AMOT expression after MI. Altogether, significant correlations of early post-ischemic 68Ga-sCD146 uptake with late heart perfusion, lower tissue fibrosis and better functional recovery, make 68Ga-sCD146 a promising radiotracer for tissue angiogenesis assessment after MI.<\/jats:p>","DOI":"10.3390\/cells10092305","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T10:59:12Z","timestamp":1630925952000},"page":"2305","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of a New 68Ga-Radiolabelled PET Imaging Agent sCD146 and RGD Peptide for In Vivo Evaluation of Angiogenesis in Mouse Model of Myocardial Infarction"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6668-6031","authenticated-orcid":false,"given":"Ana\u00efs","family":"Moyon","sequence":"first","affiliation":[{"name":"Pharmacological Faculty, Aix Marseille University, INSERM 1263, INRAE 1260, C2VN, 13385 Marseille, France"},{"name":"Medical Faculty, Aix-Marseille University, CNRS 2012, CERIMED, 13385 Marseille, France"},{"name":"APHM, Service de Radiopharmacie, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5712-2055","authenticated-orcid":false,"given":"Philippe","family":"Garrigue","sequence":"additional","affiliation":[{"name":"Pharmacological Faculty, Aix Marseille University, INSERM 1263, INRAE 1260, C2VN, 13385 Marseille, France"},{"name":"Medical Faculty, Aix-Marseille University, CNRS 2012, CERIMED, 13385 Marseille, France"},{"name":"APHM, Service de Radiopharmacie, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Medical Faculty, Aix-Marseille University, CNRS 2012, CERIMED, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1360-4092","authenticated-orcid":false,"given":"Fabien","family":"Hubert","sequence":"additional","affiliation":[{"name":"Medical Faculty, Aix Marseille University, INSERM, MMG, U 1251, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Balasse","sequence":"additional","affiliation":[{"name":"Medical Faculty, Aix-Marseille University, CNRS 2012, CERIMED, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Brige","sequence":"additional","affiliation":[{"name":"Medical Faculty, Aix-Marseille University, CNRS 2012, CERIMED, 13385 Marseille, France"},{"name":"Medical Faculty, Aix-Marseille University, UR4264, LIIE, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Hache","sequence":"additional","affiliation":[{"name":"Pharmacological Faculty, Aix Marseille University, INSERM 1263, INRAE 1260, C2VN, 13385 Marseille, France"},{"name":"Medical Faculty, Aix-Marseille University, CNRS 2012, CERIMED, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Nail","sequence":"additional","affiliation":[{"name":"Pharmacological Faculty, Aix Marseille University, INSERM 1263, INRAE 1260, C2VN, 13385 Marseille, France"},{"name":"Medical Faculty, Aix-Marseille University, CNRS 2012, CERIMED, 13385 Marseille, France"},{"name":"APHM, Service de Radiopharmacie, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Blot-Chabaud","sequence":"additional","affiliation":[{"name":"Pharmacological Faculty, Aix Marseille University, INSERM 1263, INRAE 1260, C2VN, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Dignat-George","sequence":"additional","affiliation":[{"name":"Pharmacological Faculty, Aix Marseille University, INSERM 1263, INRAE 1260, C2VN, 13385 Marseille, France"},{"name":"APHM, Service d\u2019H\u00e9matologie, H\u00f4pital Conception, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-8916","authenticated-orcid":false,"given":"Francesca","family":"Rochais","sequence":"additional","affiliation":[{"name":"Medical Faculty, Aix Marseille University, INSERM, MMG, U 1251, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Guillet","sequence":"additional","affiliation":[{"name":"Pharmacological Faculty, Aix Marseille University, INSERM 1263, INRAE 1260, C2VN, 13385 Marseille, France"},{"name":"Medical Faculty, Aix-Marseille University, CNRS 2012, CERIMED, 13385 Marseille, France"},{"name":"APHM, Service de Radiopharmacie, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0140-6736(06)68148-8","article-title":"Comparison of Primary and Facilitated Percutaneous Coronary Interventions for ST-Elevation Myocardial Infarction: Quantitative Review of Randomised Trials","volume":"367","author":"Keeley","year":"2006","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/cvr\/cvaa287","article-title":"Angiogenesis after Acute Myocardial Infarction","volume":"117","author":"Wu","year":"2021","journal-title":"Cardiovasc. 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