{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:37:22Z","timestamp":1790393842461,"version":"4.1.0"},"reference-count":59,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research at King Khalid University","award":["RGP 01\/258\/42"],"award-info":[{"award-number":["RGP 01\/258\/42"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Cryptosporidiosis is caused by an opportunistic protozoan parasite (Cryptosporidium parvum and C. hominis) known as a parasite of humans, especially children and immunocompromised patients. The current study was designed to evaluate the therapeutic efficacy of a mixture of fig and olive leaf extracts as an alternative medicinal plant. Parasitological examination for oocysts in the stool and histopathological alterations in the small intestines were examined. Additionally, biochemical analyses of liver and kidney functions in addition to antioxidant parameters such as superoxide dismutase (SOD), glutathione peroxidase (GSH) and catalase (CAT) in the plasma were evaluated. Our results showed that marked reduction in oocysts shedding and amelioration in intestinal histopathological changes and hepatic or renal functions were detected in all treated groups compared to the control infected group. Additionally, the treated groups with tested extracts at ratios 1:3 and 1:5 showed a significant decrease in the number of oocysts compared to the other treated groups. Results exhibited a significant increase in the plasma SOD, CAT and GSH levels in treated groups compared to the infected control one. This study suggested that a mixture of fig and olive leaf extracts is a convenient promising therapeutic agent for Cryptosporidiosis.<\/jats:p>","DOI":"10.3390\/cells10092419","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T21:47:21Z","timestamp":1631656041000},"page":"2419","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Anticryptosporidium Efficacy of Olea europaea and Ficus carica Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative System"],"prefix":"10.3390","volume":"10","author":[{"given":"Wafaa Fayez","family":"Abd El-Hamed","sequence":"first","affiliation":[{"name":"Biological and Environmental Sciences Department, Faculty of Home Economics, Al-Azhar University, Tanta 31732, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahed Samy","family":"Yousef","sequence":"additional","affiliation":[{"name":"Food Science and Technology Department, Faculty of Home Economics, Al-Azhar University, Tanta 31732, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8197-7483","authenticated-orcid":false,"given":"Yasser S. A.","family":"Mazrou","sequence":"additional","affiliation":[{"name":"Business Administration Department, Community College, King Khalid University, Guraiger, Abha 62529, Saudi Arabia"},{"name":"Faculty of Agriculture, Tanta University, Tanta 31512, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa A. E. S.","family":"Elkholy","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine Al-Azhar University, Tanta 11754, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5074-7730","authenticated-orcid":false,"given":"Amal I.","family":"El-Refaiy","sequence":"additional","affiliation":[{"name":"Biological and Environmental Sciences Department, Faculty of Home Economics, Al-Azhar University, Tanta 31732, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten A.","family":"Elfeky","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science (Girls), Al-Azhar University, Tanta 11754, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-1677","authenticated-orcid":false,"given":"Muayad","family":"Albadrani","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, College of Medicine, Taibah University, Madinah 41541, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed I.","family":"El-Tokhy","sequence":"additional","affiliation":[{"name":"Plant Protection Department, Faculty of Agriculture, New Valley University, El-Kharga 72511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7295-6560","authenticated-orcid":false,"given":"Khaled","family":"Abdelaal","sequence":"additional","affiliation":[{"name":"Excellence Center (EPCRS), Plant Pathology and Biotechnology Laboratory, Faculty of Agriculture, Kafrelsheikh University, Kafr Elsheikh 33516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s11686-020-00315-x","article-title":"The Efficacy of Citrus maxima Peels Aqueous Extract Against Cryptosporidiosis in Immunecompromised Mice","volume":"66","author":"Hafez","year":"2021","journal-title":"Acta Parasitol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e2007807118","DOI":"10.1073\/pnas.2007807118","article-title":"The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6","volume":"118","author":"Sateriale","year":"2021","journal-title":"Proc. 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