{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:24:58Z","timestamp":1790763898252,"version":"4.1.0"},"reference-count":368,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/N509565\/1"],"award-info":[{"award-number":["EP\/N509565\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The endoplasmic reticulum (ER) is an organelle that is responsible for many essential subcellular processes. Interconnected narrow tubules at the periphery and thicker sheet-like regions in the perinuclear region are linked to the nuclear envelope. It is becoming apparent that the complex morphology and dynamics of the ER are linked to its function. Mutations in the proteins involved in regulating ER structure and movement are implicated in many diseases including neurodegenerative diseases such as Alzheimer\u2019s, Parkinson\u2019s, and amyotrophic lateral sclerosis (ALS). The ER is also hijacked by pathogens to promote their replication. Bacteria such as Legionella pneumophila and Chlamydia trachomatis, as well as the Zika virus, bind to ER morphology and dynamics-regulating proteins to exploit the functions of the ER to their advantage. This review covers our understanding of ER morphology, including the functional subdomains and membrane contact sites that the organelle forms. We also focus on ER dynamics and the current efforts to quantify ER motion and discuss the diseases related to ER morphology and dynamics.<\/jats:p>","DOI":"10.3390\/cells10092341","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T10:24:25Z","timestamp":1631010265000},"page":"2341","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Intertwined and Finely Balanced: Endoplasmic Reticulum Morphology, Dynamics, Function, and Diseases"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3067-8907","authenticated-orcid":false,"given":"Hannah T.","family":"Perkins","sequence":"first","affiliation":[{"name":"Division of Molecular and Cellular Function, School of Biological Sciences, Michael Smith Building, The University of Manchester, Dover Street, Manchester M13 9PT, UK"},{"name":"Biological Physics, Department of Physics and Astronomy, Schuster Building, The University of Manchester, Oxford Road, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4583-0836","authenticated-orcid":false,"given":"Viki","family":"Allan","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Function, School of Biological Sciences, Michael Smith Building, The University of Manchester, Dover Street, Manchester M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nature22369","article-title":"Applying systems-level spectral imaging and analysis to reveal the organelle interactome","volume":"546","author":"Valm","year":"2017","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.cell.2005.11.047","article-title":"A class of membrane proteins shaping the tubular endoplasmic reticulum","volume":"124","author":"Voeltz","year":"2006","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1126\/science.1153634","article-title":"Membrane proteins of the endoplasmic reticulum induce high-curvature tubules","volume":"319","author":"Hu","year":"2008","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.cell.2009.05.025","article-title":"A Class of Dynamin-like GTPases Involved in the Generation of the Tubular ER Network","volume":"138","author":"Hu","year":"2009","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/nature08280","article-title":"Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin","volume":"460","author":"Orso","year":"2009","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.18605","article-title":"Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network","volume":"5","author":"Wang","year":"2016","journal-title":"Elife"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/ncb2647","article-title":"Rab10 GTPase regulates ER dynamics and morphology","volume":"15","author":"English","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1083\/jcb.201403026","article-title":"Rab18 and a Rab18 GEF complex are required for normal ER structure","volume":"205","author":"Gerondopoulos","year":"2014","journal-title":"J. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/ncb2523","article-title":"ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p","volume":"14","author":"Chen","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1073\/pnas.1423026112","article-title":"Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum","volume":"112","author":"Chen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"18252","DOI":"10.1074\/jbc.M116.737783","article-title":"Lunapark is a component of a ubiquitin ligase complex localized to the endoplasmic reticulum three-way junctions","volume":"291","author":"Zhao","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1083\/jcb.153.6.1287","article-title":"Subdomain-specific Localisation of CLIMP-63 (p63) in the Endoplamic Reticulum is Mediated by its Luminal a-helical Segment","volume":"153","author":"Klopfenstein","year":"2001","journal-title":"J. Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.cell.2010.11.007","article-title":"Mechanisms determining the morphology of the peripheral ER","volume":"143","author":"Shibata","year":"2010","journal-title":"Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.biocel.2012.05.013","article-title":"Molecular basis for sculpting the endoplasmic reticulum membrane","volume":"44","author":"Lin","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6168","DOI":"10.1093\/emboj\/17.21.6168","article-title":"A novel direct interaction of endoplasmic reticulum with microtubules","volume":"17","author":"Klopfenstein","year":"1998","journal-title":"EMBO J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1091\/mbc.e06-12-1125","article-title":"p180 is Involved in the Interaction between the Endoplasmic Reticulum and Microtubules through a Novel Microtubule-binding and Bundling Domain","volume":"18","author":"Tanaka","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1172\/JCI40979","article-title":"Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network","volume":"120","author":"Park","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s13238-018-0595-7","article-title":"Reciprocal regulation between lunapark and atlastin facilitates ER three-way junction formation","volume":"10","author":"Zhou","year":"2019","journal-title":"Protein Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1083\/jcb.128.5.879","article-title":"Protein phosphatase 1 regulates the cytoplasmic dynein-driven formation of endoplasmic reticulum networks in vitro","volume":"128","author":"Allan","year":"1995","journal-title":"J. Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1242\/jcs.041962","article-title":"Role of kinesin-1 and cytoplasmic dynein in endoplasmic reticulum movement in VERO cells","volume":"122","author":"Bola","year":"2009","journal-title":"J. Cell Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cub.2007.12.050","article-title":"STIM1 is a MT-Plus-End-Tracking Protein Involved in Remodeling of the ER","volume":"18","author":"Grigoriev","year":"2008","journal-title":"Curr. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1083\/jcb.200911024","article-title":"ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubules","volume":"190","author":"Friedman","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/S0960-9822(98)70321-5","article-title":"Endoplasmic reticulum membrane tubules are distributed by microtubules in living cells using three distinct mechanisms","volume":"8","author":"Salmon","year":"1998","journal-title":"Curr. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-08893-9","article-title":"Quantitative analysis of plant ER architecture and dynamics","volume":"10","author":"Pain","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"16474","DOI":"10.1038\/s41598-017-16570-4","article-title":"The flexibility and dynamics of the tubules in the endoplasmic reticulum","volume":"7","author":"Georgiades","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/embr.202050815","article-title":"Mobile late endosomes modulate peripheral endoplasmic reticulum network architecture","volume":"22","author":"Spits","year":"2021","journal-title":"EMBO Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-94901-2","article-title":"Network Organisation and the Dynamics of Tubules in the Endoplasmic Reticulum","volume":"11","author":"Perkins","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/tra.12647","article-title":"Conserved role for Ataxin-2 in mediating endoplasmic reticulum dynamics","volume":"20","author":"Gnazzo","year":"2019","journal-title":"Traffic"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ajhg.2011.03.012","article-title":"Loss-of-Function Mutations in RAB18 Cause Warburg Micro Syndrome","volume":"88","author":"Bem","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/embor.2010.92","article-title":"Further assembly required: Construction and dynamics of the endoplasmic reticulum network","volume":"11","author":"Park","year":"2010","journal-title":"EMBO Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.tcb.2016.06.002","article-title":"Shaping the Endoplasmic Reticulum into a Social Network","volume":"26","author":"Zhang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Sree, S., Parkkinen, I., Their, A., Airavaara, M., and Jokitalo, E. (2021). Morphological Heterogeneity of the Endoplasmic Reticulum within Neurons and Its Implications in Neurodegeneration. Cells, 10.","DOI":"10.3390\/cells10050970"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1083\/jcb.201809107","article-title":"Dynamic nanoscale morphology of the ER surveyed by STED microscopy","volume":"218","author":"Schroeder","year":"2019","journal-title":"J. Cell Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"aaf3928","DOI":"10.1126\/science.aaf3928","article-title":"Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER","volume":"354","author":"Obara","year":"2016","journal-title":"Science"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.bbamem.2016.06.004","article-title":"Shaping the endoplasmic reticulum in vitro","volume":"1858","author":"Ferencz","year":"2016","journal-title":"Biochim. Biophys. Acta-Biomembr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.06.031","article-title":"Stacked Endoplasmic Reticulum Sheets Are Connected by Helicoidal Membrane Motifs","volume":"154","author":"Terasaki","year":"2013","journal-title":"Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1091\/mbc.e09-04-0327","article-title":"Cisternal Organization of the Endoplasmic Reticulum during Mitosis","volume":"20","author":"Lu","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.cell.2018.09.057","article-title":"Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales","volume":"175","author":"Guo","year":"2018","journal-title":"Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2011.11.022","article-title":"Weaving the web of ER tubules","volume":"147","author":"Hu","year":"2011","journal-title":"Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1146\/annurev-biochem-072711-163501","article-title":"Form Follows Function: The Importance of Endoplasmic Reticulum Shape","volume":"84","author":"Westrate","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1073\/pnas.1101643108","article-title":"Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes","volume":"108","author":"Bian","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.molcel.2020.10.013","article-title":"Drp1 Tubulates the ER in a GTPase-Independent Manner","volume":"80","author":"Adachi","year":"2020","journal-title":"Mol. Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e5243","DOI":"10.1073\/pnas.1419997111","article-title":"A model for the generation and interconversion of ER morphologies","volume":"111","author":"Shemesh","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cell.2006.07.019","article-title":"Rough Sheets and Smooth Tubules","volume":"126","author":"Shibata","year":"2006","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1083\/jcb.200705112","article-title":"Endoplasmic reticulum remains continuous and undergoes sheet-to-tubule transformation during cell division in mammalian cells","volume":"179","author":"Puhka","year":"2007","journal-title":"J. Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1083\/jcb.1.6.567","article-title":"Studies on the Endoplasmic Reticulum","volume":"1","author":"Palade","year":"1955","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1083\/jcb.2.4.85","article-title":"The Endoplasmic Reticulum","volume":"2","author":"Palade","year":"1956","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Sicking, M., Lang, S., Bochen, F., Roos, A., Drenth, J.P.H., Zakaria, M., Zimmermann, R., and Linxweiler, M. (2021). Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex. Cells, 10.","DOI":"10.3390\/cells10051036"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.201011039","article-title":"A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature","volume":"193","author":"West","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0074-7696(01)05004-5","article-title":"Endoplasmic reticulum of animal cells and its organization into structural and functional domains","volume":"205","author":"Baumann","year":"2001","journal-title":"Int. Rev. Cytol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1016\/j.febslet.2015.07.021","article-title":"A sweet code for glycoprotein folding","volume":"589","author":"Caramelo","year":"2015","journal-title":"FEBS Lett."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.tibs.2019.04.012","article-title":"Compartmentalization and Selective Tagging for Disposal of Misfolded Glycoproteins","volume":"44","author":"Shenkman","year":"2019","journal-title":"Trends Biochem. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Read, A., and Schr\u00f6der, M. (2021). The unfolded protein response: An overview. Biology, 10.","DOI":"10.3390\/biology10050384"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1091\/mbc.e07-08-0781","article-title":"Bap31 is an Itinerant Protein That Moves between the Peripheral Endoplasmic Reticulum (ER) and a Juxtanuclear Compartment Related to ER-associated Degradation","volume":"19","author":"Wakana","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41422-020-00416-2","article-title":"COPII mitigates ER stress by promoting formation of ER whorls","volume":"31","author":"Xu","year":"2021","journal-title":"Cell Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ceb.2006.06.008","article-title":"Endoplasmic reticulum architecture: Structures in flux","volume":"18","author":"Borgese","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1083\/jcb.200306020","article-title":"Formation of stacked ER cisternae by low affinity protein interactions","volume":"163","author":"Snapp","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1083\/jcb.135.1.19","article-title":"The organization of endoplasmic reticulum export complexes","volume":"135","author":"Bannykh","year":"1996","journal-title":"J. Cell Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/tra.12774","article-title":"Positioning of endoplasmic reticulum exit sites around the Golgi depends on BicaudalD2 and Rab6 activity","volume":"22","author":"Shomron","year":"2021","journal-title":"Traffic"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/38001","article-title":"ER-to-Golgi transport visualized in living cells","volume":"389","author":"Presley","year":"1997","journal-title":"Nature"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1111\/j.1600-0854.2008.00811.x","article-title":"Kinesin-1 (uKHC\/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport","volume":"9","author":"Gupta","year":"2008","journal-title":"Traffic"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/tra.12654","article-title":"COPII-mediated trafficking at the ER\/ERGIC interface","volume":"20","author":"Peotter","year":"2019","journal-title":"Traffic"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1016\/j.cell.2021.03.035","article-title":"ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER","volume":"184","author":"Weigel","year":"2021","journal-title":"Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e201907224","DOI":"10.1083\/jcb.201907224","article-title":"COPII collar defines the boundary between ER and ER exit site and does not coat cargo containers","volume":"220","author":"Shomron","year":"2021","journal-title":"J. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Westrate, L.M., Hoyer, M.J., Nash, M.J., and Voeltz, G.K. (2020). Vesicular and uncoated Rab1-dependent cargo carriers facilitate ER to Golgi transport. J. Cell Sci., 133.","DOI":"10.1242\/jcs.239814"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1242\/jcs.113.12.2177","article-title":"COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites","volume":"113","author":"Stephens","year":"2000","journal-title":"J. Cell Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1083\/jcb.131.4.875","article-title":"Sequential coupling between copII and copI vesicle coats in endoplasmic reticulum to Golgi transport","volume":"131","author":"Aridor","year":"1995","journal-title":"J. Cell Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1103\/PhysRevLett.73.1392","article-title":"Instability and \u201cPearling\u201d States Produced in Tubular Membranes by Competition of Curvature and Tension","volume":"73","author":"Moses","year":"1994","journal-title":"Phys. Rev. Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"066022","DOI":"10.1088\/1478-3975\/12\/6\/066022","article-title":"Pearling instability of membrane tubes driven by curved proteins and actin polymerization","volume":"12","author":"Gov","year":"2015","journal-title":"Phys. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/ncb1206","article-title":"Coupling of ER exit to microtubules through direct interaction of COPII with dynactin","volume":"7","author":"Watson","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1242\/bio.20147633","article-title":"Opposing microtubule motors control motility, morphology and cargo segregation during ER-to-Golgi transport","volume":"3","author":"Brown","year":"2014","journal-title":"Biol. Open"},{"key":"ref_72","unstructured":"Fawcett, D. (1981). The Cell, W. B. Saunders Company. [2nd ed.]."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.1207385","article-title":"ER tubules mark sites of mitochondrial division","volume":"334","author":"Friedman","year":"2011","journal-title":"Science"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.cub.2013.05.015","article-title":"Local cytoskeletal and organelle interactions impact molecular-motor-driven early endosomal trafficking","volume":"23","author":"Zajac","year":"2013","journal-title":"Curr. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1091\/mbc.e12-10-0733","article-title":"Endoplasmic reticulum-endosome contact increases as endosomes traffic and mature","volume":"24","author":"Friedman","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"105361","DOI":"10.1016\/j.nbd.2021.105361","article-title":"STED and parallelized RESOLFT optical nanoscopy of the tubular endoplasmic reticulum and its mitochondrial contacts in neuronal cells","volume":"155","author":"Damenti","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e201907183","DOI":"10.1083\/jcb.201907183","article-title":"FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins","volume":"220","author":"Chen","year":"2021","journal-title":"J. Cell Biol."},{"key":"ref_78","first-page":"e2004","article-title":"Three-dimensional architecture of extended synaptotagmin-mediated endoplasmic reticulum-plasma membrane contact sites","volume":"112","author":"Saheki","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1083\/jcb.200604016","article-title":"Structural and functional features and significance of the physical linkage between ER and mitochondria","volume":"174","author":"Renken","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcell.2020.00675","article-title":"Sticking With It: ER-PM Membrane Contact Sites as a Coordinating Nexus for Regulating Lipids and Proteins at the Cell Cortex","volume":"8","author":"Zaman","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e4859","DOI":"10.1073\/pnas.1701078114","article-title":"Contacts between the endoplasmic reticulum and other membranes in neurons","volume":"114","author":"Wu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","first-page":"5500","article-title":"STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER","volume":"126","author":"Alpy","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nrm2971","article-title":"Non-vesicular lipid transport by lipid-transfer proteins and beyond","volume":"11","author":"Lev","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"eaan5835","DOI":"10.1126\/science.aan5835","article-title":"Here, there, and everywhere: The importance of ER membrane contact sites","volume":"361","author":"Wu","year":"2018","journal-title":"Science"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41580-019-0180-9","article-title":"The functional universe of membrane contact sites","volume":"21","author":"Prinz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"118800","DOI":"10.1016\/j.bbamcr.2020.118800","article-title":"Maintaining social contacts: The physiological relevance of organelle interactions","volume":"1867","author":"Silva","year":"2020","journal-title":"Biochim. Biophys. Acta-Mol. Cell Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/tra.12230","article-title":"Phospholipid Synthesis and Transport in Mammalian Cells","volume":"16","author":"Vance","year":"2015","journal-title":"Traffic"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0022-2275(20)34952-X","article-title":"Lipid topogenesis","volume":"22","author":"Bell","year":"1981","journal-title":"J. Lipid Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1016\/S0021-9258(19)39106-9","article-title":"Phospholipid synthesis in a membrane fraction associated with mitochondria","volume":"265","author":"Vance","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0005-2736(94)00287-Y","article-title":"Characterization of a microsomal subfraction associated with mitochondria of the yeast, Saccharomyces cerevisiae. Involvement in synthesis and import of phospholipids into mitochondria","volume":"1234","author":"Gaigg","year":"1995","journal-title":"Biochim. Biophys. Acta-Biomembr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"16655","DOI":"10.1016\/S0021-9258(19)85468-6","article-title":"Cloning and expression of a novel phosphatidylethanolamine N-methyltransferase. A specific biochemical and cytological marker for a unique membrane fraction in rat liver","volume":"268","author":"Cui","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1046\/j.1432-1327.2001.02116.x","article-title":"A subfraction of the yeast endoplasmic reticulum associates with the plasma membrane and has a high capacity to synthesize lipids","volume":"268","author":"Pichler","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/embor.2013.36","article-title":"Plasma membrane-Endoplasmic reticulum contact sites regulate phosphatidylcholine synthesis","volume":"14","author":"Tavassoli","year":"2013","journal-title":"EMBO Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.devcel.2011.09.005","article-title":"A highly dynamic ER-derived phosphatidylinositol-synthesizing organelle supplies phosphoinositides to cellular membranes","volume":"21","author":"Kim","year":"2011","journal-title":"Dev. Cell"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"40369","DOI":"10.1074\/jbc.R100050200","article-title":"The Enzymes of Neutral Lipid Synthesis","volume":"276","author":"Buhman","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1242\/jcs.076836","article-title":"Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae","volume":"124","author":"Jacquier","year":"2011","journal-title":"J. Cell Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1083\/jcb.201505067","article-title":"A conserved family of proteins facilitates nascent lipid droplet budding from the ER","volume":"211","author":"Choudhary","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1083\/jcb.201305142","article-title":"Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains","volume":"203","author":"Kassan","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev-cellbio-100616-060608","article-title":"Lipid Droplet Biogenesis","volume":"33","author":"Walther","year":"2017","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1105\/tpc.106.043695","article-title":"Tung tree DGAT1 and DGAT2 have nonredundant functions in triacylglycerol biosynthesis and are localized to different subdomains of the endoplasmic reticulum","volume":"18","author":"Shockey","year":"2006","journal-title":"Plant Cell"},{"key":"ref_101","first-page":"1","article-title":"Arf1\/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting","volume":"2014","author":"Wilfling","year":"2014","journal-title":"Elife"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1242\/jcs.045849","article-title":"Coatomer-dependent protein delivery to lipid droplets","volume":"122","author":"Soni","year":"2009","journal-title":"J. Cell Sci."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Beller, M., Sztalryd, C., Southall, N., Bell, M., J\u00e4ckle, H., Auld, D.S., and Oliver, B. (2008). COPI Complex is a Regulator of Lipid Homeostasis. PLoS Biol., 6.","DOI":"10.1371\/journal.pbio.0060292"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.devcel.2013.01.013","article-title":"Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets","volume":"24","author":"Wilfling","year":"2013","journal-title":"Dev. Cell"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nature07534","article-title":"Mitofusin 2 tethers endoplasmic reticulum to mitochondria","volume":"456","author":"Scorrano","year":"2008","journal-title":"Nature"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/ana.24488","article-title":"Hereditary spastic paraplegia-linked REEP1 modulates endoplasmic reticulum\/mitochondria contacts","volume":"78","author":"Lim","year":"2015","journal-title":"Ann. Neurol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.bbalip.2012.08.016","article-title":"Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells","volume":"1831","author":"Vance","year":"2013","journal-title":"Biochim. Biophys. Acta-Mol. Cell Biol. Lipids"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"158453","DOI":"10.1016\/j.bbalip.2019.04.013","article-title":"Vesicular and non-vesicular lipid export from the ER to the secretory pathway","volume":"1865","author":"Funato","year":"2020","journal-title":"Biochim. Biophys. Acta-Mol. Cell Biol. Lipids"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1074\/jbc.M113.479980","article-title":"The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis","volume":"289","author":"Fryer","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/ncb3339","article-title":"Control of plasma membrane lipid homeostasis by the extended synaptotagmins","volume":"18","author":"Saheki","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1073\/pnas.1517259113","article-title":"Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites","volume":"113","author":"Yu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"eaah6171","DOI":"10.1126\/science.aah6171","article-title":"Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion","volume":"355","author":"Lees","year":"2017","journal-title":"Science"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"14289","DOI":"10.1074\/jbc.M114.621375","article-title":"Phosphatidylinositol 4, 5-bisphosphate homeostasis regulated by Nir2 and Nir3 proteins at endoplasmic reticulum-plasma membrane junctions","volume":"290","author":"Chang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.devcel.2015.04.028","article-title":"Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence","volume":"33","author":"Kim","year":"2015","journal-title":"Dev. Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.aab1370","article-title":"PI4P\/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-Plasma membrane contacts","volume":"349","author":"Chung","year":"2015","journal-title":"Science"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-00861-5","article-title":"ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane","volume":"8","author":"Ghai","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nature02188","article-title":"Molecular machinery for non-vesicular trafficking of ceramide","volume":"426","author":"Hanada","year":"2003","journal-title":"Nature"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1091\/mbc.e08-05-0498","article-title":"Coordinated Lipid Transfer between the Endoplasmic Reticulum and the Golgi Complex Requires the VAP Proteins and is Essential for Golgi-mediated Transport","volume":"19","author":"Peretti","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.cell.2013.09.056","article-title":"A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol\/PI(4)P Exchange by the ER-Golgi Tether OSBP","volume":"155","author":"Mesmin","year":"2013","journal-title":"Cell"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.devcel.2016.05.005","article-title":"Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport","volume":"37","author":"Eden","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1083\/jcb.201004142","article-title":"A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking","volume":"192","author":"Du","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1161\/ATVBAHA.116.307282","article-title":"MiRNA targeting of oxysterol-binding protein-like 6 regulates cholesterol trafficking and efflux","volume":"36","author":"Ouimet","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.15252\/embj.201695917","article-title":"STARD 3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites","volume":"36","author":"Wilhelm","year":"2017","journal-title":"EMBO J."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1083\/jcb.201807019","article-title":"VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites","volume":"217","author":"Kumar","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1038\/s41467-020-18413-9","article-title":"Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation","volume":"11","author":"Shirane","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_126","first-page":"1","article-title":"PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria","volume":"11","author":"Guo","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cell.2016.06.037","article-title":"Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P","volume":"166","author":"Dong","year":"2016","journal-title":"Cell"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/tra.12587","article-title":"Mechanisms of lysosomal positioning and movement","volume":"19","author":"Cabukusta","year":"2018","journal-title":"Traffic"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.nbd.2018.05.015","article-title":"Lysosome trafficking and signaling in health and neurodegenerative diseases","volume":"122","author":"Lie","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ncb2026","article-title":"Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction","volume":"12","author":"Eden","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/MOL.0000000000000506","article-title":"Cholesterol transfer at endosomal-organelle membrane contact sites","volume":"29","author":"Ridgway","year":"2018","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0005-2760(84)90079-1","article-title":"Glycerolipid synthetic capacity of rat liver peroxisomes","volume":"795","author":"Ballas","year":"1984","journal-title":"Biochim. Biophys. Acta (BBA)\/Lipids Lipid Metab."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1749-6632.1982.tb21415.x","article-title":"Glycerolipid Biosynthesis in Peroxisomes Via the Acyl Dihydroxyacetone Phosphate Pathway","volume":"386","author":"Hajra","year":"1982","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e202010004","DOI":"10.1083\/jcb.202010004","article-title":"VPS13D bridges the ER to mitochondria and peroxisomes via Miro","volume":"220","author":"Leonzino","year":"2021","journal-title":"J. Cell Biol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Baldwin, H.A., Wang, C., Kanfer, G., Shah, H.V., Velayos-Baeza, A., Dulovic-Mahlow, M., Br\u00fcggemann, N., Anding, A., Baehrecke, E.H., and Maric, D. (2021). VPS13D promotes peroxisome biogenesis. J. Cell Biol., 220.","DOI":"10.1083\/jcb.202001188"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1083\/jcb.201607055","article-title":"ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER","volume":"216","author":"Costello","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"15785","DOI":"10.1073\/pnas.0808321105","article-title":"Nonvesicular phospholipid transfer between peroxisomes and the endoplasmic reticulum","volume":"105","author":"Raychaudhuri","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"11190","DOI":"10.1074\/jbc.270.19.11190","article-title":"Evidence that phosphatidylserine is imported into mitochondria via a mitochondria-associated membrane and that the majority of mitochondrial phosphatidylethanolamine is derived from decarboxylation of phosphatidylserine","volume":"270","author":"Shiao","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"8019","DOI":"10.1016\/S0021-9258(18)83144-1","article-title":"Reconstitution of phosphatidylserine import into rat liver mitochondria","volume":"264","author":"Voelker","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0021-9258(18)52406-6","article-title":"Newly made phosphatidylserine and phosphatidylethanolamine are preferentially translocated between rat liver mitochondria and endoplasmic reticulum","volume":"266","author":"Vance","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1126\/science.1175088","article-title":"An ER-mitochondria tethering complex revealed by a synthetic biology screen","volume":"325","author":"Kornmann","year":"2009","journal-title":"Science"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e3179","DOI":"10.1073\/pnas.1422363112","article-title":"Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly","volume":"112","author":"AhYoung","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep30777","article-title":"A phospholipid transfer function of ER-mitochondria encounter structure revealed in vitro","volume":"6","author":"Kojima","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e9502","DOI":"10.1073\/pnas.1715592114","article-title":"Crystal structures of Mmm1 and Mdm12\u2013Mmm1 reveal mechanistic insight into phospholipid trafficking at ER-mitochondria contact sites","volume":"114","author":"Jeong","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1083\/jcb.201502033","article-title":"Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts","volume":"209","author":"Murley","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.celrep.2015.06.022","article-title":"Lam6 Regulates the Extent of Contacts between Organelles","volume":"12","author":"Shinder","year":"2015","journal-title":"Cell Rep."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.07253","article-title":"A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport","volume":"4","author":"Gatta","year":"2015","journal-title":"Elife"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"9050","DOI":"10.1016\/S0021-9258(17)44630-8","article-title":"Rapid appearance of newly synthesized phosphatidylethanolamine at the plasma membrane","volume":"258","author":"Sleight","year":"1983","journal-title":"J. Biol. Chem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1083\/jcb.101.2.441","article-title":"Intracellular transport of phosphatidylcholine to the plasma membrane","volume":"101","author":"Kaplan","year":"1985","journal-title":"J. Cell Biol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1083\/jcb.101.2.446","article-title":"Transport of cholesterol from the endoplasmic reticulum to the plasma membrane","volume":"101","author":"Kaplan","year":"1985","journal-title":"J. Cell Biol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1073\/pnas.91.7.2708","article-title":"Transport of newly synthesized glucosylceramide to the plasma membrane by a non-Golgi pathway","volume":"91","author":"Warnock","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"13807","DOI":"10.1073\/pnas.96.24.13807","article-title":"Regulation of mitochondrial ATP synthesis by calcium: Evidence for a long-term metabolic priming","volume":"96","author":"Jouaville","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1054\/ceca.2001.0264","article-title":"Mitochondria respond to Ca2+ already in the submicromolar range: Correlation with redox state","volume":"31","author":"Pitter","year":"2002","journal-title":"Cell Calcium"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1126\/science.1081208","article-title":"BAX and BAK regulation of endoplasmic reticulum Ca2+: A control point for apoptosis","volume":"300","author":"Scorrano","year":"2003","journal-title":"Science"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"19599","DOI":"10.1016\/S0021-9258(18)55036-5","article-title":"SSR\u03b1 and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane","volume":"266","author":"Wada","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"21458","DOI":"10.1016\/S0021-9258(18)54661-5","article-title":"Expression of calreticulin in Escherichia coli and identification of its Ca2+ binding domains","volume":"266","author":"Baksh","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1242\/jcs.91.1.61","article-title":"Identification of a set of calcium-binding proteins in reticuloplasm, the luminal content of the endoplasmic reticulum","volume":"91","author":"Macer","year":"1988","journal-title":"J. Cell Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"12753","DOI":"10.1016\/S0021-9258(18)42340-X","article-title":"Calcium is required for folding of newly made subunits of the asialoglycoprotein receptor within the endoplasmic reticulum","volume":"267","author":"Lodish","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1021\/bi972465g","article-title":"Oligosaccharide binding characteristics of the molecular chaperones calnexin and calreticulin","volume":"37","author":"Vassilakos","year":"1998","journal-title":"Biochemistry"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/febs.14608","article-title":"Endoplasmic reticulum stress signalling\u2014From basic mechanisms to clinical applications","volume":"286","author":"Almanza","year":"2019","journal-title":"FEBS J."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.280.5370.1763","article-title":"Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses","volume":"280","author":"Rizzuto","year":"1998","journal-title":"Science"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/emboj\/18.1.96","article-title":"Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria","volume":"18","author":"Thomas","year":"1999","journal-title":"EMBO J."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1042\/bj3580147","article-title":"Calcium binding and translocation by the voltage-dependent anion channel: A possible regulatory mechanism in mitochondrial function","volume":"358","author":"Gincel","year":"2001","journal-title":"Biochem. J."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1083\/jcb.200205091","article-title":"Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria","volume":"159","author":"Rapizzi","year":"2002","journal-title":"J. Cell Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1083\/jcb.200608073","article-title":"Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels","volume":"175","author":"Szabadkai","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.phrs.2018.01.003","article-title":"Highlighting the endoplasmic reticulum-mitochondria connection: Focus on Mitofusin 2","volume":"128","author":"Filadi","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1016\/j.celrep.2018.11.064","article-title":"IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes","volume":"25","author":"Atakpa","year":"2018","journal-title":"Cell Rep."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1083\/jcb.200502019","article-title":"STIM1, an essential and conserved component of store-operated Ca2+ channel function","volume":"169","author":"Roos","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature04702","article-title":"A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function","volume":"441","author":"Feske","year":"2006","journal-title":"Nature"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1083\/jcb.200604014","article-title":"Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane","volume":"174","author":"Wu","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1091\/mbc.e14-06-1107","article-title":"Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum-plasma membrane junctions","volume":"25","author":"Wu","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ncb1842","article-title":"SOAR and the polybasic STIM1 domains gate and regulate Orai channels","volume":"11","author":"Yuan","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ceca.2009.02.010","article-title":"Visualizing the store-operated channel complex assembly in real time: Identification of SERCA2 as a new member","volume":"45","author":"Sampieri","year":"2009","journal-title":"Cell Calcium"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ceca.2010.03.001","article-title":"The sarco\/endoplasmic reticulum Ca2+ ATPase (SERCA) is the third element in capacitative calcium entry","volume":"47","author":"Alonso","year":"2010","journal-title":"Cell Calcium"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"11456","DOI":"10.1074\/jbc.M609551200","article-title":"STIM1 knockdown reveals that store-operated Ca2+ channels located close to sarco\/endoplasmic Ca2+ ATPases (SERCA) pumps silently refill the endoplasmic reticulum","volume":"282","author":"Jousset","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.cell.2014.10.023","article-title":"ER contact sites define the position and timing of endosome fission","volume":"159","author":"Rowland","year":"2014","journal-title":"Cell"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1083\/jcb.201609033","article-title":"Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia","volume":"216","author":"Allison","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.devcel.2020.12.014","article-title":"Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites","volume":"56","author":"Wu","year":"2021","journal-title":"Dev. Cell"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cell.2018.08.030","article-title":"A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission","volume":"175","author":"Hoyer","year":"2018","journal-title":"Cell"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.bpj.2018.09.007","article-title":"Diffusion of Exit Sites on the Endoplasmic Reticulum: A Random Walk on a Shivering Backbone","volume":"115","author":"Stadler","year":"2018","journal-title":"Biophys. J."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/s41556-018-0192-2","article-title":"Single particle trajectories reveal active endoplasmic reticulum luminal flow","volume":"20","author":"Holcman","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0092-8674(88)90177-8","article-title":"Dynamic behavior of endoplasmic reticulum in living cells","volume":"54","author":"Lee","year":"1988","journal-title":"Cell"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1523\/JNEUROSCI.09-06-01897.1989","article-title":"Dynamics of the endoplasmic reticulum and other membranous organelles in growth cones of cultured neurons","volume":"9","author":"Dailey","year":"1989","journal-title":"J. Neurosci."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.201308001","article-title":"Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts","volume":"203","author":"Wang","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1091\/mbc.E18-11-0698","article-title":"REEP3 and REEP4 determine the tubular morphology of the endoplasmic reticulum during mitosis","volume":"30","author":"Kumar","year":"2019","journal-title":"Mol. Biol. Cell"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1083\/jcb.103.4.1557","article-title":"Microtubules and the endoplasmic reticulum are highly interdependent structures","volume":"103","author":"Terasaki","year":"1986","journal-title":"J. Cell Biol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1091\/mbc.10.6.1909","article-title":"Microtubule-based endoplasmic reticulum motility in Xenopus laevis: Activation of membrane-associated kinesin during development","volume":"10","author":"Lane","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1091\/mbc.e13-12-0712","article-title":"ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arrays","volume":"25","author":"Joensuu","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0092-8674(88)90176-6","article-title":"The microtubule-dependent formation of a tubulovesicular network with characteristics of the ER from cultured cell extracts","volume":"54","author":"Dabora","year":"1988","journal-title":"Cell"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1083\/jcb.113.2.347","article-title":"Cell cycle control of microtuble-based membrane transport and tubule formation in vitro","volume":"113","author":"Allan","year":"1991","journal-title":"J. Cell Biol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1242\/jcs.107.7.1885","article-title":"Movement of membrane tubules along microtubules in vitro: Evidence for specialised sites of motor attachment","volume":"107","author":"Allan","year":"1994","journal-title":"J. Cell Sci."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1083\/jcb.148.5.883","article-title":"In vitro formation of the endoplasmic reticulum occurs independently of microtubules by a controlled fusion reaction","volume":"148","author":"Dreier","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1038\/sj.emboj.7601427","article-title":"Cargo selection by specific kinesin light chain 1 isoforms","volume":"25","author":"Allan","year":"2006","journal-title":"EMBO J."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuron.2019.01.030","article-title":"Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity","volume":"102","author":"Tortosa","year":"2019","journal-title":"Neuron"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41582-019-0257-2","article-title":"Axonal transport and neurological disease","volume":"15","author":"Sleigh","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1126\/science.7892610","article-title":"Kinectin, an essential anchor for kinesin-driven vesicle motility","volume":"67","author":"Kumar","year":"1995","journal-title":"Science"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"32854","DOI":"10.1074\/jbc.M005650200","article-title":"Kinectin-kinesin binding domains and their effects on organelle motility","volume":"275","author":"Ong","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"e201809020","DOI":"10.1083\/jcb.201809020","article-title":"Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum","volume":"219","author":"Guadagno","year":"2020","journal-title":"J. Cell Biol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1242\/jcs.181768","article-title":"Kinectin-dependent ER transport supports the focal complex maturation required for chemotaxis in shallow gradients","volume":"129","author":"Ng","year":"2016","journal-title":"J. Cell Sci."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1128\/MCB.21.17.6044-6055.2001","article-title":"Intact Lysosome Transport and Phagosome Function Despite Kinectin Deficiency","volume":"21","author":"Plitz","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1523\/JNEUROSCI.4496-13.2014","article-title":"JIP1 mediates anterograde transport of Rab10 cargos during neuronal polarization","volume":"34","author":"Deng","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.bbrc.2004.05.069","article-title":"The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B","volume":"319","author":"Diefenbach","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cell.2015.09.053","article-title":"A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances","volume":"163","author":"Hein","year":"2015","journal-title":"Cell"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nature14359","article-title":"Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth","volume":"520","author":"Raiborg","year":"2015","journal-title":"Nature"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"e202003063","DOI":"10.1083\/jcb.202003063","article-title":"Protrudin-mediated ER\u2013endosome contact sites promote MT1-MMP exocytosis and cell invasion","volume":"219","author":"Pedersen","year":"2020","journal-title":"J. Cell Biol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms15496","article-title":"Exploiting the kinesin-1 molecular motor to generate a virus membrane penetration site","volume":"8","author":"Ravindran","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1083\/jcb.133.3.585","article-title":"Cell cycle regulation of dynein association with membranes modulates microtubule-based organelle transport","volume":"133","author":"Niclas","year":"1996","journal-title":"J. Cell Biol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.60047","article-title":"Co-movement of astral microtubules, organelles and f-actin by dynein and actomyosin forces in frog egg cytoplasm","volume":"9","author":"Pelletier","year":"2020","journal-title":"Elife"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0960-9822(97)70092-7","article-title":"Movement of nuclei along microtubules in Xenopus egg extracts","volume":"7","author":"Reinsch","year":"1997","journal-title":"Curr. Biol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.devcel.2020.05.003","article-title":"The Perinuclear ER Scales Nuclear Size Independently of Cell Size in Early Embryos","volume":"54","author":"Mukherjee","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1083\/jcb.200204065","article-title":"Activation of myosin V-based motility and F-actin-dependent network formation of endoplasmic reticulum during mitosis","volume":"159","author":"Weiss","year":"2002","journal-title":"J. Cell Biol."},{"key":"ref_212","first-page":"3382","article-title":"Transport along the dendritic endoplasmic reticulum mediates the trafficking of GABAB receptors","volume":"127","author":"Valenzuela","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1242\/jcs.00854","article-title":"Kinesin dependent, rapid, bi-directional transport of ER sub-compartment in dendrites of hippocampal neurons","volume":"117","author":"Bannai","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1016\/j.cub.2020.05.091","article-title":"Nesprin-2 Recruitment of BicD2 to the Nuclear Envelope Controls Dynein\/Kinesin-Mediated Neuronal Migration In Vivo","volume":"30","author":"Quintremil","year":"2020","journal-title":"Curr. Biol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1177\/1535370219871965","article-title":"A network of nuclear envelope proteins and cytoskeletal force generators mediates movements of and within nuclei throughout Caenorhabditis elegans development","volume":"244","author":"Starr","year":"2019","journal-title":"Exp. Biol. Med."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nrm.2016.153","article-title":"Mechanisms and functions of nuclear envelope remodelling","volume":"18","author":"Ungricht","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Splinter, D., Tanenbaum, M.E., Lindqvist, A., Jaarsma, D., Flotho, A., Yu, K.L., Grigoriev, I., Engelsma, D., Haasdijk, E.D., and Keijzer, N. (2010). Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. PLoS Biol., 8.","DOI":"10.1371\/journal.pbio.1000350"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1073\/pnas.0808602106","article-title":"Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization","volume":"106","author":"Roux","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.abc7209","article-title":"The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes","volume":"6","author":"Lu","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a013227","article-title":"Endoplasmic reticulum structure and interconnections with other organelles","volume":"5","author":"English","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.201505086","article-title":"Peroxisomes, lipid droplets, and endoplasmic reticulum \u201chitchhike\u201d on motile early endosomes","volume":"211","author":"Guimaraes","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tcb.2016.09.005","article-title":"Hitchhiking: A Non-Canonical Mode of Microtubule-Based Transport","volume":"27","author":"Salogiannis","year":"2017","journal-title":"Trends Cell Biol."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Flores-Rodriguez, N., Rogers, S.S., Kenwright, D.A., Waigh, T.A., Woodman, P.G., and Allan, V.J. (2011). Roles of dynein and dynactin in early endosome dynamics revealed using automated tracking and global analysis. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024479"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"14954","DOI":"10.1073\/pnas.1307391110","article-title":"Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation","volume":"110","author":"Chang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcell.2020.615600","article-title":"Lipid Transfer\u2013Dependent Endosome Maturation Mediated by Protrudin and PDZD8 in Neurons","volume":"8","author":"Shirane","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1091\/mbc.e11-01-0068","article-title":"Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation","volume":"22","author":"Matsuzaki","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"ref_227","first-page":"1","article-title":"Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration","volume":"14","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_228","first-page":"1","article-title":"Sensing of nutrients by CPT1C regulates late endosome\/lysosome anterograde transport and axon growth","volume":"8","author":"Casas","year":"2019","journal-title":"Elife"},{"key":"ref_229","first-page":"1","article-title":"Concerted action of kinesins kif5b and kif13b promotes efficient secretory vesicle transport to microtubule plus ends","volume":"9","author":"Martin","year":"2020","journal-title":"Elife"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1038\/s41467-020-18202-4","article-title":"ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation","volume":"11","author":"Qin","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.bbamcr.2018.02.011","article-title":"Rab7a modulates ER stress and ER morphology","volume":"1865","author":"Mateus","year":"2018","journal-title":"Biochim. Biophys. Acta-Mol. Cell Res."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1083\/jcb.130.5.1161","article-title":"Membrane\/microtubule tip attachment complexes (TACs) allow the assembly dynamics of plus ends to push and pull membranes into tubulovesicular networks in interphase Xenopus egg extracts","volume":"130","author":"Gregory","year":"1995","journal-title":"J. Cell Biol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"5095","DOI":"10.1523\/JNEUROSCI.2496-18.2019","article-title":"STIM1 is required for remodeling of the endoplasmic reticulum and microtubule cytoskeleton in steering growth cones","volume":"39","author":"Pavez","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/s13238-017-0492-5","article-title":"Sec61\u03b2 facilitates the maintenance of endoplasmic reticulum homeostasis by associating microtubules","volume":"9","author":"Zhu","year":"2018","journal-title":"Protein Cell"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1016\/S0006-3495(04)74343-X","article-title":"Tension in Tubulovesicular Networks of Golgi and Endoplasmic Reticulum Membranes","volume":"86","author":"Upadhyaya","year":"2004","journal-title":"Biophys. J."},{"key":"ref_236","first-page":"1","article-title":"Interactions between plant endomembrane systems and the actin cytoskeleton","volume":"6","author":"Wang","year":"2015","journal-title":"Front. Plant. Sci."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/BF01282989","article-title":"Endoplasmic reticulum and cytoplasmic streaming: Fluorescence microscopical observations in adaxial epidermis cells of onion bulb scales","volume":"131","author":"Quader","year":"1986","journal-title":"Protoplasma"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ceb.2003.11.009","article-title":"Cytoplasmic streaming in plants","volume":"16","author":"Shimmen","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"9884","DOI":"10.1073\/pnas.1919820117","article-title":"MTV proteins unveil ER- And microtubule-associated compartments in the plant vacuolar trafficking pathway","volume":"117","author":"Delgadillo","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/pcp\/pcs025","article-title":"RNA processing bodies, peroxisomes, golgi bodies, mitochondria, and endoplasmic reticulum tubule junctions frequently pause at cortical microtubules","volume":"53","author":"Hamada","year":"2012","journal-title":"Plant. Cell Physiol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.61069","article-title":"The nesprin-1\/-2 ortholog anc-1 regulates organelle positioning in c. Elegans independently from its kash or actin-binding domains","volume":"10","author":"Hao","year":"2021","journal-title":"Elife"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1242\/jcs.111.21.3221","article-title":"Transport of ER vesicles on actin filaments in neurons by myosin V","volume":"111","author":"Tabb","year":"1998","journal-title":"J. Cell Sci."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1091\/mbc.e10-08-0661","article-title":"Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions","volume":"22","author":"Lynch","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/cm.970290402","article-title":"Interactions among endoplasmic reticulum, microtubules, and retrograde movements of the cell surface","volume":"29","author":"Terasaki","year":"1994","journal-title":"Cell Motil. Cytoskeleton"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"012406","DOI":"10.1103\/PhysRevE.98.012406","article-title":"Anomalous dynamics of the endoplasmic reticulum network","volume":"98","author":"Speckner","year":"2018","journal-title":"Phys. Rev. E"},{"key":"ref_246","first-page":"1761","article-title":"From Semi-Flexible Polymers to Membranes: Anomalous Diffusion and Reptation","volume":"7","author":"Granek","year":"1997","journal-title":"J. Phys. II"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.bbamem.2010.02.014","article-title":"Lipid diffusion in planar membranes investigated by fluorescence correlation spectroscopy","volume":"1798","author":"Hof","year":"2010","journal-title":"Biochim. Biophys. Acta-Biomembr."},{"key":"ref_248","first-page":"1","article-title":"Interplay between lipid lateral diffusion, dye concentration and membrane permeability unveiled by a combined spectroscopic and computational study of a model lipid bilayer","volume":"9","author":"Chandramouli","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","article-title":"Functional rafts in cell membranes","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0006-3495(02)75393-9","article-title":"Relationship of lipid rafts to transient confinement zones detected by single particle tracking","volume":"82","author":"Dietrich","year":"2002","journal-title":"Biophys. J."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/nature07596","article-title":"Direct observation of the nanoscale dynamics of membrane lipids in a living cell","volume":"457","author":"Eggeling","year":"2009","journal-title":"Nature"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1073\/pnas.79.14.4317","article-title":"Lateral and rotational diffusion of bacteriorhodopsin in lipid bilayers: Experimental test of the Saffman-Delbruck equations","volume":"79","author":"Peters","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.bbamem.2011.08.021","article-title":"Transmembrane helices can induce domain formation in crowded model membranes","volume":"1818","author":"Marrink","year":"2012","journal-title":"Biochim. Biophys. Acta-Biomembr."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.bpj.2010.06.020","article-title":"Anomalous diffusion reports on the interaction of misfolded proteins with the quality control machinery in the endoplasmic reticulum","volume":"99","author":"Malchus","year":"2010","journal-title":"Biophys. J."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1083\/jcb.200202050","article-title":"Phospholipids undergo hop diffusion in compartmentalized cell membrane","volume":"157","author":"Fujiwara","year":"2002","journal-title":"J. Cell Biol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"12307","DOI":"10.1073\/pnas.1222097110","article-title":"Fast spatiotemporal correlation spectroscopy to determine protein lateral diffusion laws in live cell membranes","volume":"110","author":"Gratton","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/jxb\/eri289","article-title":"Photoactivation of GFP reveals protein dynamics within the endoplasmic reticulum membrane","volume":"57","author":"Runions","year":"2006","journal-title":"J. Exp. Bot."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/j.bbamem.2012.05.006","article-title":"Effect of membrane tension on the physical properties of DOPC lipid bilayer membrane","volume":"1818","author":"Reddy","year":"2012","journal-title":"Biochim. Biophys. Acta-Biomembr."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/S0006-3495(99)77364-9","article-title":"Dynamical properties of phospholipid bilayers from computer simulation","volume":"76","author":"Essmann","year":"1999","journal-title":"Biophys. J."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1016\/S0006-3495(99)77438-2","article-title":"Diffusion of green fluorescent protein in the aqueous-phase lumen of endoplasmic reticulum","volume":"76","author":"Dayel","year":"1999","journal-title":"Biophys. J."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"6536","DOI":"10.1073\/pnas.0510657103","article-title":"Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells","volume":"103","author":"Snapp","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1083\/jcb.200704078","article-title":"Regulated motion of glycoproteins revealed by direct visualization of a single cargo in the endoplasmic reticulum","volume":"180","author":"Nagaya","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1103\/PhysRevE.101.012408","article-title":"Equilibrium fluctuations of a semiflexible filament cross linked into a network","volume":"101","author":"Kernes","year":"2020","journal-title":"Phys. Rev. E"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1103\/RevModPhys.86.995","article-title":"Modeling semiflexible polymer networks","volume":"86","author":"Broedersz","year":"2014","journal-title":"Rev. Mod. Phys."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1103\/PhysRevE.102.062406","article-title":"Dynamics of undulatory fluctuations of semiflexible filaments in a network","volume":"102","author":"Kernes","year":"2020","journal-title":"Phys. Rev. E"},{"key":"ref_266","first-page":"20150332","article-title":"Computational analysis of morphologies and phase transitions of cross-linked, semi-flexible polymer networks","volume":"471","author":"Cyron","year":"2015","journal-title":"Proc. R. Soc. A Math. Phys. Eng. Sci."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"248301","DOI":"10.1103\/PhysRevLett.116.248301","article-title":"Broken Detailed Balance of Filament Dynamics in Active Networks","volume":"116","author":"Gladrow","year":"2016","journal-title":"Phys. Rev. Lett."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1039\/D0SM01200A","article-title":"Anomalous diffusion of active Brownian particles cross-linked to a networked polymer: Langevin dynamics simulation and theory","volume":"16","author":"Joo","year":"2020","journal-title":"Soft Matter"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1039\/b817341a","article-title":"Phases of membrane tubules pulled by molecular motors","volume":"5","author":"Gov","year":"2009","journal-title":"Soft Matter"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jmps.2019.03.001","article-title":"Cross-linked biopolymer networks with active motors: Mechanical response and intra-network transport","volume":"127","author":"Gong","year":"2019","journal-title":"J. Mech. Phys. Solids"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.bpj.2014.06.032","article-title":"Structure and dynamics of ER: Minimal networks and biophysical constraints","volume":"107","author":"Lin","year":"2014","journal-title":"Biophys. J."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bpj.2017.05.046","article-title":"Modeling Endoplasmic Reticulum Network Maintenance in a Plant Cell","volume":"113","author":"Lin","year":"2017","journal-title":"Biophys. J."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1109\/TCBB.2015.2389226","article-title":"Modeling the Geometry and Dynamics of the Endoplasmic Reticulum Network","volume":"15","author":"Lin","year":"2018","journal-title":"IEEE\/ACM Trans. Comput. Biol. Bioinform."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-61598-8","article-title":"Impact of global structure on diffusive exploration of organelle networks","volume":"10","author":"Brown","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_275","doi-asserted-by":"crossref","unstructured":"Chen, J., Bassot, A., Giuliani, F., and Simmen, T. (2021). Amyotrophic Lateral Sclerosis (ALS): Stressed by Dysfunctional Mitochondria-Endoplasmic Reticulum Contacts (MERCs). Cells, 10.","DOI":"10.3390\/cells10071789"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2019.03147","article-title":"Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases","volume":"10","author":"Choi","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.biocel.2016.05.011","article-title":"Dialogue between endoplasmic reticulum and mitochondria as a key actor of vascular dysfunction associated to metabolic disorders","volume":"77","author":"Safiedeen","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41569-021-00511-w","article-title":"Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases","volume":"18","author":"Ren","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/15472","article-title":"Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia","volume":"23","author":"Hazan","year":"1999","journal-title":"Nat. Genet."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1086\/504927","article-title":"ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia","volume":"79","author":"Mannan","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"12946","DOI":"10.1074\/jbc.M113.528687","article-title":"Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia","volume":"289","author":"Hashimoto","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/ng1313","article-title":"Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndrome","volume":"36","author":"Windpassinger","year":"2004","journal-title":"Nat. Genet."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"20890","DOI":"10.1073\/pnas.0704154104","article-title":"The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology","volume":"104","author":"Szymanski","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1091\/mbc.E16-05-0287","article-title":"Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration","volume":"27","author":"Rao","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/ng758","article-title":"Mutations in a newly identified GTPase gene cause autosomal dominant hereditary spastic paraplegia","volume":"29","author":"Zhao","year":"2001","journal-title":"Nat. Genet."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1086\/505361","article-title":"Mutations in the novel mitochondrial protein REEP1 cause hereditary spastic paraplegia type 31","volume":"79","author":"Wang","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI60560","article-title":"Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12","volume":"122","author":"Montenegro","year":"2012","journal-title":"J. Clin. Invest."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ajhg.2013.12.005","article-title":"Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia","volume":"94","author":"Esteves","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1086\/425287","article-title":"A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis","volume":"75","author":"Nishimura","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.bbalip.2016.02.009","article-title":"VAP, a Versatile Access Point for the Endoplasmic Reticulum: Review and analysis of FFAT-like motifs in the VAPome","volume":"1861","author":"Murphy","year":"2016","journal-title":"Biochim. Biophys. Acta-Mol. Cell Biol. Lipids"},{"key":"ref_291","doi-asserted-by":"crossref","unstructured":"Borgese, N., Iacomino, N., Colombo, S.F., and Navone, F. (2021). The Link between VAPB Loss of Function and Amyotrophic Lateral Sclerosis. Cells, 10.","DOI":"10.3390\/cells10081865"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"9801","DOI":"10.1523\/JNEUROSCI.2661-07.2007","article-title":"Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates","volume":"27","author":"Teuling","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.cell.2008.04.039","article-title":"The Amyotrophic Lateral Sclerosis 8 Protein VAPB is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors","volume":"133","author":"Tsuda","year":"2008","journal-title":"Cell"},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1096\/fj.09-147850","article-title":"A VAPB mutant linked to amyotrophic lateral sclerosis generates a novel form of organized smooth endoplasmic reticulum","volume":"24","author":"Fasana","year":"2010","journal-title":"FASEB J."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1242\/jcs.102137","article-title":"Restructured endoplasmic reticulum generated by mutant amyotrophic lateral sclerosis-linked VAPB is cleared by the proteasome","volume":"125","author":"Papiani","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/hmg\/ddr559","article-title":"VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis","volume":"21","author":"Stoica","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tins.2016.01.008","article-title":"There\u2019s Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases","volume":"39","author":"Paillusson","year":"2016","journal-title":"Trends Neurosci."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/hmg\/ddt594","article-title":"The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control","volume":"23","author":"Lin","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"13850","DOI":"10.1523\/JNEUROSCI.2312-09.2009","article-title":"Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis","volume":"29","author":"Yang","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/ana.22534","article-title":"A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis","volume":"70","author":"Bohlega","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","article-title":"Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival","volume":"131","author":"Hayashi","year":"2007","journal-title":"Cell"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.15252\/emmm.201606403","article-title":"Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR 1- and SOD 1-linked ALS","volume":"8","author":"Watanabe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ng1514","article-title":"Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease","volume":"37","author":"Noureddine","year":"2005","journal-title":"Nat. Genet."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nature20555","article-title":"Multiple dynamin family members collaborate to drive mitochondrial division","volume":"540","author":"Lee","year":"2016","journal-title":"Nature"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1038\/s41586-019-1296-y","article-title":"Mitochondrial fission requires DRP1 but not dynamins","volume":"570","author":"Fonseca","year":"2019","journal-title":"Nature"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ng1341","article-title":"Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A","volume":"36","author":"Mersiyanova","year":"2004","journal-title":"Nat. Genet."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1073\/pnas.1810932116","article-title":"Altered interplay between endoplasmic reticulum and mitochondria in Charcot-Marie-Tooth type 2A neuropathy","volume":"116","author":"Juneja","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.2337\/diabetes.54.9.2685","article-title":"Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: Effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor \u03b1 and interleukin-6","volume":"54","author":"Bach","year":"2005","journal-title":"Diabetes"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1073\/pnas.1108220109","article-title":"Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis","volume":"109","author":"Sorianello","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.2337\/db13-1751","article-title":"Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance","volume":"63","author":"Tubbs","year":"2014","journal-title":"Diabetes"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ajhg.2012.12.007","article-title":"Constitutive activation of the calcium sensor STIM1 causes tubular-aggregate myopathy","volume":"92","author":"Chevessier","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1007\/s00415-014-7287-x","article-title":"Childhood onset tubular aggregate myopathy associated with de novo STIM1 mutations","volume":"261","author":"Hedberg","year":"2014","journal-title":"J. Neurol."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/humu.22621","article-title":"Gain-of-Function Mutation in STIM1 (P.R304W) is Associated with Stormorken Syndrome","volume":"35","author":"Morin","year":"2014","journal-title":"Hum. Mutat."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/humu.22544","article-title":"A Dominant STIM1 Mutation Causes Stormorken Syndrome","volume":"35","author":"Misceo","year":"2014","journal-title":"Hum. Mutat."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1073\/pnas.1312520111","article-title":"Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis","volume":"111","author":"Nesin","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1083\/jcb.200604015","article-title":"The elementary unit of store-operated Ca2+ entry: Local activation of CRAC channels by STIM1 at ER-plasma membrane junctions","volume":"174","author":"Luik","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.bbrc.2006.09.134","article-title":"Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1","volume":"350","author":"Xu","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.stem.2016.08.002","article-title":"Functional Impairment in Miro Degradation and Mitophagy is a Shared Feature in Familial and Sporadic Parkinson\u2019s Disease","volume":"19","author":"Hsieh","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41467-019-12382-4","article-title":"Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery","volume":"10","author":"Modi","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/hmg\/ddaa066","article-title":"Impaired mitochondrial-endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson\u2019s disease","volume":"29","author":"Grossmann","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbadis.2013.01.004","article-title":"Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca2+ transfer to sustain cell bioenergetics","volume":"1832","author":"Ottolini","year":"2013","journal-title":"Biochim. Biophys. Acta-Mol. Basis Dis."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10072-003-0108-0","article-title":"DJ-1 (PARK7), a novel gene for autosomal recessive, early onset parkinsonism","volume":"24","author":"Bonifati","year":"2003","journal-title":"Neurol. Sci."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1093\/hmg\/ddt068","article-title":"The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering","volume":"22","author":"Ottolini","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the \u03b1-synuclein gene identified in families with Parkinson\u2019s disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1523\/JNEUROSCI.2507-13.2014","article-title":"\u03b1-synuclein is localized to mitochondria-associated ER membranes","volume":"34","author":"Liu","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.1096284","article-title":"Hereditary early-onset Parkinson\u2019s disease caused by mutations in PINK1","volume":"304","author":"Valente","year":"2004","journal-title":"Science"},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1080\/15548627.2016.1277309","article-title":"PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation","volume":"13","author":"Gelmetti","year":"2017","journal-title":"Autophagy"},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","article-title":"Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology","volume":"44","author":"Zimprich","year":"2004","journal-title":"Neuron"},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/embj.2018100875","article-title":"LRRK 2 regulates endoplasmic reticulum\u2013mitochondrial tethering through the PERK-mediated ubiquitination pathway","volume":"39","author":"Toyofuku","year":"2020","journal-title":"EMBO J."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nm0896-864","article-title":"Secreted amyloid \u03b2\u2013protein similar to that in the senile plaques of Alzheimer\u2019s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer\u2019s disease","volume":"2","author":"Scheuner","year":"1996","journal-title":"Nat. Med."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cell.2006.06.059","article-title":"Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer\u2019s Disease-Linked Mutations","volume":"126","author":"Tu","year":"2006","journal-title":"Cell"},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/jnr.20135","article-title":"Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-\u03b2 peptide","volume":"76","author":"Ferreiro","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ceca.2006.03.005","article-title":"Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells","volume":"40","author":"Kasri","year":"2006","journal-title":"Cell Calcium"},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ceca.2006.03.002","article-title":"Presenilin mutations linked to familial Alzheimer\u2019s disease reduce endoplasmic reticulum and Golgi apparatus calcium levels","volume":"39","author":"Zatti","year":"2006","journal-title":"Cell Calcium"},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nm1088","article-title":"Reticulon family members modulate BACE1 activity and amyloid-\u03b2 peptide generation","volume":"10","author":"He","year":"2004","journal-title":"Nat. Med."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.bbrc.2005.07.012","article-title":"Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi","volume":"334","author":"Wakana","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"9163","DOI":"10.1523\/JNEUROSCI.5741-08.2009","article-title":"Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites","volume":"29","author":"Shi","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1038\/sj.emboj.7601707","article-title":"Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities","volume":"26","author":"Hu","year":"2007","journal-title":"EMBO J."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1056\/NEJMoa064436","article-title":"A Lethal Defect of Mitochondrial and Peroxisomal Fission","volume":"356","author":"Waterham","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1101\/gr.144105.112","article-title":"Autozygome-guided exome sequencing in retinal dystrophy patients reveals pathogenetic mutations and novel candidate disease genes","volume":"23","author":"Alrashed","year":"2013","journal-title":"Genome Res."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1083\/jcb.201608128","article-title":"VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis","volume":"216","author":"Hua","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1242\/jcs.02401","article-title":"Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane","volume":"118","author":"Ozeki","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/febs.15313","article-title":"The Warburg Micro Syndrome-associated Rab3GAP-Rab18 module promotes autolysosome maturation through the Vps34 Complex I","volume":"288","author":"Boda","year":"2021","journal-title":"FEBS J."},{"key":"ref_345","doi-asserted-by":"crossref","unstructured":"Marchi, S., Giorgi, C., Oparka, M., Duszynski, J., Wieckowski, M.R., and Pinton, P. (2014). Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes. Mol. Cell. Oncol., 1.","DOI":"10.4161\/23723548.2014.956469"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/brain\/awu091","article-title":"A novel missense mutation confirms ATL3 as a gene for hereditary sensory neuropathy type 1","volume":"137","author":"Fischer","year":"2014","journal-title":"Brain"},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/brain\/awt357","article-title":"Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3","volume":"137","author":"Kornak","year":"2014","journal-title":"Brain"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s13238-015-0139-3","article-title":"Human atlastin GTPases mediate differentiated fusion of endoplasmic reticulum membranes","volume":"6","author":"Hu","year":"2015","journal-title":"Protein Cell"},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/j.celrep.2018.04.071","article-title":"Sensory-Neuropathy-Causing Mutations in ATL3 Cause Aberrant ER Membrane Tethering","volume":"23","author":"Krols","year":"2018","journal-title":"Cell Rep."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ng1196-269","article-title":"Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2","volume":"14","author":"Pulst","year":"1996","journal-title":"Nat. Genet."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.15252\/embr.201743903","article-title":"ER remodeling by the large GTPase atlastin promotes vacuolar growth of Legionella pneumophila","volume":"18","author":"Steiner","year":"2017","journal-title":"EMBO Rep."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1128\/IAI.00507-15","article-title":"Endoplasmic reticulum tubule protein reticulon 4 associates with the Legionella pneumophila vacuole and with translocated substrate Ceg9","volume":"83","author":"Haenssler","year":"2015","journal-title":"Infect. Immun."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"12039","DOI":"10.1073\/pnas.1709060114","article-title":"IncV, a FFAT motif-containing Chlamydia protein, tethers the endoplasmic reticulum to the pathogen-containing vacuole","volume":"114","author":"Stanhope","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_354","doi-asserted-by":"crossref","unstructured":"Derr\u00e9, I., Swiss, R., and Agaisse, H. (2011). The lipid transfer protein CERT interacts with the Chlamydia inclusion protein IncD and participates to ER-Chlamydia inclusion membrane contact sites. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002092"},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0125671","article-title":"STIM1 is a novel component of ER-Chlamydia trachomatis inclusion membrane contact sites","volume":"10","author":"Agaisse","year":"2015","journal-title":"PLoS ONE"},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"16291","DOI":"10.1073\/pnas.1011105107","article-title":"Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function","volume":"107","author":"Diaz","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1074\/jbc.M611145200","article-title":"Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication","volume":"282","author":"Tang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/s41564-019-0586-3","article-title":"ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly","volume":"4","author":"Neufeldt","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/tra.12694","article-title":"Cytosolic aggregates in presence of non-translocated proteins perturb endoplasmic reticulum structure and dynamics","volume":"20","author":"Mookherjee","year":"2019","journal-title":"Traffic"},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1083\/jcb.201704184","article-title":"Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions","volume":"217","author":"Xu","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1994.tb44398.x","article-title":"Calcium hypothesis of Alzheimer\u2019s disease and brain aging","volume":"747","author":"Khachaturian","year":"1994","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"14717","DOI":"10.1523\/JNEUROSCI.2770-14.2014","article-title":"Unique function of Kinesin Kif5A in localization of mitochondria in axons","volume":"34","author":"Campbell","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/nbdi.1998.0176","article-title":"Calcium responses in fibroblasts from asymptomatic members of Alzheimer\u2019s disease families","volume":"5","author":"Etcheberrigaray","year":"1998","journal-title":"Neurobiol. Dis."},{"key":"ref_364","doi-asserted-by":"crossref","unstructured":"Romero-Brey, I., and Bartenschlager, R. (2016). Endoplasmic reticulum: The favorite intracellular niche for viral replication and assembly. Viruses, 8.","DOI":"10.3390\/v8060160"},{"key":"ref_365","first-page":"425","article-title":"Tiny architects: Biogenesis of intracellular replicative niches by bacterial pathogens","volume":"42","author":"Martinez","year":"2018","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1111\/cmi.12318","article-title":"Reticulon 3 interacts with NS4B of the hepatitis C virus and negatively regulates viral replication by disrupting NS4B self-interaction","volume":"16","author":"Wu","year":"2014","journal-title":"Cell. Microbiol."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"12529","DOI":"10.1128\/JVI.01798-10","article-title":"Amphipathic \u03b1-Helix AH2 is a Major Determinant for the Oligomerization of Hepatitis C Virus Nonstructural Protein 4B","volume":"84","author":"Gouttenoire","year":"2010","journal-title":"J. Virol."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/ncb2339","article-title":"BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol","volume":"13","author":"Geiger","year":"2011","journal-title":"Nat. Cell Biol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/9\/2341\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:58:05Z","timestamp":1760165885000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/9\/2341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,7]]},"references-count":368,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["cells10092341"],"URL":"https:\/\/doi.org\/10.3390\/cells10092341","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,7]]}}}